The value of 18F-FDG PET in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis.


:PTLD is a serious complication of both solid organ and BMT. This study assessed whether (18) F-FDG PET, when added to CT scan, had additional value in the initial evaluation of PTLD in pediatric patients and whether PET/CT at baseline can reliably guide biopsy. This retrospective study evaluated 34 consecutive pediatric patients (14 female), aged 3.5-17.0 yr (mean age: 9.9 yr, s.d.: 4.9 yr), who had undergone (18) F-FDG PET/CT from May 2007 to December 2014 at initial diagnosis of PTLD following heart (n = 13), lung (n = 8), kidney (n = 4), liver (n = 3), liver and bowel (n = 3), and bone marrow (n = 3) transplantation. PTLD was diagnosed histopathologically in 33 patients and was based on clinical findings, elevated EBV, and imaging and follow-up results in one patient. On lesion-based analysis, (18) F-FDG PET showed more lesions than conventional CT scan (168 vs. 134), but CT revealed 22 lesions negative on PET. On per patient analysis, PET detected more lesions in 13 patients, CT identified more abnormalities in seven, and both showed the same number of lesions in 14. Adding (18) F-FDG PET to CT scans upstaged the disease in seven patients (20.5%). A combination of (18) F-FDG PET and CT was also useful in guiding biopsy, being positive in 36 of 39 samples (92.3%). These findings indicated that (18) F-FDG PET and CT are complementary at initial staging of pediatric PTLD and that (18) F-FDG PET/CT scanning can guide biopsies.


Pediatr Transplant


Vali R,Punnett A,Bajno L,Moineddin R,Shammas A




Has Abstract


2015-12-01 00:00:00












  • Recurrence of primary disease in children after renal transplantation: an evidence-based update.

    abstract::The availability of new and more effective anti-rejection therapy has succeeded in reducing the incidence of acute cellular rejection in first months post-renal transplant. This in turn has escalated the order of significance of recurrence of primary disease in the renal allograft as a cause for patient morbidity and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Seikaly MG

    更新日期:2004-04-01 00:00:00

  • Pubertal outcomes of children transplanted with allogeneic stem cells after myeloablative total body irradiation or busulfan: Influence of age and sex is confirmed, while a role of chronic graft-versus-host disease in delayed puberty onset is revealed.

    abstract:INTRODUCTION:Myeloablative conditioning before allogeneic HSCT during childhood exposes to serious long-term complications, especially gonadal dysfunction. Pubertal issues are less described than other post-HSCT sequelae in childhood. METHODS:Pubertal development and biological gonadal parameters were assessed in a re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Weinhard S,Wiedemann A,Leheup B,Dalle JH,Lebon Labich B,Pochon C

    更新日期:2020-09-01 00:00:00

  • Fludrocortisone-a treatment for tubulopathy post-paediatric renal transplantation: A national paediatric nephrology unit experience.

    abstract::Calcineurin inhibitors post-renal transplantation are recognized to cause tubulopathies in the form of hyponatremia, hyperkalemia, and acidosis. Sodium supplementation may be required, increasing medication burden and potentially resulting in poor compliance. Fludrocortisone has been beneficial in addressing tubulopat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Ali SR,Shaheen I,Young D,Ramage I,Maxwell H,Hughes DA,Athavale D,Shaikh MG

    更新日期:2018-03-01 00:00:00

  • Bone mineral disorders in pediatric and adolescent renal transplant recipients.

    abstract::Incomplete resolution of abnormalities of mineral metabolism associated with CRF results in the relatively high prevalence of ROD in pediatric kidney recipients. This non-randomized, cross-sectional, and analytic-descriptive study on bone density, vitamin D, and mineral metabolism was performed in 57 children and adol...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Derakhshan A,Behbahan AG,Lotfi M,Omrani GH,Fallahzadeh MH,Basiratnia M,Al-Hashemi GH

    更新日期:2011-06-01 00:00:00

  • Risk for post-transplant lymphoproliferative disorder after polyclonal antibody induction in kidney transplantation.

    abstract::The adjusted relative risk (aRR) for development of post-transplant lymphoproliferative disorder (PTLD) is higher in kidney transplant recipients receiving monoclonal antibody induction therapy, but the aRR between the different available polyclonal agents has not been investigated in detail. We analyzed data from the...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Dharnidharka VR,Stevens G

    更新日期:2005-10-01 00:00:00

  • Significance of Epstein-Barr virus status and post-transplant lymphoproliferative disease in pediatric thoracic transplantation.

