The value of 18F-FDG PET in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis.


:PTLD is a serious complication of both solid organ and BMT. This study assessed whether (18) F-FDG PET, when added to CT scan, had additional value in the initial evaluation of PTLD in pediatric patients and whether PET/CT at baseline can reliably guide biopsy. This retrospective study evaluated 34 consecutive pediatric patients (14 female), aged 3.5-17.0 yr (mean age: 9.9 yr, s.d.: 4.9 yr), who had undergone (18) F-FDG PET/CT from May 2007 to December 2014 at initial diagnosis of PTLD following heart (n = 13), lung (n = 8), kidney (n = 4), liver (n = 3), liver and bowel (n = 3), and bone marrow (n = 3) transplantation. PTLD was diagnosed histopathologically in 33 patients and was based on clinical findings, elevated EBV, and imaging and follow-up results in one patient. On lesion-based analysis, (18) F-FDG PET showed more lesions than conventional CT scan (168 vs. 134), but CT revealed 22 lesions negative on PET. On per patient analysis, PET detected more lesions in 13 patients, CT identified more abnormalities in seven, and both showed the same number of lesions in 14. Adding (18) F-FDG PET to CT scans upstaged the disease in seven patients (20.5%). A combination of (18) F-FDG PET and CT was also useful in guiding biopsy, being positive in 36 of 39 samples (92.3%). These findings indicated that (18) F-FDG PET and CT are complementary at initial staging of pediatric PTLD and that (18) F-FDG PET/CT scanning can guide biopsies.


Pediatr Transplant


Vali R,Punnett A,Bajno L,Moineddin R,Shammas A




Has Abstract


2015-12-01 00:00:00












  • Sequential renal and bone marrow transplants in a child with Fanconi anemia.

    abstract::FA is an autosomal recessive disorder characterized by small stature and renal abnormalities. FA can lead to progressive bone marrow failure, myelodysplastic syndrome, or acute leukemia. Using a multidisciplinary team approach, we managed a 3-yr-old boy with FA who simultaneously developed renal and hematopoietic fail...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Vincent CL,Primack WA,Hipps J,Kasow KA

    更新日期:2016-02-01 00:00:00

  • Successful percutaneous transhepatic recanalization of a completely obstructed hepatico-jejunal anastomosis in a child with liver transplantation: Unusual employment of the transseptal puncture system.

    abstract::Stenosis of the HJ is a common complication of pediatric split LT with high morbidity and possible evolution to secondary biliary cirrhosis and re-transplantation if not treated. Because the endoscopy is generally infeasible in the Roux-en-Y, percutaneous interventional radiology management is usually the safest and m...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Paolantonio G,Pietrobattista A,Parapatt GK,Liccardo D,Natali GL,Candusso M,Spada M,Rollo M,Tomà P

    更新日期:2018-12-01 00:00:00

  • Acute lymphoblastic leukaemia: whom and when should we transplant?

    abstract::To date, the evidence upon which a decision is made to transplant a child with acute lymphoblastic leukaemia either in first or subsequent remission has rarely been based on randomized trial data. Modern era management of infection and graft-versus-host disease lessens risks but procedure-related deaths still remain h...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Eden OB

    更新日期:1999-01-01 00:00:00

  • VPS 45-associated primary infantile myelofibrosis--successful treatment with hematopoietic stem cell transplantation.

    abstract::PMF of infancy is a recently described autosomal recessive disorder presenting with severe bone marrow failure, accelerated neutrophil apoptosis, and significant platelet dysfunction, caused by a mutation in the VPS45 gene. In this study, we update our group of patients with PMF, highlighting different aspects of this...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Stepensky P,Simanovsky N,Averbuch D,Gross M,Yanir A,Mevorach D,Elpeleg O,Weintraub M

    更新日期:2013-12-01 00:00:00

  • Cognitive and emotional outcome after pediatric liver transplantation.

    abstract::The aim of the study was to evaluate the cognitive and emotional development after pediatric liver transplantation. A total of 21 patients, aged 4-16.9 yr (median 9.6 yr) were tested 1-9 yr (median 4.2 yr) after the transplantation. The pretransplant diagnoses included biliary atresia (eight patients), various metabol...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Adebäck P,Nemeth A,Fischler B

    更新日期:2003-10-01 00:00:00

  • Post-transplant epididymitis and orchitis following Listeria monocytogenes septicaemia.

