Clinical features and mutational survey of NPHS2 (podocin) in Japanese children with focal segmental glomerulosclerosis who underwent renal transplantation.

Abstract:

:Recurrent FSGS is a major challenge in the field of nephrology. To clarify the role of NPHS2 defects in the pathogenesis of FSGS recurrence, we sequenced all eight exons of NPHS2 in 11 Japanese pediatric FSGS patients with or without post-transplant recurrence. All patients had biopsy-proven primary FSGS, had no family history of renal diseases or consanguinity, were steroid-resistant, and received living-related renal transplantation. The mean age at onset was 5.0 +/- 3.1 yr and mean age at renal transplantation was 10.4 +/- 4.1 yr. Mutational analysis of NPHS2 was performed using polymerase chain reaction and direct sequencing. We found a synonymous T/C polymorphism at alanine 318 (GCC to GCT) in seven of 11 patients but no other causative NPHS2 mutations. FSGS recurred immediately after transplant in seven patients, while the remaining four patients had no recurrence for 3.2-5.8 yr. There were no differences between recurrent and non-recurrent patients in the onset age and the interval from onset to ESRD. In conclusion, we detected no causative NPHS2 mutations in Japanese pediatric FSGS patients with or without post-transplant recurrence. Further studies on the involvement of other genes are required to better understand recurrent FSGS.

journal_name

Pediatr Transplant

authors

Furue T,Hattori M,Tsukaguchi H,Kitamura A,Oomori T,Ogino D,Nakakura H,Ashida A,Miura K,Hisano M,Takahashi K,Chikamoto H,Akioka Y,Sakano T

doi

10.1111/j.1399-3046.2007.00752.x

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

341-6

issue

3

eissn

1397-3142

issn

1399-3046

pii

PTR752

journal_volume

12

pub_type

杂志文章
  • Diagnostic disagreement between clinical standard histopathological- and retrospective assessment of histopathology-based gastrointestinal graft-versus-host disease in children.

    abstract:BACKGROUND:No previous paediatric study has evaluated the frequency of diagnostic disagreement between clinical standard histopathological assessment (CSHA) and retrospective, independent, histopathological assessment (RIHA) of gastrointestinal Graft-Versus-Host Disease (GI-GVHD) METHODS: In a retrospective cohort stud...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13824

    authors: Mårtensson T,Szakos A,Mellgren K,Toporski J,Arvidson J,Mattsson J,Gustafsson B,Casswall TH

    更新日期:2020-12-01 00:00:00

  • Inter-rater reliability of the Pediatric Transplant Rating Instrument (P-TRI): challenges to reliably identifying adherence risk factors during pediatric pre-transplant evaluations.

    abstract::The purpose of this study was to assess the inter-rater reliability of the P-TRI, a 17-item instrument developed to identify risk factors associated with poor treatment adherence in pediatric solid organ transplant candidates. Because factors influencing treatment adherence may vary with age, the 89 subject samples we...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01428.x

    authors: Fisher M,Storfer-Isser A,Shaw RJ,Bernard RS,Drury S,Ularntinon S,Horwitz SM

    更新日期:2011-03-01 00:00:00

  • Psychosocial predictors of medication adherence in pediatric heart and lung organ transplantation.

    abstract::Few studies have identified the psychosocial characteristics of those children and their families associated with future non-adherence to immunosuppressive medications following a heart or lung transplant. UNOS data and medical records information were used to test the association between patient and family psychosoci...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12899

    authors: Killian MO

    更新日期:2017-06-01 00:00:00

  • Castleman disease in a pediatric liver transplant recipient: a case report and literature review.

    abstract::Castleman disease is a rare hematologic disorder, closely linked to the HHV-8, and most commonly observed in immunocompromised individuals. Thirteen months following a liver transplant for CPS-1 defect, a 15-month-old boy presented with fevers, anemia, and growth retardation. Abdominal CT scan showed splenomegaly and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2011.01570.x

    authors: Bonatti HJ,Axt J,Hunter EB,Lott SL,Frangoul H,Gillis L,Correa H,Kelly B

    更新日期:2012-09-01 00:00:00

  • Cannulation of the aorta in organ donors with aortic and caval injuries at the time of procurement.

    abstract::Injuries sustained by major vessels during procurement pose a major threat to organ viability. Aortic and inferior vena cava lacerations produce rapid hemorrhage associated with hypoperfusion and ischemic damage. We describe a technique that will prevent such damage in the event of vascular mishaps. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.00016.x

    authors: Molmenti EP,Molmenti H,Marubashi S,Sanchez EQ,Gogel B,Goldstein RM,Levy MF,Fasola CG,Gonwa TA,Klintmalm GB

