Abstract:
:Chronic rejection is the leading cause of graft loss following pediatric kidney transplantation. Our group and others have demonstrated an association between the development of Abs to self-antigens and chronic rejection following adult lung and heart transplantation. The goal of this study was to determine whether Abs to kidney-associated self-antigens develop following pediatric renal transplantation. We investigated post-transplant development of Abs to kidney-associated self-antigens angiotensin II receptor type I, Fn, and collagen IV in a pediatric cohort. Using ELISA, we measured Abs to kidney-associated self-antigens in serum. Our cohort included 29 subjects with samples collected pretransplant and for 12 months post-transplant. No samples had Abs to kidney-associated self-antigen pretransplant. In contrast, 50% (10/20) of subjects developed Abs to one or more kidney-associated self-antigen post-transplantation. The median time to antibody appearance and duration of persistence were 103 and 61 days, respectively. Development of Abs did not correlate with graft function. Half of subjects developed Abs to kidney-associated self-antigens angiotensin II receptor type I, Fn, or collagen IV in the first year after kidney transplantation--a higher rate of early antibody development than expected. In this small study, Abs did not correlate with worse clinical outcomes.
journal_name
Pediatr Transplantjournal_title
Pediatric transplantationauthors
Hesemann LE,Subramanian V,Mohanakumar T,Dharnidharka VRdoi
10.1111/petr.12531subject
Has Abstractpub_date
2015-08-01 00:00:00pages
499-503issue
5eissn
1397-3142issn
1399-3046journal_volume
19pub_type
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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journal_title:Pediatric transplantation
pub_type: 杂志文章,评审
doi:10.1034/j.1399-3046.2002.1r058.x
更新日期:2002-02-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1046/j.1397-3142.2003.00125.x
更新日期:2004-02-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13009
更新日期:2017-09-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.12224
更新日期:2014-05-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13737
更新日期:2020-09-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章,meta分析
doi:10.1111/j.1399-3046.2007.00864.x
更新日期:2008-09-01 00:00:00
abstract::Clinical grading of GI involvement during acute GVHD remains a challenging issue, especially in children. Plasma citrulline, a non-protein amino acid selectively produced and released by enterocytes, is a suitable surrogate endpoint for small intestinal epithelial cell mass, irrespective of the underlying cause of cel...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.12128
更新日期:2013-11-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章,评审
doi:10.1111/petr.12333
更新日期:2014-11-01 00:00:00
abstract::We report on survival, rejection, lymphoma and renal function following cardiac transplant using a steroid-free maintenance immunosuppressive regimen. We have performed 73 cardiac transplants in 71 children under 16 yr of age in the last 12 yr. There were eight perioperative and four late deaths giving actuarial survi...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1034/j.1399-3046.2003.00014.x
更新日期:2003-02-01 00:00:00
abstract::Children and adolescents with renal disease experience daily social, emotional, and medical challenges. Renal transplantation can help to improve quality of life but requires a lifelong regimen of immunosuppressant medication to maintain health. Adherence to a daily complex regimen can be difficult, particularly for a...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13346
更新日期:2019-03-01 00:00:00
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journal_title:Pediatric transplantation
pub_type:
doi:10.1111/petr.13915
更新日期:2020-11-20 00:00:00
abstract::In 1999, our center implemented a policy of outpatient protocol biopsies as standard practice for the clinical management of pediatric renal allograft recipients. In order to determine the safety of this procedure, we conducted a retrospective chart audit of all outpatient renal allograft biopsies performed at our cen...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2006.00659.x
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Heart transplant waitlist mortality remains high in infants <1 year of age and among those with CHD. Currently, the median accepted donor-to-recipient weight percentage is approximately 130% of the recipient's weight. We hypothesized that patients with CHD may accept a larger organ using novel 3D-derived ima...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13639
更新日期:2020-02-01 00:00:00
abstract::This prospective observational study analyzed the pharmacokinetics of busulfan in Japanese children and evaluated the predicting accuracy of previous pediatric PPK models of busulfan. This study enrolled five patients (aged 2-12 years, BW 14-48 kg) receiving a busulfan-based conditioning regimen for hematopoietic stem...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13696
更新日期:2020-06-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.12137
更新日期:2013-11-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13110
更新日期:2018-03-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2005.00326.x
更新日期:2005-08-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2010.01317.x
更新日期:2011-02-01 00:00:00
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journal_title:Pediatric transplantation
pub_type:
doi:10.1111/petr.13474
更新日期:2019-08-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1034/j.1399-3046.2000.00076.x
更新日期:2000-02-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1034/j.1399-3046.2003.00090.x
更新日期:2003-08-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.12585
更新日期:2015-11-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.12520
更新日期:2015-08-01 00:00:00