Severe cryptosporidiosis in a seven-year-old renal transplant recipient: case report and review of the literature.

Abstract:

:Cryptosporidium is an intracellular protozoa that can cause gastroenteritis in humans. In immunocompromised hosts, infection can be severe, leading to life-threatening persistent diarrhea. There is limited experience in treating this infection in solid organ transplants. Although newer drugs active against Cryptosporidium exist, they are only licensed in the USA for treatment of immunocompetent hosts. Here we describe a seven-year-old renal transplant recipient with severe cryptosporidiosis. He had a protracted course of diarrhea of up to 2 L/day. He was successfully managed with combination antimicrobial therapy including nitazoxanide, paromomycin, and azithromycin. In conjunction with this regimen, he had a reduction in immunosuppression and complete bowel rest. His stool pattern normalized in four weeks and he has had no recurrence after six months of follow up.

journal_name

Pediatr Transplant

authors

Hong DK,Wong CJ,Gutierrez K

doi

10.1111/j.1399-3046.2006.00593.x

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

94-100

issue

1

eissn

1397-3142

issn

1399-3046

pii

PTR593

journal_volume

11

pub_type

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