Outcomes of pediatric liver transplant are unaffected by the time or day of surgery.

Abstract:

BACKGROUND:In adults, the time of day for LT does not affect post-transplant outcomes. Whether this is true or not in children is unknown. In this study, we aimed to evaluate if weekend and weeknight liver transplants are associated with worse patient and graft survival in children. METHODS:We interrogated the UNOS database for outcomes of pediatric liver transplants that occurred between 1988 and 2018. We excluded liver transplants in patients >17 years as well as all multiple organ transplants. We compared weeknight and weekday, as well as weekend transplant operations. We used Cox proportional hazard ratios to determine patient and graft survival by 7, 30, 90, and 365 days post-transplant after controlling for confounding factors. RESULTS:In total, 12,610 pediatric liver transplants were included in the analysis. A total of 4590 transplants occurred during weekdays, 3671 transplants occurred during weeknights, and 4349 occurred during weekends. After controlling for confounding variables, 1-year patient survival was not associated with worse outcomes if the transplant occurred on the weeknight (HR 0.94, 95%CI 0.74-1.21) or weekend (HR 0.95, 95%CI 0.75-1.20) compared to the weekday. One-year graft survival was also not associated with worse outcomes if the transplant occurred on the weeknight (HR 0.91, 95%CI 0.76-1.09) or weekend (HR 0.91, 95%CI 0.77-1.09) compared to the weekday. CONCLUSION:Weekday, weeknight, and weekend procedures resulted in similar 1-year survival rates. Pediatric patient and graft survival outcomes are not affected by the time or day of surgery.

journal_name

Pediatr Transplant

authors

Rogers ME,Egberg MD,Sylvester F,Lichtman S,Lin FC

doi

10.1111/petr.13826

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

e13826

issue

8

eissn

1397-3142

issn

1399-3046

journal_volume

24

pub_type

杂志文章
  • Transmission of clear cell tumor in a graft liver from cadaveric donor: case report.

    abstract::Neoplasms in children after organ transplantation are related to the type and intensity of immunosuppression and the donor-recipient serostatus, especially in relation to the Epstein-Barr virus. The patient was a two-yr-old female child with biliary atresia who underwent a liver transplantation from a female cadaver d...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2012.01711.x

    authors: Backes AN,Tannuri AC,de Mello ES,Gibelli NE,de Castro Andrade W,Tannuri U

    更新日期:2012-12-01 00:00:00

  • Hepatitis C viral recurrence in a pediatric patient following liver transplantation.

    abstract::Hepatitis C virus (HCV) infections are known to have a more benign course in children than in adults. Although the natural history of HCV recurrence after liver transplantation has been well studied in adult patients, much less is known about HCV recurrence after liver transplantation in pediatric patients. Herein, we...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00519.x

    authors: Udell IW,Barshes NR,Finegold MJ,Lee TC,Scott JD,Carter B,Karpen S,Goss JA

    更新日期:2006-08-01 00:00:00

  • The value of 18F-FDG PET in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis.

    abstract::PTLD is a serious complication of both solid organ and BMT. This study assessed whether (18) F-FDG PET, when added to CT scan, had additional value in the initial evaluation of PTLD in pediatric patients and whether PET/CT at baseline can reliably guide biopsy. This retrospective study evaluated 34 consecutive pediatr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12611

    authors: Vali R,Punnett A,Bajno L,Moineddin R,Shammas A

    更新日期:2015-12-01 00:00:00

  • The significance of a defect on DMSA scan in children with renal transplants.

    abstract::Since December 1995, pediatric renal transplant recipients in our unit have received a DMSA scan as soon as possible post-transplant in order to provide a baseline for comparison in the event of subsequent complications. We retrospectively reviewed the case notes and DMSA scans of the 45 patients who underwent a scan ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-3046.2003.00073.x

    authors: Hutchinson C,Beckett M,Kiratli P,Gordon I,Trompeter RS,Rees L

    更新日期:2003-12-01 00:00:00

  • Hematopoietic stem cell transplantation-associated thrombotic microangiopathy accompanied by renal arteriolar C4d deposition.

    abstract::HSCT-associated thrombotic microangiopathy (TA-TMA) is a severe complication with a poor prognosis. Recently, it has been reported that complement system dysregulation, such as CFH autoantibodies and deletions CFH-related genes 3 and 1, induced TA-TMA. In addition, C4d-positive renal arterioles are both a good marker ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12450

    authors: Sakamoto K,Imamura T,Osone S,Nishimura A,Nishida M,Ishida H,Hosoi H

    更新日期:2015-06-01 00:00:00

  • Maternal experiences of caring for a child with a ventricular assist device.

