Varicella infection following vaccination in a pediatric kidney transplant recipient.


:Live viral vaccines have historically been avoided in children after solid organ transplantation. Multiple reports of safety and immunogenicity, largely in the pediatric liver transplant population, have led to a reconsideration of this recommendation. Here, we report the case of a 4-year-old boy who inadvertently received the live attenuated MMR-varicella vaccine (MMRV) at a routine well-child visit 16 months after receiving a living donor kidney transplant. This was not known until after he was admitted with rash and documented disseminated varicella infection 5 weeks later. He was treated with intravenous acyclovir followed by oral therapy and recovered fully. This case and its discussion illustrate what is still unknown about the risk-to-benefit ratio of live viral vaccination in any individual transplant recipient. Criteria to determine which patients should receive these vaccines should be evaluated before their use after transplant becomes routine, and all recipients and their families should be counseled to have a low threshold to seek medical care for any febrile illness or rash after live viral vaccination.


Pediatr Transplant


Bobrowski AE,Muller WJ




Has Abstract


2020-06-01 00:00:00












  • Effect of CYP3A5*1 expression on tacrolimus required dose for transplant pediatrics: A systematic review and meta-analysis.

    abstract::This systematic review was designed to find out optimal tacrolimus dose in pediatrics according to their CYP3A5*1 genotype by performing meta-analysis. PubMed, Scopus, ISI web of Science, ProQuest, Cochrane library, and were systematically searched to find studies in which tacrolimus dose and/or bloo...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Hendijani F,Azarpira N,Kaviani M

    更新日期:2018-06-19 00:00:00

  • Multiple rare-earth magnet bead ingestion in a pediatric liver-small bowel-pancreas transplant recipient: A case report and lessons learned.

    abstract::Ingestion of rare-earth magnet beads in children has been a public health concern. The potential risk of swallowing multiple magnets is related to magnet attraction to each other, resulting in serious gastrointestinal complications, such as entero-enteric fistula formation, peritonitis, bowel ischemia or necrosis, bow...

    journal_title:Pediatric transplantation



    authors: Miri A,Nakayuenyongsuk W,Vargas L,Langnas A,Vo HD

    更新日期:2020-11-20 00:00:00

  • Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.

    abstract:BACKGROUND:Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM:To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS:A re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Olio DD,Gupte G,Sharif K,Murphy MS,Lloyd C,McKiernan PJ,Kelly DA,Beath SV

    更新日期:2006-09-01 00:00:00

  • Comparative outcome analysis of pediatric kidney transplant in posterior urethral valves children with or without pretransplant Mitrofanoff procedure.

    abstract:BACKGROUND:Urinary diversion using catheterizable channel among posterior urethral valve (PUV) patients may help to alleviate the functional concerns of the bladder on the allograft. Herein, we review our series of PUV patients undergoing renal transplants at a single institution to determine outcomes between those wit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Rickard M,Chua ME,Zu'bi F,Dos Santos J,Koyle MA,Lorenzo AJ,Farhat WA

    更新日期:2020-12-01 00:00:00

  • VPS 45-associated primary infantile myelofibrosis--successful treatment with hematopoietic stem cell transplantation.

    abstract::PMF of infancy is a recently described autosomal recessive disorder presenting with severe bone marrow failure, accelerated neutrophil apoptosis, and significant platelet dysfunction, caused by a mutation in the VPS45 gene. In this study, we update our group of patients with PMF, highlighting different aspects of this...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Stepensky P,Simanovsky N,Averbuch D,Gross M,Yanir A,Mevorach D,Elpeleg O,Weintraub M

    更新日期:2013-12-01 00:00:00

  • Transfusion requirements during cadaveric and living donor pediatric liver transplantation.

    abstract::Surgical techniques that have been used during liver transplantation (LT) together with patient's coagulation profile and institutional practices are reported to have an effect on transfusion requirements. The aim of this study is to evaluate the transfusion requirement in both cadaveric (CDLT, n = 22) and living dono...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Ulukaya S,Acar L,Ayanoglu HO

    更新日期:2005-06-01 00:00:00

  • Pre-stem cell transplantation enzyme replacement therapy in Hurler syndrome does not lead to significant antibody formation or delayed recovery of the endogenous enzyme post-transplant: a case report.

