Cognitive and emotional outcome after pediatric liver transplantation.

Abstract:

:The aim of the study was to evaluate the cognitive and emotional development after pediatric liver transplantation. A total of 21 patients, aged 4-16.9 yr (median 9.6 yr) were tested 1-9 yr (median 4.2 yr) after the transplantation. The pretransplant diagnoses included biliary atresia (eight patients), various metabolic diseases (n = 6), acute liver failure (n = 3), and miscellaneous (n = 4). The cognitive functions were tested with Wechsler preschool and primary scale of intelligence (WPPSI)-R or Wechsler intelligence scale for children (WISC)-III according to age. The Piers-Harris self-concept scale and the evaluation of human figure drawings according to Koppitz were used to detect emotional problems. All tests in all patients were performed by the same psychologist. A significantly lower result on cognitive tests was seen when compared with the expected normal values (p < 0.01). The number of patients with results within or under the lower normal range was higher than expected. Although the mean value of the Piers-Harris self-concept scale was normal, there was a large spread within the group. Indicators of emotional problems were found in the human figure drawings of 50% of the patients. To some extent, low cognitive scores coincided with low scores on self-concept scale and indicators of emotional difficulties. We conclude that the high degree of cognitive and emotional problems after liver transplantation is an important argument for routine psychologic follow-up and support in these patients.

journal_name

Pediatr Transplant

authors

Adebäck P,Nemeth A,Fischler B

doi

10.1034/j.1399-3046.2003.00081.x

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

385-9

issue

5

eissn

1397-3142

issn

1399-3046

journal_volume

7

pub_type

杂志文章
  • Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging.

    abstract:UNLABELLED:Liver transplantation treats the hepatic affectation of UCDs; however, irreversible neurologic damage pretransplant is difficult to assess providing transplant teams with ethical dilemmas for liver transplantation. The purpose of our study was to determine whether pretransplant neuroimaging can predict devel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12520

    authors: Bolton SM,Campbell KM,Kukreja M,Kohli R

    更新日期:2015-08-01 00:00:00

  • Sirolimus for solid organ transplantation in children.

    abstract::Sirolimus represents a major advancement in the field of solid organ transplantation and is being used as a rescue agent for acute and chronic rejection as well as for primary immunosuppression with good graft outcome. Although initial studies with sirolimus were in adults, now significant data have accumulated on the...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00305.x

    authors: Gupta P,Kaufman S,Fishbein TM

    更新日期:2005-06-01 00:00:00

  • Prelisting predictions of early postoperative survival in infant heart transplantation using classification and regression tree analysis.

    abstract::Infants listed for heart transplantation experience high waitlist and early post-transplant mortality, and thus, optimal allocation of scarce donor organs is required. Unfortunately, the creation and validation of multivariable regression models to identify risk factors and generate individual-level predictions are ch...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13105

    authors: Chen CK,Manlhiot C,Mital S,Schwartz SM,Van Arsdell GS,Caldarone C,McCrindle BW,Dipchand AI

    更新日期:2018-03-01 00:00:00

  • Recurrent and de novo disease after renal transplantation: a report from the Renal Allograft Disease Registry.

    abstract::Recurrent and de novo disease is an increasing problem and is known to negatively impact transplant graft survival. Immunosuppressive medications have not had an impact on the prevalence of recurrent and de novo disease. Renal Allograft Disease Registry (RADR) was established to study the prevalence, impact and risk f...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00180.x

    authors: Hariharan S,Savin VJ

    更新日期:2004-08-01 00:00:00

  • Graft fibrosis in patients with biliary atresia after pediatric living-related liver transplantation.

    abstract::Although an LDLT can successfully treat biliary atresia (BA), some patients develop liver fibrosis or inflammation. To study the incidence and risk factors associated with these complications, we performed serial protocol biopsies. Twenty-four patients with BA who received a pediatric LDLT underwent protocol biopsies....

