Use of radiolabeled antibodies in the treatment of childhood acute leukemia.

Abstract:

:Despite advances in therapy for acute leukemia, relapse continues to be the major cause of treatment failure. Hematopoietic stem cell transplant can rescue some patients after relapse, but the ability to escalate the intensity of preparative regimens is limited by toxicity to normal organs. Radiolabeled monoclonal antibodies against hematopoietic antigens have emerged as an alternative to deliver targeted supplemental radiation to sites of leukemic involvement while relatively sparing normal organs. This paper will review the rationale for using this approach, our current experience with radiolabeled anti-CD45 antibody, and the potential challenges encountered in treating children with radiolabeled antibodies.

journal_name

Pediatr Transplant

authors

Nemecek ER,Matthews DC

doi

10.1034/j.1399-3046.7.s3.14.x

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

89-94

eissn

1397-3142

issn

1399-3046

pii

56

journal_volume

7 Suppl 3

pub_type

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