    abstract::We report the occurrence of epididymitis and orchitis 1 week after the onset of Listeriosis in an 11-month-old boy receiving an orthotopic liver transplantation for biliary atresia. Immunologic implications of Listeria monocytogenes-induced testicular inflammation are discussed, and the potential role of immunosuppres...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: von Schnakenburg C,Hinrichs B,Fuchs J,Kardorff R

    更新日期:2000-05-01 00:00:00

  • Serial signal-averaged electrocardiography in children after cardiac transplantation.

    abstract::In patients with myocytolysis detected in endomyocardial biopsy, there is a tendency towards a shift of ventricular electrical axes from normal to strain pattern on surface ECG. Their 12-lead signal-averaged electrocardiogram (SAECG) show a significant increase in filtered QRS duration (QRSD) compared with those with ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Bennhagen RG,Sörnmo L,Pahlm O,Pesonen E

    更新日期:2005-12-01 00:00:00

  • The development of eosinophilic colitis after liver transplantation in children.

    abstract::Tacrolimus-based immunosuppression in pediatric liver transplant recipients is known to be associated with EGID. Our goal was to determine the incidence, risk factors, and characteristics of EGID in our pediatric liver transplantation program. This study was a retrospective analysis of 38 pediatric liver transplant re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Lee JH,Park HY,Choe YH,Lee SK,Lee SI

    更新日期:2007-08-01 00:00:00

  • Post-transplantation growth among pediatric recipients of liver transplantation.

    abstract::Improving a patient's quality-of-life (QOL) post-liver transplantation is of great importance. An aspect of improved QOL is the restoration of normal growth patterns in pediatric patients. To describe the post-transplantation growth patterns of 72 children included in the National Institute of Diabetes and Digestive a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Evans IV,Belle SH,Wei Y,Penovich C,Ruppert K,Detre KM,National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database Team.

    更新日期:2005-08-01 00:00:00

  • Combined heterotopic liver-pancreas transplantation as a curative treatment for liver cirrhosis and diabetes mellitus in cystic fibrosis.

    abstract::Cystic fibrosis (CF) is an inherited disease with a defect in epithelial chloride transport that results in a multisystem disease. Although pulmonary disease remains the primary cause of morbidity and mortality, focal biliary cirrhosis and portal hypertension may develop in up to 8% of these patients. Liver transplant...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Henn C,Kapellen T,Prenzel F,Siekmeyer M,Hau HM,Kiess W,Bartels M

    更新日期:2014-02-01 00:00:00

  • Australian deceased donor kidney allocation protocols: Transplant waiting and graft quality for children and adolescents.

    abstract::DD kidney allocation protocols may influence timing of transplantation and graft quality for pediatric recipients. This study aimed to evaluate the effects of these protocols, including pediatric priority, on waiting time on dialysis, transplant type, donor age, and HLA matching according to state of transplant in Aus...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Le Page AK,Johnstone LM,Kennedy SE

    更新日期:2015-09-01 00:00:00

  • A systematic review of immunosuppressant adherence interventions in transplant recipients: Decoding the streetlight effect.

    abstract::Non-adherence to immunosuppressant medications is an important risk factor for graft dysfunction. To evaluate the effectiveness of adherence-enhancing interventions, we reviewed adherence intervention studies in solid organ transplant recipients (all ages). Using the following databases: PsycINFO, PubMed, Scopus, and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Duncan S,Annunziato RA,Dunphy C,LaPointe Rudow D,Shneider BL,Shemesh E

    更新日期:2018-02-01 00:00:00

  • Successful transplantation of a cadaveric kidney with post-infectious glomerulonephritis.

    abstract::This report describes a successful renal Tx in a patient with chronic renal failure, caused by dysplastic kidneys, who received a cadaveric kidney with post-infectious glomerulonephritis. Sequential renal biopsies were performed at 12 h before Tx, and at 1 h and on days 8 and 58 post-Tx. Post-operative hematuria disap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Mizuiri S,Shigetomi Y,Sugiyama K,Miyagi M,Hatano T,Tajima E,Aikawa A,Ohara T,Kawamura S,Hasegawa A

    更新日期:2000-02-01 00:00:00

  • Are drowned donors marginal donors? A single pediatric center experience.

    abstract::Drowning, a common cause of death in the pediatric population, is a potentially large donor pool for OLT. Anecdotally, transplant centers have deemed these organs high risk over concerns for infection and graft dysfunction. We theorized drowned donor liver allografts do not portend worse outcomes and therefore should ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Kumm KR,Galván NTN,Koohmaraie S,Rana A,Kueht M,Baugh K,Hao L,Yoeli D,Cotton R,O'Mahony CA,Goss JA

