Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.

Abstract:

:In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11 months. The donor was a male with no known history of KS, originally from an HHV-8-endemic country. Three months after transplantation, the patient developed liver nodules and portal vein thrombosis. Analysis of needle biopsy established the diagnosis of KS and confirmed that the transformed cells were donor-derived. HHV-8 viremia was detected, and ganciclovir dosing (which had been started prophylactically) was increased. Immunosuppression was changed from tacrolimus to sirolimus. After further disease progression, 8 cycles of paclitaxel were administered. Under this treatment, her nodules regressed, HHV-8 viremia resolved, and she had marked clinic improvement. Notably, the adult recipient of the right liver lobe from the same donor also developed PTKS. This is one of few pediatric PTKS cases described in the literature. It contributes to the mechanistic understanding of PTKS development, illustrating the risk posed by donors from HHV-8-endemic countries, as well as the potential for strong PTKS correlation between multiple recipients of organs from a single shared donor.

journal_name

Pediatr Transplant

authors

Ocwieja KE,Vargas SO,Elisofon SA,Shulman DS,Lee CK,Fawaz R,Collins N,Vakili K,Sharma TS

doi

10.1111/petr.13384

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

e13384

issue

3

eissn

1397-3142

issn

1399-3046

journal_volume

23

pub_type

  • Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents.

    abstract::This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12213

    authors: Park M,Lee YH,Kang HR,Lee JW,Kang HJ,Park KD,Shin HY,Ahn HS,Baek HJ,Kook H,Hwang TJ,Lee JW,Chung NG,Cho B,Kim HK,Lee SH,Yoo KH,Sung KW,Koo HH,Koh KN,Im HJ,Seo JJ,Park JE,Lim YJ,Lyu CJ,Lee JM,Hah JO,K

    更新日期:2014-03-01 00:00:00

  • The effect of peri-transplant plasmapheresis in the prevention of recurrent FSGS.

    abstract::Many pediatric centers utilize a variety of protocols including preemptive plasmapheresis to prevent the recurrence of FSGS post-transplant. But the effectiveness of this expensive, time-consuming process of plasmapheresis in the prevention of FSGS recurrence is still unclear. We retrospectively reviewed all pediatric...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13154

    authors: Verghese PS,Rheault MN,Jackson S,Matas AJ,Chinnakotla S,Chavers B

    更新日期:2018-05-01 00:00:00

  • Lung transplantation and survival in children with cystic fibrosis: solid statistics--flawed interpretation.

    abstract::In their provocative paper, "Lung transplantation and survival in children with cystic fibrosis," Liou and colleagues state that "Prolongation of life by means of lung transplantation should not be expected in children with cystic fibrosis. A prospective, randomized trial is needed to clarify whether and when patients...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00924.x

    authors: Sweet SC,Aurora P,Benden C,Wong JY,Goldfarb SB,Elidemir O,Woo MS,Mallory GB Jr,International Pediatric Lung Transplant Collaborative.

    更新日期:2008-03-01 00:00:00

  • Surveillance transbronchial biopsies in infant lung and heart-lung transplant recipients.

    abstract::There are limited published data on surveillance TBB for the identification of allograft rejection in infants after lung or heart-lung transplantation. We performed a retrospective review of children under one yr of age who underwent lung or heart-lung transplant at our institution. Since 2005, four infants were trans...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12125

    authors: Hayes D Jr,Baker PB,Kopp BT,Kirkby S,Galantowicz M,McConnell PI,Astor TL

    更新日期:2013-11-01 00:00:00

  • Outpatient pediatric renal transplant biopsy--is it safe?

    abstract::The safe observation time following pediatric renal transplant biopsy is unknown. To predict the safety of day-care pediatric renal transplant biopsy, we retrospectively evaluated the timing, incidence and severity of post-biopsy complications in children observed overnight. Biopsies were performed under real time ult...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00433.x

    authors: Sweeney C,Geary DF,Hebert D,Robinson L,Langlois V

    更新日期:2006-03-01 00:00:00

  • Effect of CYP3A5*1 expression on tacrolimus required dose for transplant pediatrics: A systematic review and meta-analysis.

    abstract::This systematic review was designed to find out optimal tacrolimus dose in pediatrics according to their CYP3A5*1 genotype by performing meta-analysis. PubMed, Scopus, ISI web of Science, ProQuest, Cochrane library, and clinicaltrail.gov were systematically searched to find studies in which tacrolimus dose and/or bloo...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13248

    authors: Hendijani F,Azarpira N,Kaviani M

    更新日期:2018-06-19 00:00:00

  • Successful allogeneic stem cell transplant for leukocyte adhesion deficiency using an adjusted busulfan-containing regimen.