    abstract::Combined enzyme replacement therapy (ERT) and stem cell transplant (SCT) were done for a two year old boy with severe Hurler syndrome(HS) with the aim to decrease transplant related complications. He tolerated both the procedures well without any major complications. Urine glycosaminoglycans (GAGs) decreased post-tran...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Soni S,Hente M,Breslin N,Hersh J,Whitley C,Cheerva A,Bertolone S

    更新日期:2007-08-01 00:00:00

  • Single versus en bloc kidney transplant from donors less than or equal to 15 kg to pediatric recipients.

    abstract::With small kidneys, EBKTs could provide sufficient renal mass but could lead to inefficient use of resources, while SKTs could result in insufficient function due to small renal mass. We aimed to compare the outcomes of EBKT and SKT from small donors weighing ≤15 kg to pediatric recipients. We retrospectively reviewed...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Mo H,Ko H,Chung CTY,Kim HK,Han A,Min S,Ha J

    更新日期:2020-05-06 00:00:00

  • Australian deceased donor kidney allocation protocols: Transplant waiting and graft quality for children and adolescents.

    abstract::DD kidney allocation protocols may influence timing of transplantation and graft quality for pediatric recipients. This study aimed to evaluate the effects of these protocols, including pediatric priority, on waiting time on dialysis, transplant type, donor age, and HLA matching according to state of transplant in Aus...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Le Page AK,Johnstone LM,Kennedy SE

    更新日期:2015-09-01 00:00:00

  • Safety and utility of surveillance biopsies in pediatric kidney transplant patients.

    abstract::There is currently no way to diagnose a rejection before a change in serum creatinine. This had led some to start doing SB, but little data exist on the utility and safety of SB in pediatric patients. There is also little known on practice patterns of pediatric nephrologists. A retrospective review of pediatric kidney...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Nazario M,Nicoara O,Becton L,Self S,Hill J,Mack E,Evans M,Twombley K

    更新日期:2018-06-01 00:00:00

  • A national conference to determine research priorities in pediatric solid organ transplantation.

    abstract::The need for evidence-based practice guidelines requires high quality, carefully controlled clinical research trials. This multidisciplinary conference attempted to: identify urgent clinical and research issues, identify obstacles to performing clinical trials, develop concepts for organ-specific and all-organ researc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Bartosh SM,Ryckman FC,Shaddy R,Michaels MG,Platt JL,Sweet SC

    更新日期:2008-03-01 00:00:00

  • Mobilization of peripheral blood progenitor cells using 16 versus 10 mg/kg/d G-CSF in children with malignancies.

    abstract::Administration of hematopoietic growth factors, with or without chemotherapy, can augment progenitor cell numbers available for collection. The dose of granulocyte colony stimulating factor (G-CSF) used for mobilization of peripheral blood progenitor cells (PBPC) is controversial, and doses between 5 and 32 microg/kg/...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kurekci AE,Kiss JE,Koehler M

    更新日期:1998-05-01 00:00:00

  • Outcomes of pediatric liver transplant are unaffected by the time or day of surgery.

    abstract:BACKGROUND:In adults, the time of day for LT does not affect post-transplant outcomes. Whether this is true or not in children is unknown. In this study, we aimed to evaluate if weekend and weeknight liver transplants are associated with worse patient and graft survival in children. METHODS:We interrogated the UNOS da...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Rogers ME,Egberg MD,Sylvester F,Lichtman S,Lin FC

    更新日期:2020-12-01 00:00:00

  • Functional capacity after pediatric liver transplantation: a pilot study.

    abstract::The prospective cross-sectional study investigated the 6MWT performance in pediatric group of liver transplant recipients (6-17 yr, median post-transplantation time of 22 months) and compared to the normal values obtained in healthy children as well as evaluated the reproducibility of the 6MWT. We analyzed the relatio...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Maria da Silva R,Brunow de Carvalho W,Johnston C,Borba de Castro M,Manta Ferreira I,Patti CL,Anthero de Azevedo R,Miziara Gonzalez A,Moura Linhares M,Augusto Salzedas-Netto A

    更新日期:2014-09-01 00:00:00

  • Minimum mycophenolic acid levels are associated with donor-specific antibody formation.

    abstract::Although de novo DSA are associated with inferior graft survival, there are no effective strategies to prevent their formation. Underexposure to MPA (prodrug: MMF) also contributes to rejection rates early after transplantation, but the effect of this phenomenon on the formation of DSA long-term post-transplantation i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Filler G,Todorova EK,Bax K,Alvarez-Elías AC,Huang SH,Kobrzynski MC

