Non-adherence in pediatric liver transplant recipients--an assessment of risk factors and natural history.

Abstract:

:Despite the fact that non-adherence to medical therapy is one of the major causes of late morbidity and mortality in pediatric liver transplant recipients, little is known of the risk factors involved in this behavior. Three cases of fatal non-adherence are reported. Factors associated with non-adherence were investigated by performing a retrospective chart review of a panel of 27 variables in an age-matched cohort of 15 pediatric liver transplant recipients. The most striking differences between the severely non-adherent group and the age-matched cohort included history of substance abuse, child abuse (physical or sexual), not having two parents at home, having received public assistance, having been diagnosed with a psychiatric disorder, and history of school dropout. In addition it appeared that a pretransplant diagnosis of autoimmune hepatitis was associated with more significant medical sequelae related to non-adherence. These findings are preliminary owing to the retrospective design of this study, but could be used as a starting point for a prospective study of this important phenomenon.

journal_name

Pediatr Transplant

authors

Lurie S,Shemesh E,Sheiner PA,Emre S,Tindle HL,Melchionna L,Shneider BL

doi

10.1034/j.1399-3046.2000.00110.x

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

200-6

issue

3

eissn

1397-3142

issn

1399-3046

journal_volume

4

pub_type

杂志文章
  • Perceived barriers to medication adherence in pediatric and adolescent solid organ transplantation.

    abstract::Comparisons of perceived barriers to adherence in pediatric and adolescent SOT have not been systematically conducted despite association between medication non-adherence and poor outcome. Fifteen centers in CTOT-C enrolled patients in a cross-sectional study. Subjects' guardians completed the PMBS and subjects over e...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12648

    authors: Danziger-Isakov L,Frazier TW,Worley S,Williams N,Shellmer D,Dharnidharka VR,Gupta NA,Ikle D,Sweet SC,CTOTC-05 Consortium.

    更新日期:2016-03-01 00:00:00

  • EBV-negative lymphoproliferative disease with hyper-IgA, in a child with combined liver and small bowel transplantation.

    abstract::A 4-year-old boy presented 14 months after liver and small bowel transplantation with fever, diarrhea, elevated liver enzymes, thrombocytopenia and autoantibodies. Total gammaglobulins level was normal but the level of plasma IgA1 was very high. The blood PCR for Epstein-Barr virus (EBV) was negative. The ileal biopsy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00174.x

    authors: Robert CD,Lacaille F,Canioni D,Quartier-dit-Maire P,Talbotec C,Goulet O

    更新日期:2004-06-01 00:00:00

  • Successful transplantation of a cadaveric kidney with post-infectious glomerulonephritis.

    abstract::This report describes a successful renal Tx in a patient with chronic renal failure, caused by dysplastic kidneys, who received a cadaveric kidney with post-infectious glomerulonephritis. Sequential renal biopsies were performed at 12 h before Tx, and at 1 h and on days 8 and 58 post-Tx. Post-operative hematuria disap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2000.00076.x

    authors: Mizuiri S,Shigetomi Y,Sugiyama K,Miyagi M,Hatano T,Tajima E,Aikawa A,Ohara T,Kawamura S,Hasegawa A

    更新日期:2000-02-01 00:00:00

  • Invasive diagnostic procedures for pulmonary infiltrates in pediatric hematopoietic stem cell transplant recipients.

    abstract::To evaluate the role of BAL, CTB, and OLB in the management of pulmonary infiltrates in pediatric HSCT recipients, we conducted a retrospective review of clinical records of pediatric HSCT recipients. Data were analyzed using Chi-square for dichotomous and anova for continuous variables. Logistic regression was used t...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00733.x

    authors: Armenian SH,Hoffman JA,Butturini AM,Kapoor N,Mascarenhas L

    更新日期:2007-11-01 00:00:00

  • Conversion from tacrolimus to sirolimus as a treatment modality in de novo allergies and immune-mediated disorders in pediatric liver transplant recipients.

    abstract::De novo PTAID may develop in pediatric solid organ transplant recipients, have a diverse spectrum, and are occasionally treatment resistant. Previous reports showed resolution of immune cytopenias in solid organ transplant recipients following replacement of the calcineurin inhibitor tacrolimus with the mTOR inhibitor...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13737

    authors: Kehar M,Grunebaum E,Jimenez-Rivera C,Mozer-Glassberg Y,Jamal A,Ng VL,Avitzur Y

    更新日期:2020-09-01 00:00:00

  • Focal segmental glomerulosclerosis associated with acute cytomegalovirus infection in a renal transplant.

