Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury.

Abstract:

:Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two genders during ischemia/reperfusion injury. In male and female Wistar rats, renal ischemia was induced followed by a reperfusion period of two, eight, 16, 24, or 48 h. We applied flow cytometry to measure renin content and multiphoton imaging to visualize renin granules and changes of peritubular diameters in vivo during ischemia/reperfusion. Renin content decreased in CD in the first eight h of reperfusion; however, after 16 h, its amount increased. In males, the production of renin was more pronounced, and the duration of vasoconstriction was longer with a subsequent phase of vessel hyperdilation compared to females. Renal ischemia/reperfusion injury induces renin response not only in the JGA, but also in the CD segment. Renin production is more explicit in males than in females which, via increased angiotensin II production, might explain the different dynamism of renal vessel regulation between the two genders.

journal_name

Pediatr Transplant

authors

Csohány R,Prókai Á,Sziksz E,Balicza-Himer L,Pap D,Kosik A,Sugár D,Vannay Á,Kis-Petik K,Fekete A,Szabó AJ

doi

10.1111/petr.12712

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

619-26

issue

5

eissn

1397-3142

issn

1399-3046

journal_volume

20

pub_type

杂志文章
  • Comparison of generic tacrolimus and Prograf drug levels in a pediatric kidney transplant program: brief communication.

    abstract::A generic version of tacrolimus was approved for use in the USA in August 2009. These narrow therapeutic index generics are tested for bioequivalence only in adults. No data are available on generic tacrolimus levels in children with allografts. Four patients with stable renal allografts in our pediatric program were ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01393.x

    authors: Abdulnour HA,Araya CE,Dharnidharka VR

    更新日期:2010-12-01 00:00:00

  • Waiting for transplant: physical, psychosocial, and nutritional status considerations for pediatric candidates and implications for care.

    abstract::The waiting period for an organ transplant has been described as a time of tremendous uncertainty and vulnerability, posing unique challenges and stressors for pediatric transplant candidates and their families. It has been identified as the most stressful stage of the transplant journey, yet little attention has been...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12305

    authors: Anthony SJ,Annunziato RA,Fairey E,Kelly VL,So S,Wray J

    更新日期:2014-08-01 00:00:00

  • Single versus en bloc kidney transplant from donors less than or equal to 15 kg to pediatric recipients.

    abstract::With small kidneys, EBKTs could provide sufficient renal mass but could lead to inefficient use of resources, while SKTs could result in insufficient function due to small renal mass. We aimed to compare the outcomes of EBKT and SKT from small donors weighing ≤15 kg to pediatric recipients. We retrospectively reviewed...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13719

    authors: Mo H,Ko H,Chung CTY,Kim HK,Han A,Min S,Ha J

    更新日期:2020-05-06 00:00:00

  • Sleep quality is associated with psychosocial functioning and health-related quality of life in pediatric transplant recipients.

    abstract::This study examined patient-reported sleep quality in a single-center cross-sectional sample of adolescents with solid organ transplants and evaluated associations between sleep quality, psychosocial functioning (ie, depression/anxiety symptoms), and HRQOL. Health disparities associated with minority race/ethnicity an...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13577

    authors: Gutierrez-Colina AM,Quast LF,Eaton CK,LaMotte J,Stolz MG,Mee L,George R,Lee J,Reed B,Rich KL,Blount RL

    更新日期:2019-12-01 00:00:00

  • Mobilization of peripheral blood progenitor cells using 16 versus 10 mg/kg/d G-CSF in children with malignancies.

    abstract::Administration of hematopoietic growth factors, with or without chemotherapy, can augment progenitor cell numbers available for collection. The dose of granulocyte colony stimulating factor (G-CSF) used for mobilization of peripheral blood progenitor cells (PBPC) is controversial, and doses between 5 and 32 microg/kg/...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kurekci AE,Kiss JE,Koehler M

    更新日期:1998-05-01 00:00:00

  • The challenge of long-term follow-up of survivors of childhood acute leukemia after hematopoietic stem cell transplantation in resource-limited countries: A single-center report from Brazil.

    abstract::With the number of long-term HSCT survivors steadily increasing, attention needs to be focused on the late complications and quality of life. We therefore analyzed the outcome of 101 pediatric patients (<18 years old at the time of HSCT) transplanted for acute leukemia between 1981 and 2015 at Complexo Hospital de Clí...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13691

    authors: Marinho DH,Ribeiro LL,Nichele S,Loth G,Koliski A,Mousquer RTG,Funke VAM,Page K,Fasth A,Pasquini R,Boguszewski MCDS,Bonfim C

