Psychosocial predictors of medication adherence in pediatric heart and lung organ transplantation.

Abstract:

:Few studies have identified the psychosocial characteristics of those children and their families associated with future non-adherence to immunosuppressive medications following a heart or lung transplant. UNOS data and medical records information were used to test the association between patient and family psychosocial characteristics and medication adherence. Medication adherence outcomes were obtained using the physician assessments in the UNOS data and measured through patient-level standard deviation scores of immunosuppressive medication blood levels. Complete data were collected on 105 pediatric heart and lung transplant recipients and their families. Multivariate, stepwise analyses were conducted with each adherence outcome. Physician reports of adherence were associated with age of the child at transplantation, parental education, two-parent families, significant psychosocial problems, and the pretransplant life support status of the child. The resulting model (χ2 =28.146, df=5, P<.001) explained approximately 39.5% of the variance in physician reports of adherence (Nagelkerke r2 =.395). Blood level standard deviation scores were predicted by age at transplant (F=5.624, P=.02, r2 =.05). Results point to the difficulties experienced by children and families when undergoing a heart or lung transplantation. Efforts to develop standardized and evidence-based pretransplant psychosocial assessments in pediatric populations are suggested, especially those surrounding familial risk factors.

journal_name

Pediatr Transplant

authors

Killian MO

doi

10.1111/petr.12899

subject

Has Abstract

pub_date

2017-06-01 00:00:00

issue

4

eissn

1397-3142

issn

1399-3046

journal_volume

21

pub_type

杂志文章
  • Proven Epstein-Barr encephalitis with negative EBV-DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia.

    abstract::We report a case of EBV encephalitis in a seven-yr-old child with Ph+ ALL. Two months after an allogeneic HSCT from his HLA mismatched mother, the patient showed an altered sensorium, generalized seizures, and a left hemiparesis. Brain MRI demonstrated multiple lesions highly suggestive for viral encephalitis. Blood a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12386

    authors: Barberi W,Perrone S,Iori AP,Torelli GF,Testi AM,Moleti ML,Ceglie T,Papoff P,Caresta E,Antonelli M,Gianno F,Melone A,Badiali M,Giangaspero F,Foà R,Gentile G

    更新日期:2015-02-01 00:00:00

  • ABPM vs office blood pressure to define blood pressure control in treated hypertensive paediatric renal transplant recipients.

    abstract::While 24-h ambulatory blood pressure monitoring (ABPM) is an established tool for monitoring antihypertensive therapy in adults, data in children are scarce. We retrospectively analysed whether office blood pressure (BP) is reliable for the diagnosis of BP control in 26 treated hypertensive paediatric renal transplant...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00595.x

    authors: Ferraris JR,Ghezzi L,Waisman G,Krmar RT

    更新日期:2007-02-01 00:00:00

  • Post-transplant lymphoproliferative disorder in children: recent outcomes and response to dual rituximab/low-dose chemotherapy combination.

    abstract::PTLD is a major complication after transplantation. Treatment options for PTLD are not standardized, usually sequential, starting with reduction in immunosuppression. Recently, we have used a dual combination of rituximab and reduced dose chemotherapy (R/C) directly after failed RI. We retrospectively identified 30 pe...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01370.x

    authors: Gupta S,Fricker FJ,González-Peralta RP,Slayton WB,Schuler PM,Dharnidharka VR

    更新日期:2010-11-01 00:00:00

  • Concomitant oral findings in children after cardiac transplant.

    abstract::Heart transplantations have been performed in the Centre for Paediatric Heart Surgery at the Justus Liebig University in Giessen (Germany) since 1988. For further consultation and therapy, some affected children subsequently present at the Polyclinic for Paediatric Dentistry. In all these cases problematic oral findin...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00429.x

    authors: Ansari F,Ferring V,Schulz-Weidner N,Wetzel WE

    更新日期:2006-03-01 00:00:00

  • Plasma cell-rich acute cellular rejection of a transplanted kidney associated with antibody to the red cell Kidd antigen.

    abstract::Plasma cell-rich acute cellular rejection of a transplanted kidney is described in association with the identification of serum antibody to the red cell Kidd antigen, Jk-b, which is also found in the kidney. This antibody was formed without a history of a recent blood transfusion or exposure to intravenous immunoglobu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00608.x

    authors: Hamilton MS,Singh V,Warady BA

    更新日期:2006-12-01 00:00:00

  • Outcomes of Pneumocystis jiroveci pneumonia infections in pediatric heart transplant recipients.