    更新日期:2001-10-01 00:00:00

  • National risk factors and estimated costs for redo ureteroneocystostomy after pediatric renal transplant.

    abstract::Approximately 800 pediatric renal transplants are performed annually in the United States. VUR or obstruction may cause graft failure requiring redo ureteroneocystostomy. We examined possible risk factors and cost using the PHIS national database. We examined the PHIS for 8.5 yr to determine the association between re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12522

    authors: Godebu E,Palazzi K,Bush R,Marietti S,Chiang G

    更新日期:2015-08-01 00:00:00

  • Evaluation of arterial structure and function in pediatric patients with end-stage renal disease on dialysis and after renal transplantation.

    abstract::CVD is a major cause of morbidity and mortality in pediatric patients with CKD. It is unclear whether vascular abnormalities in these patients are reversible, and if transplantation portends salutary effects on arterial function. We compared FMD, PWV, AI75, and CIMT in 15 dialysis (D), 14 transplant patients (T), and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01721.x

    authors: Tawadrous H,Kamran H,Salciccioli L,Schoeneman MJ,Lazar J

    更新日期:2012-08-01 00:00:00

  • Utility of thrombophilia screening in pediatric renal transplant recipients.

    abstract::Thrombosis after kidney transplantation may result in catastrophic outcomes, including graft loss. Thrombophilia has been implicated in post-transplant thrombosis; data, however, are inconclusive on the impact of acquired and inherited thrombophilia and resultant thrombosis in renal graft recipients. We aimed to evalu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13314

    authors: Bock ME,Bobrowski AE,Bhat R

    更新日期:2019-02-01 00:00:00

  • Immune-mediated nephropathies in kidney transplants: recurrent or de novo diseases.

    abstract::IMN contribute to ESRD in 13% children with renal transplant (txp). Recurrent or de novo IMN can cause graft dysfunction and/or failure, but the details regarding incidence, therapy, and outcome remain poorly understood. Retrospective single-center study of all pediatric kidney txp was carried out since 1998. Clinical...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12789

    authors: Roberti I,Vyas S

    更新日期:2016-11-01 00:00:00

  • Psychopathology, quality of life, and related factors in pediatric liver transplantation candidates and recipients.

    abstract:BACKGROUND:Liver transplantation (LT) has been accepted as a standard treatment of pediatric liver diseases that can progress to end-stage liver disease or lead to acute liver failure. However, there is a lack of studies clarifying quality of life (QoL) and the characteristics and the prevalence of common psychiatric d...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13633

    authors: Ünay M,Önder A,Gizli Çoban Ö,Atalay A,Sürer Adanir A,Artan R,Özatalay E

    更新日期:2020-02-01 00:00:00

  • Complications of Cryptosporidium infection after pediatric liver transplantation: Diarrhea, rejection, and biliary disease.

    abstract:BACKGROUND:Cryptosporidium enteritis can be devastating in the immunocompromised host. In pediatric liver transplant recipients, infection may be complicated by prolonged carriage of the parasite, rejection, and biliary tree damage and fibrosis. Herein, we report on six patients and their long-term outcomes following c...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13807

    authors: Fischer RT,Day JC,Wasserkrug H,Faseler M,Kats A,Daniel JF,Slowik V,Andrews W,Hendrickson RJ

    更新日期:2020-12-01 00:00:00

  • Liver transplantation for neonatal hemochromatosis: analysis of the UNOS database.

    abstract::NH is the most common identifiable cause of ALF in the neonate. LT is the definitive treatment for neonates with NH who have failed medical therapy. Our aim was to determine the outcomes of LT in infants with NH. Patients (less than one yr of age) with NH who were listed for LT and patients who underwent LT between 19...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12418

    authors: Sheflin-Findling S,Annunziato RA,Chu J,Arvelakis A,Mahon D,Arnon R

    更新日期:2015-03-01 00:00:00

  • A clinical description of children with solid organ transplants who present with feeding disorder.

    abstract::Pediatric solid organ transplant recipients have long-standing malnutrition concerns related to their pretransplant medical status. The targeted nutrition therapy utilized pre-, peri-, and post-transplantation may have the adverse effect of impeding normally developing feeding skills, particularly in very young childr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13389

    authors: Lerret SM,Erato G,Goday PS,Silverman AH

    更新日期:2019-05-01 00:00:00

  • Dyslipidemia after pediatric renal transplantation-The impact of immunosuppressive regimens.

