Surgical treatment of primary liver tumors in children: outcomes analysis of resection and transplantation in the SEER database.

Abstract:

:Adjusted survival outcomes following hepatic resection and transplantation for pediatric liver tumors have not been compared. To address this question, we conducted a retrospective cohort study using the SEER registry. While SEER lacks certain specifics regarding staging, chemotherapy, comorbidities, and recurrence, important hypothesis-generating data are available and were analyzed using Kaplan-Meier statistics and Cox proportional hazards regression. All SEER patients under the age of 20 yr undergoing surgery for HB (n = 318) or HCC (n = 80) between 1998 and 2009 were included. Of HB patients, 83.3% underwent resection and 16.7% transplantation. Advanced disease, vascular invasion, and satellite lesions were more common among transplant patients. Unadjusted five-yr survival was equivalent, as was the adjusted hazard of death for transplant relative to resection (HR = 0.58, p = 0.63). Of HCC patients, 75.0% underwent resection and 25.0% transplantation. Transplant patients had a higher prevalence of vascular invasion and satellite lesions. Five-yr survival was 53.4% after resection and 85.3% after transplant, and the adjusted hazard of death was significantly lower after transplantation (HR = 0.05, p = 0.045). While transplantation is generally reserved for unresectable tumors, the favorable survival seen in HCC patients suggests that liberalized transplant criteria might improve survival, although further prospective data are needed.

journal_name

Pediatr Transplant

authors

McAteer JP,Goldin AB,Healey PJ,Gow KW

doi

10.1111/petr.12144

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

744-50

issue

8

eissn

1397-3142

issn

1399-3046

journal_volume

17

pub_type

杂志文章
  • Infusion-related febrile reaction after haploidentical stem cell transplantation in children is associated with higher rates of engraftment syndrome and acute graft-versus-host disease.

    abstract::The clinical significance and prognostic impact of IRFR in pediatric recipients of haploidentical SCT are not clearly understood. Therefore, we attempted to determine how IRFR affects clinical outcomes in children. Clinical data from 100 consecutive pediatric patients (60 boys and 40 girls; median age, 12 yr [range, 2...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12586

    authors: Chen Y,Huang XJ,Liu KY,Chen H,Chen YH,Zhang XH,Wang FR,Han W,Wang JZ,Wang Y,Yan CH,Zhang YY,Sun YQ,Xu LP

    更新日期:2015-12-01 00:00:00

  • Comparison of melphalan- And busulfan-based myeloablative conditioning in children undergoing allogeneic transplantation for acute myeloid leukemia or myelodysplasia.

    abstract:BACKGROUND:The optimal conditioning regimen for alloHCT in children with myeloid malignancies remains undefined. PROCEDURE:We performed a retrospective review of children undergoing alloHCT for AML and MDS over a 10-year period (2008-2018) at our institution, comparing the outcomes of recipients of either a myeloablat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13672

    authors: Oshrine B,Adams L,Nguyen ATH,Amankwah E,Shyr D,Hale G,Petrovic A

    更新日期:2020-06-01 00:00:00

  • The effect of peri-transplant plasmapheresis in the prevention of recurrent FSGS.

    abstract::Many pediatric centers utilize a variety of protocols including preemptive plasmapheresis to prevent the recurrence of FSGS post-transplant. But the effectiveness of this expensive, time-consuming process of plasmapheresis in the prevention of FSGS recurrence is still unclear. We retrospectively reviewed all pediatric...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13154

    authors: Verghese PS,Rheault MN,Jackson S,Matas AJ,Chinnakotla S,Chavers B

    更新日期:2018-05-01 00:00:00

  • Sequential renal and bone marrow transplants in a child with Fanconi anemia.

    abstract::FA is an autosomal recessive disorder characterized by small stature and renal abnormalities. FA can lead to progressive bone marrow failure, myelodysplastic syndrome, or acute leukemia. Using a multidisciplinary team approach, we managed a 3-yr-old boy with FA who simultaneously developed renal and hematopoietic fail...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12619

    authors: Vincent CL,Primack WA,Hipps J,Kasow KA

    更新日期:2016-02-01 00:00:00

  • Characteristics of long-term live-donor pediatric renal transplant survivors: a single-center experience.

    abstract:OBJECTIVES:To study the characteristics and the predictors of survival observed in our pediatric live-donor renal transplant recipients with an allograft that functioned for more than 10 yr. METHODS:One hundred fifteen children underwent renal transplantation between 1976 and 1995. Of these, 30 had functioning allogra...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00455.x

    authors: El-Husseini AA,Foda MA,Osman YM,Sobh MA

    更新日期:2006-05-01 00:00:00

  • Severe cryptosporidiosis in a seven-year-old renal transplant recipient: case report and review of the literature.

