Eight-year follow-up in pediatric living donor kidney recipients receiving alemtuzumab induction.

Abstract:

:Recipient lymphocytes are crucial for direct and indirect pathways of allorecognition. We proposed that the administration of alemtuzumab several weeks pretransplantation could eradicate peripheral lymphatic cells and promote donor-specific acceptance. This was a single-center, retrospective review of 101 consecutive living donor kidney transplantations in pediatric patients (age 7 months-18 years), performed between September 2006 and April 2010. IS protocol included two 30 mg doses of alemtuzumab: The first was given 12-29 days prior to transplantation, and the second at the time of transplantation. Maintenance IS was based on combination of low-dose CNI and mycophenolate, with steroids tapered over the first 5 days post-transplantation. Patients were followed for 7.8±1.3 years, and protocol biopsies were taken 1 month, 1, 3, and 5 years post-transplant. The Kaplan-Meier 8-year patient and graft survival rates in the cyclosporine-treated patients were 82.0±7.3% and 71.6±7.3, and in the tacrolimus-treated patients were 97.2±5.4 and 83.8±6.0%. Biopsy-proven acute rejection developed in 35% of cyclosporine-treated patients and in 8% of tacrolimus-treated patients. Alemtuzumab pretreatment prior to LRD kidney transplantation, followed by maintenance immunosuppression with tacrolimus and MMF, is associated with reasonable long-term results in pediatric patients.

journal_name

Pediatr Transplant

authors

Kaabak MM,Babenko NN,Shapiro R,Maschan AA,Zokoev AK,Schekaturov SV,Vyunkova JN,Dymova OV

doi

10.1111/petr.12941

subject

Has Abstract

pub_date

2017-08-01 00:00:00

issue

5

eissn

1397-3142

issn

1399-3046

journal_volume

21

pub_type

杂志文章
  • Comparison of generic tacrolimus and Prograf drug levels in a pediatric kidney transplant program: brief communication.

    abstract::A generic version of tacrolimus was approved for use in the USA in August 2009. These narrow therapeutic index generics are tested for bioequivalence only in adults. No data are available on generic tacrolimus levels in children with allografts. Four patients with stable renal allografts in our pediatric program were ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01393.x

    authors: Abdulnour HA,Araya CE,Dharnidharka VR

    更新日期:2010-12-01 00:00:00

  • Cardiac magnetic resonance imaging in children with chronic kidney disease and renal transplantation.

    abstract::CV disease is the major cause of death in patients with CKD. Recently, CMR imaging emerges as a complementary method providing advantages in cardiac assessment; however, data on CMR in pediatric CKD are scarce. We performed CMR in 15 children: two with CKD, six on peritoneal dialysis, seven on hemodialysis, and in 18 ...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-3046.2012.01672.x

    authors: Schaefer B,Rusai K,Toth A,Pasti K,Ujszaszi A,Kreko M,Horvath E,Sallay P,Reusz GS,Merkely B,Tulassay T,Szabo AJ

    更新日期:2012-06-01 00:00:00

  • Use of intravenous immunoglobulin in a highly sensitized pediatric renal transplant recipient with severe BK DNAemia and rising DSA.

    abstract::BK DNAemia in renal transplant recipients is a significant cause of allograft dysfunction and can lead to graft loss due to BK polyomavirus-associated nephropathy or to graft rejection due to immunosuppression reduction. Currently, the first-line treatment for BK DNAemia is immunosuppression reduction. Second-line tre...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13600

    authors: Piburn KH,Al-Akash S

    更新日期:2020-02-01 00:00:00

  • Early hepatic arterial thrombosis in liver transplantation: Systemic intravenous alteplase as a potential rescue treatment after failed surgical revascularization.

    abstract::eHAT is one of the most dreaded post-LT complication. Treatment approaches include retransplantation, revascularization, or observation. Systemic thrombolytic therapy is used in pediatric patients with thromboembolic events. However, there is no previous study reporting on the use of systemic r-tPA to treat eHAT. The ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13902

    authors: Feier FH,Melere MU,Trein CS,da Silva CS,Lucchese A,Horbe A,Tonet F,Ricachinevsky C,Ferreira CT,Chedid MF,Kalil AN

    更新日期:2020-10-27 00:00:00

  • Plasmapheresis-resistant acute humoral rejection successfully treated with anti-C5 antibody.

    abstract::Even if kidney graft survival has improved during the last decades, sensitized pediatric patients are an emerging problem. We describe a 17-yr-old male who lost his first graft due to chronic rejection becoming hyperimmunized (CDC PRA 99.61%). A desensitization protocol based on high-dose IVIG, PP, and two Mabthera(®)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12187

    authors: Ghirardo G,Benetti E,Poli F,Vidal E,Della Vella M,Cozzi E,Murer L

    更新日期:2014-02-01 00:00:00

  • Genetic variation and hematopoietic stem cell transplantation: expansion of the paradigm.