    abstract::The purpose of this study was to gain a deeper understanding of maternal experiences of caring for their child with a VAD at home as a bridge to transplant. A descriptive, qualitative study was conducted via telephone-recorded guided interviews. Participants were caring for or had a child with a VAD between 4 and 16 y...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13620

    authors: DiFusco LA,Saylor JL,Schell KA

    更新日期:2020-02-01 00:00:00

  • Anellovirus loads are associated with outcomes in pediatric lung transplantation.

    abstract::Anelloviruses are DNA viruses ubiquitously present in human blood. Due to their elevated levels in immunosuppressed patients, anellovirus levels have been proposed as a marker of immune status. We hypothesized that low anellovirus levels, reflecting relative immunocompetence, would be associated with adverse outcomes ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13069

    authors: Blatter JA,Sweet SC,Conrad C,Danziger-Isakov LA,Faro A,Goldfarb SB,Hayes D Jr,Melicoff E,Schecter M,Storch G,Visner GA,Williams NM,Wang D

    更新日期:2018-02-01 00:00:00

  • Approaches to acute liver failure in children.

    abstract::Acute liver failure (ALF) is a rare but often fatal disorder in childhood. Its aetiology includes infections, toxins, metabolic disorders, infiltrative diseases, autoimmune hepatitis, ischaemia, irradiation damage, but in a high proportion of cases it remains unknown. In contrast to adults, in children with ALF hepati...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00292.x

    authors: Dhawan A,Cheeseman P,Mieli-Vergani G

    更新日期:2004-12-01 00:00:00

  • Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia.

    abstract::AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13291

    authors: Abu-Arja RF,Dargart JL,Bajwa RPS,Kahwash SB,Auletta JJ,Rangarajan HG

    更新日期:2018-12-01 00:00:00

  • Airway plaque presenting after alteration of immunosuppression in a pediatric patient remote from heart transplantation.

    abstract::Success after solid organ transplantation is dependent on the proper balance of immunosuppression to prevent rejection of the allograft while limiting the risk of developing infections and malignancy. We present a 9-year-old girl, remote from transplant, who presented with airway plaque after a change in immunosuppres...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13046

    authors: Ryan TD,Absalon MJ,de Alarcon A,Gupta A,Peters AL,Lorts A,Danziger-Isakov LA,Chin C

    更新日期:2017-11-01 00:00:00

  • Vesico-ureteral reflux in pediatric kidney transplants: clinical relevance to graft and patient outcome.

    abstract::From June 1985 to December 1998, 173 pediatric renal transplants were carried out in 170 patients at our center. From this pool, 73 patients (34 males and 39 females) with a follow-up of 48 months were examined. In all patients, ureteroneocystostomy was performed according to the Lich-Grégoire procedure. All patients ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.1999.00017.x

    authors: Fontana I,Ginevri F,Arcuri V,Basile G,Nocera A,Beatini M,Bonato L,Barocci S,Bertocchi M,Manolitsi O,Valente R,Draghi P,Gusmano R,Valente U

    更新日期:1999-08-01 00:00:00

  • Towards minimizing immunosuppression in pediatric liver transplant recipients.

    abstract::Immunosuppression regimens after liver transplantation focus mainly on preventing rejection and subsequent graft loss. However, in children, morbidity and mortality rates from infections exceed those from rejection after transplant, and immunosuppression can hinder growth, renal function, and graft tolerance. We hypot...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01061.x

    authors: Turmelle YP,Nadler ML,Anderson CD,Doyle MB,Lowell JA,Shepherd RW

    更新日期:2009-08-01 00:00:00

  • Parents in transition: Experiences of parents of young people with a liver transplant transferring to adult services.

    abstract::Predictors of successful transition from pediatric to adult services include ability to self-manage and engage with healthcare services. Parents have a key role in healthcare management throughout childhood and adolescence including encouraging development of self-management skills in their children. Transition to adu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12760

    authors: Wright J,Elwell L,McDonagh JE,Kelly DA,Wray J

    更新日期:2017-02-01 00:00:00

  • New-onset diabetes mellitus presenting with diabetic ketoacidosis after pediatric liver transplantation.

