Treatment of chronic hepatitis C in children.

Abstract:

:Since the discovery of hepatitis C virus (HCV) in 1989, significant advances have been made in our understanding of this important viral pathogen. Children at risk for HCV infection include recipients of potentially contaminated blood products and organ transplants, and infants born to HCV-infected mothers. Chronic HCV infection is usually asymptomatic in children but active hepatitis, cirrhosis and hepatocellular carcinoma can occur. The development of treatment strategies for chronic hepatitis C in children has directly evolved from clinical trials in adults. Sustained virologic response, defined by undetectable HCV RNA in serum 24 wk after completion of treatment, occurs in approximately 36% of children treated with conventional interferon alone and in about 50% of those given conventional interferon in combination with ribavirin. Pegylated interferon-based treatment regimens are better than those based on conventional interferon in adults but little is known about pegylated interferon in children. Factors associated with a favorable response to antiviral therapy in children are similar to those in adults and include infection with HCV genotype 2 or 3 and low pretreatment serum HCV RNA levels. Treatment related adverse events in children include 'flu-like' syndrome, fatigue, anorexia, weight loss, depression, anemia, leukopenia and thrombocytopenia.

journal_name

Pediatr Transplant

authors

González-Peralta RP

doi

10.1111/j.1399-3046.2004.00250.x

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

639-43

issue

6

eissn

1397-3142

issn

1399-3046

pii

PTR250

journal_volume

8

pub_type

杂志文章
  • Pediatric cardiac transplant: results using a steroid-free maintenance regimen.

    abstract::We report on survival, rejection, lymphoma and renal function following cardiac transplant using a steroid-free maintenance immunosuppressive regimen. We have performed 73 cardiac transplants in 71 children under 16 yr of age in the last 12 yr. There were eight perioperative and four late deaths giving actuarial survi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00014.x

    authors: Leonard H,Hornung T,Parry G,Dark JH

    更新日期:2003-02-01 00:00:00

  • Use of intravenous immunoglobulin in a highly sensitized pediatric renal transplant recipient with severe BK DNAemia and rising DSA.

    abstract::BK DNAemia in renal transplant recipients is a significant cause of allograft dysfunction and can lead to graft loss due to BK polyomavirus-associated nephropathy or to graft rejection due to immunosuppression reduction. Currently, the first-line treatment for BK DNAemia is immunosuppression reduction. Second-line tre...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13600

    authors: Piburn KH,Al-Akash S

    更新日期:2020-02-01 00:00:00

  • Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.

    abstract::The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p =...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01625.x

    authors: Anastaze Stelle K,Belli DC,Parvex P,Girardin E,Giroud A,Wildhaber B,McLin VA

    更新日期:2012-05-01 00:00:00

  • Liver transplantation as a treatment option for three siblings with homozygous familial hypercholesterolemia.

    abstract::FH is a hereditary inherited disorder of cholesterol metabolism. Homozygous form of the disease associates severe form of atherosclerotic disease. Clinicians have been tried to inhibit the progression of the homozygous FH with medical and surgical treatment. We here present three siblings with homozygous FH who were s...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01469.x

    authors: Küçükkartallar T,Yankol Y,Kanmaz T,Topaloğlu S,Acarli K,Kalayoglu M

    更新日期:2011-05-01 00:00:00

  • Frequency of urinary tract infection in pediatric liver transplantation candidates.

    abstract::An increased frequency of infections has been reported in patients with chronic liver disease. The tendency of patients in this population to acquire UTI is not completely understood. We aimed at investigating the incidence of UTI in children with cirrhosis, before liver transplantation. Twenty-six children (9 girls, ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00674.x

    authors: Baskin E,Ozçay F,Sakalli H,Agras PI,Karakayali H,Canan O,Haberal M

    更新日期:2007-06-01 00:00:00

  • Health-related quality of life among siblings of kidney transplant recipients.

    abstract::Studies are increasingly recognizing health-related quality of life (HRQOL) as a key pediatric outcome in both clinical and research settings and an essential health outcome measure to assess the effectiveness of medical treatment. However, it has not yet been studied among the healthy siblings of kidney transplant re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13734

    authors: Velasco J,Ferraris JR,Eymann A,Ghezzi LFR,Coccia PA,Ferraris V

    更新日期:2020-08-01 00:00:00

  • A clinical description of children with solid organ transplants who present with feeding disorder.