    abstract::PJP is known to cause significant morbidity and rarely death in immunosuppressed patients. The prevalence and outcomes of PJP in pediatric solid-organ transplant patients are not well established. This study utilizes data from the PHTS to establish the prevalence and outcome of PJP in pediatric heart transplant recipi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01589.x

    authors: Ng B,Dipchand A,Naftel D,Rusconi P,Boyle G,Zaoutis T,Edens RE

    更新日期:2011-12-01 00:00:00

  • Denying renal transplantation to an adolescent medical cannabis user: An ethical case study.

    abstract::Medical cannabis is now legal in over half of the United States. As more patients adopt this unconventional therapy, it is inevitable that potential transplant recipients will disclose their cannabis use during transplant evaluation. Transplant teams are tasked with the decision to utilize a pressure resource, often w...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13467

    authors: Ryan JE,Noeder M,Burke C,Stubblefield SC,Sulieman S,Miller EG

    更新日期:2019-08-01 00:00:00

  • Outcome of hematopoietic stem cell transplant in children with congenital heart disease.

    abstract::CHD is the most commonly occurring birth defect in the United States. Improvements in supportive care for CHD result in increasing numbers of survivors who may develop benign or malignant conditions for which HSCT is indicated. However, the ability of individuals with CHD to tolerate HSCT is unknown. Retrospective med...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01317.x

    authors: Guinan EC,Hewett EK,Domaney NM,Margossian R

    更新日期:2011-02-01 00:00:00

  • Hepatitis C viral recurrence in a pediatric patient following liver transplantation.

    abstract::Hepatitis C virus (HCV) infections are known to have a more benign course in children than in adults. Although the natural history of HCV recurrence after liver transplantation has been well studied in adult patients, much less is known about HCV recurrence after liver transplantation in pediatric patients. Herein, we...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00519.x

    authors: Udell IW,Barshes NR,Finegold MJ,Lee TC,Scott JD,Carter B,Karpen S,Goss JA

    更新日期:2006-08-01 00:00:00

  • Sirolimus for solid organ transplantation in children.

    abstract::Sirolimus represents a major advancement in the field of solid organ transplantation and is being used as a rescue agent for acute and chronic rejection as well as for primary immunosuppression with good graft outcome. Although initial studies with sirolimus were in adults, now significant data have accumulated on the...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00305.x

    authors: Gupta P,Kaufman S,Fishbein TM

    更新日期:2005-06-01 00:00:00

  • Bone mineral disorders in pediatric and adolescent renal transplant recipients.

    abstract::Incomplete resolution of abnormalities of mineral metabolism associated with CRF results in the relatively high prevalence of ROD in pediatric kidney recipients. This non-randomized, cross-sectional, and analytic-descriptive study on bone density, vitamin D, and mineral metabolism was performed in 57 children and adol...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01492.x

    authors: Derakhshan A,Behbahan AG,Lotfi M,Omrani GH,Fallahzadeh MH,Basiratnia M,Al-Hashemi GH

    更新日期:2011-06-01 00:00:00

  • Favorable four-yr outcome after renal transplantation in a patient with complement factor H antibody and CFHR1/CFHR3 gene mutation-associated HUS.

    abstract:UNLABELLED:aHUS is a clinical challenge for successful renal transplantation. CASE REPORT:A 14-yr-old girl lost her kidneys at the age of 7, due to CFH antibodies and CFH-related protein (CFHR1/CFHR3) homozygous deletion-associated aHUS. CFH, CFI, and MCP gene mutations were excluded. The patient was a candidate for r...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12537

    authors: Grenda R,Jarmużek W,Rubik J,Prokurat S,Miklaszewska M,Drozdz D,Zachwieja K,Ardissino G,Hofer J

    更新日期:2015-09-01 00:00:00

  • Re-evaluation of the indications for liver transplantation in Wilson's disease based on the outcomes of patients referred to a transplant center.

    abstract::The aim of this study was to re-evaluate the indications and timing of LT for WD. From 2000 to 2009, eight patients with WD who had been referred to our institution for LT were enrolled in this study. The mean patient age was 15.9 yr (range, 7-37 yr). Four patients could not receive LT, because there were no available...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12085

    authors: Ohya Y,Okajima H,Honda M,Hayashida S,Suda H,Matsumoto S,Lee KJ,Yamamoto H,Takeichi T,Mitsubuchi H,Asonuma K,Endo F,Inomata Y

    更新日期:2013-06-01 00:00:00

  • Evaluation of cardiac manifestations in pediatric liver transplant candidates.

