Quantitation of allograft fibrosis and chronic allograft nephropathy.

Abstract:

:Despite improvements in the prevention and treatment of acute renal allograft rejection, the long-term survival of renal transplants has not increased. Immunologic and non-immunologic factors contribute to the gradual deterioration of graft function and to the histologic lesion characterized by vascular and interstitial fibrosis ('chronic rejection'). Quantitation of this process has been attempted using various invasive and non-invasive methods. These methods, performed at different times post-transplant, are reviewed in this article. In particular, pathology scoring systems and the potential of using computerized image analysis of biopsy material are discussed.

journal_name

Pediatr Transplant

authors

Grimm PC,Nickerson P,Gough J,McKenna R,Jeffery J,Birk P,Rush DN

doi

10.1034/j.1399-3046.1999.00044.x

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

257-70

issue

4

eissn

1397-3142

issn

1399-3046

journal_volume

3

pub_type

杂志文章,评审
  • Sustained seroconversion of chronic hepatitis B infection after stem cell transplantation.

    abstract::  We present an 18-yr-old adolescent with acute lymphocytic leukemia, who underwent peripheral blood SCT with serologically and histologically documented chronic hepatitis B infection. Prior and during the transplant process, lamivudine was administered orally and he underwent SCT with a twofold decrease in viral load...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01272.x

    authors: Serap A,Funda O,Bengu K,Mehmet K,Nazan C,Rasit Y,Savas K

    更新日期:2011-08-01 00:00:00

  • Pulmonary function following allogeneic stem cell transplantation in childhood: a retrospective cohort study of 51 patients.

    abstract::HSCT is associated with a high risk of late morbidity. The aim of this study was to evaluate the frequency, time frame, risk factors, and possible etiology of pulmonary dysfunction following allogeneic HSCT in childhood. We evaluated the pulmonary function of 51 HSCT patients (>6 yr), by including FVC and FEV1 values ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12313

    authors: Madanat-Harjuoja LM,Valjento S,Vettenranta K,Kajosaari M,Dyba T,Taskinen M

    更新日期:2014-09-01 00:00:00

  • The development of eosinophilic colitis after liver transplantation in children.

    abstract::Tacrolimus-based immunosuppression in pediatric liver transplant recipients is known to be associated with EGID. Our goal was to determine the incidence, risk factors, and characteristics of EGID in our pediatric liver transplantation program. This study was a retrospective analysis of 38 pediatric liver transplant re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00693.x

    authors: Lee JH,Park HY,Choe YH,Lee SK,Lee SI

    更新日期:2007-08-01 00:00:00

  • The value of 18F-FDG PET in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis.

    abstract::PTLD is a serious complication of both solid organ and BMT. This study assessed whether (18) F-FDG PET, when added to CT scan, had additional value in the initial evaluation of PTLD in pediatric patients and whether PET/CT at baseline can reliably guide biopsy. This retrospective study evaluated 34 consecutive pediatr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12611

    authors: Vali R,Punnett A,Bajno L,Moineddin R,Shammas A

    更新日期:2015-12-01 00:00:00

  • High depression rates among pediatric renal replacement therapy patients: A cross-sectional study.

    abstract::Depression is common in pediatric chronic kidney disease (CKD) patients. Depression is associated with inferior long-term outcomes. There is a paucity of studies that evaluate depression and possible associated factors in children and adolescents requiring renal replacement therapy (RRT). Cross-sectional study using C...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13591

    authors: Rodriguez Cuellar CI,García de la Puente S,Hernández Moraria J,Bojórquez Ochoa A,Filler G,Zaltzman Grishevich S

    更新日期:2019-12-01 00:00:00

  • Imaging in pediatric renal transplantation.

    abstract::Renal transplantation is the therapy of choice in children with ESKD. Radiological investigations are required in both pre- and post-transplant assessment, although there is paucity of both consensus-based statements and evidence-based imaging guidelines in pediatric renal transplantation. The phases of pediatric ESKD...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12885

    authors: Damasio MB,Ording Muller LS,Piaggio G,Marks SD,Riccabona M

    更新日期:2017-05-01 00:00:00

  • Therapeutic drug monitoring of tacrolimus in pediatric liver transplant patients.