    abstract::Cryptosporidium is an intracellular protozoa that can cause gastroenteritis in humans. In immunocompromised hosts, infection can be severe, leading to life-threatening persistent diarrhea. There is limited experience in treating this infection in solid organ transplants. Although newer drugs active against Cryptospori...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2006.00593.x

    authors: Hong DK,Wong CJ,Gutierrez K

    更新日期:2007-02-01 00:00:00

  • Optimal immunosuppression in teenagers.

    abstract::Adolescence is a difficult time for transplant recipients, who need to cope with the challenges of becoming independent from their parents, as well as taking responsibility for their own behavior and medication. They need to balance their developing sexuality with a body image which may be affected by the side-effects...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2002.01090.x

    authors: Kelly DA

    更新日期:2002-12-01 00:00:00

  • Pre-stem cell transplantation enzyme replacement therapy in Hurler syndrome does not lead to significant antibody formation or delayed recovery of the endogenous enzyme post-transplant: a case report.

    abstract::Combined enzyme replacement therapy (ERT) and stem cell transplant (SCT) were done for a two year old boy with severe Hurler syndrome(HS) with the aim to decrease transplant related complications. He tolerated both the procedures well without any major complications. Urine glycosaminoglycans (GAGs) decreased post-tran...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00720.x

    authors: Soni S,Hente M,Breslin N,Hersh J,Whitley C,Cheerva A,Bertolone S

    更新日期:2007-08-01 00:00:00

  • Use of tissue expansion to facilitate liver and small bowel transplant in young children with contracted abdominal cavities.

    abstract::Liver and small bowel transplant is an established treatment for infants with IFALD. Despite organ reduction techniques, mortality on the waiting list remains high due to shortage of size-matched pediatric donors. Small abdominal cavity volume due to previous intestinal resection poses a significant challenge to achie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12138

    authors: Vidyadharan R,van Bommel AC,Kuti K,Gupte GL,Sharif K,Richard BM

    更新日期:2013-11-01 00:00:00

  • Subcutaneous IgG replacement after pediatric SCT.

    abstract::Hypogammaglobulinemia is common after pediatric SCT and IgG replacement is recommended. Some children will have a prolonged hypogammaglobulinemia but may have poor venous access which impedes further iv IgG replacement. In primary antibody deficiencies, sc IgG replacement, performed by parents at home, has been shown ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01783.x

    authors: Sundin M,Nordin K,Jostemyr Y,Winiarski J

    更新日期:2012-12-01 00:00:00

  • Preliminary quantitative investigation of predictors of treatment non-adherence in pediatric transplantation: a brief report.

    abstract::The examination of predictors of non-adherence in transplantation populations offers the potential to identify high-risk individuals and concomitantly generate effective adherence-promoting interventions. The present paper aggregated quantitative estimates of various correlates of treatment adherence in studies of ped...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1399-3046.2007.00864.x

    authors: Kahana SY,Frazier TW,Drotar D

    更新日期:2008-09-01 00:00:00

  • Are drowned donors marginal donors? A single pediatric center experience.

    abstract::Drowning, a common cause of death in the pediatric population, is a potentially large donor pool for OLT. Anecdotally, transplant centers have deemed these organs high risk over concerns for infection and graft dysfunction. We theorized drowned donor liver allografts do not portend worse outcomes and therefore should ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13009

    authors: Kumm KR,Galván NTN,Koohmaraie S,Rana A,Kueht M,Baugh K,Hao L,Yoeli D,Cotton R,O'Mahony CA,Goss JA

    更新日期:2017-09-01 00:00:00

  • Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.

    abstract::In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left latera...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13384

    authors: Ocwieja KE,Vargas SO,Elisofon SA,Shulman DS,Lee CK,Fawaz R,Collins N,Vakili K,Sharma TS

    更新日期:2019-05-01 00:00:00

  • High prevalence of latent tuberculosis in hematopoietic stem cell transplant recipients: A First Report.

    abstract::TB is an increasing health problem, and patients undergoing HSCT are more prone to develop tuberculosis. The aim of our study was to evaluate prevalence of latent tuberculosis in HSCT recipients. In this study, 84 patients (2 months to 18 years) who were candidates for HSCT at the referral hospital of Tehran Children'...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13770

    authors: Mahmoudi S,Pourakbari B,Sadeghi RH,Hamidieh AA,Safari Sharari A,Salajegheh P,Aziz-Ahari A,Mamishi S