    abstract::Knowledge concerning the involvement of the cardiovascular system in children awaiting liver transplant is limited. Therefore, no guidelines have been established on evaluating this group of patients for cardiac disease. This review examines the diverse cardiovascular manifestations of liver disease in children. We al...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2012.01667.x

    authors: Madan N,Arnon R,Arnon R

    更新日期:2012-06-01 00:00:00

  • Chronic Mycoplasma pneumoniae infection in a child after renal transplantation.

    abstract::Mycoplasma pneumoniae has rarely been reported in renal transplant recipients. We present the case of a 10-yr-old boy with a six-month history of chronic cough, recurrent pyrexia, and weight loss three yr after RTx. The patient's post-transplant course was complicated by recurrence of NS that resolved with plasmaphere...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01130.x

    authors: Schwerk N,Hartmann C,Baumann U,Pape L,Ehrich JH,Hansen G

    更新日期:2010-05-01 00:00:00

  • The value of 18F-FDG PET in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis.

    abstract::PTLD is a serious complication of both solid organ and BMT. This study assessed whether (18) F-FDG PET, when added to CT scan, had additional value in the initial evaluation of PTLD in pediatric patients and whether PET/CT at baseline can reliably guide biopsy. This retrospective study evaluated 34 consecutive pediatr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12611

    authors: Vali R,Punnett A,Bajno L,Moineddin R,Shammas A

    更新日期:2015-12-01 00:00:00

  • Association of mast cells and liver allograft rejection.

    abstract::MCs are important effector cells in a broad range of immune responses. Their role in liver allograft rejection is not clear. Twenty-one liver transplant recipients (mean age +/- s.d.; 10.2 +/- 4.1 yr) who experienced a rejection episode are included in this study. Biopsy specimens from normal livers (allograft biopsy ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00819.x

    authors: Arikan C,Nart D,Kilic M,Yuksekkaya HA,Aydogdu S

    更新日期:2008-05-01 00:00:00

  • Graft fibrosis in patients with biliary atresia after pediatric living-related liver transplantation.

    abstract::Although an LDLT can successfully treat biliary atresia (BA), some patients develop liver fibrosis or inflammation. To study the incidence and risk factors associated with these complications, we performed serial protocol biopsies. Twenty-four patients with BA who received a pediatric LDLT underwent protocol biopsies....

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01483.x

    authors: Ueno T,Tanaka N,Ihara Y,Takama Y,Yamada H,Mushiake S,Fukuzawa M

    更新日期:2011-08-01 00:00:00

  • Lipoprotein profile changes in children after renal transplantation in the modern immunosuppression era.

    abstract::There are little data on prevalence of dyslipidemia in pediatric kidney TX recipients in the modern IS era. LP profiles of 38 TX recipients receiving triple IS with MMF, prednisone, and tacrolimus were compared with those of 11 children on HD using mixed model multiple linear regression analysis of repeated measures a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00905.x

    authors: Sgambat K,He J,McCarter RJ,Moudgil A

    更新日期:2008-11-01 00:00:00

  • Plasmapheresis-resistant acute humoral rejection successfully treated with anti-C5 antibody.

    abstract::Even if kidney graft survival has improved during the last decades, sensitized pediatric patients are an emerging problem. We describe a 17-yr-old male who lost his first graft due to chronic rejection becoming hyperimmunized (CDC PRA 99.61%). A desensitization protocol based on high-dose IVIG, PP, and two Mabthera(®)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12187

    authors: Ghirardo G,Benetti E,Poli F,Vidal E,Della Vella M,Cozzi E,Murer L

    更新日期:2014-02-01 00:00:00

  • Calcineurin-inhibitor-induced pain syndrome after a second allogeneic bone marrow transplantation for a child with aplastic anemia.

    abstract::We report a 10-yr-old boy who developed CIPS after a second allogeneic BMT for severe aplastic anemia. He received the second BMT from the same HLA-matched sibling donor 16 months after the first BMT due to secondary graft failure. The preparative regimen for the second BMT consisted of fludarabine, cyclophosphamide, ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01009.x

    authors: Nishikawa T,Okamoto Y,Tanabe T,Shinkoda Y,Kodama Y,Tsuru Y,Kawano Y

    更新日期:2009-08-01 00:00:00

  • Liver failure and x-linked immunodeficiency type 47.

    abstract::Patients with defects in the ATP6AP1 gene have rarely been described. ATP6AP1-related disorders are a subtype of CDG, which result in enzyme deficiencies affecting multiple organ systems ranging from mild to life-threatening. Of the 13 patients described, all had hepatopathy, but this is the first case to be successfu...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13808

    authors: Gumm AJ,Basel DG,Thakrar P,Suchi M,Telega G

    更新日期:2020-12-01 00:00:00

  • Coronary artery involvement in chronic graft-versus-host disease presenting as sudden cardiac arrest.