    abstract::The clinical utility of tacrolimus monitoring in adults has been well documented. The present study compared tacrolimus monitoring in a pediatric population of 34 liver transplant patients in four US centers with an adult population of 111 patients in six US centers. Subjects (adult and pediatric) were evaluated, at d...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2000.00000.x

    authors: MacFarlane GD,Venkataramanan R,McDiarmid SV,Pirsch JD,Scheller DG,Ersfeld DL,Fitzsimmons WE

    更新日期:2001-04-01 00:00:00

  • Reduced-intensity allogeneic hematopoietic cell transplantation: Graft versus tumor effects with decreased toxicity.

    abstract::The potentially curative role of allogeneic hematopoietic cell transplantation (HCT) in neoplastic and non-neoplastic diseases is offset by the substantial risks of morbidity and mortality from complications of the intensive myeloablative and immunosuppressive preparative regimen. These regimen-related toxicities have...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2003.00016.x

    authors: Schwartz JE,Yeager AM

    更新日期:2003-06-01 00:00:00

  • Growth and weight gain of prepubertal children after cardiac transplantation.

    abstract::This study evaluated changes in growth parameters after pediatric heart transplantation and identified factors associated with the changes after pediatric heart transplantation (OHT). We retrospectively evaluated the somatic growth of 46 children <11 yr of age who underwent OHT for changes in weight, height, and BMI. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00826.x

    authors: Peterson RE,Perens GS,Alejos JC,Wetzel GT,Chang RK

    更新日期:2008-06-01 00:00:00

  • Prevalence of clinical rejection after surveillance biopsies in pediatric renal transplants: does early subclinical rejection predispose to subsequent rejection episodes?

    abstract::We analyzed rates of both SCR and CR in children receiving SB at three months post-transplant to determine if SCR predisposed patients to acute CR. Acute rejection was defined according to Banff criteria to include borderline classification or higher. All cases of SCR and CR were treated with anti-rejection protocols....

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01200.x

    authors: Hymes LC,Warshaw BL,Hennigar RA,Amaral SG,Greenbaum LA

    更新日期:2009-11-01 00:00:00

  • Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury.

    abstract::Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two gen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12712

    authors: Csohány R,Prókai Á,Sziksz E,Balicza-Himer L,Pap D,Kosik A,Sugár D,Vannay Á,Kis-Petik K,Fekete A,Szabó AJ

    更新日期:2016-08-01 00:00:00

  • ABPM vs office blood pressure to define blood pressure control in treated hypertensive paediatric renal transplant recipients.

    abstract::While 24-h ambulatory blood pressure monitoring (ABPM) is an established tool for monitoring antihypertensive therapy in adults, data in children are scarce. We retrospectively analysed whether office blood pressure (BP) is reliable for the diagnosis of BP control in 26 treated hypertensive paediatric renal transplant...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00595.x

    authors: Ferraris JR,Ghezzi L,Waisman G,Krmar RT

    更新日期:2007-02-01 00:00:00

  • The challenge of long-term follow-up of survivors of childhood acute leukemia after hematopoietic stem cell transplantation in resource-limited countries: A single-center report from Brazil.

    abstract::With the number of long-term HSCT survivors steadily increasing, attention needs to be focused on the late complications and quality of life. We therefore analyzed the outcome of 101 pediatric patients (<18 years old at the time of HSCT) transplanted for acute leukemia between 1981 and 2015 at Complexo Hospital de Clí...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13691

    authors: Marinho DH,Ribeiro LL,Nichele S,Loth G,Koliski A,Mousquer RTG,Funke VAM,Page K,Fasth A,Pasquini R,Boguszewski MCDS,Bonfim C

    更新日期:2020-06-01 00:00:00

  • Living donor lobar lung transplantation: the pediatric experience.

    abstract::Living donor (LD) lobar lung transplantation is now an accepted alternative to cadaveric lung transplantation in selected patients with end-stage lung disease. This study reviews the Childrens Hospital Los Angeles LD experience of 17 patients (mean 13.2 +/- 2.7 yrs; range 9.3-18.5 yrs). 12 LD patients had end-stage cy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Woo MS,MacLaughlin EF,Horn MV,Wong PC,Rowland JM,Barr ML,Starnes VA