    abstract::Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD) is a serious complication of organ and bone marrow transplantation. The importance of EBV matching between recipient and donor remains unclear. Between October 1987 and December 1997, 64 pediatric cardio-pulmonary transplants were p...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Harwood JS,Gould FK,McMaster A,Hamilton JR,Corris PA,Hasan A,Gennery AR,Dark JH

    更新日期:1999-05-01 00:00:00

  • Heart transplantation in children: indications. Report of the Ad Hoc Subcommittee of the Pediatric Committee of the American Society of Transplantation (AST).

    abstract::This review details the indications for heart transplantation in children. Contraindications have evolved from absolute to relative. Controversial issues remain and this paper represents a consensus of more than a dozen centers that have programs that remain active performing pediatric heart transplants. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Fricker FJ,Addonizio L,Bernstein D,Boucek M,Boucek R,Canter C,Chinnock R,Chin C,Kichuk M,Lamour J,Pietra B,Morrow R,Rotundo K,Shaddy R,Schuette EP,Schowengerdt KO,Sondheimer H,Webber S

    更新日期:1999-11-01 00:00:00

  • Controlling the blood glucose of type 1 diabetes mice by co-culturing MIN-6 β cells on 3D scaffold.

    abstract::T1D is an autoimmune disease, which may be caused by lack of insulin-secreting β cells due to damage of autoimmune system. Living with T1D is a challenge for the child and the family; cell transplantation is a treatment option for diabetes in children. To establish a microenvironment suitable for cell growth and proli...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Yuan X,Huang Y,Guo Y,Wang L,Guo Q,Xu T,Wu D,Zhou P,Zhu S,Wang Y,Fan X,Zhu M,Lu Y,Wang Z

    更新日期:2015-06-01 00:00:00

  • Parental functioning improves the developmental quotient of pediatric liver transplant recipients.

    abstract::Psychomotor development in pediatric liver transplant (LT) recipients depends on several factors. Our aim was to evaluate the importance of parental involvement and family dynamics on psychomotor development by assessing (i) children and parents individually, (ii) the parent-child relationship, and (iii) the correlati...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Posfay-Barbe KM,Barbe RP,Wetterwald R,Belli DC,McLin VA

    更新日期:2013-06-01 00:00:00

  • Post-transplant glucose status in 61 pediatric renal transplant recipients: preliminary results of five Turkish pediatric nephrology centers.

    abstract::To assess the incidence, risk factors and outcomes of PTDM, a total of 61 non-diabetic children (24 girls, 37 boys, age: 14.5 +/- 2.1 yr) were examined after their first kidney transplantation (37.3 +/- 21.6 months) with an OGTT. At baseline, 16 (26.2%) patients had IGT, 45 (73.8%) had NGT, and no patient had PTDM. No...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Buyan N,Bilge I,Turkmen MA,Bayrakci U,Emre S,Fidan K,Baskin E,Gok F,Bas F,Bideci A

    更新日期:2010-03-01 00:00:00

  • Scurvy: a new problem for patients with chronic GVHD involving mucous membranes; an easy problem to resolve.

    abstract::Vitamin C deficiency in developed countries is typically observed in patients with unique clinical conditions such as cystic fibrosis or anorexia nervosa, or in patients on long-term tube feeds. We report here a clinical observation in six pediatric and adolescent patients (median age 17.5 yr, range 9.8-23.5 yr) with ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Kletzel M,Powers K,Hayes M

    更新日期:2014-08-01 00:00:00

  • Intra-arterial nitroglycerin for intra-operative arterial vasospasm during pediatric renal transplantation.

    abstract::Intra-operative arterial vasospasm during pediatric renal transplantation is an urgent clinical situation resulting in end-organ ischemia, associated changes in parenchymal turgor and color, diminished flow on ultrasound, and if left untreated, allograft loss. We hypothesized that intra-operative intra-arterial inject...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Penna FJ,Harvey E,John P,Armstrong D,Luginbuehl I,Odeh RI,Alyami F,Koyle MA,Lorenzo AJ

    更新日期:2016-05-01 00:00:00

  • Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents.

    abstract::This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Park M,Lee YH,Kang HR,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Baek HJ,Kook H,Hwang TJ,Lee JW,Chung NG,Cho B,Kim HK,Lee SH,Yoo KH,Sung KW,Koo HH,Koh KN,Im HJ,Seo JJ,Park JE,Lim YJ,Lyu CJ,Lee JM,Hah JO,K

    更新日期:2014-03-01 00:00:00

  • Dyslipidemia after pediatric renal transplantation-The impact of immunosuppressive regimens.

