Primary HHV 6 infection after liver transplantation with acute graft rejection and multi-organ failure: successful treatment with a 2.5-fold dose of cidofovir and reduction of immunosuppression.

Abstract:

:HHV type 6 has been reported with enhanced pathogenicity in immunocompromised patients. Herein, we report about a two-yr-old girl who experienced primary HHV 6 infection after liver transplantation. She clinically presented with graft rejection and necrotic hepatitis as well as high fever, pneumonitis with respiratory failure and a rash. Therapy with cidofovir of 5 mg/kg per wk did not show improvement, so that a full pharmacokinetic profile of cidofovir was performed. It demonstrated enhanced body weight normalized clearance of cidofovir and cidofovir dosage was augmented to 12 mg/kg per wk to reach adequate drug exposure. With additional reduction of immunosuppression, the patient dramatically improved and liver function stabilized.

journal_name

Pediatr Transplant

authors

Dohna-Schwake C,Fiedler M,Gierenz N,Gerner P,Ballauf A,Breddemann A,Läer S,Baba HA,Hoyer PF

doi

10.1111/j.1399-3046.2010.01310.x

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

E126-9

issue

6

eissn

1397-3142

issn

1399-3046

pii

PTR1310

journal_volume

15

pub_type

杂志文章
  • Successful umbilical cord blood hematopoietic stem cell transplantation in pediatric patients with MDS/AML associated with underlying GATA2 mutations: two case reports and review of literature.

    abstract::Germline GATA2 mutations have been associated with a vast array of clinical manifestations, as well as hematological deficiencies and a propensity to AML or MDS. We present two cases of pediatric AML/MDS with underlying GATA2 mutations who underwent a successful umbilical cord hematopoietic stem cell transplantation u...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12764

    authors: Mallhi K,Dix DB,Niederhoffer KY,Armstrong L,Rozmus J

    更新日期:2016-11-01 00:00:00

  • Long-term follow-up in adult living donors for combined liver/bowel transplant in pediatric recipients: a single center experience.

    abstract::Pediatric candidates for combined liver/bowel transplant (LBTx) experience a very high mortality on the cadaver waiting list. Our transplant center has successfully used adult living donors to treat pediatric candidates for LBTx. We report the long-term follow-up of this unique cohort of organ donors. The charts of si...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01501.x

    authors: Ghafari JL,Bhati C,John E,Tzvetanov IG,Testa G,Jeon H,Oberholzer J,Benedetti E

    更新日期:2011-06-01 00:00:00

  • Varicella infection following vaccination in a pediatric kidney transplant recipient.

    abstract::Live viral vaccines have historically been avoided in children after solid organ transplantation. Multiple reports of safety and immunogenicity, largely in the pediatric liver transplant population, have led to a reconsideration of this recommendation. Here, we report the case of a 4-year-old boy who inadvertently rec...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13667

    authors: Bobrowski AE,Muller WJ

    更新日期:2020-06-01 00:00:00

  • Successful transplantation of a cadaveric kidney with post-infectious glomerulonephritis.

    abstract::This report describes a successful renal Tx in a patient with chronic renal failure, caused by dysplastic kidneys, who received a cadaveric kidney with post-infectious glomerulonephritis. Sequential renal biopsies were performed at 12 h before Tx, and at 1 h and on days 8 and 58 post-Tx. Post-operative hematuria disap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2000.00076.x

    authors: Mizuiri S,Shigetomi Y,Sugiyama K,Miyagi M,Hatano T,Tajima E,Aikawa A,Ohara T,Kawamura S,Hasegawa A

    更新日期:2000-02-01 00:00:00

  • Characteristics of long-term live-donor pediatric renal transplant survivors: a single-center experience.

    abstract:OBJECTIVES:To study the characteristics and the predictors of survival observed in our pediatric live-donor renal transplant recipients with an allograft that functioned for more than 10 yr. METHODS:One hundred fifteen children underwent renal transplantation between 1976 and 1995. Of these, 30 had functioning allogra...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00455.x

    authors: El-Husseini AA,Foda MA,Osman YM,Sobh MA

    更新日期:2006-05-01 00:00:00

  • The effects of gender on health-related quality of life in pediatric live-donor kidney transplantation: a single-center experience in a developing country.

