Renal function following liver transplantation in children.

Abstract:

:The literature regarding the etiology and incidence of short and long-term renal functional impairment in pediatric liver allograft recipients was reviewed. Most of the reports include recipients receiving cyclosporine as the primary immunosuppressant. Using calculated glomerular filtration rate (cGFR), creatinine clearance or the serum creatinine level will lead to an overestimation of GFR. In contrast to data in adults, there are a limited number of pediatric recipients whose renal dysfunction has progressed to chronic kidney disease or end-state renal disease. Calcineurin inhibitors minimization has proven effective in reversing or preventing progressive deterioration of GFR; however, rejection episodes and complications have limited efficacy of this approach. Future multicenter studies using optimal GFR measurements are required to delineate the magnitude of renal dysfunction in pediatric recipients.

journal_name

Pediatr Transplant

authors

Fine RN

doi

10.1111/j.1399-3046.2005.00381.x

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

680-4

issue

5

eissn

1397-3142

issn

1399-3046

pii

PTR381

journal_volume

9

pub_type

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