    更新日期:2016-02-01 00:00:00

  • Calcineurin-inhibitor-induced pain syndrome after a second allogeneic bone marrow transplantation for a child with aplastic anemia.

    abstract::We report a 10-yr-old boy who developed CIPS after a second allogeneic BMT for severe aplastic anemia. He received the second BMT from the same HLA-matched sibling donor 16 months after the first BMT due to secondary graft failure. The preparative regimen for the second BMT consisted of fludarabine, cyclophosphamide, ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Nishikawa T,Okamoto Y,Tanabe T,Shinkoda Y,Kodama Y,Tsuru Y,Kawano Y

    更新日期:2009-08-01 00:00:00

  • Pharmacokinetic analysis for model-supported therapeutic drug monitoring of busulfan in Japanese pediatric hematopoietic stem cell transplantation recipients.

    abstract::This prospective observational study analyzed the pharmacokinetics of busulfan in Japanese children and evaluated the predicting accuracy of previous pediatric PPK models of busulfan. This study enrolled five patients (aged 2-12 years, BW 14-48 kg) receiving a busulfan-based conditioning regimen for hematopoietic stem...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Kishimoto K,Hasegawa D,Irie K,Okada A,Nakamura S,Tamura A,Yamamoto N,Kozaki A,Saito A,Ishida T,Fukushima S,Kosaka Y

    更新日期:2020-06-01 00:00:00

  • Pediatric Transplant Rating Instrument - a scale for the pretransplant psychiatric evaluation of pediatric organ transplant recipients.

    abstract::Although the majority of pediatric solid organ transplant centers in the United States employ psychosocial criteria to assess the suitability of potential transplant candidates, there are no standardized pretransplant psychosocial assessment measures. Assessment scales that have been developed were designed for adult ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Fung E,Shaw RJ

    更新日期:2008-02-01 00:00:00

  • Outcome of allogeneic hematopoietic stem cell transplantation for children with acute myelogenous leukemia in second complete remission: single center experience.

    abstract::We reviewed 26 consecutive patients with AML who were transplanted in second CR2 between 1994 and 2005. The most common conditioning regimen was CY and TBI. Median age at transplant was 8.9 yr (range 2.2-18.2). Nine patients received related donor, 16 patients received unrelated donors, and one patient received unrela...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Ishaqi MK,Afzal S,Dupuis A,Doyle J,Gassas A

    更新日期:2009-12-01 00:00:00

  • Predictive value of pretransplantation cyclosporine pharmacokinetic studies on initial post-transplantation dosing in pediatric kidney allograft recipients.

    abstract::Despite the introduction of a variety of new immunosuppressive agents, cyclosporine A (CsA) has maintained a strong position in pediatric transplantation (Tx). Post-Tx dosing with CsA is a challenging task because of the narrow therapeutic window of the drug, the great individual variability of metabolism and the lack...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Seikku P,Hoppu K,Jalanko H,Holmberg C

    更新日期:2003-04-01 00:00:00

  • Use of genetic risks in pediatric organ transplantation listing decisions: A national survey.

    abstract::There is a limited supply of organs for all those who need them for survival. Thus, careful decisions must be made about who is listed for transplant. Studies show that manifesting genetic disease can impact listing eligibility. What has not yet been studied is the impact genetic risks for future disease have on a pat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究


    authors: Graf M,Char D,Hanson-Kahn A,Magnus D

    更新日期:2019-06-01 00:00:00

  • Frequency of urinary tract infection in pediatric liver transplantation candidates.

    abstract::An increased frequency of infections has been reported in patients with chronic liver disease. The tendency of patients in this population to acquire UTI is not completely understood. We aimed at investigating the incidence of UTI in children with cirrhosis, before liver transplantation. Twenty-six children (9 girls, ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Baskin E,Ozçay F,Sakalli H,Agras PI,Karakayali H,Canan O,Haberal M

    更新日期:2007-06-01 00:00:00

  • A typology of non-adherence in pediatric renal transplant recipients.

    abstract::We reviewed 112 pediatric renal transplant recipients to document the rate of medication non-adherence (NA) and to examine the relationships between NA, comorbid psychiatric illness, and the outcome variables of acute and chronic rejection and graft loss. A total of 32.5% of subjects had clinically significant NA with...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Shaw RJ,Palmer L,Blasey C,Sarwal M