    abstract::LAD is a rare and fatal congenital disorder in which there is a defect of the leukocyte adhesion molecule (CD18) on neutrophils. Severe LAD results in frequent and potentially fatal infections. Although allogeneic HSCT is the only curative treatment for severe LAD, strategies for HSCT remain to be established since a ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00723.x

    authors: Yoshimoto A,Hashii Y,Kashiwagi H,Koizumi M,Tokimasa S,Fujisaki H,Ohta H,Hanai N,Ozono K,Hara J

    更新日期:2007-06-01 00:00:00

  • Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.

    abstract::The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p =...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01625.x

    authors: Anastaze Stelle K,Belli DC,Parvex P,Girardin E,Giroud A,Wildhaber B,McLin VA

    更新日期:2012-05-01 00:00:00

  • Sirolimus for solid organ transplantation in children.

    abstract::Sirolimus represents a major advancement in the field of solid organ transplantation and is being used as a rescue agent for acute and chronic rejection as well as for primary immunosuppression with good graft outcome. Although initial studies with sirolimus were in adults, now significant data have accumulated on the...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00305.x

    authors: Gupta P,Kaufman S,Fishbein TM

    更新日期:2005-06-01 00:00:00

  • Primary HHV 6 infection after liver transplantation with acute graft rejection and multi-organ failure: successful treatment with a 2.5-fold dose of cidofovir and reduction of immunosuppression.

    abstract::HHV type 6 has been reported with enhanced pathogenicity in immunocompromised patients. Herein, we report about a two-yr-old girl who experienced primary HHV 6 infection after liver transplantation. She clinically presented with graft rejection and necrotic hepatitis as well as high fever, pneumonitis with respiratory...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01310.x

    authors: Dohna-Schwake C,Fiedler M,Gierenz N,Gerner P,Ballauf A,Breddemann A,Läer S,Baba HA,Hoyer PF

    更新日期:2011-09-01 00:00:00

  • Augmented immunosuppression and PTCY-based haploidentical hematopoietic stem cell transplantation for thalassemia major.

    abstract::Alternate donor HSCT for thalassemia major from a matched unrelated donor or haploidentical family donor is a feasible therapeutic option in children with no matched family donor. Aggressive pretransplant immunosuppression, reduced toxicity conditioning, and PTCY result in excellent thalassemia-free survival. We descr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13893

    authors: Vellaichamy Swaminathan V,Ravichandran N,Ramanan KM,Meena SK,Varla H,Ramakrishnan B,Jayakumar I,Uppuluri R,Raj R

    更新日期:2020-10-27 00:00:00

  • Portal vein phlebolithiasis found post-liver transplantation in the native liver of a child with biliary atresia.

    abstract::Biliary atresia is defined as partial or total obliteration of the extra-hepatic bile ducts. In advanced cases, liver transplantation (LTx) is considered the most appropriate treatment. This report describes a female patient whose biliary atresia and subsequent cirrhosis required LTx at 1 yr of age. Macroscopic inspec...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.t01-1-00020.x

    authors: Bilezikçi B,Demirhan B,Kiyici H,Haberal M

    更新日期:2001-02-01 00:00:00

  • Post-transplant glucose status in 61 pediatric renal transplant recipients: preliminary results of five Turkish pediatric nephrology centers.

    abstract::To assess the incidence, risk factors and outcomes of PTDM, a total of 61 non-diabetic children (24 girls, 37 boys, age: 14.5 +/- 2.1 yr) were examined after their first kidney transplantation (37.3 +/- 21.6 months) with an OGTT. At baseline, 16 (26.2%) patients had IGT, 45 (73.8%) had NGT, and no patient had PTDM. No...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1399-3046.2009.01192.x

    authors: Buyan N,Bilge I,Turkmen MA,Bayrakci U,Emre S,Fidan K,Baskin E,Gok F,Bas F,Bideci A

    更新日期:2010-03-01 00:00:00

  • Hepatic veno-occlusive disease.

    abstract::Hepatic veno-occlusive disease (VOD) after stem cell transplantation is a toxic manifestation of the conditioning regimen most probably emphasized by the allogeneic reaction. Its overall mortality rate is < 4% in adults as well as in children. Recent progress has been achieved in the diagnosis of this complication. Ho...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.1999.00077.x

    authors: Ribaud P,Gluckman E

    更新日期:1999-01-01 00:00:00

  • Waiting for transplant: physical, psychosocial, and nutritional status considerations for pediatric candidates and implications for care.

