Immunosuppression in infants with short bowel syndrome undergoing isolated liver transplantation.

Abstract:

BACKGROUND:Little data exist on immunosuppressive drug absorption in children with short bowel syndrome and intestinal failure associated liver disease (SBS-IFALD). AIM:To evaluate the absorption of immunosuppressive medications in children with SBS-IFALD undergoing isolated liver transplantation (iLTx). METHODS:A retrospective review was performed in children with SBS-IFALD undergoing LTx and comparison made with weight, age-matched children undergoing iLTX (extra-hepatic biliary atresia (EHBA) and normal intestinal length and function). RESULTS:Seven children with SBS-IFALD undergoing iLTx (median residual bowel length, 60 cm, range 40-80) were compared with 15 children undergoing LTx for EHBA. SBS-IFALD children had significantly lower trough tacrolimus levels at three months (5.8 vs. 7.9 ng/mL, p<0.05) and six months (5.0 vs. 8.0 ng/mL, p<0.05), but equivalent levels at 12 months after iLTx. The median calculated dose-normalized concentrations indicated that systemic availability of tacrolimus was comparable in two groups at 3, 6, 12 months (33.1 vs. 23.3; 42.4 vs. 36; 51 vs. 52.9) despite the differences in enteral function. The incidence of acute rejection was 1/7 (SBS-IFALD) and 10/15 (EHBA) group (p = 0.06). CONCLUSION:Children with SBS-IFALD demonstrated adequate absorption of oral tacrolimus without significant acute rejection rate after iLTx suggesting that modification of immunosuppression is not necessary.

journal_name

Pediatr Transplant

authors

Olio DD,Gupte G,Sharif K,Murphy MS,Lloyd C,McKiernan PJ,Kelly DA,Beath SV

doi

10.1111/j.1399-3046.2006.00504.x

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

677-81

issue

6

eissn

1397-3142

issn

1399-3046

pii

PTR504

journal_volume

10

pub_type

杂志文章
  • Neuroradiologic findings in children with renal transplantation under 5 years of age.

    abstract::Chronic renal failure (CRF) is known to have adverse effects on the neurodevelopmental outcome of affected children. Some of these effects can be ameliorated by transplantation (TX). The cause and nature of the underlying brain injury is not known. We performed a brain magnetic resonance imaging (MRI) study on a group...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2003.00125.x

    authors: Valanne L,Qvist E,Jalanko H,Holmberg C,Pihko H

    更新日期:2004-02-01 00:00:00

  • Use of genetic risks in pediatric organ transplantation listing decisions: A national survey.

    abstract::There is a limited supply of organs for all those who need them for survival. Thus, careful decisions must be made about who is listed for transplant. Studies show that manifesting genetic disease can impact listing eligibility. What has not yet been studied is the impact genetic risks for future disease have on a pat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/petr.13402

    authors: Graf M,Char D,Hanson-Kahn A,Magnus D

    更新日期:2019-06-01 00:00:00

  • Concomitant oral findings in children after cardiac transplant.

    abstract::Heart transplantations have been performed in the Centre for Paediatric Heart Surgery at the Justus Liebig University in Giessen (Germany) since 1988. For further consultation and therapy, some affected children subsequently present at the Polyclinic for Paediatric Dentistry. In all these cases problematic oral findin...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00429.x

    authors: Ansari F,Ferring V,Schulz-Weidner N,Wetzel WE

    更新日期:2006-03-01 00:00:00

  • Planning for the future of a pediatric kidney transplant recipient with special needs: A parent's perspective.

    abstract::I was asked to write this article to share with medical professionals, my view as a parent with a child who has special needs and needs a transplant. It is a detailed story from a parent's point of view on what it is like to have a child with special needs with serious medical complications and how I went about findin...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13906

    authors: Carney MT

    更新日期:2021-02-01 00:00:00

  • A case of Chediak-Higashi syndrome presented with accelerated phase could be treated effectively by unrelated cord blood transplantation.

    abstract::CHS is a rare immunodeficiency syndrome with defects in the functions of cytotoxic cells and neutrophils. Approximately 85% of patients with CHS undergo an AP within the first decade, which is similar to FHLH. Chemotherapy could induce transient remission, but only allogeneic HCT could correct the underlying genetic d...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13014

    authors: Zhang Y,Gao Z,Yu X

    更新日期:2017-11-01 00:00:00

  • Transplantation of adult-size kidneys in small pediatric recipients: A single-center experience.

