Health-related quality of life and sleep among Chinese children after living donor liver transplantation.

Abstract:

:LDLT is a well-established treatment for most terminal liver diseases in children. Survival rates have improved, yet few studies have considered HRQoL or sleep problems in LDLT recipients. In this cross-sectional study, we enrolled 51 children who had undergone LDLT in Renji Hospital. PedsQL(™) 4.0 Generic Core Scales, PedsQL(™) 3.0 Transplant Module, and Pediatric Sleep Questionnaire were used to assess outcomes. Of all participants, 11.8% (6/51) reported low total HRQoL scores. Participants' scores on most HRQoL subscales were comparable to the scores of healthy children. However, compared with solid organ transplant recipients, LDLT recipients scored significantly lower in About My Medicines II (t = 3.092, p = 0.002) and Worry (t = 2.760, p = 0.006). Sleep problems (41.2%) were common among participants. Hierarchical regression analyses showed that SRBD accounted for significant variance in HRQoL on total generic HRQoL (R(2) = 0.446, p < 0.001), psychosocial health (R(2) = 0.372, p = 0.001), physical health (R(2) = 0.345, p = 0.003), total transplant-specific HRQoL (R(2) = 0.514, p < 0.001), About My Medicines I (R(2) = 0.365, p = 0.013), My Transplant and Others (R(2) = 0.334, p = 0.005), Pain and Hurt (R(2) = 0.544, p < 0.001), Worry (R(2) = 0.401, p = 0.001), Treatment Anxiety (R(2) = 0.526, p < 0.001), How I Look (R(2) = 0.221, p = 0.040), and Communication (R(2) = 0.343, p = 0.012). In conclusion, sleep problems are non-negligible in children after LDLT and predicted significant variance on HRQoL.

journal_name

Pediatr Transplant

authors

He K,Shen C,Chen X,Han L,Xi Z,Zhou T,Zhang J,Xia Q

doi

10.1111/petr.12532

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

547-54

issue

5

eissn

1397-3142

issn

1399-3046

journal_volume

19

pub_type

杂志文章
  • School re-entry of the pediatric heart transplant recipient.

    abstract::Pediatric cardiac transplant has become increasingly frequent in the last decade and survival rates have improved remarkably. Outcome research on this population suggests that the majority of children have the capacity for healthy adaptation although 25-40% have been shown to have some type of psychiatric difficulties...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00586.x

    authors: Weil CM,Rodgers S,Rubovits S

    更新日期:2006-12-01 00:00:00

  • Post-transplant glucose status in 61 pediatric renal transplant recipients: preliminary results of five Turkish pediatric nephrology centers.

    abstract::To assess the incidence, risk factors and outcomes of PTDM, a total of 61 non-diabetic children (24 girls, 37 boys, age: 14.5 +/- 2.1 yr) were examined after their first kidney transplantation (37.3 +/- 21.6 months) with an OGTT. At baseline, 16 (26.2%) patients had IGT, 45 (73.8%) had NGT, and no patient had PTDM. No...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1399-3046.2009.01192.x

    authors: Buyan N,Bilge I,Turkmen MA,Bayrakci U,Emre S,Fidan K,Baskin E,Gok F,Bas F,Bideci A

    更新日期:2010-03-01 00:00:00

  • Imaging in pediatric renal transplantation.

    abstract::Renal transplantation is the therapy of choice in children with ESKD. Radiological investigations are required in both pre- and post-transplant assessment, although there is paucity of both consensus-based statements and evidence-based imaging guidelines in pediatric renal transplantation. The phases of pediatric ESKD...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12885

    authors: Damasio MB,Ording Muller LS,Piaggio G,Marks SD,Riccabona M

    更新日期:2017-05-01 00:00:00

  • Endoscopic treatment in biliary strictures after pediatric liver transplantation.

    abstract:BACKGROUND AND AIM:The aim of the study was to assess efficacy and safety of endoscopic treatment in BS after pediatric LTx. METHODS:We retrospectively reviewed data of patients with DDA who developed BS and underwent ERCP. RESULTS:Of 189 transplanted patients with DDA, strictures developed in 30 (16%). In this subgr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13271

    authors: Czubkowski P,Pertkiewicz J,Markiewicz-Kijewska M,Kaliciński P,Rurarz M,Jankowska I,Pawłowska J

    更新日期:2018-11-01 00:00:00

  • Hybrid stage 1 palliation as a bridge to cardiac transplantation in patients with high-risk single ventricle physiology.