    更新日期:2003-12-01 00:00:00

  • Primary HHV 6 infection after liver transplantation with acute graft rejection and multi-organ failure: successful treatment with a 2.5-fold dose of cidofovir and reduction of immunosuppression.

    abstract::HHV type 6 has been reported with enhanced pathogenicity in immunocompromised patients. Herein, we report about a two-yr-old girl who experienced primary HHV 6 infection after liver transplantation. She clinically presented with graft rejection and necrotic hepatitis as well as high fever, pneumonitis with respiratory...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Dohna-Schwake C,Fiedler M,Gierenz N,Gerner P,Ballauf A,Breddemann A,Läer S,Baba HA,Hoyer PF

    更新日期:2011-09-01 00:00:00

  • Nocturnal hypertension and left ventricular hypertrophy in pediatric renal transplant recipients in South India.

    abstract::HTN after renal transplantation is associated with cardiovascular morbidity. ABPM allows diagnosis of masked HTN and isolated nocturnal HTN. Longitudinal ABPM data in children post-transplant are limited. ABPM was performed in children post-transplant and repeated in 6-12 months. BP indices were used to determine the ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Pais P,Dello Strologo L,Iyengar A,Velusamy V,Greenbaum LA

    更新日期:2020-06-01 00:00:00

  • Virologic response with 2 different cidofovir dosing regimens for preemptive treatment of adenovirus DNAemia in pediatric solid organ transplant recipients.

    abstract::ADV is frequently seen in our pediatric SOT population. It presents in a variety of clinical presentation and can cause severe disease. In this population, there are very few studies to determine the safety of CDV as a potential therapeutic agent. We present the findings of our retrospective study evaluating the effic...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Guerra Sanchez CH,Lorica CD,Arheart KL,Perez MM,Tekin A,Gonzalez IA

    更新日期:2018-06-03 00:00:00

  • Anellovirus loads are associated with outcomes in pediatric lung transplantation.

    abstract::Anelloviruses are DNA viruses ubiquitously present in human blood. Due to their elevated levels in immunosuppressed patients, anellovirus levels have been proposed as a marker of immune status. We hypothesized that low anellovirus levels, reflecting relative immunocompetence, would be associated with adverse outcomes ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Blatter JA,Sweet SC,Conrad C,Danziger-Isakov LA,Faro A,Goldfarb SB,Hayes D Jr,Melicoff E,Schecter M,Storch G,Visner GA,Williams NM,Wang D

    更新日期:2018-02-01 00:00:00

  • Pharmacodynamic monitoring of cyclosporine A by NFAT-regulated gene expression and the relationship with infectious complications in pediatric renal transplant recipients.

    abstract::Pharmacokinetic monitoring of CsA is unsatisfactory, because at comparable CsA blood concentrations, the frequency and severity of adverse effects vary considerably among patients. We have therefore recently developed a precise, reliable, and robust whole-blood pharmacodynamic assay that measures the suppression of Cs...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Billing H,Giese T,Sommerer C,Zeier M,Feneberg R,Meuer S,Tönshoff B

    更新日期:2010-11-01 00:00:00

  • The effect of peri-transplant plasmapheresis in the prevention of recurrent FSGS.

    abstract::Many pediatric centers utilize a variety of protocols including preemptive plasmapheresis to prevent the recurrence of FSGS post-transplant. But the effectiveness of this expensive, time-consuming process of plasmapheresis in the prevention of FSGS recurrence is still unclear. We retrospectively reviewed all pediatric...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Verghese PS,Rheault MN,Jackson S,Matas AJ,Chinnakotla S,Chavers B

    更新日期:2018-05-01 00:00:00

  • A trial of plerixafor adjunctive therapy in allogeneic hematopoietic cell transplantation with minimal conditioning for severe combined immunodeficiency.

    abstract::For infants with SCID, the ideal conditioning regimen before allogeneic HCT would omit cytotoxic chemotherapy to minimize short- and long-term complications. We performed a prospective pilot trial with G-CSF plus plerixafor given to the host to mobilize HSC from their niches. We enrolled six patients who received CD34...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Dvorak CC,Horn BN,Puck JM,Czechowicz A,Shizuru JA,Ko RM,Cowan MJ

    更新日期:2014-09-01 00:00:00