    abstract::The development of NODM is a common metabolic complication after liver transplantation. Presentation of post-liver transplant diabetes mellitus with DKA is rare especially among pediatric patients. We reported three pediatric patients who presented with DKA after liver transplantation. The underlying diseases leading ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01117.x

    authors: Dehghani SM,Nikeghbalian S,Eshraghian A,Haghighat M,Imanieh MH,Bahador A,Kazemi K,Malek-Hosseini SA

    更新日期:2009-08-01 00:00:00

  • Minimum mycophenolic acid levels are associated with donor-specific antibody formation.

    abstract::Although de novo DSA are associated with inferior graft survival, there are no effective strategies to prevent their formation. Underexposure to MPA (prodrug: MMF) also contributes to rejection rates early after transplantation, but the effect of this phenomenon on the formation of DSA long-term post-transplantation i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12637

    authors: Filler G,Todorova EK,Bax K,Alvarez-Elías AC,Huang SH,Kobrzynski MC

    更新日期:2016-02-01 00:00:00

  • Latin American Registry of Pediatric Renal Transplantation 2004-2008.

    abstract:UNLABELLED:The Latin American Pediatric Nephrology Association (ALANEPE) reports the first regional kidney transplant registry in Latin America. A mean range of 75%, 30% to 100% renal transplant recipients under 21 yr old were included. Out of 20 countries invited to participate, 14 performed renal transplant, 11 had u...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01331.x

    authors: Latin American Pediatric Nephrology Association.,Latin American Pediatric Renal Transplant Cooperative Study.

    更新日期:2010-09-01 00:00:00

  • Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury.

    abstract::Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two gen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12712

    authors: Csohány R,Prókai Á,Sziksz E,Balicza-Himer L,Pap D,Kosik A,Sugár D,Vannay Á,Kis-Petik K,Fekete A,Szabó AJ

    更新日期:2016-08-01 00:00:00

  • Predictive value of pretransplantation cyclosporine pharmacokinetic studies on initial post-transplantation dosing in pediatric kidney allograft recipients.

    abstract::Despite the introduction of a variety of new immunosuppressive agents, cyclosporine A (CsA) has maintained a strong position in pediatric transplantation (Tx). Post-Tx dosing with CsA is a challenging task because of the narrow therapeutic window of the drug, the great individual variability of metabolism and the lack...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00025.x

    authors: Seikku P,Hoppu K,Jalanko H,Holmberg C

    更新日期:2003-04-01 00:00:00

  • Medication adherence in pediatric renal transplant patients: The role of family functioning and parent health locus of control.

    abstract::Children and adolescents with renal disease experience daily social, emotional, and medical challenges. Renal transplantation can help to improve quality of life but requires a lifelong regimen of immunosuppressant medication to maintain health. Adherence to a daily complex regimen can be difficult, particularly for a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13346

    authors: Kraenbring MM,Zelikovsky N,Meyers KEC

    更新日期:2019-03-01 00:00:00

  • Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient.

    abstract::EBV is associated with various malignancies in patients with acquired or induced immune impairment. EBV-SMT is very uncommon in immunocompromised patients, and a kidney localization has been described only anecdotally. We report the case of a 17-yr-old kidney transplant recipient diagnosed as having an EBV-SMT inside ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01213.x

    authors: Belingheri M,Comoli P,Locatelli F,Baldanti F,Martina V,Giani M,Ferraresso M,Cro L,Edefonti A,Ghio L

    更新日期:2010-12-01 00:00:00

  • Impact of pretransplant minimal residual disease on the post-transplant outcome of pediatric acute lymphoblastic leukemia.

    abstract::There are few reports on the clinical significance of MRD before HSCT in pediatric ALL. We retrospectively analyzed the clinical significance of FCM-based detection of MRD (FCM-MRD) before allogeneic HSCT in pediatric ALL. Of 38 pediatric patients who underwent allogeneic HSCT for the first time between 1998 and 2014,...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12732

    authors: Umeda K,Hiramatsu H,Kawaguchi K,Iwai A,Mikami M,Nodomi S,Saida S,Heike T,Ohomori K,Adachi S

    更新日期:2016-08-01 00:00:00

  • Case series and systematic review of acquired diaphragmatic hernia after liver transplantation.

    abstract:BACKGROUND:ADH is a rare and potentially fatal complication following LT. In this study, a systematic review was completed to identify risk factors which may contribute to ADH. METHODS:Transplant databases at three LT programs were reviewed. Four pediatric and zero adult cases were identified. Next, a systematic revie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13296

    authors: Emamaullee JA,Nekrasov V,Gilmour S,Kneteman N,Yanni G,Kohli R,Thomas D,Genyk Y