    abstract::RTx of adult-size kidneys presents a size mismatch in small pediatric recipients, and there are potential surgical complications. This study reveals the outcomes of intra- and extraperitoneal RTx in low-weight (less than 15 kg) pediatric recipients. We studied 51 pediatric patients weighing less than 15 kg who receive...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13401

    authors: Muramatsu M,Mizutani T,Hamasaki Y,Takahashi Y,Itabashi Y,Kubota M,Hashimoto J,Oguchi H,Sakurabayashi K,Hyodo Y,Shinoda K,Kawamura T,Sakai K,Shishido S

    更新日期:2019-06-01 00:00:00

  • May-Thurner syndrome in a pediatric renal transplant recipient--case report and literature review.

    abstract::Vascular complications post-renal transplantation are not very common and can be associated with increased risk of graft loss. We report an unusual case of a young, female teenager with asymmetrical leg swelling. After one month of transplantation, the patient developed a rise in serum creatinine with right leg swelli...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00941.x

    authors: Vyas S,Roberti I,McCarthy C

    更新日期:2008-09-01 00:00:00

  • Pediatric Transplant Rating Instrument - a scale for the pretransplant psychiatric evaluation of pediatric organ transplant recipients.

    abstract::Although the majority of pediatric solid organ transplant centers in the United States employ psychosocial criteria to assess the suitability of potential transplant candidates, there are no standardized pretransplant psychosocial assessment measures. Assessment scales that have been developed were designed for adult ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00785.x

    authors: Fung E,Shaw RJ

    更新日期:2008-02-01 00:00:00

  • New-onset diabetes mellitus presenting with diabetic ketoacidosis after pediatric liver transplantation.

    abstract::The development of NODM is a common metabolic complication after liver transplantation. Presentation of post-liver transplant diabetes mellitus with DKA is rare especially among pediatric patients. We reported three pediatric patients who presented with DKA after liver transplantation. The underlying diseases leading ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01117.x

    authors: Dehghani SM,Nikeghbalian S,Eshraghian A,Haghighat M,Imanieh MH,Bahador A,Kazemi K,Malek-Hosseini SA

    更新日期:2009-08-01 00:00:00

  • Pre-stem cell transplantation enzyme replacement therapy in Hurler syndrome does not lead to significant antibody formation or delayed recovery of the endogenous enzyme post-transplant: a case report.

    abstract::Combined enzyme replacement therapy (ERT) and stem cell transplant (SCT) were done for a two year old boy with severe Hurler syndrome(HS) with the aim to decrease transplant related complications. He tolerated both the procedures well without any major complications. Urine glycosaminoglycans (GAGs) decreased post-tran...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00720.x

    authors: Soni S,Hente M,Breslin N,Hersh J,Whitley C,Cheerva A,Bertolone S

    更新日期:2007-08-01 00:00:00

  • Fulminant recurrence of atypical hemolytic uremic syndrome during a calcineurin inhibitor-free immunosuppression regimen.

    abstract::Recurrence of hemolytic uremic syndrome (HUS) after kidney transplantation is frequent, occurring almost exclusively in patients with atypical HUS, which is not caused by Escherichia coli gastroenteritis and in which diarrhea is absent. Calcineurin inhibitors are associated with recurrence of HUS. In two children who ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.t01-1-00002.x

    authors: Florman S,Benchimol C,Lieberman K,Burrows L,Bromberg JS

    更新日期:2002-08-01 00:00:00

  • The significance of a defect on DMSA scan in children with renal transplants.

    abstract::Since December 1995, pediatric renal transplant recipients in our unit have received a DMSA scan as soon as possible post-transplant in order to provide a baseline for comparison in the event of subsequent complications. We retrospectively reviewed the case notes and DMSA scans of the 45 patients who underwent a scan ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1399-3046.2003.00073.x

    authors: Hutchinson C,Beckett M,Kiratli P,Gordon I,Trompeter RS,Rees L

    更新日期:2003-12-01 00:00:00

  • Cannulation of the aorta in organ donors with aortic and caval injuries at the time of procurement.

    abstract::Injuries sustained by major vessels during procurement pose a major threat to organ viability. Aortic and inferior vena cava lacerations produce rapid hemorrhage associated with hypoperfusion and ischemic damage. We describe a technique that will prevent such damage in the event of vascular mishaps. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.00016.x

    authors: Molmenti EP,Molmenti H,Marubashi S,Sanchez EQ,Gogel B,Goldstein RM,Levy MF,Fasola CG,Gonwa TA,Klintmalm GB

    更新日期:2001-10-01 00:00:00

  • Denying renal transplantation to an adolescent medical cannabis user: An ethical case study.