    abstract::To evaluate the effects of gender on HRQOL and overall health status in our pediatric kidney transplants. We performed a cross-sectional study in 77 children who received living renal allo-transplants in our center between 1981 and 2003. The patients were given a questionnaire at a post-transplant visit. After complet...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01174.x

    authors: El-Husseini A,Hassan R,Sobh M,Ghoneim M

    更新日期:2010-03-01 00:00:00

  • Low incidence of adverse events in outpatient pediatric renal allograft biopsies.

    abstract::In 1999, our center implemented a policy of outpatient protocol biopsies as standard practice for the clinical management of pediatric renal allograft recipients. In order to determine the safety of this procedure, we conducted a retrospective chart audit of all outpatient renal allograft biopsies performed at our cen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00659.x

    authors: Birk PE,Blydt-Hansen TD,Dart AB,Kaita LM,Proulx C,Taylor G

    更新日期:2007-03-01 00:00:00

  • Severe cryptosporidiosis in a seven-year-old renal transplant recipient: case report and review of the literature.

    abstract::Cryptosporidium is an intracellular protozoa that can cause gastroenteritis in humans. In immunocompromised hosts, infection can be severe, leading to life-threatening persistent diarrhea. There is limited experience in treating this infection in solid organ transplants. Although newer drugs active against Cryptospori...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2006.00593.x

    authors: Hong DK,Wong CJ,Gutierrez K

    更新日期:2007-02-01 00:00:00

  • Cyclosporine-induced white and grey matter central nervous system lesions in a pediatric renal transplant patient.

    abstract::Major neurologic complications secondary to cyclosporine are well documented and are known to include confusion, cortical blindness, seizure, spasticity, paresis, ataxia and coma. Most previous reports attribute these to white matter central nervous system (CNS) lesions or white/grey matter border lesions. Many predis...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:

    authors: Jeruss J,Braun SV,Reese JC,Guillot A

    更新日期:1998-02-01 00:00:00

  • Post-transplant glucose status in 61 pediatric renal transplant recipients: preliminary results of five Turkish pediatric nephrology centers.

    abstract::To assess the incidence, risk factors and outcomes of PTDM, a total of 61 non-diabetic children (24 girls, 37 boys, age: 14.5 +/- 2.1 yr) were examined after their first kidney transplantation (37.3 +/- 21.6 months) with an OGTT. At baseline, 16 (26.2%) patients had IGT, 45 (73.8%) had NGT, and no patient had PTDM. No...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1399-3046.2009.01192.x

    authors: Buyan N,Bilge I,Turkmen MA,Bayrakci U,Emre S,Fidan K,Baskin E,Gok F,Bas F,Bideci A

    更新日期:2010-03-01 00:00:00

  • Mycophenolate mofetil for treatment of steroid-refractory acute graft-versus-host disease after pediatric hematopoietic stem cell transplantation.

    abstract::A standard treatment is yet to be established for steroid-refractory acute aGVHD following HSCT. The effects of MMF have not been well studied in children with aGVHD. We evaluated the effectiveness of oral MMF in 14 children with steroid-refractory aGVHD (grade II in one patient, grade III to IV in 13 patients). The m...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12545

    authors: Inagaki J,Kodama Y,Fukano R,Noguchi M,Okamura J

    更新日期:2015-09-01 00:00:00

  • The value of 18F-FDG PET in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis.

    abstract::PTLD is a serious complication of both solid organ and BMT. This study assessed whether (18) F-FDG PET, when added to CT scan, had additional value in the initial evaluation of PTLD in pediatric patients and whether PET/CT at baseline can reliably guide biopsy. This retrospective study evaluated 34 consecutive pediatr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12611

    authors: Vali R,Punnett A,Bajno L,Moineddin R,Shammas A

    更新日期:2015-12-01 00:00:00

  • EBV-negative lymphoproliferative disease with hyper-IgA, in a child with combined liver and small bowel transplantation.

    abstract::A 4-year-old boy presented 14 months after liver and small bowel transplantation with fever, diarrhea, elevated liver enzymes, thrombocytopenia and autoantibodies. Total gammaglobulins level was normal but the level of plasma IgA1 was very high. The blood PCR for Epstein-Barr virus (EBV) was negative. The ileal biopsy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00174.x

    authors: Robert CD,Lacaille F,Canioni D,Quartier-dit-Maire P,Talbotec C,Goulet O

    更新日期:2004-06-01 00:00:00

  • Scurvy: a new problem for patients with chronic GVHD involving mucous membranes; an easy problem to resolve.