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01483.x

    authors: Ueno T,Tanaka N,Ihara Y,Takama Y,Yamada H,Mushiake S,Fukuzawa M

    更新日期:2011-08-01 00:00:00

  • Immune-mediated hemolytic anemia in pediatric renal transplantation.

    abstract::The aim of the study was to demonstrate clinical course of the first reported cases of PLS in pediatric kidney transplantation and therapeutic outcome for such condition using a combination of high-dose corticosteroid and tacrolimus. We report a single case (a nine-year-old Thai boy) with end-stage kidney disease seco...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00560.x

    authors: Pattaragarn A,Viprakasit V,Supavekin S,Sumboonnanonda A

    更新日期:2006-09-01 00:00:00

  • Factors predicting health-related quality of life in pediatric liver transplant recipients in the functional outcomes group.

    abstract::Data from 997 pediatric LT recipients were used to model demographic and medical variables as predictors of lower levels of HRQOL. Data were collected through SPLIT FOG project. Patients were between 2 and 18 yr of age and survived LT by at least 12 months. Parents and children (age ≥ 8 yr) completed PedsQL™ 4.0 Gener...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12126

    authors: Alonso EM,Martz K,Wang D,Yi MS,Neighbors K,Varni JW,Bucuvalas JC,Studies of Pediatric Liver Transplantation (SPLIT) Functional Outcomes Group (FOG).

    更新日期:2013-11-01 00:00:00

  • Frequency of urinary tract infection in pediatric liver transplantation candidates.

    abstract::An increased frequency of infections has been reported in patients with chronic liver disease. The tendency of patients in this population to acquire UTI is not completely understood. We aimed at investigating the incidence of UTI in children with cirrhosis, before liver transplantation. Twenty-six children (9 girls, ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00674.x

    authors: Baskin E,Ozçay F,Sakalli H,Agras PI,Karakayali H,Canan O,Haberal M

    更新日期:2007-06-01 00:00:00

  • Micronutrient deficiencies in pediatric and young adult intestinal transplant patients.

    abstract::Intestinal transplant recipients are at risk of micronutrient deficiency due to the slow process of post-transplant adaptation. Another contributing factor is calcineurin inhibitor-induced renal tubular dysfunction. Patients are typically supplemented with micronutrients during PN; however, the risk of deficiency may ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12132

    authors: Ubesie AC,Cole CR,Nathan JD,Tiao GM,Alonso MH,Mezoff AG,Henderson CJ,Kocoshis SA

    更新日期:2013-11-01 00:00:00

  • Successful liver retransplantation for recurrent hepatopulmonary syndrome.

    abstract::HPS is defined as arterial hypoxemia because of pulmonary vasodilation as a result of cirrhotic or non-cirrhotic portal hypertension. This report describes a teenager with HPS because of primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome requiring OLT. HPS resolved completely within three months of O...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00790.x

    authors: Rajwal SR,Davison SM,Prasad R,Brownlee K,McClean P

    更新日期:2007-12-01 00:00:00

  • Virologic response with 2 different cidofovir dosing regimens for preemptive treatment of adenovirus DNAemia in pediatric solid organ transplant recipients.

    abstract::ADV is frequently seen in our pediatric SOT population. It presents in a variety of clinical presentation and can cause severe disease. In this population, there are very few studies to determine the safety of CDV as a potential therapeutic agent. We present the findings of our retrospective study evaluating the effic...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13231

    authors: Guerra Sanchez CH,Lorica CD,Arheart KL,Perez MM,Tekin A,Gonzalez IA

    更新日期:2018-06-03 00:00:00

  • Successful transplantation of a cadaveric kidney with post-infectious glomerulonephritis.

    abstract::This report describes a successful renal Tx in a patient with chronic renal failure, caused by dysplastic kidneys, who received a cadaveric kidney with post-infectious glomerulonephritis. Sequential renal biopsies were performed at 12 h before Tx, and at 1 h and on days 8 and 58 post-Tx. Post-operative hematuria disap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2000.00076.x

    authors: Mizuiri S,Shigetomi Y,Sugiyama K,Miyagi M,Hatano T,Tajima E,Aikawa A,Ohara T,Kawamura S,Hasegawa A

    更新日期:2000-02-01 00:00:00

  • Evaluation of a three-session biliary dilation protocol following transplant-related biliary stricture in pediatric patients.

    abstract::To evaluate whether a serial biliary dilation protocol improves outcomes and decreases total biliary drainage time for biliary strictures following pediatric liver transplantation. From 2006 to 2016, 213 orthotopic deceased and living related liver transplants were performed in 199 patients with a median patient age o...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13551

    authors: Reis SP,Bruestle K,Brejt S,Tulin-Silver S,Frenkel J,Mobley DG,England RW,Sobolevsky S,Griesemer AD,Sperling D,Schlossberg P,Susman J,Weintraub JL