    abstract::Genetic variation has been the mainstay of hematopoietic stem cell transplantation since the first transplants were attempted. A significant expansion of genetic knowledge is under way, as the draft sequence of the human genome is annotated. Hematopoietic stem cell transplantation is a field that will greatly benefit ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.7.s3.4.x

    authors: Savage SA,Chanock S

    更新日期:2003-01-01 00:00:00

  • Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia.

    abstract::AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13291

    authors: Abu-Arja RF,Dargart JL,Bajwa RPS,Kahwash SB,Auletta JJ,Rangarajan HG

    更新日期:2018-12-01 00:00:00

  • Utility of thrombophilia screening in pediatric renal transplant recipients.

    abstract::Thrombosis after kidney transplantation may result in catastrophic outcomes, including graft loss. Thrombophilia has been implicated in post-transplant thrombosis; data, however, are inconclusive on the impact of acquired and inherited thrombophilia and resultant thrombosis in renal graft recipients. We aimed to evalu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13314

    authors: Bock ME,Bobrowski AE,Bhat R

    更新日期:2019-02-01 00:00:00

  • Post-transplant epididymitis and orchitis following Listeria monocytogenes septicaemia.

    abstract::We report the occurrence of epididymitis and orchitis 1 week after the onset of Listeriosis in an 11-month-old boy receiving an orthotopic liver transplantation for biliary atresia. Immunologic implications of Listeria monocytogenes-induced testicular inflammation are discussed, and the potential role of immunosuppres...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2000.00113.x

    authors: von Schnakenburg C,Hinrichs B,Fuchs J,Kardorff R

    更新日期:2000-05-01 00:00:00

  • Haploidentical hematopoietic stem cell transplantation for paediatric high-risk T-cell acute lymphoblastic leukaemia.

    abstract::Paediatric HR T-cell ALL demonstrates dismal prognosis with chemotherapy, and poor outcomes could be improved with allo-SCT. HID-SCT is an almost immediately available choice; however, few studies have focused on the outcomes of HID-SCT for paediatric HR T-ALL. Forty-eight consecutive HR T-ALL children who underwent H...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12704

    authors: Xu ZL,Huang XJ,Liu KY,Chen H,Zhang XH,Han W,Chen YH,Wang FR,Wang JZ,Wang Y,Chen Y,Yan CH,Xu LP

    更新日期:2016-06-01 00:00:00

  • School re-entry of the pediatric heart transplant recipient.

    abstract::Pediatric cardiac transplant has become increasingly frequent in the last decade and survival rates have improved remarkably. Outcome research on this population suggests that the majority of children have the capacity for healthy adaptation although 25-40% have been shown to have some type of psychiatric difficulties...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00586.x

    authors: Weil CM,Rodgers S,Rubovits S

    更新日期:2006-12-01 00:00:00

  • Hepatic osteodystrophy in chronic cholestasis: evidence for a multifactorial etiology.

    abstract::Children with cholestatic liver disease have been thought to develop hepatic osteodystrophy resulting from vitamin D and calcium malabsorption, resulting in secondary hyperparathyroidism and osteomalacia or rickets. However, treatment with vitamin D has not always proven successful in improving the bone disturbance. T...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.01060.x

    authors: Klein GL,Soriano H,Shulman RJ,Levy M,Jones G,Langman CB

    更新日期:2002-04-01 00:00:00

  • Multiple rare-earth magnet bead ingestion in a pediatric liver-small bowel-pancreas transplant recipient: A case report and lessons learned.

    abstract::Ingestion of rare-earth magnet beads in children has been a public health concern. The potential risk of swallowing multiple magnets is related to magnet attraction to each other, resulting in serious gastrointestinal complications, such as entero-enteric fistula formation, peritonitis, bowel ischemia or necrosis, bow...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13915

    authors: Miri A,Nakayuenyongsuk W,Vargas L,Langnas A,Vo HD

    更新日期:2020-11-20 00:00:00

  • Graft fibrosis in patients with biliary atresia after pediatric living-related liver transplantation.

    abstract::Although an LDLT can successfully treat biliary atresia (BA), some patients develop liver fibrosis or inflammation. To study the incidence and risk factors associated with these complications, we performed serial protocol biopsies. Twenty-four patients with BA who received a pediatric LDLT underwent protocol biopsies....