    更新日期:2020-09-01 00:00:00

  • Living donor liver transplantation for hepatoblastoma with Beckwith-Wiedemann syndrome.

    abstract::BWS is one of the most well-known somatic overgrowth syndromes, which is characterized by macroglossia, organomegaly, abdominal wall defects, and predisposition to embryonal tumors, such as Wilms' tumor, hepatoblastoma, and adrenocortical carcinoma. We report a case of BWS in a girl with unresectable hepatoblastoma, w...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01198.x

    authors: Sasaki K,Kasahara M,Fukuda A,Shigeta T,Tanaka H,Nakagawa S,Mitsui K,Harada R,Nakagawa A

    更新日期:2010-11-01 00:00:00

  • Diet quality of children post-liver transplantation does not differ from healthy children.

    abstract::Little has been studied regarding the diets of children following LTX. The study aim was to assess and compare dietary intake and DQ of healthy children and children post-LTX. Children and adolescents (2-18 years) post-LTX (n=27) and healthy children (n=28) were studied. Anthropometric and demographic data and two 24-...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12944

    authors: Alzaben AS,MacDonald K,Robert C,Haqq A,Gilmour SM,Yap J,Mager DR

    更新日期:2017-09-01 00:00:00

  • Evaluation of a three-session biliary dilation protocol following transplant-related biliary stricture in pediatric patients.

    abstract::To evaluate whether a serial biliary dilation protocol improves outcomes and decreases total biliary drainage time for biliary strictures following pediatric liver transplantation. From 2006 to 2016, 213 orthotopic deceased and living related liver transplants were performed in 199 patients with a median patient age o...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13551

    authors: Reis SP,Bruestle K,Brejt S,Tulin-Silver S,Frenkel J,Mobley DG,England RW,Sobolevsky S,Griesemer AD,Sperling D,Schlossberg P,Susman J,Weintraub JL

    更新日期:2019-11-01 00:00:00

  • Association of mast cells and liver allograft rejection.

    abstract::MCs are important effector cells in a broad range of immune responses. Their role in liver allograft rejection is not clear. Twenty-one liver transplant recipients (mean age +/- s.d.; 10.2 +/- 4.1 yr) who experienced a rejection episode are included in this study. Biopsy specimens from normal livers (allograft biopsy ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00819.x

    authors: Arikan C,Nart D,Kilic M,Yuksekkaya HA,Aydogdu S

    更新日期:2008-05-01 00:00:00

  • Re-evaluation of the indications for liver transplantation in Wilson's disease based on the outcomes of patients referred to a transplant center.

    abstract::The aim of this study was to re-evaluate the indications and timing of LT for WD. From 2000 to 2009, eight patients with WD who had been referred to our institution for LT were enrolled in this study. The mean patient age was 15.9 yr (range, 7-37 yr). Four patients could not receive LT, because there were no available...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12085

    authors: Ohya Y,Okajima H,Honda M,Hayashida S,Suda H,Matsumoto S,Lee KJ,Yamamoto H,Takeichi T,Mitsubuchi H,Asonuma K,Endo F,Inomata Y

    更新日期:2013-06-01 00:00:00

  • Ultrasonography, laboratory, and cholangiography correlation of biliary complications in pediatric liver transplantation.

    abstract::The aim of this study is to correlate the US, laboratory, and cholangiography findings in pediatric liver transplant patients with biliary complications, trying to identify reliable decision-making tools for the management of these complications. Retrospective review was carried out of US results in 39 consecutive pat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12421

    authors: Teplisky D,Urueña Tincani E,Halac E,Garriga M,Cervio G,Imventarza O,Sierre S

    更新日期:2015-03-01 00:00:00

  • Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study.

    abstract::The development of malignancy in a renal transplant graft is an uncommon phenomenon. A renal neoplasm developing in the adult donor kidney of a pediatric transplant recipient has only rarely been reported. We report a case of collecting duct carcinoma arising in association with BK virus nephropathy in an adult living...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00855.x

    authors: Emerson LL,Carney HM,Layfield LJ,Sherbotie JR

    更新日期:2008-08-01 00:00:00

  • Liver retransplantation in an infant requiring cavoportal hemi transposition.

    abstract::Historically inability to achieve portal inflow to the liver allograft operatively was felt to be a contraindication to orthotopic liver transplantation (OLTx). Cavoportal hemi transposition has been utilized more recently in adult OLTx recipients but rarely in pediatric recipients. Here we report the case of a 10-mon...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00196.x

    authors: Verran D,Crawford M,Stormon M,Shun A

    更新日期:2004-08-01 00:00:00

  • Growth and weight gain of prepubertal children after cardiac transplantation.