    abstract:BACKGROUND:The hybrid stage 1 palliation for hypoplastic left heart syndrome (HLHS) was first described in 1993 as a bridge to heart transplant for HLHS. There are limited data on this strategy as primary heart transplantation for HLHS has become less common. METHODS:This is an observational, single-center study compa...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13307

    authors: Morray BH,Albers EL,Jones TK,Kemna MS,Permut LC,Law YM

    更新日期:2018-12-01 00:00:00

  • Clinical predictors of autoimmune and severe atopic disease in pediatric heart transplant recipients.

    abstract::Autoimmune and allergic diseases cause morbidity and diminished quality of life in pediatric organ transplant recipients. We hypothesize that younger age at transplantation and immunosuppression regimen play a role in the development of immune-mediated disease following heart transplant. A single institution retrospec...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12205

    authors: Mouledoux JH,Albers EL,Lu Z,Saville BR,Moore DJ,Dodd DA

    更新日期:2014-03-01 00:00:00

  • Percutaneous endovascular management of ascending aortic pseudoaneurysm after heart transplantation in a pediatric patient.

    abstract::Ascending aortic pseudoaneurysm is a rare complication after HT. Surgery is the most conventional management, but in some patients, it is risky. We report the case of a ten-year-old child who underwent HT and developed an ascending aortic pseudoaneurysm in the aortic anastomosis. He was successfully treated with two c...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13958

    authors: Skrabonja-Crespo A,Chavarri-Velarde F,Pinto-Salinas M,Tauma-Arrué A

    更新日期:2020-12-17 00:00:00

  • Outcome of hematopoietic stem cell transplant in children with congenital heart disease.

    abstract::CHD is the most commonly occurring birth defect in the United States. Improvements in supportive care for CHD result in increasing numbers of survivors who may develop benign or malignant conditions for which HSCT is indicated. However, the ability of individuals with CHD to tolerate HSCT is unknown. Retrospective med...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01317.x

    authors: Guinan EC,Hewett EK,Domaney NM,Margossian R

    更新日期:2011-02-01 00:00:00

  • Pediatric cardiac transplant: results using a steroid-free maintenance regimen.

    abstract::We report on survival, rejection, lymphoma and renal function following cardiac transplant using a steroid-free maintenance immunosuppressive regimen. We have performed 73 cardiac transplants in 71 children under 16 yr of age in the last 12 yr. There were eight perioperative and four late deaths giving actuarial survi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00014.x

    authors: Leonard H,Hornung T,Parry G,Dark JH

    更新日期:2003-02-01 00:00:00

  • Health-related quality of life changes following renal transplantation in children.

    abstract:BACKGROUND:Studies of HRQoL after kidney transplant have yielded conflicting results. We sought to assess the impact of kidney transplant on HRQoL. METHODS:We performed a retrospective study using the PedsQL3.0ESRD module during dialysis and at 3 and 12 months following kidney transplant in 56 recipients. For the enti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13333

    authors: Wightman A,Bradford MC,Smith J

    更新日期:2019-03-01 00:00:00

  • Impact of pretransplant splenectomy on patients with beta-thalassemia major undergoing a matched-related allogeneic stem cell transplantation.

    abstract::Impact of pretransplant splenectomy in patients with beta-thalassemia major undergoing an allogeneic SCT has never been addressed. Twenty-seven class III patients (29 transplants) had a pretransplant splenectomy. The outcome of these 29 transplants was compared with 76 transplants in class III who did not have a splen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00953.x

    authors: Mathews V,George B,Lakshmi KM,Viswabandya A,John JM,Sitaram U,Daniel D,Chandy M,Srivastava A

    更新日期:2009-03-01 00:00:00

  • Allograft rejection in pediatric liver transplantation: Comparison between cadaveric and living related donors.

    abstract::The aim of this study was to determine whether living related liver transplantation has an immunological advantage compared with cadaveric liver transplants in children. The records of 100 pediatric primary liver transplant recipients performed between January 1992 and December 1998 at the University of California, Sa...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.02013.x

    authors: Toyoki Y,Renz JF,Mudge C,Ascher NL,Roberts JP,Rosenthal P

    更新日期:2002-08-01 00:00:00

  • Hematopoietic stem cell transplantation from unrelated donors in children with DOCK8 deficiency.

    abstract::DIDS is a unique form of combined immune deficiency characterized by an unusual susceptibility to cutaneous viral infections, severe allergies with eosinophilia and elevated immunoglobulin E titers, autoimmunity, and cancer. HSCT is considered the standard of care for this deadly disease. We have retrospectively analy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13015

    authors: Uygun DFK,Uygun V,Reisli İ,Keleş S,Özen A,Yılmaz M,Sayar EH,Daloğlu H,Öztürkmen SI,Çakı S,Karasu GT,Yeşilipek A

    更新日期:2017-11-01 00:00:00

  • Approaches to graft-vs-host disease.