    abstract::Vitamin C deficiency in developed countries is typically observed in patients with unique clinical conditions such as cystic fibrosis or anorexia nervosa, or in patients on long-term tube feeds. We report here a clinical observation in six pediatric and adolescent patients (median age 17.5 yr, range 9.8-23.5 yr) with ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12285

    authors: Kletzel M,Powers K,Hayes M

    更新日期:2014-08-01 00:00:00

  • Focal segmental glomerulosclerosis associated with acute cytomegalovirus infection in a renal transplant.

    abstract::Focal segmental glomerulosclerosis (FSGS) occurring in association with cytomegalovirus (CMV) infection in a renal transplant patient with no previous history of FSGS has rarely been reported. We present a case of a 16-year-old renal transplant recipient who developed acute hepatitis, leukopenia, nephrotic syndrome, a...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13538

    authors: Wynd E,Stewart A,Burke J

    更新日期:2019-09-01 00:00:00

  • Quantitation of allograft fibrosis and chronic allograft nephropathy.

    abstract::Despite improvements in the prevention and treatment of acute renal allograft rejection, the long-term survival of renal transplants has not increased. Immunologic and non-immunologic factors contribute to the gradual deterioration of graft function and to the histologic lesion characterized by vascular and interstiti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.1999.00044.x

    authors: Grimm PC,Nickerson P,Gough J,McKenna R,Jeffery J,Birk P,Rush DN

    更新日期:1999-11-01 00:00:00

  • Airway plaque presenting after alteration of immunosuppression in a pediatric patient remote from heart transplantation.

    abstract::Success after solid organ transplantation is dependent on the proper balance of immunosuppression to prevent rejection of the allograft while limiting the risk of developing infections and malignancy. We present a 9-year-old girl, remote from transplant, who presented with airway plaque after a change in immunosuppres...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13046

    authors: Ryan TD,Absalon MJ,de Alarcon A,Gupta A,Peters AL,Lorts A,Danziger-Isakov LA,Chin C

    更新日期:2017-11-01 00:00:00

  • High prevalence of latent tuberculosis in hematopoietic stem cell transplant recipients: A First Report.

    abstract::TB is an increasing health problem, and patients undergoing HSCT are more prone to develop tuberculosis. The aim of our study was to evaluate prevalence of latent tuberculosis in HSCT recipients. In this study, 84 patients (2 months to 18 years) who were candidates for HSCT at the referral hospital of Tehran Children'...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13770

    authors: Mahmoudi S,Pourakbari B,Sadeghi RH,Hamidieh AA,Safari Sharari A,Salajegheh P,Aziz-Ahari A,Mamishi S

    更新日期:2020-09-01 00:00:00

  • Experience of 100 solid organ transplants over a five-yr period from the first successful pediatric multi-organ transplant program in India.

    abstract::To analyze the clinical profile and outcome of pediatric patients who had undergone a liver and/or RT at our center over a five yr period, case records of all the patients who had undergone a liver or RT were analyzed retrospectively. One hundred solid organ transplants were performed at our center between January 200...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12324

    authors: Sibal A,Malhotra S,Guru FR,Bhatia V,Kapoor A,Seth S,Jerath N,Jasuja S,Rajkumari V,Wadhawan M,Aggarwal DK,Guleria S,Shrivastava RN,Gupta S

    更新日期:2014-11-01 00:00:00

  • Squamous cell carcinoma development in Fanconi anemia patients who underwent hematopoietic stem cell transplantation.

    abstract::We examined SCC development of 24 FA patients, who received HSCT from HLA-matched relatives. In our BMT center, we applied low-dose CY + LFI + ATG (n:13) as conditioning regimen for FA patients between 1992 and 1999, and CY + BU + ATG (n:11) between 1999 and 2002. The aim of this study was to investigate SCC developme...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13706

    authors: Anak S,Yalman N,Bilgen H,Sepet E,Deviren A,Gürtekin B,Tunca F,Başaran B

    更新日期:2020-06-01 00:00:00

  • Behavioral economics-A framework for donor organ decision-making in pediatric heart transplantation.

    abstract::The high discard rate of pediatric donor hearts presents a major challenge for children awaiting heart transplantation. Recent literature identifies several factors that contribute to the disparities in pediatric donor heart usage, including regulatory oversight, the absence of guidelines on pediatric donor heart acce...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13655

    authors: Butler A,Chapman G,Johnson JN,Amodeo A,Böhmer J,Camino M,Davies RR,Dipchand AI,Godown J,Miera O,Pérez-Blanco A,Rosenthal DN,Zangwill S,Kirk R

