Abstract:
:Children who undergo heart transplantation are at risk for long-term neurodevelopmental sequelae secondary to heart disease and its treatment. Detailed neuropsychological profiles in clinical sample status post-pediatric heart transplantation are sparse in the literature, and there is little information regarding predictors of neuropsychological functioning or how it relates to medication adherence in this population. The present study examined these questions in a retrospective analysis of 27 pediatric heart transplantation recipients referred for clinical neuropsychological evaluation. The sample demonstrated mild-to-moderate decrements across domains of neuropsychological functioning. Children with premorbid congenital heart disease performed more poorly in working memory, word reading, and parent-rated conceptual adaptive skills compared to children with premorbid cardiomyopathy. Additionally, a higher number of rejection episodes were related to poorer verbal memory. Children with parent-reported attention problems had better adherence to immunosuppressant medication, which may have represented greater caregiver involvement in medication management. Taken together, clinically referred children with history of heart transplantation showed broad-based difficulties across neuropsychological domains according to formal testing and parent rating scales. This population requires routine neuropsychological monitoring and intervention.
journal_name
Pediatr Transplantjournal_title
Pediatric transplantationauthors
Wolfe KR,Kelly SL,Steinberg E,Pliego J,Everitt MDdoi
10.1111/petr.13615subject
Has Abstractpub_date
2020-02-01 00:00:00pages
e13615issue
1eissn
1397-3142issn
1399-3046journal_volume
24pub_type
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
pub_type: 杂志文章,评审
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1034/j.1399-3046.2002.t01-1-00002.x
更新日期:2002-08-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2007.00871.x
更新日期:2008-03-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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journal_title:Pediatric transplantation
pub_type:
doi:10.1111/petr.13915
更新日期:2020-11-20 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13770
更新日期:2020-09-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2011.01640.x
更新日期:2012-03-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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pub_type:
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更新日期:2016-09-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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journal_title:Pediatric transplantation
pub_type:
doi:10.1111/petr.13046
更新日期:2017-11-01 00:00:00
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journal_title:Pediatric transplantation
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pub_type: 临床试验,杂志文章
doi:10.1111/petr.12707
更新日期:2016-06-01 00:00:00