    更新日期:2020-06-01 00:00:00

  • Hematopoietic stem cell transplantation-associated thrombotic microangiopathy accompanied by renal arteriolar C4d deposition.

    abstract::HSCT-associated thrombotic microangiopathy (TA-TMA) is a severe complication with a poor prognosis. Recently, it has been reported that complement system dysregulation, such as CFH autoantibodies and deletions CFH-related genes 3 and 1, induced TA-TMA. In addition, C4d-positive renal arterioles are both a good marker ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12450

    authors: Sakamoto K,Imamura T,Osone S,Nishimura A,Nishida M,Ishida H,Hosoi H

    更新日期:2015-06-01 00:00:00

  • Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia.

    abstract::AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13291

    authors: Abu-Arja RF,Dargart JL,Bajwa RPS,Kahwash SB,Auletta JJ,Rangarajan HG

    更新日期:2018-12-01 00:00:00

  • Surgeon crossover between pediatric and adult centers is associated with decreased rate of loss to follow-up among adolescent renal transplantation recipients.

    abstract::The risk of adverse outcomes for pediatric renal transplant patients is highest during the transition from pediatric to adult care. While there have been many studies focus on graft failure and death, loss to follow-up likely plays a large role in patient outcomes. We hypothesize patients are lost to follow-up during ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13547

    authors: Hung YC,Williams JE,Bababekov YJ,Rickert CG,Chang DC,Yeh H

    更新日期:2019-11-01 00:00:00

  • Clinical features and mutational survey of NPHS2 (podocin) in Japanese children with focal segmental glomerulosclerosis who underwent renal transplantation.

    abstract::Recurrent FSGS is a major challenge in the field of nephrology. To clarify the role of NPHS2 defects in the pathogenesis of FSGS recurrence, we sequenced all eight exons of NPHS2 in 11 Japanese pediatric FSGS patients with or without post-transplant recurrence. All patients had biopsy-proven primary FSGS, had no famil...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00752.x

    authors: Furue T,Hattori M,Tsukaguchi H,Kitamura A,Oomori T,Ogino D,Nakakura H,Ashida A,Miura K,Hisano M,Takahashi K,Chikamoto H,Akioka Y,Sakano T

    更新日期:2008-05-01 00:00:00

  • Liver transplantation for neonatal hemochromatosis: analysis of the UNOS database.

    abstract::NH is the most common identifiable cause of ALF in the neonate. LT is the definitive treatment for neonates with NH who have failed medical therapy. Our aim was to determine the outcomes of LT in infants with NH. Patients (less than one yr of age) with NH who were listed for LT and patients who underwent LT between 19...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12418

    authors: Sheflin-Findling S,Annunziato RA,Chu J,Arvelakis A,Mahon D,Arnon R

    更新日期:2015-03-01 00:00:00

  • Parental functioning improves the developmental quotient of pediatric liver transplant recipients.

    abstract::Psychomotor development in pediatric liver transplant (LT) recipients depends on several factors. Our aim was to evaluate the importance of parental involvement and family dynamics on psychomotor development by assessing (i) children and parents individually, (ii) the parent-child relationship, and (iii) the correlati...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12080

    authors: Posfay-Barbe KM,Barbe RP,Wetterwald R,Belli DC,McLin VA

    更新日期:2013-06-01 00:00:00

  • Unexpectedly high prevalence of pretransplant abnormal glucose tolerance in pediatric kidney transplant recipients.

    abstract::Several studies suggested that the incidence of new-onset diabetes following pediatric kidney transplantation has increased markedly in recent years, with reported incidence of up to 20%. However, limited information is available regarding the incidence and features of pretransplant status of abnormal glucose toleranc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00459.x

    authors: Shishido S,Sato H,Asanuma H,Shindo M,Hataya H,Ishikura K,Hamasaki Y,Goto M,Ikeda M,Honda M

    更新日期:2006-02-01 00:00:00

  • Pre-stem cell transplantation enzyme replacement therapy in Hurler syndrome does not lead to significant antibody formation or delayed recovery of the endogenous enzyme post-transplant: a case report.