    abstract::Graft-vs-host disease (GVHD) is one of the most difficult problems in stem cell transplantation. It is best considered in the context of the normal immune response. The role of the immune system is to identify and eliminate foreign antigens. In the case of GVHD, the antigens are minor histocompatibility antigens (mHA)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2005.00441.x

    authors: Antin JH

    更新日期:2005-12-01 00:00:00

  • Castleman disease in a pediatric liver transplant recipient: a case report and literature review.

    abstract::Castleman disease is a rare hematologic disorder, closely linked to the HHV-8, and most commonly observed in immunocompromised individuals. Thirteen months following a liver transplant for CPS-1 defect, a 15-month-old boy presented with fevers, anemia, and growth retardation. Abdominal CT scan showed splenomegaly and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2011.01570.x

    authors: Bonatti HJ,Axt J,Hunter EB,Lott SL,Frangoul H,Gillis L,Correa H,Kelly B

    更新日期:2012-09-01 00:00:00

  • Outcome after pediatric liver transplantation for staged abdominal wall closure with use of biological mesh-Study with long-term follow-up.

    abstract::Abdominal wall closure after pediatric liver transplantation (pLT) in infants may be hampered by graft-to-recipient size discrepancy. Herein, we describe the use of a porcine dermal collagen acellular graft (PDCG) as a biological mesh (BM) for abdominal wall closure in pLT recipients. Patients <2 years of age, who und...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13683

    authors: Gül-Klein S,Dziodzio T,Martin F,Kästner A,Witzel C,Globke B,Jara M,Ritschl PV,Henning S,Gratopp A,Bufler P,Schöning W,Schmelzle M,Pratschke J,Öllinger R

    更新日期:2020-05-01 00:00:00

  • The impact of RSV, adenovirus, influenza, and parainfluenza infection in pediatric patients receiving stem cell transplant, solid organ transplant, or cancer chemotherapy.

    abstract::RVIs are a significant cause of morbidity and mortality in immunocompromised children. We analyzed the characteristics and outcomes of infection by four respiratory viruses (RSV, adenovirus, influenza, and parainfluenza) treated at a pediatric tertiary care hospital in a retrospective cohort of patients who had receiv...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12022

    authors: Lo MS,Lee GM,Gunawardane N,Burchett SK,Lachenauer CS,Lehmann LE

    更新日期:2013-03-01 00:00:00

  • Challenges for paediatric transplantation in Africa.

    abstract::Transplantation is the accepted mode of treatment for patients with end-stage organ disease affecting the heart, lungs, kidney, pancreas, liver and intestine. Long-term outcomes have significantly improved and the aim of management is no longer only long-term survival, but also focuses on quality of life especially in...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12333

    authors: Spearman CW,McCulloch MI

    更新日期:2014-11-01 00:00:00

  • Case series and systematic review of acquired diaphragmatic hernia after liver transplantation.

    abstract:BACKGROUND:ADH is a rare and potentially fatal complication following LT. In this study, a systematic review was completed to identify risk factors which may contribute to ADH. METHODS:Transplant databases at three LT programs were reviewed. Four pediatric and zero adult cases were identified. Next, a systematic revie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13296

    authors: Emamaullee JA,Nekrasov V,Gilmour S,Kneteman N,Yanni G,Kohli R,Thomas D,Genyk Y

    更新日期:2018-12-01 00:00:00

  • Renal injury and recovery in pediatric patients after ventricular assist device implantation and cardiac transplant.

    abstract:BACKGROUND:The use of ventricular assist devices (VADs) in children with heart failure may be of particular benefit to those with accompanying renal failure, as improved renal function is seen in some, but not all recipients. We hypothesized that persistent renal dysfunction at 7 days and/or 1 month after VAD implantat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13477

    authors: Hollander SA,Cantor RS,Sutherland SM,Koehl DA,Pruitt E,McDonald N,Kirklin JK,Ravekes WJ,Ameduri R,Chrisant M,Hoffman TM,Lytrivi ID,Conway J

    更新日期:2019-08-01 00:00:00

  • Donor-specific HLA antibodies and graft function in kidney-transplanted children - the Vienna cohort.

    abstract::In the pediatric population, little is known on de novo DSA development, its impact on graft function, and association with suboptimal IS. We assessed the prevalence of de novo DSA in the Vienna cohort of 40 renal transplanted children and adolescents and prospectively followed its association with clinical parameters...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/petr.12707

    authors: Rusai K,Dworak J,Potemkina A,Fischer G,Csaicsich D,Arbeiter K,Aufricht C,Müller-Sacherer T

    更新日期:2016-06-01 00:00:00

  • Fulminant recurrence of atypical hemolytic uremic syndrome during a calcineurin inhibitor-free immunosuppression regimen.