    更新日期:2019-11-01 00:00:00

  • High depression rates among pediatric renal replacement therapy patients: A cross-sectional study.

    abstract::Depression is common in pediatric chronic kidney disease (CKD) patients. Depression is associated with inferior long-term outcomes. There is a paucity of studies that evaluate depression and possible associated factors in children and adolescents requiring renal replacement therapy (RRT). Cross-sectional study using C...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13591

    authors: Rodriguez Cuellar CI,García de la Puente S,Hernández Moraria J,Bojórquez Ochoa A,Filler G,Zaltzman Grishevich S

    更新日期:2019-12-01 00:00:00

  • Renal retransplantation of children: is a policy 'first cadaver donor, then live donor' an acceptable option?

    abstract::Retransplantation is often a necessity for children with end-stage renal disease (ESRD), as kidney graft survival is still not infinite. If a suitable live donor is present, the current policy is to use the live donor first, in order to obtain excellent long-term outcome and to prevent human leucocyte antigen (HLA) se...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.00049.x

    authors: De Meester J,Smits JM,Offner G,Persijn GG

    更新日期:2001-06-01 00:00:00

  • Maternal experiences of caring for a child with a ventricular assist device.

    abstract::The purpose of this study was to gain a deeper understanding of maternal experiences of caring for their child with a VAD at home as a bridge to transplant. A descriptive, qualitative study was conducted via telephone-recorded guided interviews. Participants were caring for or had a child with a VAD between 4 and 16 y...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13620

    authors: DiFusco LA,Saylor JL,Schell KA

    更新日期:2020-02-01 00:00:00

  • Hepatic veno-occlusive disease.

    abstract::Hepatic veno-occlusive disease (VOD) after stem cell transplantation is a toxic manifestation of the conditioning regimen most probably emphasized by the allogeneic reaction. Its overall mortality rate is < 4% in adults as well as in children. Recent progress has been achieved in the diagnosis of this complication. Ho...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.1999.00077.x

    authors: Ribaud P,Gluckman E

    更新日期:1999-01-01 00:00:00

  • Reduced-intensity allogeneic hematopoietic cell transplantation: Graft versus tumor effects with decreased toxicity.

    abstract::The potentially curative role of allogeneic hematopoietic cell transplantation (HCT) in neoplastic and non-neoplastic diseases is offset by the substantial risks of morbidity and mortality from complications of the intensive myeloablative and immunosuppressive preparative regimen. These regimen-related toxicities have...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2003.00016.x

    authors: Schwartz JE,Yeager AM

    更新日期:2003-06-01 00:00:00

  • Early hepatic arterial thrombosis in liver transplantation: Systemic intravenous alteplase as a potential rescue treatment after failed surgical revascularization.

    abstract::eHAT is one of the most dreaded post-LT complication. Treatment approaches include retransplantation, revascularization, or observation. Systemic thrombolytic therapy is used in pediatric patients with thromboembolic events. However, there is no previous study reporting on the use of systemic r-tPA to treat eHAT. The ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13902

    authors: Feier FH,Melere MU,Trein CS,da Silva CS,Lucchese A,Horbe A,Tonet F,Ricachinevsky C,Ferreira CT,Chedid MF,Kalil AN

    更新日期:2020-10-27 00:00:00

  • Long-term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: case report.

    abstract::Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two-thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1399-3046.2009.01129.x

    authors: Woolfrey A,Storek J,Bowyer S,Nelson R,Robertson M,Wallace C

    更新日期:2010-09-01 00:00:00

  • Prevalence and outcomes of renal transplantation in children with intellectual disability.

    abstract::To describe the prevalence and outcomes of renal transplantation in children with ID we performed a retrospective cohort analysis of all children receiving a first kidney-alone transplant in the UNOS dataset from 2008 to 2011. Recipients with definite, probable, and without ID were compared using chi-square tests. Kap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12339

    authors: Wightman A,Young B,Bradford M,Dick A,Healey P,McDonald R,Smith J

    更新日期:2014-11-01 00:00:00

  • Optimal immunosuppression in teenagers.