    abstract::Focal segmental glomerulosclerosis (FSGS) occurring in association with cytomegalovirus (CMV) infection in a renal transplant patient with no previous history of FSGS has rarely been reported. We present a case of a 16-year-old renal transplant recipient who developed acute hepatitis, leukopenia, nephrotic syndrome, a...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13538

    authors: Wynd E,Stewart A,Burke J

    更新日期:2019-09-01 00:00:00

  • Haploidentical hematopoietic stem cell transplantation for a case with X-linked chronic granulomatous disease.

    abstract::CGD is a rare primary immunodeficiency with high mortality rates when treated conventionally, especially for the X-chromosome-linked form. HSCT is the only curative therapy for CGD; however, haploidentical transplantation in CGD is rare. Here, we report a case of X-linked CGD treated successfully by haploidentical HSC...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.12861

    authors: Zhou L,Dong LJ,Gao ZY,Yu XJ,Lu DP

    更新日期:2017-02-01 00:00:00

  • The efficacy of serum brain natriuretic peptide for the early detection of portopulmonary hypertension in biliary atresia patients before liver transplantation.

    abstract::Severe portopulmonary hypertension (POPH) is a contraindication for liver transplantation (LT) because of the high risk of postoperative heart failure. The early detection of POPH is important for patients with biliary atresia (BA). Brain natriuretic peptide (BNP) is known to be correlated with liver fibrosis in patie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13203

    authors: Yoshimaru K,Matsuura T,Takahashi Y,Yanagi Y,Nagata H,Ohga S,Taguchi T

    更新日期:2018-08-01 00:00:00

  • Evaluation of cardiac manifestations in pediatric liver transplant candidates.

    abstract::Knowledge concerning the involvement of the cardiovascular system in children awaiting liver transplant is limited. Therefore, no guidelines have been established on evaluating this group of patients for cardiac disease. This review examines the diverse cardiovascular manifestations of liver disease in children. We al...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2012.01667.x

    authors: Madan N,Arnon R,Arnon R

    更新日期:2012-06-01 00:00:00

  • Allograft rejection in pediatric liver transplantation: Comparison between cadaveric and living related donors.

    abstract::The aim of this study was to determine whether living related liver transplantation has an immunological advantage compared with cadaveric liver transplants in children. The records of 100 pediatric primary liver transplant recipients performed between January 1992 and December 1998 at the University of California, Sa...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.02013.x

    authors: Toyoki Y,Renz JF,Mudge C,Ascher NL,Roberts JP,Rosenthal P

    更新日期:2002-08-01 00:00:00

  • The reduced left lateral segment in pediatric liver transplantation: an alternative to the monosegment graft.

    abstract::Tailoring graft size to small paediatric recipients is a challenge. We have developed a reduced left lateral segment as an alternative to monosegment transplantation for small size recipients. Since November 2000, 89 children have been transplanted with 100 deceased donor liver grafts in our unit. Our median patient a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00882.x

    authors: Attia MS,Stringer MD,McClean P,Prasad KR

    更新日期:2008-09-01 00:00:00

  • Plasma cell-rich acute cellular rejection of a transplanted kidney associated with antibody to the red cell Kidd antigen.

    abstract::Plasma cell-rich acute cellular rejection of a transplanted kidney is described in association with the identification of serum antibody to the red cell Kidd antigen, Jk-b, which is also found in the kidney. This antibody was formed without a history of a recent blood transfusion or exposure to intravenous immunoglobu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00608.x

    authors: Hamilton MS,Singh V,Warady BA

    更新日期:2006-12-01 00:00:00

  • Fulminant recurrence of atypical hemolytic uremic syndrome during a calcineurin inhibitor-free immunosuppression regimen.

    abstract::Recurrence of hemolytic uremic syndrome (HUS) after kidney transplantation is frequent, occurring almost exclusively in patients with atypical HUS, which is not caused by Escherichia coli gastroenteritis and in which diarrhea is absent. Calcineurin inhibitors are associated with recurrence of HUS. In two children who ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.t01-1-00002.x

    authors: Florman S,Benchimol C,Lieberman K,Burrows L,Bromberg JS

    更新日期:2002-08-01 00:00:00

  • Out-of-reach obscure bleeding: single-balloon enteroscopy to diagnose and treat varices in hepaticojejunostomy after pediatric liver transplant.