    更新日期:2017-09-01 00:00:00

  • Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging.

    abstract:UNLABELLED:Liver transplantation treats the hepatic affectation of UCDs; however, irreversible neurologic damage pretransplant is difficult to assess providing transplant teams with ethical dilemmas for liver transplantation. The purpose of our study was to determine whether pretransplant neuroimaging can predict devel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Bolton SM,Campbell KM,Kukreja M,Kohli R

    更新日期:2015-08-01 00:00:00

  • Aspergillus "fungus ball" of the bladder after hematopoietic transplantation in a pediatric patient: successful treatment with intravesical voriconazole and surgery.

    abstract::Aspergillosis is an important cause of mortality in allogeneic HSCT. A "fungus ball" formation of Aspergillus in the bladder has seldom been reported. We report a child that underwent HSCT and developed possible disseminated aspergillosis with an intravesical "fungus ball," diagnosed by genitourinary MRI and PCR of th...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: González-Vicent M,Lassaletta A,López-Pino MA,Romero-Tejada JC,de la Fuente-Trabado M,Díaz MA

    更新日期:2008-03-01 00:00:00

  • Invasive diagnostic procedures for pulmonary infiltrates in pediatric hematopoietic stem cell transplant recipients.

    abstract::To evaluate the role of BAL, CTB, and OLB in the management of pulmonary infiltrates in pediatric HSCT recipients, we conducted a retrospective review of clinical records of pediatric HSCT recipients. Data were analyzed using Chi-square for dichotomous and anova for continuous variables. Logistic regression was used t...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Armenian SH,Hoffman JA,Butturini AM,Kapoor N,Mascarenhas L

    更新日期:2007-11-01 00:00:00

  • A clinical description of children with solid organ transplants who present with feeding disorder.

    abstract::Pediatric solid organ transplant recipients have long-standing malnutrition concerns related to their pretransplant medical status. The targeted nutrition therapy utilized pre-, peri-, and post-transplantation may have the adverse effect of impeding normally developing feeding skills, particularly in very young childr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Lerret SM,Erato G,Goday PS,Silverman AH

    更新日期:2019-05-01 00:00:00

  • The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients.

    abstract::SR-aGVHD remains a significant cause of morbidity and mortality in allogeneic HCT recipients. Alemtuzumab has been used with success in adult patients but has not been studied in the pediatric setting. To estimate the effectiveness of alemtuzumab for the treatment of SR-aGVHD in pediatric patients, we retrospectively ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Khandelwal P,Lawrence J,Filipovich AH,Davies SM,Bleesing JJ,Jordan MB,Mehta P,Jodele S,Grimley MS,Kumar A,Myers K,Marsh RA

    更新日期:2014-02-01 00:00:00

  • Surgical treatment of primary liver tumors in children: outcomes analysis of resection and transplantation in the SEER database.

    abstract::Adjusted survival outcomes following hepatic resection and transplantation for pediatric liver tumors have not been compared. To address this question, we conducted a retrospective cohort study using the SEER registry. While SEER lacks certain specifics regarding staging, chemotherapy, comorbidities, and recurrence, i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: McAteer JP,Goldin AB,Healey PJ,Gow KW

    更新日期:2013-12-01 00:00:00

  • Planning for the future of a pediatric kidney transplant recipient with special needs: A parent's perspective.

    abstract::I was asked to write this article to share with medical professionals, my view as a parent with a child who has special needs and needs a transplant. It is a detailed story from a parent's point of view on what it is like to have a child with special needs with serious medical complications and how I went about findin...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Carney MT

    更新日期:2021-02-01 00:00:00

  • Prevalence of clinical rejection after surveillance biopsies in pediatric renal transplants: does early subclinical rejection predispose to subsequent rejection episodes?

    abstract::We analyzed rates of both SCR and CR in children receiving SB at three months post-transplant to determine if SCR predisposed patients to acute CR. Acute rejection was defined according to Banff criteria to include borderline classification or higher. All cases of SCR and CR were treated with anti-rejection protocols....

