Reversal of tacrolimus-related hypertrophic cardiomyopathy after conversion to rapamycin in a pediatric liver transplant recipient.

Abstract:

:Tacrolimus (Tac)-related hypertrophic cardiomyopathy (HCM) has been reported to be an unusual but serious complication affecting pediatric patients after solid organ transplantation. Herein, we present a case of young liver transplant recipient with Tac-induced HCM, treated by discontinuation of Tac followed by conversion to rapamycin (Rap). Our case report points out the potential but rather low risk of HCM during Tac immunosuppression in pediatric liver transplants and demonstrates that replacement of calcineurin inhibitors with mammalian target of Rap (mTOR) inhibitors may be an efficacious therapeutic tool to effect regression of established cardiac hypertrophy.

journal_name

Pediatr Transplant

authors

Turska-Kmieć A,Jankowska I,Pawłowska J,Kaliciński P,Kawalec W,Tomyn M,Markiewicz M,Teisseyre J,Czubkowski P,Rekawek J,Socha J

doi

10.1111/j.1399-3046.2006.00633.x

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

319-23

issue

3

eissn

1397-3142

issn

1399-3046

pii

PTR633

journal_volume

11

pub_type

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