Varicella infection following vaccination in a pediatric kidney transplant recipient.

Abstract:

:Live viral vaccines have historically been avoided in children after solid organ transplantation. Multiple reports of safety and immunogenicity, largely in the pediatric liver transplant population, have led to a reconsideration of this recommendation. Here, we report the case of a 4-year-old boy who inadvertently received the live attenuated MMR-varicella vaccine (MMRV) at a routine well-child visit 16 months after receiving a living donor kidney transplant. This was not known until after he was admitted with rash and documented disseminated varicella infection 5 weeks later. He was treated with intravenous acyclovir followed by oral therapy and recovered fully. This case and its discussion illustrate what is still unknown about the risk-to-benefit ratio of live viral vaccination in any individual transplant recipient. Criteria to determine which patients should receive these vaccines should be evaluated before their use after transplant becomes routine, and all recipients and their families should be counseled to have a low threshold to seek medical care for any febrile illness or rash after live viral vaccination.

journal_name

Pediatr Transplant

authors

Bobrowski AE,Muller WJ

doi

10.1111/petr.13667

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

e13667

issue

4

eissn

1397-3142

issn

1399-3046

journal_volume

24

pub_type

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    authors: Hendijani F,Azarpira N,Kaviani M

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    authors: Miri A,Nakayuenyongsuk W,Vargas L,Langnas A,Vo HD

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    abstract:BACKGROUND:Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM:To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS:A re...

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    authors: Olio DD,Gupte G,Sharif K,Murphy MS,Lloyd C,McKiernan PJ,Kelly DA,Beath SV

    更新日期:2006-09-01 00:00:00

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    authors: Rickard M,Chua ME,Zu'bi F,Dos Santos J,Koyle MA,Lorenzo AJ,Farhat WA

    更新日期:2020-12-01 00:00:00

  • VPS 45-associated primary infantile myelofibrosis--successful treatment with hematopoietic stem cell transplantation.

    abstract::PMF of infancy is a recently described autosomal recessive disorder presenting with severe bone marrow failure, accelerated neutrophil apoptosis, and significant platelet dysfunction, caused by a mutation in the VPS45 gene. In this study, we update our group of patients with PMF, highlighting different aspects of this...

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    更新日期:2013-12-01 00:00:00

  • Transfusion requirements during cadaveric and living donor pediatric liver transplantation.

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    journal_title:Pediatric transplantation

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    doi:10.1111/j.1399-3046.2005.00284.x

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    更新日期:2005-06-01 00:00:00

  • Pre-stem cell transplantation enzyme replacement therapy in Hurler syndrome does not lead to significant antibody formation or delayed recovery of the endogenous enzyme post-transplant: a case report.

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    journal_title:Pediatric transplantation

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    authors: Soni S,Hente M,Breslin N,Hersh J,Whitley C,Cheerva A,Bertolone S

    更新日期:2007-08-01 00:00:00

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    abstract::With small kidneys, EBKTs could provide sufficient renal mass but could lead to inefficient use of resources, while SKTs could result in insufficient function due to small renal mass. We aimed to compare the outcomes of EBKT and SKT from small donors weighing ≤15 kg to pediatric recipients. We retrospectively reviewed...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

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    authors: Mo H,Ko H,Chung CTY,Kim HK,Han A,Min S,Ha J

    更新日期:2020-05-06 00:00:00

  • Australian deceased donor kidney allocation protocols: Transplant waiting and graft quality for children and adolescents.

    abstract::DD kidney allocation protocols may influence timing of transplantation and graft quality for pediatric recipients. This study aimed to evaluate the effects of these protocols, including pediatric priority, on waiting time on dialysis, transplant type, donor age, and HLA matching according to state of transplant in Aus...

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    更新日期:2015-09-01 00:00:00

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    journal_title:Pediatric transplantation

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    doi:10.1111/petr.13178

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    更新日期:2018-06-01 00:00:00

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    更新日期:2008-03-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

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    authors: Rogers ME,Egberg MD,Sylvester F,Lichtman S,Lin FC

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    更新日期:2003-04-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2011-09-01 00:00:00

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    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13710

    authors: Pais P,Dello Strologo L,Iyengar A,Velusamy V,Greenbaum LA

    更新日期:2020-06-01 00:00:00

  • Virologic response with 2 different cidofovir dosing regimens for preemptive treatment of adenovirus DNAemia in pediatric solid organ transplant recipients.

    abstract::ADV is frequently seen in our pediatric SOT population. It presents in a variety of clinical presentation and can cause severe disease. In this population, there are very few studies to determine the safety of CDV as a potential therapeutic agent. We present the findings of our retrospective study evaluating the effic...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13231

    authors: Guerra Sanchez CH,Lorica CD,Arheart KL,Perez MM,Tekin A,Gonzalez IA

    更新日期:2018-06-03 00:00:00

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    abstract::Anelloviruses are DNA viruses ubiquitously present in human blood. Due to their elevated levels in immunosuppressed patients, anellovirus levels have been proposed as a marker of immune status. We hypothesized that low anellovirus levels, reflecting relative immunocompetence, would be associated with adverse outcomes ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13069

    authors: Blatter JA,Sweet SC,Conrad C,Danziger-Isakov LA,Faro A,Goldfarb SB,Hayes D Jr,Melicoff E,Schecter M,Storch G,Visner GA,Williams NM,Wang D

    更新日期:2018-02-01 00:00:00

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    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01354.x

    authors: Billing H,Giese T,Sommerer C,Zeier M,Feneberg R,Meuer S,Tönshoff B

    更新日期:2010-11-01 00:00:00

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    abstract::Many pediatric centers utilize a variety of protocols including preemptive plasmapheresis to prevent the recurrence of FSGS post-transplant. But the effectiveness of this expensive, time-consuming process of plasmapheresis in the prevention of FSGS recurrence is still unclear. We retrospectively reviewed all pediatric...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13154

    authors: Verghese PS,Rheault MN,Jackson S,Matas AJ,Chinnakotla S,Chavers B

    更新日期:2018-05-01 00:00:00

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    abstract::For infants with SCID, the ideal conditioning regimen before allogeneic HCT would omit cytotoxic chemotherapy to minimize short- and long-term complications. We performed a prospective pilot trial with G-CSF plus plerixafor given to the host to mobilize HSC from their niches. We enrolled six patients who received CD34...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12309

    authors: Dvorak CC,Horn BN,Puck JM,Czechowicz A,Shizuru JA,Ko RM,Cowan MJ

    更新日期:2014-09-01 00:00:00