Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia.

Abstract:

:AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for MRD by flow cytometry (<0.01%) unlike Twin B's bone marrow (0.07%). Twin A is alive in remission 3 years from transplant. Twin B developed primary graft failure, but subsequently rescued with a haploidentical stem cell transplant. However, she relapsed and died 13 months from diagnosis. The twins' clinical courses demonstrate that upfront intensive chemotherapy to achieve negative MRD, followed by allogeneic hematopoietic stem cell transplant as postremission intensification strategy, should be considered in this high-risk AML.

journal_name

Pediatr Transplant

authors

Abu-Arja RF,Dargart JL,Bajwa RPS,Kahwash SB,Auletta JJ,Rangarajan HG

doi

10.1111/petr.13291

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

e13291

issue

8

eissn

1397-3142

issn

1399-3046

journal_volume

22

pub_type

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    更新日期:2013-02-01 00:00:00

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    更新日期:2007-12-01 00:00:00

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