    abstract::Pediatric solid organ transplant recipients have long-standing malnutrition concerns related to their pretransplant medical status. The targeted nutrition therapy utilized pre-, peri-, and post-transplantation may have the adverse effect of impeding normally developing feeding skills, particularly in very young childr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13389

    authors: Lerret SM,Erato G,Goday PS,Silverman AH

    更新日期:2019-05-01 00:00:00

  • Renal retransplantation of children: is a policy 'first cadaver donor, then live donor' an acceptable option?

    abstract::Retransplantation is often a necessity for children with end-stage renal disease (ESRD), as kidney graft survival is still not infinite. If a suitable live donor is present, the current policy is to use the live donor first, in order to obtain excellent long-term outcome and to prevent human leucocyte antigen (HLA) se...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.00049.x

    authors: De Meester J,Smits JM,Offner G,Persijn GG

    更新日期:2001-06-01 00:00:00

  • Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation.

    abstract::Impact of pretransplant splenectomy in patients with beta-thalassemia major undergoing an allogeneic SCT has never been addressed. Twenty-seven class III patients (29 transplants) had a pretransplant splenectomy. The outcome of these 29 transplants was compared with 76 transplants in class III who did not have a splen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00953.x

    authors: Mathews V,George B,Lakshmi KM,Viswabandya A,John JM,Sitaram U,Daniel D,Chandy M,Srivastava A

    更新日期:2009-03-01 00:00:00

  • Complications in pediatric intestine transplantation in the absence of peri-operative donor or recipient bowel decontamination.

    abstract::This study reports the clinical complication and infection rates of an active pediatric IT program that has never utilized bowel decontamination in either the donor or the recipient. All patients undergoing IT from 2003 to 2015 at a single pediatric IT center were reviewed. Post-transplant surgical, infectious, and im...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13164

    authors: Clouse JW,Kubal CA,Fridell JA,Mangus RS

    更新日期:2018-05-01 00:00:00

  • Successful treatment of influenza A virus by oseltamivir in bone marrow transplant recipients.

    abstract::INFVA is an important cause of pulmonary infections in patients receiving BMT, and is associated with considerable morbidity and mortality for a readily preventable and treatable infection. Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT. The aim of thi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01114.x

    authors: Mellouli F,Ouederni M,Dhouib N,Hajkacem MA,Slim A,Bejaoui M

    更新日期:2010-03-01 00:00:00

  • Lung transplantation and survival in children with cystic fibrosis: solid statistics--flawed interpretation.

    abstract::In their provocative paper, "Lung transplantation and survival in children with cystic fibrosis," Liou and colleagues state that "Prolongation of life by means of lung transplantation should not be expected in children with cystic fibrosis. A prospective, randomized trial is needed to clarify whether and when patients...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00924.x

    authors: Sweet SC,Aurora P,Benden C,Wong JY,Goldfarb SB,Elidemir O,Woo MS,Mallory GB Jr,International Pediatric Lung Transplant Collaborative.

    更新日期:2008-03-01 00:00:00

  • Controlling the blood glucose of type 1 diabetes mice by co-culturing MIN-6 β cells on 3D scaffold.

    abstract::T1D is an autoimmune disease, which may be caused by lack of insulin-secreting β cells due to damage of autoimmune system. Living with T1D is a challenge for the child and the family; cell transplantation is a treatment option for diabetes in children. To establish a microenvironment suitable for cell growth and proli...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12443

    authors: Yuan X,Huang Y,Guo Y,Wang L,Guo Q,Xu T,Wu D,Zhou P,Zhu S,Wang Y,Fan X,Zhu M,Lu Y,Wang Z

    更新日期:2015-06-01 00:00:00

  • Cyclosporine-induced white and grey matter central nervous system lesions in a pediatric renal transplant patient.

    abstract::Major neurologic complications secondary to cyclosporine are well documented and are known to include confusion, cortical blindness, seizure, spasticity, paresis, ataxia and coma. Most previous reports attribute these to white matter central nervous system (CNS) lesions or white/grey matter border lesions. Many predis...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Jeruss J,Braun SV,Reese JC,Guillot A