    更新日期:1998-08-01 00:00:00

  • Neonates with severe infantile hepatic hemangioendothelioma: limitations of liver transplantation.

    abstract::IHHE as the most common vascular tumor of the liver in infancy can present with acute postnatal liver and congestive heart failure. LTx may be a lifesaving option, but can be complicated by extrahepatic involvement and bleeding complications, especially in neonates. Here we discuss the benefit of LTx in cases of acute...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01039.x

    authors: Grabhorn E,Richter A,Fischer L,Krebs-Schmitt D,Ganschow R

    更新日期:2009-08-01 00:00:00

  • The use of porcine dermal collagen implants in assisting abdominal wall closure of pediatric renal transplant recipients with donor size discrepancy.

    abstract::Children may have kidneys transplanted from donors larger than themselves. Abdominal wall closure may be difficult, with risks of abdominal compartment syndrome and graft compromise. Meshes used to facilitate closure may cause dense intra-abdominal adhesions, making further surgery or peritoneal dialysis difficult. We...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00824.x

    authors: Pentlow A,Smart NJ,Richards SK,Inward CD,Morgan JD

    更新日期:2008-02-01 00:00:00

  • Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation.

    abstract::Impact of pretransplant splenectomy in patients with beta-thalassemia major undergoing an allogeneic SCT has never been addressed. Twenty-seven class III patients (29 transplants) had a pretransplant splenectomy. The outcome of these 29 transplants was compared with 76 transplants in class III who did not have a splen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00953.x

    authors: Mathews V,George B,Lakshmi KM,Viswabandya A,John JM,Sitaram U,Daniel D,Chandy M,Srivastava A

    更新日期:2009-03-01 00:00:00

  • Small bowel transplantation in children.

    abstract::Small bowel transplantation has become a life-saving procedure for selected adults and children with intestinal failure who are intolerant to parental nutrition. There are few pediatric data available on the results of this procedure. In this article we review the background of intestinal transplantation, present the ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Atkison P,Chatzipetrou M,Tsaroucha A,Lehmann R,Tzakis A,Grant D

    更新日期:1997-11-01 00:00:00

  • Successful treatment of influenza A virus by oseltamivir in bone marrow transplant recipients.

    abstract::INFVA is an important cause of pulmonary infections in patients receiving BMT, and is associated with considerable morbidity and mortality for a readily preventable and treatable infection. Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT. The aim of thi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01114.x

    authors: Mellouli F,Ouederni M,Dhouib N,Hajkacem MA,Slim A,Bejaoui M

    更新日期:2010-03-01 00:00:00

  • Oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation: clinical outcomes in a context of specialized oral care using low-level laser therapy.

    abstract::OM is a painful inflammatory condition of the oral mucosa, derived from the toxic effects of chemotherapy and radiotherapy. High OM severity is frequently present in HSCT pediatric patients, who exhibit multiple painful ulcers that limit their mastication and swallowing, leading to poor nutritional status. Few studies...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12440

    authors: Eduardo Fde P,Bezinelli LM,de Carvalho DL,Lopes RM,Fernandes JF,Brumatti M,Vince CS,de Azambuja AM,Vogel C,Hamerschlak N,Correa L

    更新日期:2015-05-01 00:00:00

  • Health-related quality of life changes following renal transplantation in children.

    abstract:BACKGROUND:Studies of HRQoL after kidney transplant have yielded conflicting results. We sought to assess the impact of kidney transplant on HRQoL. METHODS:We performed a retrospective study using the PedsQL3.0ESRD module during dialysis and at 3 and 12 months following kidney transplant in 56 recipients. For the enti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13333

    authors: Wightman A,Bradford MC,Smith J

    更新日期:2019-03-01 00:00:00

  • A typology of non-adherence in pediatric renal transplant recipients.

    abstract::We reviewed 112 pediatric renal transplant recipients to document the rate of medication non-adherence (NA) and to examine the relationships between NA, comorbid psychiatric illness, and the outcome variables of acute and chronic rejection and graft loss. A total of 32.5% of subjects had clinically significant NA with...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2003.00117.x

    authors: Shaw RJ,Palmer L,Blasey C,Sarwal M

    更新日期:2003-12-01 00:00:00

  • The efficacy of serum brain natriuretic peptide for the early detection of portopulmonary hypertension in biliary atresia patients before liver transplantation.