    abstract::Graft-versus-host disease (GVHD) is related to considerable morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Cardiac complications associated with GVHD are uncommon, and coronary artery involvement is even more unusual. We report on a male pediatric patient with chronic GVHD who...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13474

    authors: Kim DH,You JJ,Im HJ,Ko JK

    更新日期:2019-08-01 00:00:00

  • Neonates with severe infantile hepatic hemangioendothelioma: limitations of liver transplantation.

    abstract::IHHE as the most common vascular tumor of the liver in infancy can present with acute postnatal liver and congestive heart failure. LTx may be a lifesaving option, but can be complicated by extrahepatic involvement and bleeding complications, especially in neonates. Here we discuss the benefit of LTx in cases of acute...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01039.x

    authors: Grabhorn E,Richter A,Fischer L,Krebs-Schmitt D,Ganschow R

    更新日期:2009-08-01 00:00:00

  • Mycophenolate mofetil and reduced doses of cyclosporine in pediatric liver transplantation with chronic renal dysfunction: changes in the immune responses.

    abstract::The aim of this study was to study the incidence of chronic renal dysfunction in patients with more than 5 yr of follow-up following liver transplantation and to evaluate the benefit of decreasing cyclosporine A (CsA) dose combined with mycophenolate mofetil (MMF) on renal function and immune response in these patient...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00172.x

    authors: Ferraris JR,Duca P,Prigoshin N,Tambutti ML,Boldrini G,Cardoni RL,D'Agostino D

    更新日期:2004-10-01 00:00:00

  • Sequential renal and bone marrow transplants in a child with Fanconi anemia.

    abstract::FA is an autosomal recessive disorder characterized by small stature and renal abnormalities. FA can lead to progressive bone marrow failure, myelodysplastic syndrome, or acute leukemia. Using a multidisciplinary team approach, we managed a 3-yr-old boy with FA who simultaneously developed renal and hematopoietic fail...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12619

    authors: Vincent CL,Primack WA,Hipps J,Kasow KA

    更新日期:2016-02-01 00:00:00

  • Long-term outcome after liver transplantation in children.

    abstract::Children (defined as under 18 yr of age) account for approximately 12.5% of all liver transplants in the United States. Even though the annual number of liver transplantation procedures remains relatively constant, the population of long-term survivors of liver transplantation has grown. Presently, the population of l...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2002.1r058.x

    authors: Bucuvalas JC,Ryckman FC

    更新日期:2002-02-01 00:00:00

  • Perioperative management in pediatric heart transplantation from 1988 to 2001: anesthetic experience in a single center.

    abstract::Pediatric cardiac transplantation is currently an accepted option for end-stage heart disease and congenital cardiac malformations. This report focuses on the anesthetic perioperative management in 12 yr. From 1988 to 2001 we performed 90 heart transplantations in 88 children, infants and neonates. The pediatric heart...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00155.x

    authors: Schindler E,Müller M,Akintürk H,Valeske K,Bauer J,Zickmann B,Hempelmann G

    更新日期:2004-06-01 00:00:00

  • Reno- and splenoportal anastomosis for a retransplant patient with situs inversus.

    abstract::PV thrombosis following pediatric LT is a serious complication that may lead to graft loss. LDLT poses limitations with regard to the availability of vein grafts for complex PV reconstructions. We herein report a unique reconstruction of the PV inflow in a one-yr-old boy with situs inversus undergoing re-LDLT. The inf...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.12703

    authors: Uchida H,Fukuda A,Sasaki K,Shigeta T,Hirata Y,Kanazawa H,Mali VP,Miyazaki O,Nosaka S,Sakamoto S,Mureo K

    更新日期:2016-06-01 00:00:00

  • Haploidentical hematopoietic stem cell transplantation for paediatric high-risk T-cell acute lymphoblastic leukaemia.

    abstract::Paediatric HR T-cell ALL demonstrates dismal prognosis with chemotherapy, and poor outcomes could be improved with allo-SCT. HID-SCT is an almost immediately available choice; however, few studies have focused on the outcomes of HID-SCT for paediatric HR T-ALL. Forty-eight consecutive HR T-ALL children who underwent H...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12704

    authors: Xu ZL,Huang XJ,Liu KY,Chen H,Zhang XH,Han W,Chen YH,Wang FR,Wang JZ,Wang Y,Chen Y,Yan CH,Xu LP

    更新日期:2016-06-01 00:00:00