    更新日期:1998-02-01 00:00:00

  • EBV-negative lymphoproliferative disease with hyper-IgA, in a child with combined liver and small bowel transplantation.

    abstract::A 4-year-old boy presented 14 months after liver and small bowel transplantation with fever, diarrhea, elevated liver enzymes, thrombocytopenia and autoantibodies. Total gammaglobulins level was normal but the level of plasma IgA1 was very high. The blood PCR for Epstein-Barr virus (EBV) was negative. The ileal biopsy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00174.x

    authors: Robert CD,Lacaille F,Canioni D,Quartier-dit-Maire P,Talbotec C,Goulet O

    更新日期:2004-06-01 00:00:00

  • The reduced left lateral segment in pediatric liver transplantation: an alternative to the monosegment graft.

    abstract::Tailoring graft size to small paediatric recipients is a challenge. We have developed a reduced left lateral segment as an alternative to monosegment transplantation for small size recipients. Since November 2000, 89 children have been transplanted with 100 deceased donor liver grafts in our unit. Our median patient a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00882.x

    authors: Attia MS,Stringer MD,McClean P,Prasad KR

    更新日期:2008-09-01 00:00:00

  • ABO-incompatible deceased donor pediatric liver transplantation: Novel titer-based management protocol and outcomes.

    abstract::ABO-ILT have re-emerged as an alternate option for select patients awaiting transplant. However, treatment protocols for children undergoing deceased donor ABO-ILT are not standardized. We implemented a novel IS protocol for children undergoing deceased donor ABO-ILT based on pretransplant IH titers. Children with hig...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13263

    authors: Mysore KR,Himes RW,Rana A,Teruya J,Desai MS,Srivaths PR,Zaruca K,Calvert A,Guffey D,Minard CG,Morita E,Hensch L,Losos M,Kostousov V,Hui SR,Orange JS,Goss JA,Nicholas SK

    更新日期:2018-11-01 00:00:00

  • Risk for post-transplant lymphoproliferative disorder after polyclonal antibody induction in kidney transplantation.

    abstract::The adjusted relative risk (aRR) for development of post-transplant lymphoproliferative disorder (PTLD) is higher in kidney transplant recipients receiving monoclonal antibody induction therapy, but the aRR between the different available polyclonal agents has not been investigated in detail. We analyzed data from the...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00361.x

    authors: Dharnidharka VR,Stevens G

    更新日期:2005-10-01 00:00:00

  • A typology of non-adherence in pediatric renal transplant recipients.

    abstract::We reviewed 112 pediatric renal transplant recipients to document the rate of medication non-adherence (NA) and to examine the relationships between NA, comorbid psychiatric illness, and the outcome variables of acute and chronic rejection and graft loss. A total of 32.5% of subjects had clinically significant NA with...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2003.00117.x

    authors: Shaw RJ,Palmer L,Blasey C,Sarwal M

    更新日期:2003-12-01 00:00:00

  • Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience.

    abstract::Delayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, some of the previous studies have shown that ELT seems to enhance platelet recovery for post-allogen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13962

    authors: Yaman Y,Elli M,Şahin Ş,Özdilli K,Bilgen H,Bayram N,Nepesov S,Anak S

    更新日期:2021-01-16 00:00:00

  • Predictors of neuropsychological functioning and medication adherence in pediatric heart transplant recipients referred for neuropsychological evaluation.

    abstract::Children who undergo heart transplantation are at risk for long-term neurodevelopmental sequelae secondary to heart disease and its treatment. Detailed neuropsychological profiles in clinical sample status post-pediatric heart transplantation are sparse in the literature, and there is little information regarding pred...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13615

    authors: Wolfe KR,Kelly SL,Steinberg E,Pliego J,Everitt MD

    更新日期:2020-02-01 00:00:00

  • Recurrence of non-alcoholic steatohepatitis after liver transplantation in a 13-yr-old boy.

    abstract::Nonalcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease (NAFLD). The aim of our study was to highlight NASH as a rare but possible problem in children. We present a case of 13-yr-boy with a well-established diagnosis of liver cirrhosis secondary to NASH, who underwent orthotopi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00767.x

    authors: Jankowska I,Socha P,Pawlowska J,Teisseyre M,Gliwicz D,Czubkowski P,Kalicinski P,Cielecka-Kuszyk J,Socha J