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Hymes LC,Warshaw BL,Hennigar RA,Amaral SG,Greenbaum LA

    更新日期:2009-11-01 00:00:00

  • Sequential liver-kidney transplantation in a boy with congenital hepatic fibrosis and nephronophthisis from a living donor.

    abstract::A five-yr-old boy developed chronic liver failure and ESKD because of CHF and juvenile NPHP. He underwent sequential liver and kidney transplantation with a compatible blood type from his father, at five yr, seven months and five yr, 11 months old, respectively. Because the patient was not in ESKD, we initially perfor...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Udagawa T,Kamei K,Ogura M,Tsutsumi A,Noda S,Kasahara M,Fukuda A,Sakamoto S,Shigeta S,Tanaka H,Kuroda T,Matsuoka K,Nakazawa A,Nagai T,Uemura O,Ito S

    更新日期:2012-11-01 00:00:00

  • Attitudes toward xenotransplantation: A survey of parents and pediatric cardiac providers.

    abstract:BACKGROUND:Scientific advancements are occurring in cardiac xenotransplantation (XTx). However, there have been religious and social concerns surrounding this allotransplantation alternative. The purpose of this study was to explore the acceptance of XTx among stakeholders of the congenital heart disease (CHD) communit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Padilla LA,Rhodes L,Sorabella RA,Hurst DJ,Cleveland DC,Dabal RJ,Cooper DK,Paris W,Carlo WF

    更新日期:2020-10-06 00:00:00

  • Oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation: clinical outcomes in a context of specialized oral care using low-level laser therapy.

    abstract::OM is a painful inflammatory condition of the oral mucosa, derived from the toxic effects of chemotherapy and radiotherapy. High OM severity is frequently present in HSCT pediatric patients, who exhibit multiple painful ulcers that limit their mastication and swallowing, leading to poor nutritional status. Few studies...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Eduardo Fde P,Bezinelli LM,de Carvalho DL,Lopes RM,Fernandes JF,Brumatti M,Vince CS,de Azambuja AM,Vogel C,Hamerschlak N,Correa L

    更新日期:2015-05-01 00:00:00

  • Simultaneous surgical and interventional radiological approach to treat complicated biliary strictures after pediatric liver transplantation.

    abstract::Post-transplantation biliary strictures occur in 5-15% of the pediatric liver transplant patients and are conventionally managed by interventional radiological techniques. Failure of this treatment leads to reoperation and sometimes to retransplantation. Herein, we describe a surgical approach and interventional radio...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Salvalaggio PR,Bambini DA,Donaldson J,Saker M,Whitington PF,Alonso EM,Superina RA

    更新日期:2004-10-01 00:00:00

  • Outcome after pediatric liver transplantation for staged abdominal wall closure with use of biological mesh-Study with long-term follow-up.

    abstract::Abdominal wall closure after pediatric liver transplantation (pLT) in infants may be hampered by graft-to-recipient size discrepancy. Herein, we describe the use of a porcine dermal collagen acellular graft (PDCG) as a biological mesh (BM) for abdominal wall closure in pLT recipients. Patients <2 years of age, who und...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Gül-Klein S,Dziodzio T,Martin F,Kästner A,Witzel C,Globke B,Jara M,Ritschl PV,Henning S,Gratopp A,Bufler P,Schöning W,Schmelzle M,Pratschke J,Öllinger R

    更新日期:2020-05-01 00:00:00

  • Surveillance transbronchial biopsies in infant lung and heart-lung transplant recipients.

    abstract::There are limited published data on surveillance TBB for the identification of allograft rejection in infants after lung or heart-lung transplantation. We performed a retrospective review of children under one yr of age who underwent lung or heart-lung transplant at our institution. Since 2005, four infants were trans...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Hayes D Jr,Baker PB,Kopp BT,Kirkby S,Galantowicz M,McConnell PI,Astor TL

    更新日期:2013-11-01 00:00:00

  • Scurvy: a new problem for patients with chronic GVHD involving mucous membranes; an easy problem to resolve.

    abstract::Vitamin C deficiency in developed countries is typically observed in patients with unique clinical conditions such as cystic fibrosis or anorexia nervosa, or in patients on long-term tube feeds. We report here a clinical observation in six pediatric and adolescent patients (median age 17.5 yr, range 9.8-23.5 yr) with ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Kletzel M,Powers K,Hayes M

    更新日期:2014-08-01 00:00:00

  • Quantitation of allograft fibrosis and chronic allograft nephropathy.

    abstract::Despite improvements in the prevention and treatment of acute renal allograft rejection, the long-term survival of renal transplants has not increased. Immunologic and non-immunologic factors contribute to the gradual deterioration of graft function and to the histologic lesion characterized by vascular and interstiti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Grimm PC,Nickerson P,Gough J,McKenna R,Jeffery J,Birk P,Rush DN

    更新日期:1999-11-01 00:00:00