    abstract::Adolescence is a difficult time for transplant recipients, who need to cope with the challenges of becoming independent from their parents, as well as taking responsibility for their own behavior and medication. They need to balance their developing sexuality with a body image which may be affected by the side-effects...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2002.01090.x

    authors: Kelly DA

    更新日期:2002-12-01 00:00:00

  • Fludrocortisone-a treatment for tubulopathy post-paediatric renal transplantation: A national paediatric nephrology unit experience.

    abstract::Calcineurin inhibitors post-renal transplantation are recognized to cause tubulopathies in the form of hyponatremia, hyperkalemia, and acidosis. Sodium supplementation may be required, increasing medication burden and potentially resulting in poor compliance. Fludrocortisone has been beneficial in addressing tubulopat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13134

    authors: Ali SR,Shaheen I,Young D,Ramage I,Maxwell H,Hughes DA,Athavale D,Shaikh MG

    更新日期:2018-03-01 00:00:00

  • Cyclosporine-induced white and grey matter central nervous system lesions in a pediatric renal transplant patient.

    abstract::Major neurologic complications secondary to cyclosporine are well documented and are known to include confusion, cortical blindness, seizure, spasticity, paresis, ataxia and coma. Most previous reports attribute these to white matter central nervous system (CNS) lesions or white/grey matter border lesions. Many predis...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Jeruss J,Braun SV,Reese JC,Guillot A

    更新日期:1998-02-01 00:00:00

  • Transfusion requirements during cadaveric and living donor pediatric liver transplantation.

    abstract::Surgical techniques that have been used during liver transplantation (LT) together with patient's coagulation profile and institutional practices are reported to have an effect on transfusion requirements. The aim of this study is to evaluate the transfusion requirement in both cadaveric (CDLT, n = 22) and living dono...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00284.x

    authors: Ulukaya S,Acar L,Ayanoglu HO

    更新日期:2005-06-01 00:00:00

  • Evaluation of arterial structure and function in pediatric patients with end-stage renal disease on dialysis and after renal transplantation.

    abstract::CVD is a major cause of morbidity and mortality in pediatric patients with CKD. It is unclear whether vascular abnormalities in these patients are reversible, and if transplantation portends salutary effects on arterial function. We compared FMD, PWV, AI75, and CIMT in 15 dialysis (D), 14 transplant patients (T), and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01721.x

    authors: Tawadrous H,Kamran H,Salciccioli L,Schoeneman MJ,Lazar J

    更新日期:2012-08-01 00:00:00

  • Transplanting patients with a positive donor-specific crossmatch: a single center's perspective.

    abstract::An increasing number of individuals with end-stage renal disease have become sensitized to human leukocyte antigens (HLA). Sensitization can have a profound impact on the likelihood of obtaining a requisite negative crossmatch (-XM) with a potential donor. Technologic breakthroughs in our ability to diagnose antibody-...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00214.x

    authors: Montgomery RA,Zachary AA

    更新日期:2004-12-01 00:00:00

  • Liver retransplantation in an infant requiring cavoportal hemi transposition.

    abstract::Historically inability to achieve portal inflow to the liver allograft operatively was felt to be a contraindication to orthotopic liver transplantation (OLTx). Cavoportal hemi transposition has been utilized more recently in adult OLTx recipients but rarely in pediatric recipients. Here we report the case of a 10-mon...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00196.x

    authors: Verran D,Crawford M,Stormon M,Shun A

    更新日期:2004-08-01 00:00:00

  • Surveillance transbronchial biopsies in infant lung and heart-lung transplant recipients.

    abstract::There are limited published data on surveillance TBB for the identification of allograft rejection in infants after lung or heart-lung transplantation. We performed a retrospective review of children under one yr of age who underwent lung or heart-lung transplant at our institution. Since 2005, four infants were trans...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12125

    authors: Hayes D Jr,Baker PB,Kopp BT,Kirkby S,Galantowicz M,McConnell PI,Astor TL

    更新日期:2013-11-01 00:00:00

  • History of pediatric stem cell transplantation.

    abstract::During the past 50 yr, intensive studies into the use of hematopoietic cell transplantation (HCT) for therapy of cancer and non-malignant hematologic diseases have changed this treatment modality from one that was thought to be plagued by insurmountable complications to one that is now standard therapy for some diseas...

    journal_title:Pediatric transplantation

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1398-2265.2004.00203.x

    authors: Storb R

    更新日期:2004-06-01 00:00:00