    abstract::The waiting period for an organ transplant has been described as a time of tremendous uncertainty and vulnerability, posing unique challenges and stressors for pediatric transplant candidates and their families. It has been identified as the most stressful stage of the transplant journey, yet little attention has been...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12305

    authors: Anthony SJ,Annunziato RA,Fairey E,Kelly VL,So S,Wray J

    更新日期:2014-08-01 00:00:00

  • Serial signal-averaged electrocardiography in children after cardiac transplantation.

    abstract::In patients with myocytolysis detected in endomyocardial biopsy, there is a tendency towards a shift of ventricular electrical axes from normal to strain pattern on surface ECG. Their 12-lead signal-averaged electrocardiogram (SAECG) show a significant increase in filtered QRS duration (QRSD) compared with those with ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00384.x

    authors: Bennhagen RG,Sörnmo L,Pahlm O,Pesonen E

    更新日期:2005-12-01 00:00:00

  • Successful kidney transplantation in a patient with neonatal-onset ILNEB.

    abstract:BACKGROUND:ILNEB constitute an autosomal recessive disorder caused by homozygous or compound heterozygous mutation of the gene for the ITGA3. To date, 8 ILNEB patients have been reported, but all 6 neonatal-onset ILNEB patients suffered early death within 2 years. The most common cause of death among previously reporte...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13971

    authors: Okamoto T,Nakamura A,Hayashi A,Yamaguchi T,Ogawa Y,Natsuga K,Yanagi K,Hotta K

    更新日期:2021-01-20 00:00:00

  • Micronutrient deficiencies in pediatric and young adult intestinal transplant patients.

    abstract::Intestinal transplant recipients are at risk of micronutrient deficiency due to the slow process of post-transplant adaptation. Another contributing factor is calcineurin inhibitor-induced renal tubular dysfunction. Patients are typically supplemented with micronutrients during PN; however, the risk of deficiency may ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12132

    authors: Ubesie AC,Cole CR,Nathan JD,Tiao GM,Alonso MH,Mezoff AG,Henderson CJ,Kocoshis SA

    更新日期:2013-11-01 00:00:00

  • Vesico-ureteral reflux in pediatric kidney transplants: clinical relevance to graft and patient outcome.

    abstract::From June 1985 to December 1998, 173 pediatric renal transplants were carried out in 170 patients at our center. From this pool, 73 patients (34 males and 39 females) with a follow-up of 48 months were examined. In all patients, ureteroneocystostomy was performed according to the Lich-Grégoire procedure. All patients ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.1999.00017.x

    authors: Fontana I,Ginevri F,Arcuri V,Basile G,Nocera A,Beatini M,Bonato L,Barocci S,Bertocchi M,Manolitsi O,Valente R,Draghi P,Gusmano R,Valente U

    更新日期:1999-08-01 00:00:00

  • Preparing for a kidney transplant: Medical nephrectomy in children with nephrotic syndrome.

    abstract::Nephrotic syndrome is characterized by proteinuria, hypoalbuminemia, and general edema. These symptoms may persist in children who reach ESRD, which is unfavorable for the patient's allograft outcome. In addition, this may hamper early diagnosis of a relapse after transplantation. Surgical bilateral nephrectomy is oft...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13703

    authors: Vos E,Koster-Kamphuis L,van de Kar NCAJ,Bootsma-Robroeks CMHHT,Cornelissen EAM,Schreuder MF

    更新日期:2020-06-01 00:00:00

  • Outcome of allogeneic hematopoietic stem cell transplantation for children with acute myelogenous leukemia in second complete remission: single center experience.

    abstract::We reviewed 26 consecutive patients with AML who were transplanted in second CR2 between 1994 and 2005. The most common conditioning regimen was CY and TBI. Median age at transplant was 8.9 yr (range 2.2-18.2). Nine patients received related donor, 16 patients received unrelated donors, and one patient received unrela...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01101.x

    authors: Ishaqi MK,Afzal S,Dupuis A,Doyle J,Gassas A

    更新日期:2009-12-01 00:00:00

  • Sleep quality is associated with psychosocial functioning and health-related quality of life in pediatric transplant recipients.