    abstract::Medical cannabis is now legal in over half of the United States. As more patients adopt this unconventional therapy, it is inevitable that potential transplant recipients will disclose their cannabis use during transplant evaluation. Transplant teams are tasked with the decision to utilize a pressure resource, often w...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13467

    authors: Ryan JE,Noeder M,Burke C,Stubblefield SC,Sulieman S,Miller EG

    更新日期:2019-08-01 00:00:00

  • Tracking of blood pressure and its impact on graft function in pediatric renal transplant patients.

    abstract::We studied tracking of BP and its impact on GFR in 44 PRTP followed for 56 months. Three months PT 77% had elevated SBP percentile. First year SBP and DBP correlated positively with final values (p < 0.0001, 0.0002, respectively). Pretransplant and three month PT SBP correlated positively (p = 0.02). At one yr, SBP an...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00753.x

    authors: Silverstein DM,Leblanc P,Hempe JM,Ramcharan T,Boudreaux JP

    更新日期:2007-12-01 00:00:00

  • Sleep quality is associated with psychosocial functioning and health-related quality of life in pediatric transplant recipients.

    abstract::This study examined patient-reported sleep quality in a single-center cross-sectional sample of adolescents with solid organ transplants and evaluated associations between sleep quality, psychosocial functioning (ie, depression/anxiety symptoms), and HRQOL. Health disparities associated with minority race/ethnicity an...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13577

    authors: Gutierrez-Colina AM,Quast LF,Eaton CK,LaMotte J,Stolz MG,Mee L,George R,Lee J,Reed B,Rich KL,Blount RL

    更新日期:2019-12-01 00:00:00

  • Ultrasonography, laboratory, and cholangiography correlation of biliary complications in pediatric liver transplantation.

    abstract::The aim of this study is to correlate the US, laboratory, and cholangiography findings in pediatric liver transplant patients with biliary complications, trying to identify reliable decision-making tools for the management of these complications. Retrospective review was carried out of US results in 39 consecutive pat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12421

    authors: Teplisky D,Urueña Tincani E,Halac E,Garriga M,Cervio G,Imventarza O,Sierre S

    更新日期:2015-03-01 00:00:00

  • Low incidence of adverse events in outpatient pediatric renal allograft biopsies.

    abstract::In 1999, our center implemented a policy of outpatient protocol biopsies as standard practice for the clinical management of pediatric renal allograft recipients. In order to determine the safety of this procedure, we conducted a retrospective chart audit of all outpatient renal allograft biopsies performed at our cen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00659.x

    authors: Birk PE,Blydt-Hansen TD,Dart AB,Kaita LM,Proulx C,Taylor G

    更新日期:2007-03-01 00:00:00

  • Pleural disease in patients undergoing lung transplantation for cystic fibrosis.

    abstract::Cystic fibrosis (CF) is associated with varying degrees of pleural inflammatory reaction that occurs as a result of chronic pulmonary infections and intervention to pleural space. The amount of pleural reaction is associated with the difficulty involved when performing the pneumonectomy at the time of lung replacement...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Dosanjh A,Jones L,Yuh D,Robbins RC

    更新日期:1998-11-01 00:00:00

  • The reduced left lateral segment in pediatric liver transplantation: an alternative to the monosegment graft.

    abstract::Tailoring graft size to small paediatric recipients is a challenge. We have developed a reduced left lateral segment as an alternative to monosegment transplantation for small size recipients. Since November 2000, 89 children have been transplanted with 100 deceased donor liver grafts in our unit. Our median patient a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00882.x

    authors: Attia MS,Stringer MD,McClean P,Prasad KR

    更新日期:2008-09-01 00:00:00

  • Delayed short-term administration of granulocyte colony-stimulating factor is a good mobilization strategy for harvesting autologous peripheral blood stem cells in pediatric patients with solid tumors.

    abstract::PBSCs have become the preferred source of autologous stem cells for supporting high-dose chemotherapy in childhood solid tumors. The aims of this retrospective study were to examine the optimal timing for administration of G-CSF after chemotherapy and to identify the patients from whom an optimal dose of PBSCs can be ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12137

    authors: Takahashi H,Kato M,Kikuchi A,Hanada R,Koh K

    更新日期:2013-11-01 00:00:00

  • Sequential liver-kidney transplantation in a boy with congenital hepatic fibrosis and nephronophthisis from a living donor.

    abstract::A five-yr-old boy developed chronic liver failure and ESKD because of CHF and juvenile NPHP. He underwent sequential liver and kidney transplantation with a compatible blood type from his father, at five yr, seven months and five yr, 11 months old, respectively. Because the patient was not in ESKD, we initially perfor...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01611.x

    authors: Udagawa T,Kamei K,Ogura M,Tsutsumi A,Noda S,Kasahara M,Fukuda A,Sakamoto S,Shigeta S,Tanaka H,Kuroda T,Matsuoka K,Nakazawa A,Nagai T,Uemura O,Ito S