    abstract::Combined enzyme replacement therapy (ERT) and stem cell transplant (SCT) were done for a two year old boy with severe Hurler syndrome(HS) with the aim to decrease transplant related complications. He tolerated both the procedures well without any major complications. Urine glycosaminoglycans (GAGs) decreased post-tran...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00720.x

    authors: Soni S,Hente M,Breslin N,Hersh J,Whitley C,Cheerva A,Bertolone S

    更新日期:2007-08-01 00:00:00

  • The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease.

    abstract::We present the unique case of a pediatric patient who received chemotherapy for a diagnosis of CD, while mechanically supported with a Berlin EXCOR LVAD secondary to restrictive cardiomyopathy. A four-yr-old previously healthy male with restrictive cardiomyopathy required MCS after cardiac arrest but was diagnosed wit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12398

    authors: Thomas TO,Chandrakasan S,O'Brien M,Jefferies JL,Ryan TD,Wilmot I,Baker ML,Madueme PC,Morales D,Lorts A

    更新日期:2015-02-01 00:00:00

  • Prevalence of clinical rejection after surveillance biopsies in pediatric renal transplants: does early subclinical rejection predispose to subsequent rejection episodes?

    abstract::We analyzed rates of both SCR and CR in children receiving SB at three months post-transplant to determine if SCR predisposed patients to acute CR. Acute rejection was defined according to Banff criteria to include borderline classification or higher. All cases of SCR and CR were treated with anti-rejection protocols....

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01200.x

    authors: Hymes LC,Warshaw BL,Hennigar RA,Amaral SG,Greenbaum LA

    更新日期:2009-11-01 00:00:00

  • Liver transplantation as a treatment option for three siblings with homozygous familial hypercholesterolemia.

    abstract::FH is a hereditary inherited disorder of cholesterol metabolism. Homozygous form of the disease associates severe form of atherosclerotic disease. Clinicians have been tried to inhibit the progression of the homozygous FH with medical and surgical treatment. We here present three siblings with homozygous FH who were s...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01469.x

    authors: Küçükkartallar T,Yankol Y,Kanmaz T,Topaloğlu S,Acarli K,Kalayoglu M

    更新日期:2011-05-01 00:00:00

  • Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience.

    abstract::Delayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, some of the previous studies have shown that ELT seems to enhance platelet recovery for post-allogen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13962

    authors: Yaman Y,Elli M,Şahin Ş,Özdilli K,Bilgen H,Bayram N,Nepesov S,Anak S

    更新日期:2021-01-16 00:00:00

  • VPS 45-associated primary infantile myelofibrosis--successful treatment with hematopoietic stem cell transplantation.

    abstract::PMF of infancy is a recently described autosomal recessive disorder presenting with severe bone marrow failure, accelerated neutrophil apoptosis, and significant platelet dysfunction, caused by a mutation in the VPS45 gene. In this study, we update our group of patients with PMF, highlighting different aspects of this...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12169

    authors: Stepensky P,Simanovsky N,Averbuch D,Gross M,Yanir A,Mevorach D,Elpeleg O,Weintraub M

    更新日期:2013-12-01 00:00:00

  • Social framework of pediatric heart recipients who have survived more than 15 post-transplant years: A single-center experience.

    abstract::To evaluate social development of pediatric heart transplant (tx) recipients who have lived 15 or more years after transplantation. Among 498 pediatric patients, age less than 18 years, who underwent heart transplantation, at a single institution, 337 were performed between 1985 and 1998. We identified all who survive...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12853

    authors: Copeland H,Razzouk A,Beckham A,Chinnock R,Hasaniya N,Bailey L

    更新日期:2017-03-01 00:00:00

  • Stabilization of blood methylmalonic acid level in methylmalonic acidemia after liver transplantation.

    abstract::Methylmalonic acidemia with complete mutase deficiency (mut(0) type) is an inborn error of metabolism with high mortality and morbidity. LT has been suggested to be a solution to this disease, but elevation of urinary and blood MMA was still observed after LT. In this study, we measured dry blood spot MMA and its prec...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01227.x

    authors: Chen PW,Hwu WL,Ho MC,Lee NC,Chien YH,Ni YH,Lee PH

    更新日期:2010-05-01 00:00:00

  • Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.

    abstract:BACKGROUND:Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM:To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS:A re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00504.x

    authors: Olio DD,Gupte G,Sharif K,Murphy MS,Lloyd C,McKiernan PJ,Kelly DA,Beath SV

