Long-term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: case report.

Abstract:

:Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two-thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.

journal_name

Pediatr Transplant

authors

Woolfrey A,Storek J,Bowyer S,Nelson R,Robertson M,Wallace C

doi

10.1111/j.1399-3046.2009.01129.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

E65-9

issue

6

eissn

1397-3142

issn

1399-3046

pii

PTR1129

journal_volume

14

pub_type

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