    更新日期:2018-12-01 00:00:00

  • Adolescent classroom education on knowledge and attitudes about deceased organ donation: a systematic review.

    abstract::In many countries, adolescents can choose to register a deceased organ donation wish when they apply for a driver's license. They often receive education about deceased organ donation in order to make an informed choice. The objective of this review was to describe the effectiveness of school-based educational program...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12045

    authors: Li AH,Rosenblum AM,Nevis IF,Garg AX

    更新日期:2013-03-01 00:00:00

  • Oseltamivir-resistant 2009 H1N1 influenza pneumonia during therapy in a renal transplant recipient.

    abstract::The emergence of oseltamivir-resistant 2009 H1N1 influenza virus (conferred by the H275Y substitution in NA) during therapy or prophylaxis in immunocompromised patients is a serious concern. The optimal therapy for immunosuppressed patients with oseltamivir-resistant 2009 H1N1 influenza virus is unknown and few option...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01489.x

    authors: Shetty AK,Ross GA,Pranikoff T,Gubareva LV,Sechrist C,Guirand DM,Abramson J,Lin JJ

    更新日期:2012-08-01 00:00:00

  • Percutaneous endovascular management of ascending aortic pseudoaneurysm after heart transplantation in a pediatric patient.

    abstract::Ascending aortic pseudoaneurysm is a rare complication after HT. Surgery is the most conventional management, but in some patients, it is risky. We report the case of a ten-year-old child who underwent HT and developed an ascending aortic pseudoaneurysm in the aortic anastomosis. He was successfully treated with two c...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13958

    authors: Skrabonja-Crespo A,Chavarri-Velarde F,Pinto-Salinas M,Tauma-Arrué A

    更新日期:2020-12-17 00:00:00

  • Preemptive plasmapheresis and recurrence of focal segmental glomerulosclerosis in pediatric renal transplantation.

    abstract::  FSGS has a high recurrence rate after renal transplantation. To examine the effects of the use of preemptive and post-transplant PP on recurrence and graft outcome, we conducted a retrospective study on 34 pediatric patients (mean age 13±5 yr) with biopsy-proven pretransplant FSGS and who underwent a renal transplan...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01478.x

    authors: Gonzalez E,Ettenger R,Rianthavorn P,Tsai E,Malekzadeh M

    更新日期:2011-08-01 00:00:00

  • Sirolimus for solid organ transplantation in children.

    abstract::Sirolimus represents a major advancement in the field of solid organ transplantation and is being used as a rescue agent for acute and chronic rejection as well as for primary immunosuppression with good graft outcome. Although initial studies with sirolimus were in adults, now significant data have accumulated on the...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00305.x

    authors: Gupta P,Kaufman S,Fishbein TM

    更新日期:2005-06-01 00:00:00

  • Hybrid stage 1 palliation as a bridge to cardiac transplantation in patients with high-risk single ventricle physiology.

    abstract:BACKGROUND:The hybrid stage 1 palliation for hypoplastic left heart syndrome (HLHS) was first described in 1993 as a bridge to heart transplant for HLHS. There are limited data on this strategy as primary heart transplantation for HLHS has become less common. METHODS:This is an observational, single-center study compa...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13307

    authors: Morray BH,Albers EL,Jones TK,Kemna MS,Permut LC,Law YM

    更新日期:2018-12-01 00:00:00

  • Longitudinal gonadal function after bone marrow transplantation for acute lymphoblastic leukemia during childhood.

    abstract::Total body irradiation and high-dose chemotherapy, applied as a preparatory regimen for bone marrow transplantation (BMT) in children with acute lymphoblastic leukemia (ALL), are particularly hazardous to the gonads and, in addition, can impair hypothalamo pituitary-gonadal control. Longitudinal data on pubertal devel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.1999.00006.x

    authors: Mayer EI,Dopfer RE,Klingebiel T,Scheel-Walter H,Ranke MB,Niethammer D

    更新日期:1999-02-01 00:00:00

  • Hepatic veno-occlusive disease.

    abstract::Hepatic veno-occlusive disease (VOD) after stem cell transplantation is a toxic manifestation of the conditioning regimen most probably emphasized by the allogeneic reaction. Its overall mortality rate is < 4% in adults as well as in children. Recent progress has been achieved in the diagnosis of this complication. Ho...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.1999.00077.x

    authors: Ribaud P,Gluckman E

    更新日期:1999-01-01 00:00:00