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01483.x

    authors: Ueno T,Tanaka N,Ihara Y,Takama Y,Yamada H,Mushiake S,Fukuzawa M

    更新日期:2011-08-01 00:00:00

  • The effects of gender on health-related quality of life in pediatric live-donor kidney transplantation: a single-center experience in a developing country.

    abstract::To evaluate the effects of gender on HRQOL and overall health status in our pediatric kidney transplants. We performed a cross-sectional study in 77 children who received living renal allo-transplants in our center between 1981 and 2003. The patients were given a questionnaire at a post-transplant visit. After complet...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01174.x

    authors: El-Husseini A,Hassan R,Sobh M,Ghoneim M

    更新日期:2010-03-01 00:00:00

  • Intraoperative blood loss and transfusion during primary pediatric liver transplantation: A single-center experience.

    abstract::Children undergoing liver transplantation are at a significant risk for intraoperative hemorrhage and thrombotic complications, we aim to identify novel risk factors for massive intraoperative blood loss and transfusion in PLT recipients and describe its impact on graft survival and hospital LOS. We reviewed all prima...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13449

    authors: Villarreal JA,Yoeli D,Ackah RL,Sigireddi RR,Yoeli JK,Kueht ML,Galvan NTN,Cotton RT,Rana A,O'Mahony CA,Goss JA

    更新日期:2019-06-01 00:00:00

  • The impact of donor age and sex on the nucleated cell count and CD34 count in healthy bone marrow donors.

    abstract::BM remains an important source of stem cells. The BM characteristics change with age but the estimation of CD34 calculation of one CD34+ cell per 100 nucleated cells is used for all donors including pediatric donors in the operating room before getting the actual CD34 count. In order to see whether this formula is app...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12453

    authors: Ince EU,Ileri T,Dogu F,Ates C,Cakmakli H,Dalva K,Ikinciogullari A,Uysal Z,Ertem M

    更新日期:2015-06-01 00:00:00

  • Renal function following liver transplantation in children.

    abstract::The literature regarding the etiology and incidence of short and long-term renal functional impairment in pediatric liver allograft recipients was reviewed. Most of the reports include recipients receiving cyclosporine as the primary immunosuppressant. Using calculated glomerular filtration rate (cGFR), creatinine cle...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2005.00381.x

    authors: Fine RN

    更新日期:2005-10-01 00:00:00

  • Second transplant with two unrelated cord blood units for early graft failure after cord blood transplantation for thalassemia.

    abstract::Early GF is a frequent complication following hematopoietic stem cell transplantation for patients with thalassemia. We report the outcome of double-unit CBT in three patients who developed early GF after CBT. The initial conditioning regimen consisted of i.v. Bu 14 mg/kg (day -9 to -6), i.v. Cy 200 mg/kg (day -5 to -...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01021.x

    authors: Jaing TH,Hung IJ,Yang CP,Tsai MH,Lee WI,Sun CF

    更新日期:2009-09-01 00:00:00

  • Prevalence and subtypes of BK virus in pediatric renal transplant recipients in Russia.

    abstract::BKV reactivation is associated with impaired graft function in kidney transplant patients. The objective of our study was to determine the prevalence of BKV infection in consecutive pediatric kidney transplant recipients at our center. Fifty-eight pediatric kidney transplant recipients were studied. The mean age at sc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01640.x

    authors: Momynaliev KT,Gorbatenko EV,Shevtsov AB,Gribanov OG,Babenko NN,Kaabak MM

    更新日期:2012-03-01 00:00:00

  • EBV-negative lymphoproliferative disease with hyper-IgA, in a child with combined liver and small bowel transplantation.

    abstract::A 4-year-old boy presented 14 months after liver and small bowel transplantation with fever, diarrhea, elevated liver enzymes, thrombocytopenia and autoantibodies. Total gammaglobulins level was normal but the level of plasma IgA1 was very high. The blood PCR for Epstein-Barr virus (EBV) was negative. The ileal biopsy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00174.x

    authors: Robert CD,Lacaille F,Canioni D,Quartier-dit-Maire P,Talbotec C,Goulet O

    更新日期:2004-06-01 00:00:00

  • The effect of peri-transplant plasmapheresis in the prevention of recurrent FSGS.

    abstract::Many pediatric centers utilize a variety of protocols including preemptive plasmapheresis to prevent the recurrence of FSGS post-transplant. But the effectiveness of this expensive, time-consuming process of plasmapheresis in the prevention of FSGS recurrence is still unclear. We retrospectively reviewed all pediatric...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13154

    authors: Verghese PS,Rheault MN,Jackson S,Matas AJ,Chinnakotla S,Chavers B

    更新日期:2018-05-01 00:00:00

  • Outcome of allogeneic hematopoietic stem cell transplantation for children with acute myelogenous leukemia in second complete remission: single center experience.