    abstract::This study evaluated changes in growth parameters after pediatric heart transplantation and identified factors associated with the changes after pediatric heart transplantation (OHT). We retrospectively evaluated the somatic growth of 46 children <11 yr of age who underwent OHT for changes in weight, height, and BMI. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00826.x

    authors: Peterson RE,Perens GS,Alejos JC,Wetzel GT,Chang RK

    更新日期:2008-06-01 00:00:00

  • Impact of laparoscopic donor nephrectomy on allograft function in pediatric renal transplant recipients: a single-center report.

    abstract::Laparoscopic donor nephrectomy (LDN) is rapidly becoming the preferred technique for the procurement of living donor kidneys. An association of this technique with delayed graft function and higher risk for rejection has been reported in pediatric recipients. We reviewed our experience of 17 pediatric patients who rec...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00478.x

    authors: Baqi N,Stock J,Lombardo SA,Geffner S,Roberti I

    更新日期:2006-05-01 00:00:00

  • Impact of acute cellular rejection on coagulation and fibrinolysis biomarkers within the immediate post-operative period in pediatric liver transplantation.

    abstract::We studied restoration of the coagulation and fibrinolysis system in pediatric patients following liver transplantation and biomarkers of blood coagulation and fibrinolysis for suspecting the occurrence of acute cellular rejection. Coagulation activity recovered rapidly within two days following transplantation, but i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01248.x

    authors: Mimuro J,Mizuta K,Kawano Y,Hishikawa S,Hamano A,Kashiwakura Y,Ishiwata A,Ohmori T,Madoiwa S,Kawarasaki H,Sakata Y

    更新日期:2010-05-01 00:00:00

  • De novo development of antibodies to kidney-associated self-antigens angiotensin II receptor type I, collagen IV, and fibronectin occurs at early time points after kidney transplantation in children.

    abstract::Chronic rejection is the leading cause of graft loss following pediatric kidney transplantation. Our group and others have demonstrated an association between the development of Abs to self-antigens and chronic rejection following adult lung and heart transplantation. The goal of this study was to determine whether Ab...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12531

    authors: Hesemann LE,Subramanian V,Mohanakumar T,Dharnidharka VR

    更新日期:2015-08-01 00:00:00

  • Hematopoietic stem cell transplantation in CD40 ligand deficiency: A single-center experience.

    abstract::Deficiency of the CD40L, expressed on the surface of T lymphocytes, is caused by mutations in the glycoprotein CD40L (CD154) gene. Resulting defective humoral and cellular responses cause a clinical presentation that includes recurrent sinopulmonary bacterial infections, opportunistic infections, sclerosing cholangiti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13768

    authors: Uygun DFK,Uygun V,Karasu GT,Daloğlu H,Öztürkmen SI,Çelmeli F,Törün SH,Özen A,Barış S,Aydıner EK,Yalçın K,Kılıç SÇ,Hazar V,Bingöl A,Yeşilipek A

    更新日期:2020-09-01 00:00:00

  • Mycophenolate mofetil for treatment of steroid-refractory acute graft-versus-host disease after pediatric hematopoietic stem cell transplantation.

    abstract::A standard treatment is yet to be established for steroid-refractory acute aGVHD following HSCT. The effects of MMF have not been well studied in children with aGVHD. We evaluated the effectiveness of oral MMF in 14 children with steroid-refractory aGVHD (grade II in one patient, grade III to IV in 13 patients). The m...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12545

    authors: Inagaki J,Kodama Y,Fukano R,Noguchi M,Okamura J

    更新日期:2015-09-01 00:00:00

  • Coronary artery involvement in chronic graft-versus-host disease presenting as sudden cardiac arrest.

    abstract::Graft-versus-host disease (GVHD) is related to considerable morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Cardiac complications associated with GVHD are uncommon, and coronary artery involvement is even more unusual. We report on a male pediatric patient with chronic GVHD who...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13474

    authors: Kim DH,You JJ,Im HJ,Ko JK

    更新日期:2019-08-01 00:00:00

  • Latin American Registry of Pediatric Renal Transplantation 2004-2008.

    abstract:UNLABELLED:The Latin American Pediatric Nephrology Association (ALANEPE) reports the first regional kidney transplant registry in Latin America. A mean range of 75%, 30% to 100% renal transplant recipients under 21 yr old were included. Out of 20 countries invited to participate, 14 performed renal transplant, 11 had u...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01331.x

    authors: Latin American Pediatric Nephrology Association.,Latin American Pediatric Renal Transplant Cooperative Study.

    更新日期:2010-09-01 00:00:00