    abstract::Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Dat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12914

    authors: Habbig S,Volland R,Krupka K,Querfeld U,Dello Strologo L,Noyan A,Yalcinkaya F,Topaloglu R,Webb NJ,Kemper MJ,Pape L,Bald M,Kranz B,Taylan C,Höcker B,Tönshoff B,Weber LT

    更新日期:2017-05-01 00:00:00

  • The use of porcine dermal collagen implants in assisting abdominal wall closure of pediatric renal transplant recipients with donor size discrepancy.

    abstract::Children may have kidneys transplanted from donors larger than themselves. Abdominal wall closure may be difficult, with risks of abdominal compartment syndrome and graft compromise. Meshes used to facilitate closure may cause dense intra-abdominal adhesions, making further surgery or peritoneal dialysis difficult. We...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00824.x

    authors: Pentlow A,Smart NJ,Richards SK,Inward CD,Morgan JD

    更新日期:2008-02-01 00:00:00

  • Successful treatment of influenza A virus by oseltamivir in bone marrow transplant recipients.

    abstract::INFVA is an important cause of pulmonary infections in patients receiving BMT, and is associated with considerable morbidity and mortality for a readily preventable and treatable infection. Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT. The aim of thi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01114.x

    authors: Mellouli F,Ouederni M,Dhouib N,Hajkacem MA,Slim A,Bejaoui M

    更新日期:2010-03-01 00:00:00

  • Immunization practices among pediatric transplant hepatologists.

    abstract::Vaccination of pediatric liver transplant candidates and recipients represents an opportunity to decrease infectious complications following transplant. Although vaccine recommendations exist, studies have shown that many transplant candidates and recipients are under-immunized. The goals of this study were to assess ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12765

    authors: Feldman AG,Kempe A,Beaty BL,Sundaram SS,Studies of Pediatric Liver Transplantation (SPLIT) Research Group.

    更新日期:2016-12-01 00:00:00

  • Preliminary quantitative investigation of predictors of treatment non-adherence in pediatric transplantation: a brief report.

    abstract::The examination of predictors of non-adherence in transplantation populations offers the potential to identify high-risk individuals and concomitantly generate effective adherence-promoting interventions. The present paper aggregated quantitative estimates of various correlates of treatment adherence in studies of ped...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1399-3046.2007.00864.x

    authors: Kahana SY,Frazier TW,Drotar D

    更新日期:2008-09-01 00:00:00

  • Comparative outcome analysis of pediatric kidney transplant in posterior urethral valves children with or without pretransplant Mitrofanoff procedure.

    abstract:BACKGROUND:Urinary diversion using catheterizable channel among posterior urethral valve (PUV) patients may help to alleviate the functional concerns of the bladder on the allograft. Herein, we review our series of PUV patients undergoing renal transplants at a single institution to determine outcomes between those wit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13798

    authors: Rickard M,Chua ME,Zu'bi F,Dos Santos J,Koyle MA,Lorenzo AJ,Farhat WA

    更新日期:2020-12-01 00:00:00

  • Ultrasonography, laboratory, and cholangiography correlation of biliary complications in pediatric liver transplantation.

    abstract::The aim of this study is to correlate the US, laboratory, and cholangiography findings in pediatric liver transplant patients with biliary complications, trying to identify reliable decision-making tools for the management of these complications. Retrospective review was carried out of US results in 39 consecutive pat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12421

    authors: Teplisky D,Urueña Tincani E,Halac E,Garriga M,Cervio G,Imventarza O,Sierre S

    更新日期:2015-03-01 00:00:00

  • Augmented immunosuppression and PTCY-based haploidentical hematopoietic stem cell transplantation for thalassemia major.

    abstract::Alternate donor HSCT for thalassemia major from a matched unrelated donor or haploidentical family donor is a feasible therapeutic option in children with no matched family donor. Aggressive pretransplant immunosuppression, reduced toxicity conditioning, and PTCY result in excellent thalassemia-free survival. We descr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13893

    authors: Vellaichamy Swaminathan V,Ravichandran N,Ramanan KM,Meena SK,Varla H,Ramakrishnan B,Jayakumar I,Uppuluri R,Raj R

    更新日期:2020-10-27 00:00:00

  • The development of eosinophilic colitis after liver transplantation in children.

    abstract::Tacrolimus-based immunosuppression in pediatric liver transplant recipients is known to be associated with EGID. Our goal was to determine the incidence, risk factors, and characteristics of EGID in our pediatric liver transplantation program. This study was a retrospective analysis of 38 pediatric liver transplant re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00693.x

    authors: Lee JH,Park HY,Choe YH,Lee SK,Lee SI

    更新日期:2007-08-01 00:00:00

  • Post-transplantation growth among pediatric recipients of liver transplantation.

    abstract::Improving a patient's quality-of-life (QOL) post-liver transplantation is of great importance. An aspect of improved QOL is the restoration of normal growth patterns in pediatric patients. To describe the post-transplantation growth patterns of 72 children included in the National Institute of Diabetes and Digestive a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00326.x

    authors: Evans IV,Belle SH,Wei Y,Penovich C,Ruppert K,Detre KM,National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database Team.