    abstract::Obscure gastrointestinal (GI) bleeding is defined as bleeding from the GI tract that persists or recurs, with no obvious etiology, after esophagogastroduodenoscopy (EGD), colonoscopy, and radiologic evaluation of the small bowel. We present the case of a 17-yr-old girl who for two years had been suffering from recurre...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01425.x

    authors: Curcio G,Sciveres M,Mocciaro F,Riva S,Spada M,Tarantino I,Barresi L,Traina M

    更新日期:2012-05-01 00:00:00

  • Fludrocortisone-a treatment for tubulopathy post-paediatric renal transplantation: A national paediatric nephrology unit experience.

    abstract::Calcineurin inhibitors post-renal transplantation are recognized to cause tubulopathies in the form of hyponatremia, hyperkalemia, and acidosis. Sodium supplementation may be required, increasing medication burden and potentially resulting in poor compliance. Fludrocortisone has been beneficial in addressing tubulopat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13134

    authors: Ali SR,Shaheen I,Young D,Ramage I,Maxwell H,Hughes DA,Athavale D,Shaikh MG

    更新日期:2018-03-01 00:00:00

  • Intravenous and oral sequential itraconazole antifungal prophylaxis in paediatric stem cell transplantation recipients: a pilot study for evaluation of safety and efficacy.

    abstract::This single-centre, retrospective, observational pilot study was performed to evaluate the safety and efficacy of intravenous and oral itraconazole prophylaxis in paediatric haematopoietic stem cell transplantation (HCT). Study end-points were proven invasive fungal infection (IFI), survival, adverse reactions and gra...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00643.x

    authors: Grigull L,Kuehlke O,Beilken A,Sander A,Linderkamp C,Schmid H,Seidemann K,Sykora KW,Schuster FR,Welte K

    更新日期:2007-05-01 00:00:00

  • Outpatient pediatric renal transplant biopsy--is it safe?

    abstract::The safe observation time following pediatric renal transplant biopsy is unknown. To predict the safety of day-care pediatric renal transplant biopsy, we retrospectively evaluated the timing, incidence and severity of post-biopsy complications in children observed overnight. Biopsies were performed under real time ult...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00433.x

    authors: Sweeney C,Geary DF,Hebert D,Robinson L,Langlois V

    更新日期:2006-03-01 00:00:00

  • Serial signal-averaged electrocardiography in children after cardiac transplantation.

    abstract::In patients with myocytolysis detected in endomyocardial biopsy, there is a tendency towards a shift of ventricular electrical axes from normal to strain pattern on surface ECG. Their 12-lead signal-averaged electrocardiogram (SAECG) show a significant increase in filtered QRS duration (QRSD) compared with those with ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00384.x

    authors: Bennhagen RG,Sörnmo L,Pahlm O,Pesonen E

    更新日期:2005-12-01 00:00:00

  • Clinical features and mutational survey of NPHS2 (podocin) in Japanese children with focal segmental glomerulosclerosis who underwent renal transplantation.

    abstract::Recurrent FSGS is a major challenge in the field of nephrology. To clarify the role of NPHS2 defects in the pathogenesis of FSGS recurrence, we sequenced all eight exons of NPHS2 in 11 Japanese pediatric FSGS patients with or without post-transplant recurrence. All patients had biopsy-proven primary FSGS, had no famil...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00752.x

    authors: Furue T,Hattori M,Tsukaguchi H,Kitamura A,Oomori T,Ogino D,Nakakura H,Ashida A,Miura K,Hisano M,Takahashi K,Chikamoto H,Akioka Y,Sakano T

    更新日期:2008-05-01 00:00:00

  • Mycophenolate mofetil and reduced doses of cyclosporine in pediatric liver transplantation with chronic renal dysfunction: changes in the immune responses.

    abstract::The aim of this study was to study the incidence of chronic renal dysfunction in patients with more than 5 yr of follow-up following liver transplantation and to evaluate the benefit of decreasing cyclosporine A (CsA) dose combined with mycophenolate mofetil (MMF) on renal function and immune response in these patient...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00172.x

    authors: Ferraris JR,Duca P,Prigoshin N,Tambutti ML,Boldrini G,Cardoni RL,D'Agostino D

    更新日期:2004-10-01 00:00:00

  • Simultaneous surgical and interventional radiological approach to treat complicated biliary strictures after pediatric liver transplantation.

    abstract::Post-transplantation biliary strictures occur in 5-15% of the pediatric liver transplant patients and are conventionally managed by interventional radiological techniques. Failure of this treatment leads to reoperation and sometimes to retransplantation. Herein, we describe a surgical approach and interventional radio...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00212.x

    authors: Salvalaggio PR,Bambini DA,Donaldson J,Saker M,Whitington PF,Alonso EM,Superina RA