    更新日期:2012-11-01 00:00:00

  • Should we retransplant a patient who is non-adherent? A literature review and critical reflection.

    abstract::The majority of transplant centers around the world face an ethical debate whether to retransplant a young non-adherent patient. Non-adherence to lifelong immunosuppressants presents a significant risk for graft loss, yet rates remain consistently high. Despite a number of these patients presenting for retransplantati...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2011.01633.x

    authors: Dobbels F,Hames A,Aujoulat I,Heaton N,Samyn M

    更新日期:2012-02-01 00:00:00

  • Impact of growth hormone treatment on a Belgian population of short children with renal allografts.

    abstract::We retrospectively analyzed the effects of recombinant human growth hormone (rhGH) in a Belgian population of 36 short children with renal allografts. Seven children were dropped from the growth study: 1 had skeletal dysplasia and in 6 cases rhGH was given for less than 1 yr (1 died, 1 developed genu valgum, 2 were no...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Janssen F,Van Damme-Lombaerts R,Van Dyck M,Hall M,Schurmans T,Herman J,Hooghe L,Van Damme B

    更新日期:1997-11-01 00:00:00

  • Acute lymphoblastic leukaemia: whom and when should we transplant?

    abstract::To date, the evidence upon which a decision is made to transplant a child with acute lymphoblastic leukaemia either in first or subsequent remission has rarely been based on randomized trial data. Modern era management of infection and graft-versus-host disease lessens risks but procedure-related deaths still remain h...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.1999.00055.x

    authors: Eden OB

    更新日期:1999-01-01 00:00:00

  • Significance of Epstein-Barr virus status and post-transplant lymphoproliferative disease in pediatric thoracic transplantation.

    abstract::Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD) is a serious complication of organ and bone marrow transplantation. The importance of EBV matching between recipient and donor remains unclear. Between October 1987 and December 1997, 64 pediatric cardio-pulmonary transplants were p...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.1999.00019.x

    authors: Harwood JS,Gould FK,McMaster A,Hamilton JR,Corris PA,Hasan A,Gennery AR,Dark JH

    更新日期:1999-05-01 00:00:00

  • Matched related donor hematopoietic stem cell transplantation results in a long-term follow-up of a pediatric acquired severe aplastic anemia subset: A stem cell source perspective.

    abstract::HSCT has substantially improved pediatric acquired SAA patients' outcomes. Retrospectively, we attempted to assess the outcome of MRD HSCT in 65 pediatric patients referred to a single center from 1992 to 2012. We were particularly interested to find out whether source of SC (PB, n = 40 and BM, n = 25) significantly i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12458

    authors: Hamidieh AA,Mozafari M,Noshad S,Alimoghaddam K,Behfar M,Ghavamzadeh A

    更新日期:2015-06-01 00:00:00

  • Eight-year follow-up in pediatric living donor kidney recipients receiving alemtuzumab induction.

    abstract::Recipient lymphocytes are crucial for direct and indirect pathways of allorecognition. We proposed that the administration of alemtuzumab several weeks pretransplantation could eradicate peripheral lymphatic cells and promote donor-specific acceptance. This was a single-center, retrospective review of 101 consecutive ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12941

    authors: Kaabak MM,Babenko NN,Shapiro R,Maschan AA,Zokoev AK,Schekaturov SV,Vyunkova JN,Dymova OV

    更新日期:2017-08-01 00:00:00

  • Haploidentical hematopoietic stem cell transplantation for a case with X-linked chronic granulomatous disease.

    abstract::CGD is a rare primary immunodeficiency with high mortality rates when treated conventionally, especially for the X-chromosome-linked form. HSCT is the only curative therapy for CGD; however, haploidentical transplantation in CGD is rare. Here, we report a case of X-linked CGD treated successfully by haploidentical HSC...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.12861

    authors: Zhou L,Dong LJ,Gao ZY,Yu XJ,Lu DP

    更新日期:2017-02-01 00:00:00

  • Extrahepatic portal vein aneurysm after liver transplantation in a child: case report.

    abstract::Portal vein aneurysms are very rare and represent <3% of all venous aneurysms. They can be congenital or acquired. Most patients do not have liver disease at diagnosis. Although uncommon, portal vein aneurysm has been described after liver transplant. We report the case of a six-yr-old girl who presented with an aneur...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01782.x

    authors: Molinares B,Alvarez S,García V,Sepúlveda ME,Yepes NL,Peláez S

    更新日期:2013-02-01 00:00:00