Immune-mediated nephropathies in kidney transplants: recurrent or de novo diseases.

Abstract:

:IMN contribute to ESRD in 13% children with renal transplant (txp). Recurrent or de novo IMN can cause graft dysfunction and/or failure, but the details regarding incidence, therapy, and outcome remain poorly understood. Retrospective single-center study of all pediatric kidney txp was carried out since 1998. Clinical presentation, pathology, therapy, and graft outcomes of children with recurrent or de novo IMN were reviewed. IMN was the primary etiology of ESRD in 28 of the 149 txp recipients. Eleven children had biopsy-proven post-txp IMN-six were recurrent and five had de novo. Presentation varied with changes in SCr and/or proteinuria. Initial therapy included higher doses of steroids, MMF, and tacrolimus. Outcome was excellent with only one late graft loss. Full remission was achieved in all other patients, but some had re-recurrence of the IMN. Median follow-up time was 11.8 years. IMN (recurrent or de novo) occurred in 7.4% (11 of 149) of all kidney txp performed at our center. IMN post-txp was often seen late post-txp, usually asymptomatic and noted to have relapsing pattern. Early diagnosis and prompt therapy resulted in excellent long-term outcome in children diagnosed with post-txp IMN.

journal_name

Pediatr Transplant

authors

Roberti I,Vyas S

doi

10.1111/petr.12789

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

946-951

issue

7

eissn

1397-3142

issn

1399-3046

journal_volume

20

pub_type

杂志文章
  • Multivisceral transplantation using a 2.9 kg neonatal donor.

    abstract::Prematurity and very low birthweight have often been considered relative contraindications to neonatal organ donation. Organ procurement from neonatal donors is further complicated by unclear guidelines regarding neonatal brain death. We report a successful case of multivisceral transplantation using a graft from a 10...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01739.x

    authors: Cauley RP,Suh MY,Kamin DS,Lillehei CW,Jenkins RL,Jonas MM,Vakili K,Kim HB

    更新日期:2012-12-01 00:00:00

  • Pediatric cardiac waitlist mortality-Still too high.

    abstract::Cardiac transplantation for children with end-stage cardiac disease with no other medical or surgical options is now standard. The number of children in need of cardiac transplant continues to exceed the number of donors considered "acceptable." Therefore, there is an urgent need to understand which recipients are in ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13671

    authors: Denfield SW,Azeka E,Das B,Garcia-Guereta L,Irving C,Kemna M,Reinhardt Z,Thul J,Dipchand AI,Kirk R,Davies RR,Miera O

    更新日期:2020-05-01 00:00:00

  • Combined heterotopic liver-pancreas transplantation as a curative treatment for liver cirrhosis and diabetes mellitus in cystic fibrosis.

    abstract::Cystic fibrosis (CF) is an inherited disease with a defect in epithelial chloride transport that results in a multisystem disease. Although pulmonary disease remains the primary cause of morbidity and mortality, focal biliary cirrhosis and portal hypertension may develop in up to 8% of these patients. Liver transplant...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12157

    authors: Henn C,Kapellen T,Prenzel F,Siekmeyer M,Hau HM,Kiess W,Bartels M

    更新日期:2014-02-01 00:00:00

  • Liver failure and x-linked immunodeficiency type 47.

    abstract::Patients with defects in the ATP6AP1 gene have rarely been described. ATP6AP1-related disorders are a subtype of CDG, which result in enzyme deficiencies affecting multiple organ systems ranging from mild to life-threatening. Of the 13 patients described, all had hepatopathy, but this is the first case to be successfu...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13808

    authors: Gumm AJ,Basel DG,Thakrar P,Suchi M,Telega G

    更新日期:2020-12-01 00:00:00

  • Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.

    abstract::In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left latera...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13384

    authors: Ocwieja KE,Vargas SO,Elisofon SA,Shulman DS,Lee CK,Fawaz R,Collins N,Vakili K,Sharma TS

    更新日期:2019-05-01 00:00:00

  • Small bowel transplantation in children.

    abstract::Small bowel transplantation has become a life-saving procedure for selected adults and children with intestinal failure who are intolerant to parental nutrition. There are few pediatric data available on the results of this procedure. In this article we review the background of intestinal transplantation, present the ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Atkison P,Chatzipetrou M,Tsaroucha A,Lehmann R,Tzakis A,Grant D