    abstract::Severe portopulmonary hypertension (POPH) is a contraindication for liver transplantation (LT) because of the high risk of postoperative heart failure. The early detection of POPH is important for patients with biliary atresia (BA). Brain natriuretic peptide (BNP) is known to be correlated with liver fibrosis in patie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13203

    authors: Yoshimaru K,Matsuura T,Takahashi Y,Yanagi Y,Nagata H,Ohga S,Taguchi T

    更新日期:2018-08-01 00:00:00

  • Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia.

    abstract::AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13291

    authors: Abu-Arja RF,Dargart JL,Bajwa RPS,Kahwash SB,Auletta JJ,Rangarajan HG

    更新日期:2018-12-01 00:00:00

  • Complications in pediatric intestine transplantation in the absence of peri-operative donor or recipient bowel decontamination.

    abstract::This study reports the clinical complication and infection rates of an active pediatric IT program that has never utilized bowel decontamination in either the donor or the recipient. All patients undergoing IT from 2003 to 2015 at a single pediatric IT center were reviewed. Post-transplant surgical, infectious, and im...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13164

    authors: Clouse JW,Kubal CA,Fridell JA,Mangus RS

    更新日期:2018-05-01 00:00:00

  • Monitoring and modulation of Epstein-Barr virus loads in pediatric transplant patients.

    abstract::A major risk faced by bone-marrow and solid organ transplant patients is the development of post-transplant lymphoproliferative disease or post-transplant lymphoma (PTLD). In pediatric transplantation, PTLD onset is often associated with a rapid rise in Epstein-Barr virus (EBV) load in peripheral blood mononuclear cel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00090.x

    authors: Orentas RJ,Schauer DW Jr,Ellis FW,Walczak J,Casper JT,Margolis DA

    更新日期:2003-08-01 00:00:00

  • Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation.

    abstract::The clinical significance of parvovirus B19 infection in pediatric solid-organ and bone marrow transplanted patients is unclear. The overall prevalence of parvovirus B19 infection in these patients is about 1-2% during the first year after transplantation. The most common symptom is anemia, but leukopenia and thromboc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2001.00035.x

    authors: Broliden K

    更新日期:2001-10-01 00:00:00

  • Mobilization of peripheral blood progenitor cells using 16 versus 10 mg/kg/d G-CSF in children with malignancies.

    abstract::Administration of hematopoietic growth factors, with or without chemotherapy, can augment progenitor cell numbers available for collection. The dose of granulocyte colony stimulating factor (G-CSF) used for mobilization of peripheral blood progenitor cells (PBPC) is controversial, and doses between 5 and 32 microg/kg/...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kurekci AE,Kiss JE,Koehler M

    更新日期:1998-05-01 00:00:00

  • Virologic response with 2 different cidofovir dosing regimens for preemptive treatment of adenovirus DNAemia in pediatric solid organ transplant recipients.

    abstract::ADV is frequently seen in our pediatric SOT population. It presents in a variety of clinical presentation and can cause severe disease. In this population, there are very few studies to determine the safety of CDV as a potential therapeutic agent. We present the findings of our retrospective study evaluating the effic...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13231

    authors: Guerra Sanchez CH,Lorica CD,Arheart KL,Perez MM,Tekin A,Gonzalez IA

    更新日期:2018-06-03 00:00:00

  • Pharmacokinetic analysis for model-supported therapeutic drug monitoring of busulfan in Japanese pediatric hematopoietic stem cell transplantation recipients.

    abstract::This prospective observational study analyzed the pharmacokinetics of busulfan in Japanese children and evaluated the predicting accuracy of previous pediatric PPK models of busulfan. This study enrolled five patients (aged 2-12 years, BW 14-48 kg) receiving a busulfan-based conditioning regimen for hematopoietic stem...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13696

    authors: Kishimoto K,Hasegawa D,Irie K,Okada A,Nakamura S,Tamura A,Yamamoto N,Kozaki A,Saito A,Ishida T,Fukushima S,Kosaka Y

    更新日期:2020-06-01 00:00:00