    更新日期:2006-09-01 00:00:00

  • Outcome of kidney transplantation in Canadian Aboriginal children in the province of British Columbia.

    abstract::Renal transplantation remains the therapy of choice for children and adolescents with ESRD. Differences in graft survival are observed in kidney transplant recipients of different race and ethnicities. Data in pediatric populations are limited and confounded by disparities in access to health care. We performed a retr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01074.x

    authors: Matsuda-Abedini M,Al-AlSheikh K,Hurley RM,Matsell DG,Chow J,Carter JE,Lirenman DS

    更新日期:2009-11-01 00:00:00

  • Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation.

    abstract::Impact of pretransplant splenectomy in patients with beta-thalassemia major undergoing an allogeneic SCT has never been addressed. Twenty-seven class III patients (29 transplants) had a pretransplant splenectomy. The outcome of these 29 transplants was compared with 76 transplants in class III who did not have a splen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00953.x

    authors: Mathews V,George B,Lakshmi KM,Viswabandya A,John JM,Sitaram U,Daniel D,Chandy M,Srivastava A

    更新日期:2009-03-01 00:00:00

  • Successful liver retransplantation for recurrent hepatopulmonary syndrome.

    abstract::HPS is defined as arterial hypoxemia because of pulmonary vasodilation as a result of cirrhotic or non-cirrhotic portal hypertension. This report describes a teenager with HPS because of primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome requiring OLT. HPS resolved completely within three months of O...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00790.x

    authors: Rajwal SR,Davison SM,Prasad R,Brownlee K,McClean P

    更新日期:2007-12-01 00:00:00

  • Improved outcomes in pediatric liver transplantation for acute liver failure.

    abstract:UNLABELLED:OLT is a life-saving option for ALF. AIM:To evaluate our outcomes in pediatric OLT for ALF. METHODS:Retrospective review of our data between 1992 and 2007. RESULTS:Of 142 children with ALF, 126 were listed, of which 40 spontaneously improved, nine died, and 77 underwent OLT (median waiting time four days)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01356.x

    authors: Miloh T,Kerkar N,Parkar S,Emre S,Annunziato R,Mendez C,Arnon R,Suchy F,Rodriguez-Laiz G,Del Rio Martin J,Sturdevant M,Iyer K

    更新日期:2010-11-01 00:00:00

  • Extracorporeal membrane oxygenation use in the first 24 hours following pediatric heart transplantation: Incidence, risk factors, and outcomes.

    abstract::Primary graft dysfunction following HTx is associated with significant morbidity and mortality. This study aimed to assess the incidence of, risk factors for, and outcomes of children requiring ECMO within 24 hours of HTx. This study utilized a linked PHIS/SRTR database of pediatric HTx recipients (2002-2016). Post-HT...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13414

    authors: Godown J,Bearl DW,Thurm C,Hall M,Feingold B,Soslow JH,Mettler BA,Smith AH,Profita EL,Singh TP,Dodd DA

    更新日期:2019-06-01 00:00:00

  • A clinical description of children with solid organ transplants who present with feeding disorder.

    abstract::Pediatric solid organ transplant recipients have long-standing malnutrition concerns related to their pretransplant medical status. The targeted nutrition therapy utilized pre-, peri-, and post-transplantation may have the adverse effect of impeding normally developing feeding skills, particularly in very young childr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13389

    authors: Lerret SM,Erato G,Goday PS,Silverman AH

    更新日期:2019-05-01 00:00:00

  • Approaches to graft-vs-host disease.

    abstract::Graft-vs-host disease (GVHD) is one of the most difficult problems in stem cell transplantation. It is best considered in the context of the normal immune response. The role of the immune system is to identify and eliminate foreign antigens. In the case of GVHD, the antigens are minor histocompatibility antigens (mHA)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2005.00441.x

    authors: Antin JH

    更新日期:2005-12-01 00:00:00

  • Portal vein phlebolithiasis found post-liver transplantation in the native liver of a child with biliary atresia.

    abstract::Biliary atresia is defined as partial or total obliteration of the extra-hepatic bile ducts. In advanced cases, liver transplantation (LTx) is considered the most appropriate treatment. This report describes a female patient whose biliary atresia and subsequent cirrhosis required LTx at 1 yr of age. Macroscopic inspec...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.t01-1-00020.x

    authors: Bilezikçi B,Demirhan B,Kiyici H,Haberal M

    更新日期:2001-02-01 00:00:00