    更新日期:2005-08-01 00:00:00

  • Donor-specific HLA antibodies in paediatric cardiac transplant recipients are associated with poor graft survival.

    abstract::There is increasing evidence that DSA are associated with poor graft survival, although there are little data in children. We aimed to describe the incidence of DSA in this group and to determine correlation with graft survival. HLA antibodies were analysed in 59 paediatric cardiac transplant recipients. Mean age 10.4...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01446.x

    authors: Irving C,Carter V,Parry G,Hasan A,Kirk R

    更新日期:2011-03-01 00:00:00

  • Vesico-ureteral reflux in pediatric kidney transplants: clinical relevance to graft and patient outcome.

    abstract::From June 1985 to December 1998, 173 pediatric renal transplants were carried out in 170 patients at our center. From this pool, 73 patients (34 males and 39 females) with a follow-up of 48 months were examined. In all patients, ureteroneocystostomy was performed according to the Lich-Grégoire procedure. All patients ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.1999.00017.x

    authors: Fontana I,Ginevri F,Arcuri V,Basile G,Nocera A,Beatini M,Bonato L,Barocci S,Bertocchi M,Manolitsi O,Valente R,Draghi P,Gusmano R,Valente U

    更新日期:1999-08-01 00:00:00

  • Adaptive functioning and its correlates after intestine and liver transplantation.

    abstract::In this cross-sectional study, we compared levels of adaptive functioning and examined potential correlates of adaptive functioning in 18 pediatric intestine (ITX) and 22 liver (LTX) recipients transplanted between June 2003 and March 2009. Family caregivers completed the ABAS-II scale and provided socio-demographic i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12011

    authors: Shellmer DA,DeVito Dabbs A,Dew MA,Terhorst L,Noll RB,Kosmach-Park B,Mazariegos G

    更新日期:2013-02-01 00:00:00

  • Improved outcomes in pediatric liver transplantation for acute liver failure.

    abstract:UNLABELLED:OLT is a life-saving option for ALF. AIM:To evaluate our outcomes in pediatric OLT for ALF. METHODS:Retrospective review of our data between 1992 and 2007. RESULTS:Of 142 children with ALF, 126 were listed, of which 40 spontaneously improved, nine died, and 77 underwent OLT (median waiting time four days)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01356.x

    authors: Miloh T,Kerkar N,Parkar S,Emre S,Annunziato R,Mendez C,Arnon R,Suchy F,Rodriguez-Laiz G,Del Rio Martin J,Sturdevant M,Iyer K

    更新日期:2010-11-01 00:00:00

  • Parents in transition: Experiences of parents of young people with a liver transplant transferring to adult services.

    abstract::Predictors of successful transition from pediatric to adult services include ability to self-manage and engage with healthcare services. Parents have a key role in healthcare management throughout childhood and adolescence including encouraging development of self-management skills in their children. Transition to adu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12760

    authors: Wright J,Elwell L,McDonagh JE,Kelly DA,Wray J

    更新日期:2017-02-01 00:00:00

  • Outcomes of pediatric liver transplant are unaffected by the time or day of surgery.

    abstract:BACKGROUND:In adults, the time of day for LT does not affect post-transplant outcomes. Whether this is true or not in children is unknown. In this study, we aimed to evaluate if weekend and weeknight liver transplants are associated with worse patient and graft survival in children. METHODS:We interrogated the UNOS da...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13826

    authors: Rogers ME,Egberg MD,Sylvester F,Lichtman S,Lin FC

    更新日期:2020-12-01 00:00:00

  • Pediatric discard risk index for predicting pediatric liver allograft discard.

    abstract:BACKGROUND:Of the 600 pediatric candidates added to the liver waiting list annually, 100 will remain waiting while over 100 liver allografts are discarded, often for subjective reasons. METHODS:We created a risk index to predict discard to better optimize donor supply. We used the UNOS database to retrospectively anal...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13963

    authors: Malik T,Joshi M,Godfrey E,Galvan T,O'Mahony CA,Cotton R,Goss J,Rana A

    更新日期:2021-01-06 00:00:00