    更新日期:2007-11-01 00:00:00

  • School re-entry of the pediatric heart transplant recipient.

    abstract::Pediatric cardiac transplant has become increasingly frequent in the last decade and survival rates have improved remarkably. Outcome research on this population suggests that the majority of children have the capacity for healthy adaptation although 25-40% have been shown to have some type of psychiatric difficulties...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00586.x

    authors: Weil CM,Rodgers S,Rubovits S

    更新日期:2006-12-01 00:00:00

  • Matched related donor hematopoietic stem cell transplantation results in a long-term follow-up of a pediatric acquired severe aplastic anemia subset: A stem cell source perspective.

    abstract::HSCT has substantially improved pediatric acquired SAA patients' outcomes. Retrospectively, we attempted to assess the outcome of MRD HSCT in 65 pediatric patients referred to a single center from 1992 to 2012. We were particularly interested to find out whether source of SC (PB, n = 40 and BM, n = 25) significantly i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12458

    authors: Hamidieh AA,Mozafari M,Noshad S,Alimoghaddam K,Behfar M,Ghavamzadeh A

    更新日期:2015-06-01 00:00:00

  • Use of radiolabeled antibodies in the treatment of childhood acute leukemia.

    abstract::Despite advances in therapy for acute leukemia, relapse continues to be the major cause of treatment failure. Hematopoietic stem cell transplant can rescue some patients after relapse, but the ability to escalate the intensity of preparative regimens is limited by toxicity to normal organs. Radiolabeled monoclonal ant...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.7.s3.14.x

    authors: Nemecek ER,Matthews DC

    更新日期:2003-01-01 00:00:00

  • Portal vein phlebolithiasis found post-liver transplantation in the native liver of a child with biliary atresia.

    abstract::Biliary atresia is defined as partial or total obliteration of the extra-hepatic bile ducts. In advanced cases, liver transplantation (LTx) is considered the most appropriate treatment. This report describes a female patient whose biliary atresia and subsequent cirrhosis required LTx at 1 yr of age. Macroscopic inspec...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.t01-1-00020.x

    authors: Bilezikçi B,Demirhan B,Kiyici H,Haberal M

    更新日期:2001-02-01 00:00:00

  • Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury.

    abstract::Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two gen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12712

    authors: Csohány R,Prókai Á,Sziksz E,Balicza-Himer L,Pap D,Kosik A,Sugár D,Vannay Á,Kis-Petik K,Fekete A,Szabó AJ

    更新日期:2016-08-01 00:00:00

  • Pneumatosis intestinalis and diarrhea in a child following renal transplantation.

    abstract::Pneumatosis intestinalis is an uncommon finding beyond the neonatal period, but it has been reported in immunocompromized pediatric patients. The association of pneumatosis intestinalis in children following renal transplantation has to the best of our knowledge been only reported once in children. We describe a 4-yea...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2003.00061.x

    authors: Chelimsky G,Blanchard S,Sivit C,Davis I,Czinn S

    更新日期:2003-06-01 00:00:00

  • Transplantation in pediatric aHUS within the era of eculizumab therapy.

    abstract::aHUS is caused by the over-activation and dysregulation of the alternative complement pathway. Data regarding outcomes of pediatric aHUS patients after kidney transplantation are still very scarce. Accordingly, the aim of this study was to describe the clinical findings and outcomes of pediatric aHUS patients after re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13914

    authors: Özçakar ZB,Ozaltin F,Gülhan B,Çomak E,Parmaksız G,Baskın E,Topaloğlu R,Kasap Demir B,Canpolat N,Yuruk Yildirim Z,Demircioğlu Kılıç B,Yüksel S,Söylemezoğlu O

    更新日期:2020-11-20 00:00:00

  • Liver retransplantation in an infant requiring cavoportal hemi transposition.

    abstract::Historically inability to achieve portal inflow to the liver allograft operatively was felt to be a contraindication to orthotopic liver transplantation (OLTx). Cavoportal hemi transposition has been utilized more recently in adult OLTx recipients but rarely in pediatric recipients. Here we report the case of a 10-mon...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00196.x

    authors: Verran D,Crawford M,Stormon M,Shun A

    更新日期:2004-08-01 00:00:00