    更新日期:1997-11-01 00:00:00

  • Perceived barriers to medication adherence in pediatric and adolescent solid organ transplantation.

    abstract::Comparisons of perceived barriers to adherence in pediatric and adolescent SOT have not been systematically conducted despite association between medication non-adherence and poor outcome. Fifteen centers in CTOT-C enrolled patients in a cross-sectional study. Subjects' guardians completed the PMBS and subjects over e...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12648

    authors: Danziger-Isakov L,Frazier TW,Worley S,Williams N,Shellmer D,Dharnidharka VR,Gupta NA,Ikle D,Sweet SC,CTOTC-05 Consortium.

    更新日期:2016-03-01 00:00:00

  • Invasive mold infections in iatrogenically immunocompromised children: an eight-yr review.

    abstract::IMI are emerging as an important cause of mortality and morbidity among the growing number of immunocompromised children. A retrospective chart review was performed in all patients with a proven diagnosis of IMI over an eight-yr period (1997-2004) at The Hospital for Sick Children, Toronto, Canada to document the inci...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01056.x

    authors: Al-Rezqi A,Hawkes M,Doyle J,Richardson SE,Allen U

    更新日期:2009-08-01 00:00:00

  • Successful umbilical cord blood hematopoietic stem cell transplantation in pediatric patients with MDS/AML associated with underlying GATA2 mutations: two case reports and review of literature.

    abstract::Germline GATA2 mutations have been associated with a vast array of clinical manifestations, as well as hematological deficiencies and a propensity to AML or MDS. We present two cases of pediatric AML/MDS with underlying GATA2 mutations who underwent a successful umbilical cord hematopoietic stem cell transplantation u...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12764

    authors: Mallhi K,Dix DB,Niederhoffer KY,Armstrong L,Rozmus J

    更新日期:2016-11-01 00:00:00

  • Maternal experiences of caring for a child with a ventricular assist device.

    abstract::The purpose of this study was to gain a deeper understanding of maternal experiences of caring for their child with a VAD at home as a bridge to transplant. A descriptive, qualitative study was conducted via telephone-recorded guided interviews. Participants were caring for or had a child with a VAD between 4 and 16 y...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13620

    authors: DiFusco LA,Saylor JL,Schell KA

    更新日期:2020-02-01 00:00:00

  • Prevalence and outcomes of renal transplantation in children with intellectual disability.

    abstract::To describe the prevalence and outcomes of renal transplantation in children with ID we performed a retrospective cohort analysis of all children receiving a first kidney-alone transplant in the UNOS dataset from 2008 to 2011. Recipients with definite, probable, and without ID were compared using chi-square tests. Kap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12339

    authors: Wightman A,Young B,Bradford M,Dick A,Healey P,McDonald R,Smith J

    更新日期:2014-11-01 00:00:00

  • Focal segmental glomerulosclerosis associated with acute cytomegalovirus infection in a renal transplant.

    abstract::Focal segmental glomerulosclerosis (FSGS) occurring in association with cytomegalovirus (CMV) infection in a renal transplant patient with no previous history of FSGS has rarely been reported. We present a case of a 16-year-old renal transplant recipient who developed acute hepatitis, leukopenia, nephrotic syndrome, a...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13538

    authors: Wynd E,Stewart A,Burke J

    更新日期:2019-09-01 00:00:00

  • The development of eosinophilic colitis after liver transplantation in children.

    abstract::Tacrolimus-based immunosuppression in pediatric liver transplant recipients is known to be associated with EGID. Our goal was to determine the incidence, risk factors, and characteristics of EGID in our pediatric liver transplantation program. This study was a retrospective analysis of 38 pediatric liver transplant re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00693.x

    authors: Lee JH,Park HY,Choe YH,Lee SK,Lee SI

    更新日期:2007-08-01 00:00:00

  • Double-unit unrelated cord blood transplantation for thalassemia major: Comparison with HLA-identical sibling bone marrow transplantation.

    abstract::UCBT recipients with TM are at high risk of EF related to low number of stem cells and prior alloimmunization after multiple blood transfusions. Here, we evaluated the safety and efficacy of double-unit UCBT using TT-containing conditioning regimens in TM. Retrospective analysis of children who underwent double-unit U...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13901

    authors: Feng J,Lee V,Leung AWK,Lam GKS,Chow TTW,Cheng FWT,Yan CLS,Lee CK,Yuen PMP,Li CK