    更新日期:2004-10-01 00:00:00

  • Dyslipidemia after pediatric renal transplantation-The impact of immunosuppressive regimens.

    abstract::Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Dat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12914

    authors: Habbig S,Volland R,Krupka K,Querfeld U,Dello Strologo L,Noyan A,Yalcinkaya F,Topaloglu R,Webb NJ,Kemper MJ,Pape L,Bald M,Kranz B,Taylan C,Höcker B,Tönshoff B,Weber LT

    更新日期:2017-05-01 00:00:00

  • Second transplant with two unrelated cord blood units for early graft failure after cord blood transplantation for thalassemia.

    abstract::Early GF is a frequent complication following hematopoietic stem cell transplantation for patients with thalassemia. We report the outcome of double-unit CBT in three patients who developed early GF after CBT. The initial conditioning regimen consisted of i.v. Bu 14 mg/kg (day -9 to -6), i.v. Cy 200 mg/kg (day -5 to -...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01021.x

    authors: Jaing TH,Hung IJ,Yang CP,Tsai MH,Lee WI,Sun CF

    更新日期:2009-09-01 00:00:00

  • Grading acute graft-versus-host disease: time to reconsider.

    abstract::Acute graft-versus-host disease (GVHD) is a common and serious complication of allogeneic blood and marrow transplantation. Acute GVHD is commonly graded according to modified Glucksberg criteria. There is considerable within-grade heterogeneity with different patterns of skin, liver, or gut involvement. In this comme...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12433

    authors: Goyal RK,Goyal M,Sankaranarayan K

    更新日期:2015-05-01 00:00:00

  • Cyclosporine-induced white and grey matter central nervous system lesions in a pediatric renal transplant patient.

    abstract::Major neurologic complications secondary to cyclosporine are well documented and are known to include confusion, cortical blindness, seizure, spasticity, paresis, ataxia and coma. Most previous reports attribute these to white matter central nervous system (CNS) lesions or white/grey matter border lesions. Many predis...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Jeruss J,Braun SV,Reese JC,Guillot A

    更新日期:1998-02-01 00:00:00

  • Cognitive and emotional outcome after pediatric liver transplantation.

    abstract::The aim of the study was to evaluate the cognitive and emotional development after pediatric liver transplantation. A total of 21 patients, aged 4-16.9 yr (median 9.6 yr) were tested 1-9 yr (median 4.2 yr) after the transplantation. The pretransplant diagnoses included biliary atresia (eight patients), various metabol...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00081.x

    authors: Adebäck P,Nemeth A,Fischler B

    更新日期:2003-10-01 00:00:00

  • Liver retransplantation in an infant requiring cavoportal hemi transposition.

    abstract::Historically inability to achieve portal inflow to the liver allograft operatively was felt to be a contraindication to orthotopic liver transplantation (OLTx). Cavoportal hemi transposition has been utilized more recently in adult OLTx recipients but rarely in pediatric recipients. Here we report the case of a 10-mon...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00196.x

    authors: Verran D,Crawford M,Stormon M,Shun A

    更新日期:2004-08-01 00:00:00

  • Health-related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients.

    abstract:PURPOSE:The understanding of the HRQOL issues for parent donors of children who underwent LDLT is lacking. We evaluated the HRQOL of donor and non-donor parents, described their subjective experiences and identified factors associated with lower HRQOL post-donation. METHODS:This is a cross-sectional study of parent do...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13337

    authors: Yuen WY,Tan A,Karthik SV,Quak SH,Kow AW,Aw MM

    更新日期:2019-03-01 00:00:00

  • The value of 18F-FDG PET in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis.

    abstract::PTLD is a serious complication of both solid organ and BMT. This study assessed whether (18) F-FDG PET, when added to CT scan, had additional value in the initial evaluation of PTLD in pediatric patients and whether PET/CT at baseline can reliably guide biopsy. This retrospective study evaluated 34 consecutive pediatr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12611

    authors: Vali R,Punnett A,Bajno L,Moineddin R,Shammas A

    更新日期:2015-12-01 00:00:00

  • Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience.

    abstract::Delayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, some of the previous studies have shown that ELT seems to enhance platelet recovery for post-allogen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13962

    authors: Yaman Y,Elli M,Şahin Ş,Özdilli K,Bilgen H,Bayram N,Nepesov S,Anak S

    更新日期:2021-01-16 00:00:00