    abstract::Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Dat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Habbig S,Volland R,Krupka K,Querfeld U,Dello Strologo L,Noyan A,Yalcinkaya F,Topaloglu R,Webb NJ,Kemper MJ,Pape L,Bald M,Kranz B,Taylan C,Höcker B,Tönshoff B,Weber LT

    更新日期:2017-05-01 00:00:00

  • Reduced-intensity allogeneic hematopoietic cell transplantation: Graft versus tumor effects with decreased toxicity.

    abstract::The potentially curative role of allogeneic hematopoietic cell transplantation (HCT) in neoplastic and non-neoplastic diseases is offset by the substantial risks of morbidity and mortality from complications of the intensive myeloablative and immunosuppressive preparative regimen. These regimen-related toxicities have...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Schwartz JE,Yeager AM

    更新日期:2003-06-01 00:00:00

  • Plasma cell-rich acute cellular rejection of a transplanted kidney associated with antibody to the red cell Kidd antigen.

    abstract::Plasma cell-rich acute cellular rejection of a transplanted kidney is described in association with the identification of serum antibody to the red cell Kidd antigen, Jk-b, which is also found in the kidney. This antibody was formed without a history of a recent blood transfusion or exposure to intravenous immunoglobu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Hamilton MS,Singh V,Warady BA

    更新日期:2006-12-01 00:00:00

  • Chronic neutrophilic leukemia, an extremely rare cause of neutrophilia in childhood: Cure with hematopoietic stem cell transplantation.

    abstract::CNL is a rare myeloproliferative disorder frequently seen in older adults. A significant proportion of patients show progression to AML. Here, we report the case of a patient with FA who was monitored for leukopenia but who developed leukocytosis during the follow-up and was diagnosed with CNL probably after an acquir...

    journal_title:Pediatric transplantation



    authors: Uygun V,Daloğlu H,Öztürkmen S,Karasu G,Avcı Z,Yeşilipek A

    更新日期:2018-08-01 00:00:00

  • Preemptive plasmapheresis and recurrence of focal segmental glomerulosclerosis in pediatric renal transplantation.

    abstract::  FSGS has a high recurrence rate after renal transplantation. To examine the effects of the use of preemptive and post-transplant PP on recurrence and graft outcome, we conducted a retrospective study on 34 pediatric patients (mean age 13±5 yr) with biopsy-proven pretransplant FSGS and who underwent a renal transplan...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Gonzalez E,Ettenger R,Rianthavorn P,Tsai E,Malekzadeh M

    更新日期:2011-08-01 00:00:00

  • Successful percutaneous transhepatic recanalization of a completely obstructed hepatico-jejunal anastomosis in a child with liver transplantation: Unusual employment of the transseptal puncture system.

    abstract::Stenosis of the HJ is a common complication of pediatric split LT with high morbidity and possible evolution to secondary biliary cirrhosis and re-transplantation if not treated. Because the endoscopy is generally infeasible in the Roux-en-Y, percutaneous interventional radiology management is usually the safest and m...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Paolantonio G,Pietrobattista A,Parapatt GK,Liccardo D,Natali GL,Candusso M,Spada M,Rollo M,Tomà P

    更新日期:2018-12-01 00:00:00

  • ABPM vs office blood pressure to define blood pressure control in treated hypertensive paediatric renal transplant recipients.

    abstract::While 24-h ambulatory blood pressure monitoring (ABPM) is an established tool for monitoring antihypertensive therapy in adults, data in children are scarce. We retrospectively analysed whether office blood pressure (BP) is reliable for the diagnosis of BP control in 26 treated hypertensive paediatric renal transplant...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Ferraris JR,Ghezzi L,Waisman G,Krmar RT

    更新日期:2007-02-01 00:00:00

  • Outcomes of pediatric liver transplant are unaffected by the time or day of surgery.

    abstract:BACKGROUND:In adults, the time of day for LT does not affect post-transplant outcomes. Whether this is true or not in children is unknown. In this study, we aimed to evaluate if weekend and weeknight liver transplants are associated with worse patient and graft survival in children. METHODS:We interrogated the UNOS da...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Rogers ME,Egberg MD,Sylvester F,Lichtman S,Lin FC

    更新日期:2020-12-01 00:00:00

  • The efficacy of serum brain natriuretic peptide for the early detection of portopulmonary hypertension in biliary atresia patients before liver transplantation.

    abstract::Severe portopulmonary hypertension (POPH) is a contraindication for liver transplantation (LT) because of the high risk of postoperative heart failure. The early detection of POPH is important for patients with biliary atresia (BA). Brain natriuretic peptide (BNP) is known to be correlated with liver fibrosis in patie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Yoshimaru K,Matsuura T,Takahashi Y,Yanagi Y,Nagata H,Ohga S,Taguchi T