    abstract::This study examined patient-reported sleep quality in a single-center cross-sectional sample of adolescents with solid organ transplants and evaluated associations between sleep quality, psychosocial functioning (ie, depression/anxiety symptoms), and HRQOL. Health disparities associated with minority race/ethnicity an...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13577

    authors: Gutierrez-Colina AM,Quast LF,Eaton CK,LaMotte J,Stolz MG,Mee L,George R,Lee J,Reed B,Rich KL,Blount RL

    更新日期:2019-12-01 00:00:00

  • Mycophenolate mofetil in pediatric renal transplantation: a single center experience.

    abstract::We assessed our long-term experience with regards to the safety and efficacy of MMF in our pediatric renal transplant population and compared it retrospectively to our previous non-MMF immunosuppressive regimen. Forty-seven pediatric renal transplants received MMF as part of their immunosuppressive protocol in the per...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01179.x

    authors: Raheem OA,Kamel MH,Daly PJ,Mohan P,Little DM,Awan A,Hickey DP

    更新日期:2011-05-01 00:00:00

  • Post-transplantation growth among pediatric recipients of liver transplantation.

    abstract::Improving a patient's quality-of-life (QOL) post-liver transplantation is of great importance. An aspect of improved QOL is the restoration of normal growth patterns in pediatric patients. To describe the post-transplantation growth patterns of 72 children included in the National Institute of Diabetes and Digestive a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00326.x

    authors: Evans IV,Belle SH,Wei Y,Penovich C,Ruppert K,Detre KM,National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database Team.

    更新日期:2005-08-01 00:00:00

  • Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging.

    abstract:UNLABELLED:Liver transplantation treats the hepatic affectation of UCDs; however, irreversible neurologic damage pretransplant is difficult to assess providing transplant teams with ethical dilemmas for liver transplantation. The purpose of our study was to determine whether pretransplant neuroimaging can predict devel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12520

    authors: Bolton SM,Campbell KM,Kukreja M,Kohli R

    更新日期:2015-08-01 00:00:00

  • Varicella infection following vaccination in a pediatric kidney transplant recipient.

    abstract::Live viral vaccines have historically been avoided in children after solid organ transplantation. Multiple reports of safety and immunogenicity, largely in the pediatric liver transplant population, have led to a reconsideration of this recommendation. Here, we report the case of a 4-year-old boy who inadvertently rec...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13667

    authors: Bobrowski AE,Muller WJ

    更新日期:2020-06-01 00:00:00

  • Variation in resource utilization in liver transplantation at freestanding children's hospitals.

    abstract::We sought to examine the relationship between liver transplant-related total cost, patient outcome, and hospital resource utilization at freestanding children's hospitals. Using the PHIS database, a retrospective study of 374 patients that underwent liver transplantation at 15 freestanding children's hospitals from Ju...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12783

    authors: Minneman JA,Grijalva JL,LaQuaglia MJ,Kim HB,Rangel SJ,Vakili K

    更新日期:2016-11-01 00:00:00

  • Expanding the donor pool for congenital heart disease transplant candidates by implementing 3D imaging-derived total cardiac volumes.

    abstract:BACKGROUND:Heart transplant waitlist mortality remains high in infants <1 year of age and among those with CHD. Currently, the median accepted donor-to-recipient weight percentage is approximately 130% of the recipient's weight. We hypothesized that patients with CHD may accept a larger organ using novel 3D-derived ima...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13639

    authors: Shugh SB,Szugye NA,Zafar F,Riggs KW,Villa C,Lorts A,Morales DLS,Moore RA

    更新日期:2020-02-01 00:00:00

  • Efficacy and safety of three times daily dosing of tacrolimus in pediatric kidney transplantation patients: A single-center comparative study.

    abstract:BACKGROUND/AIM:Several PK studies have shown that most pediatric patients may require higher doses on a mg/kg basis compared to adults to attain similar therapeutic trough concentrations. The aim of this study was to compare the efficacy and safety of three times daily to twice a day dosing of tacrolimus in pediatric k...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13733

    authors: Alabdulkarim Z,Al-Jedai A,Alkortas D,Alhasan K,Devol E

    更新日期:2020-09-01 00:00:00

  • Ureterocystoplasty (bladder augmentation) with a solitary kidney.

    abstract::Children who develop end-stage renal disease (ESRD) as a result of obstructive uropathies require evaluation and treatment of associated bladder dysfunction to ensure a good outcome following renal transplantation. Bladder dynamics can often be optimized medically, although surgical intervention is occasionally necess...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.01078.x

    authors: Kurzrock EA,Butani L,Kakker SP,Perez RV,Lavjay Butani.

    更新日期:2002-06-01 00:00:00