    abstract::Recurrence of hemolytic uremic syndrome (HUS) after kidney transplantation is frequent, occurring almost exclusively in patients with atypical HUS, which is not caused by Escherichia coli gastroenteritis and in which diarrhea is absent. Calcineurin inhibitors are associated with recurrence of HUS. In two children who ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.t01-1-00002.x

    authors: Florman S,Benchimol C,Lieberman K,Burrows L,Bromberg JS

    更新日期:2002-08-01 00:00:00

  • Transfusion requirements during cadaveric and living donor pediatric liver transplantation.

    abstract::Surgical techniques that have been used during liver transplantation (LT) together with patient's coagulation profile and institutional practices are reported to have an effect on transfusion requirements. The aim of this study is to evaluate the transfusion requirement in both cadaveric (CDLT, n = 22) and living dono...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00284.x

    authors: Ulukaya S,Acar L,Ayanoglu HO

    更新日期:2005-06-01 00:00:00

  • Outcomes of Berlin Heart EXCOR® pediatric ventricular assist device support in patients with restrictive and hypertrophic cardiomyopathy.

    abstract::The outcomes of pediatric ventricular assist device support in patients with diastolic heart failure have not been well described. This study reviews the North American experience with Berlin Heart EXCOR® ventricular assist device implants in children with such physiology. The Berlin Heart clinical database was review...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13048

    authors: Su JA,Menteer J

    更新日期:2017-12-01 00:00:00

  • Psychosocial functioning in pediatric heart transplant recipients and their families.

    abstract::Across pediatric organ transplant populations, patient and family psychosocial functioning is associated with important health-related outcomes. Research has suggested that pediatric heart transplant recipients and their families are at increased risk for adverse psychosocial outcomes; however, recent investigation of...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13110

    authors: Cousino MK,Schumacher KR,Rea KE,Eder S,Zamberlan M,Jordan J,Fredericks EM

    更新日期:2018-03-01 00:00:00

  • Successful percutaneous transhepatic recanalization of a completely obstructed hepatico-jejunal anastomosis in a child with liver transplantation: Unusual employment of the transseptal puncture system.

    abstract::Stenosis of the HJ is a common complication of pediatric split LT with high morbidity and possible evolution to secondary biliary cirrhosis and re-transplantation if not treated. Because the endoscopy is generally infeasible in the Roux-en-Y, percutaneous interventional radiology management is usually the safest and m...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13293

    authors: Paolantonio G,Pietrobattista A,Parapatt GK,Liccardo D,Natali GL,Candusso M,Spada M,Rollo M,Tomà P

    更新日期:2018-12-01 00:00:00

  • New insights into the functions of B cells.

    abstract::Organ transplants between genetically different individuals elicit powerful immune responses that invariably cause rejection in the absence of immune suppression. Among the immune responses elicited by organ allografts, B-cell responses causing antibody-mediated rejection are one of the most vexing. However, recent ad...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00867.x

    authors: Balin SJ,Platt JL,Cascalho M

    更新日期:2008-08-01 00:00:00

  • Intravenous and oral sequential itraconazole antifungal prophylaxis in paediatric stem cell transplantation recipients: a pilot study for evaluation of safety and efficacy.

    abstract::This single-centre, retrospective, observational pilot study was performed to evaluate the safety and efficacy of intravenous and oral itraconazole prophylaxis in paediatric haematopoietic stem cell transplantation (HCT). Study end-points were proven invasive fungal infection (IFI), survival, adverse reactions and gra...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00643.x

    authors: Grigull L,Kuehlke O,Beilken A,Sander A,Linderkamp C,Schmid H,Seidemann K,Sykora KW,Schuster FR,Welte K

    更新日期:2007-05-01 00:00:00

  • Sodium ferric gluconate for post-transplant anemia in pediatric and young adult renal transplant recipients.

    abstract::Post-transplant anemia is a widespread problem among pediatric renal transplant recipients. Many clinicians treat post-transplant anemia in a manner similar to treatment of anemia in dialysis patients, including the use of intravenous iron, such as sodium ferric gluconate (SFG). Data on pediatric dosing of SFG are lim...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00258.x

    authors: Gillespie RS,Symons JM

    更新日期:2005-02-01 00:00:00

  • Resistance to growth hormone in children with chronic liver disease.

    abstract::Malnutrition adversely affects mortality and morbidity before and after liver transplantation. Outcome might be improved if liver transplant recipients were in a better nutritional state at the time of transplantation. In this review, we will examine the potential use of GH and IGF-I to improve nutritional status in p...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Bucuvalas JC,Horn JA,Chernausek SD

    更新日期:1997-08-01 00:00:00