Cyclosporine-induced white and grey matter central nervous system lesions in a pediatric renal transplant patient.

Abstract:

:Major neurologic complications secondary to cyclosporine are well documented and are known to include confusion, cortical blindness, seizure, spasticity, paresis, ataxia and coma. Most previous reports attribute these to white matter central nervous system (CNS) lesions or white/grey matter border lesions. Many predisposing factors have been identified, including: elevated levels of cyclosporine, hypomagnesemia, hypocholesterolemia, aluminium toxicity, high dose steroids, hypertension and infection. However CNS events attributed to cyclosporine have been reported without any of these risk factors. We report a case of a child developing multiple white and grey matter thalamic and cortical lesions along with acute neurologic deterioration, and then review cyclosporine mediated CNS injury, including the roles of P-glycoprotein and cyclophilin.

journal_name

Pediatr Transplant

authors

Jeruss J,Braun SV,Reese JC,Guillot A

keywords:

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

45-50

issue

1

eissn

1397-3142

issn

1399-3046

journal_volume

2

pub_type

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