    更新日期:2020-11-02 00:00:00

  • Neuroradiologic findings in children with renal transplantation under 5 years of age.

    abstract::Chronic renal failure (CRF) is known to have adverse effects on the neurodevelopmental outcome of affected children. Some of these effects can be ameliorated by transplantation (TX). The cause and nature of the underlying brain injury is not known. We performed a brain magnetic resonance imaging (MRI) study on a group...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2003.00125.x

    authors: Valanne L,Qvist E,Jalanko H,Holmberg C,Pihko H

    更新日期:2004-02-01 00:00:00

  • Pharmacokinetic analysis for model-supported therapeutic drug monitoring of busulfan in Japanese pediatric hematopoietic stem cell transplantation recipients.

    abstract::This prospective observational study analyzed the pharmacokinetics of busulfan in Japanese children and evaluated the predicting accuracy of previous pediatric PPK models of busulfan. This study enrolled five patients (aged 2-12 years, BW 14-48 kg) receiving a busulfan-based conditioning regimen for hematopoietic stem...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13696

    authors: Kishimoto K,Hasegawa D,Irie K,Okada A,Nakamura S,Tamura A,Yamamoto N,Kozaki A,Saito A,Ishida T,Fukushima S,Kosaka Y

    更新日期:2020-06-01 00:00:00

  • Adolescent classroom education on knowledge and attitudes about deceased organ donation: a systematic review.

    abstract::In many countries, adolescents can choose to register a deceased organ donation wish when they apply for a driver's license. They often receive education about deceased organ donation in order to make an informed choice. The objective of this review was to describe the effectiveness of school-based educational program...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12045

    authors: Li AH,Rosenblum AM,Nevis IF,Garg AX

    更新日期:2013-03-01 00:00:00

  • Indications, results, and complications of tacrolimus conversion in pediatric renal transplantation.

    abstract::It is the practice of many pediatric renal transplant programs to 'convert' children taking cyclosporin A (CsA) to tacrolimus, although the indications for, outcome, and complications of this practice remain obscure. To better understand these aspects of tacrolimus 'conversion', a fax survey was sent to 119 North Amer...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Flynn JT,Bunchman TE,Sherbotie JR

    更新日期:2001-12-01 00:00:00

  • Arterioportal fistulae following segmental liver transplantation in a child.

    abstract::We report a case of arterio-portal fistulae in a 12-month-old-child following a segmental liver transplantation. The fistula, probably the result of mass ligature of a vascular pedicle during back table allograft reduction, is to our knowledge the first such case reported. Diagnosed on the third post-operative day, th...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.t01-2-00002.x

    authors: Mieles LA,Waldman D,Orloff MS

    更新日期:2002-10-01 00:00:00

  • C2 blood concentrations of orally administered cyclosporine in pediatric liver graft recipients with a body weight below 10 kg.

    abstract::Pharmacokinetic studies in adult and pediatric liver transplant recipients have shown that the C(2) monitoring is superior to the traditional determination of CsA trough levels (C(0)) as an estimate of CsA exposure. However, target reference values for C(2) in very small infants have not been established yet. The obje...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-3046.2003.00138.x

    authors: Ganschow R,Richter A,Grabhorn E,Schulz A,von Hugo A,Mir TS,Broering DC,Rogiers X,Hinrichs B,Burdelski M

    更新日期:2004-04-01 00:00:00

  • The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease.

    abstract::We present the unique case of a pediatric patient who received chemotherapy for a diagnosis of CD, while mechanically supported with a Berlin EXCOR LVAD secondary to restrictive cardiomyopathy. A four-yr-old previously healthy male with restrictive cardiomyopathy required MCS after cardiac arrest but was diagnosed wit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12398

    authors: Thomas TO,Chandrakasan S,O'Brien M,Jefferies JL,Ryan TD,Wilmot I,Baker ML,Madueme PC,Morales D,Lorts A

    更新日期:2015-02-01 00:00:00

  • Cannulation of the aorta in organ donors with aortic and caval injuries at the time of procurement.