    更新日期:2018-08-01 00:00:00

  • An unusual case of anemia in a cardiac transplant recipient.

    abstract::Anemia is a well-described comorbidity in patients with heart failure and has been associated with decreased survival rates after heart transplant. The causes of anemia are broad, and identification of the underlying etiology is critical for management. Herein, we report an unusual case of severe anemia complicating c...

    journal_title:Pediatric transplantation



    authors: Lehto E,Raj A,Sparks J

    更新日期:2018-06-01 00:00:00

  • The evaluation of bone metabolism in children with renal transplantation.

    abstract::This study aims to evaluate BMD and bone biomarkers and to investigate the effects of immunosuppressives on bone disease after RTx. Thirty-three RTR aged 16.7 ± 3.7 yr and healthy controls (n = 32) were enrolled. There was no difference between pre-RTx BMD and BMD at the time of study (45.9 ± 30.9 months after RTx), w...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Büyükkaragöz B,Bakkaloglu SA,Kandur Y,Isiyel E,Akcaboy M,Buyan N,Hasanoglu E

    更新日期:2015-06-01 00:00:00

  • Experience of 100 solid organ transplants over a five-yr period from the first successful pediatric multi-organ transplant program in India.

    abstract::To analyze the clinical profile and outcome of pediatric patients who had undergone a liver and/or RT at our center over a five yr period, case records of all the patients who had undergone a liver or RT were analyzed retrospectively. One hundred solid organ transplants were performed at our center between January 200...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Sibal A,Malhotra S,Guru FR,Bhatia V,Kapoor A,Seth S,Jerath N,Jasuja S,Rajkumari V,Wadhawan M,Aggarwal DK,Guleria S,Shrivastava RN,Gupta S

    更新日期:2014-11-01 00:00:00

  • Approaches to acute liver failure in children.

    abstract::Acute liver failure (ALF) is a rare but often fatal disorder in childhood. Its aetiology includes infections, toxins, metabolic disorders, infiltrative diseases, autoimmune hepatitis, ischaemia, irradiation damage, but in a high proportion of cases it remains unknown. In contrast to adults, in children with ALF hepati...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Dhawan A,Cheeseman P,Mieli-Vergani G

    更新日期:2004-12-01 00:00:00

  • Impact of donor cardiopulmonary resuscitation on pediatric heart transplant outcome.

    abstract::Mortality is the highest of any solid organ in pediatric patients awaiting heart transplantation. Strategies to increase the donor pool are needed if survival to transplant is to improve. There can be reluctance to accept pediatric hearts for transplantation if the donor has received cardiopulmonary resuscitation (CPR...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: L'Ecuyer T,Sloan K,Tang L

    更新日期:2011-11-01 00:00:00

  • Successful transplantation of a cadaveric kidney with post-infectious glomerulonephritis.

    abstract::This report describes a successful renal Tx in a patient with chronic renal failure, caused by dysplastic kidneys, who received a cadaveric kidney with post-infectious glomerulonephritis. Sequential renal biopsies were performed at 12 h before Tx, and at 1 h and on days 8 and 58 post-Tx. Post-operative hematuria disap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Mizuiri S,Shigetomi Y,Sugiyama K,Miyagi M,Hatano T,Tajima E,Aikawa A,Ohara T,Kawamura S,Hasegawa A

    更新日期:2000-02-01 00:00:00

  • Longitudinal gonadal function after bone marrow transplantation for acute lymphoblastic leukemia during childhood.

    abstract::Total body irradiation and high-dose chemotherapy, applied as a preparatory regimen for bone marrow transplantation (BMT) in children with acute lymphoblastic leukemia (ALL), are particularly hazardous to the gonads and, in addition, can impair hypothalamo pituitary-gonadal control. Longitudinal data on pubertal devel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Mayer EI,Dopfer RE,Klingebiel T,Scheel-Walter H,Ranke MB,Niethammer D

    更新日期:1999-02-01 00:00:00

  • Quantitation of allograft fibrosis and chronic allograft nephropathy.

    abstract::Despite improvements in the prevention and treatment of acute renal allograft rejection, the long-term survival of renal transplants has not increased. Immunologic and non-immunologic factors contribute to the gradual deterioration of graft function and to the histologic lesion characterized by vascular and interstiti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Grimm PC,Nickerson P,Gough J,McKenna R,Jeffery J,Birk P,Rush DN

    更新日期:1999-11-01 00:00:00