    abstract::We reviewed 26 consecutive patients with AML who were transplanted in second CR2 between 1994 and 2005. The most common conditioning regimen was CY and TBI. Median age at transplant was 8.9 yr (range 2.2-18.2). Nine patients received related donor, 16 patients received unrelated donors, and one patient received unrela...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01101.x

    authors: Ishaqi MK,Afzal S,Dupuis A,Doyle J,Gassas A

    更新日期:2009-12-01 00:00:00

  • Preparing for a kidney transplant: Medical nephrectomy in children with nephrotic syndrome.

    abstract::Nephrotic syndrome is characterized by proteinuria, hypoalbuminemia, and general edema. These symptoms may persist in children who reach ESRD, which is unfavorable for the patient's allograft outcome. In addition, this may hamper early diagnosis of a relapse after transplantation. Surgical bilateral nephrectomy is oft...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13703

    authors: Vos E,Koster-Kamphuis L,van de Kar NCAJ,Bootsma-Robroeks CMHHT,Cornelissen EAM,Schreuder MF

    更新日期:2020-06-01 00:00:00

  • Health-related quality of life among siblings of kidney transplant recipients.

    abstract::Studies are increasingly recognizing health-related quality of life (HRQOL) as a key pediatric outcome in both clinical and research settings and an essential health outcome measure to assess the effectiveness of medical treatment. However, it has not yet been studied among the healthy siblings of kidney transplant re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13734

    authors: Velasco J,Ferraris JR,Eymann A,Ghezzi LFR,Coccia PA,Ferraris V

    更新日期:2020-08-01 00:00:00

  • Antithrombotic management and thrombosis rates in children post-liver transplantation: A case series and literature review.

    abstract::Thrombosis is a major postoperative complication in pediatric liver transplantation. There is marked heterogeneity in prophylactic antithrombotic therapies used, without established guidelines. This review summarizes current worldwide incidence of thrombotic events and compares antithrombotic therapies in children pos...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13420

    authors: Flynn E,Huang JY,Hardikar W,Herd L,Hodgson A,Monagle P

    更新日期:2019-06-01 00:00:00

  • Cognitive and emotional outcome after pediatric liver transplantation.

    abstract::The aim of the study was to evaluate the cognitive and emotional development after pediatric liver transplantation. A total of 21 patients, aged 4-16.9 yr (median 9.6 yr) were tested 1-9 yr (median 4.2 yr) after the transplantation. The pretransplant diagnoses included biliary atresia (eight patients), various metabol...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00081.x

    authors: Adebäck P,Nemeth A,Fischler B

    更新日期:2003-10-01 00:00:00

  • Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant.

    abstract::Vascular complications remain the most common cause of early renal allograft loss in patients with end-stage renal failure. Underlying thrombophilic disorders increase the risk of early graft thrombosis. A male adolescent with high-risk thrombophilia because of combined heterozygous factor V Leiden (G1691A) and prothr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00398.x

    authors: John U,Kentouche K,Nowak G,Schubert J,Misselwitz J

    更新日期:2006-02-01 00:00:00

  • ABO-incompatible deceased donor pediatric liver transplantation: Novel titer-based management protocol and outcomes.

    abstract::ABO-ILT have re-emerged as an alternate option for select patients awaiting transplant. However, treatment protocols for children undergoing deceased donor ABO-ILT are not standardized. We implemented a novel IS protocol for children undergoing deceased donor ABO-ILT based on pretransplant IH titers. Children with hig...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13263

    authors: Mysore KR,Himes RW,Rana A,Teruya J,Desai MS,Srivaths PR,Zaruca K,Calvert A,Guffey D,Minard CG,Morita E,Hensch L,Losos M,Kostousov V,Hui SR,Orange JS,Goss JA,Nicholas SK

    更新日期:2018-11-01 00:00:00

  • Outcome after pediatric liver transplantation for staged abdominal wall closure with use of biological mesh-Study with long-term follow-up.

    abstract::Abdominal wall closure after pediatric liver transplantation (pLT) in infants may be hampered by graft-to-recipient size discrepancy. Herein, we describe the use of a porcine dermal collagen acellular graft (PDCG) as a biological mesh (BM) for abdominal wall closure in pLT recipients. Patients <2 years of age, who und...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13683

    authors: Gül-Klein S,Dziodzio T,Martin F,Kästner A,Witzel C,Globke B,Jara M,Ritschl PV,Henning S,Gratopp A,Bufler P,Schöning W,Schmelzle M,Pratschke J,Öllinger R

    更新日期:2020-05-01 00:00:00