    abstract::Injuries sustained by major vessels during procurement pose a major threat to organ viability. Aortic and inferior vena cava lacerations produce rapid hemorrhage associated with hypoperfusion and ischemic damage. We describe a technique that will prevent such damage in the event of vascular mishaps. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.00016.x

    authors: Molmenti EP,Molmenti H,Marubashi S,Sanchez EQ,Gogel B,Goldstein RM,Levy MF,Fasola CG,Gonwa TA,Klintmalm GB

    更新日期:2001-10-01 00:00:00

  • Long-term outcome after liver transplantation in children.

    abstract::Children (defined as under 18 yr of age) account for approximately 12.5% of all liver transplants in the United States. Even though the annual number of liver transplantation procedures remains relatively constant, the population of long-term survivors of liver transplantation has grown. Presently, the population of l...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2002.1r058.x

    authors: Bucuvalas JC,Ryckman FC

    更新日期:2002-02-01 00:00:00

  • Surgical treatment of primary liver tumors in children: outcomes analysis of resection and transplantation in the SEER database.

    abstract::Adjusted survival outcomes following hepatic resection and transplantation for pediatric liver tumors have not been compared. To address this question, we conducted a retrospective cohort study using the SEER registry. While SEER lacks certain specifics regarding staging, chemotherapy, comorbidities, and recurrence, i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12144

    authors: McAteer JP,Goldin AB,Healey PJ,Gow KW

    更新日期:2013-12-01 00:00:00

  • Renal function following liver transplantation in children.

    abstract::The literature regarding the etiology and incidence of short and long-term renal functional impairment in pediatric liver allograft recipients was reviewed. Most of the reports include recipients receiving cyclosporine as the primary immunosuppressant. Using calculated glomerular filtration rate (cGFR), creatinine cle...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2005.00381.x

    authors: Fine RN

    更新日期:2005-10-01 00:00:00

  • Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience.

    abstract::Delayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, some of the previous studies have shown that ELT seems to enhance platelet recovery for post-allogen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13962

    authors: Yaman Y,Elli M,Şahin Ş,Özdilli K,Bilgen H,Bayram N,Nepesov S,Anak S

    更新日期:2021-01-16 00:00:00

  • Single versus en bloc kidney transplant from donors less than or equal to 15 kg to pediatric recipients.

    abstract::With small kidneys, EBKTs could provide sufficient renal mass but could lead to inefficient use of resources, while SKTs could result in insufficient function due to small renal mass. We aimed to compare the outcomes of EBKT and SKT from small donors weighing ≤15 kg to pediatric recipients. We retrospectively reviewed...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13719

    authors: Mo H,Ko H,Chung CTY,Kim HK,Han A,Min S,Ha J

    更新日期:2020-05-06 00:00:00

  • What is the long-term outlook for young people following liver transplant? A single-centre retrospective analysis of physical and psychosocial outcomes.

    abstract::LT is a successful treatment for end-stage liver disease. The long-term outcome of patients transplanted in childhood has not previously been widely reported. This project assessed the long-term impact of transplantation in patients surviving >15 years. Retrospective data on growth, end-organ damage and psychosocial d...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13782

    authors: Ruth N,Sharif K,Legarda M,Smith M,Lewis P,Lloyd C,Mirza D,Kelly D

    更新日期:2020-11-01 00:00:00

  • Outcome of allogeneic hematopoietic stem cell transplantation for children with acute myelogenous leukemia in second complete remission: single center experience.

    abstract::We reviewed 26 consecutive patients with AML who were transplanted in second CR2 between 1994 and 2005. The most common conditioning regimen was CY and TBI. Median age at transplant was 8.9 yr (range 2.2-18.2). Nine patients received related donor, 16 patients received unrelated donors, and one patient received unrela...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01101.x

    authors: Ishaqi MK,Afzal S,Dupuis A,Doyle J,Gassas A

    更新日期:2009-12-01 00:00:00

  • Safety and utility of surveillance biopsies in pediatric kidney transplant patients.

    abstract::There is currently no way to diagnose a rejection before a change in serum creatinine. This had led some to start doing SB, but little data exist on the utility and safety of SB in pediatric patients. There is also little known on practice patterns of pediatric nephrologists. A retrospective review of pediatric kidney...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13178

    authors: Nazario M,Nicoara O,Becton L,Self S,Hill J,Mack E,Evans M,Twombley K

    更新日期:2018-06-01 00:00:00