    更新日期:2020-05-01 00:00:00

  • A national conference to determine research priorities in pediatric solid organ transplantation.

    abstract::The need for evidence-based practice guidelines requires high quality, carefully controlled clinical research trials. This multidisciplinary conference attempted to: identify urgent clinical and research issues, identify obstacles to performing clinical trials, develop concepts for organ-specific and all-organ researc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00811.x

    authors: Bartosh SM,Ryckman FC,Shaddy R,Michaels MG,Platt JL,Sweet SC

    更新日期:2008-03-01 00:00:00

  • Latin American Registry of Pediatric Renal Transplantation 2004-2008.

    abstract:UNLABELLED:The Latin American Pediatric Nephrology Association (ALANEPE) reports the first regional kidney transplant registry in Latin America. A mean range of 75%, 30% to 100% renal transplant recipients under 21 yr old were included. Out of 20 countries invited to participate, 14 performed renal transplant, 11 had u...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01331.x

    authors: Latin American Pediatric Nephrology Association.,Latin American Pediatric Renal Transplant Cooperative Study.

    更新日期:2010-09-01 00:00:00

  • Use of a virtual community as a psychosocial support system in pediatric transplantation.

    abstract::Despite significant interest by pediatric transplant patients in meeting others who have undergone transplantation, geographic distances combined with their daily routines make this difficult. This mixed-method study describes the use of Zora, a Web-based virtual community designed to create a support system for these...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01271.x

    authors: Bers MU,Beals LM,Chau C,Satoh K,Blume ED,DeMaso DR,Gonzalez-Heydrich J

    更新日期:2010-03-01 00:00:00

  • Prevalence and subtypes of BK virus in pediatric renal transplant recipients in Russia.

    abstract::BKV reactivation is associated with impaired graft function in kidney transplant patients. The objective of our study was to determine the prevalence of BKV infection in consecutive pediatric kidney transplant recipients at our center. Fifty-eight pediatric kidney transplant recipients were studied. The mean age at sc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01640.x

    authors: Momynaliev KT,Gorbatenko EV,Shevtsov AB,Gribanov OG,Babenko NN,Kaabak MM

    更新日期:2012-03-01 00:00:00

  • Tracking of blood pressure and its impact on graft function in pediatric renal transplant patients.

    abstract::We studied tracking of BP and its impact on GFR in 44 PRTP followed for 56 months. Three months PT 77% had elevated SBP percentile. First year SBP and DBP correlated positively with final values (p < 0.0001, 0.0002, respectively). Pretransplant and three month PT SBP correlated positively (p = 0.02). At one yr, SBP an...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00753.x

    authors: Silverstein DM,Leblanc P,Hempe JM,Ramcharan T,Boudreaux JP

    更新日期:2007-12-01 00:00:00

  • Lipoprotein profile changes in children after renal transplantation in the modern immunosuppression era.

    abstract::There are little data on prevalence of dyslipidemia in pediatric kidney TX recipients in the modern IS era. LP profiles of 38 TX recipients receiving triple IS with MMF, prednisone, and tacrolimus were compared with those of 11 children on HD using mixed model multiple linear regression analysis of repeated measures a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00905.x

    authors: Sgambat K,He J,McCarter RJ,Moudgil A

    更新日期:2008-11-01 00:00:00

  • The impact of length and weight on survival after heart transplantation in children less than 24 months of age.

    abstract::Adults, older children, and adolescent patients with a BMI categorized as overweight or obese have decreased survival after HTx. Anthropometric correlates of survival after HTx in infants have not been well defined. In a retrospective analysis of the UNOS registry, patients age 0-24 months were classified according to...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12822

    authors: McKee C,Tumin D,Hayes D Jr,Tobias JD

    更新日期:2016-12-01 00:00:00

  • Cognitive abilities, behaviour and quality of life in children after liver transplantation.

    abstract:AIMS:We investigated interrelations between cognitive abilities, behavioural problems, quality of life and disease-related variables of children after LTX. METHODS:Our sample consisted of 25 children. They were 8.5/2.8 (M/SD) years old and had received the transplant 5.5/3.1 years previously. For assessment we used we...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01257.x

    authors: Kaller T,Boeck A,Sander K,Richterich A,Burdelski M,Ganschow R,Schulz KH

    更新日期:2010-06-01 00:00:00

  • New-onset diabetes mellitus presenting with diabetic ketoacidosis after pediatric liver transplantation.

    abstract::The development of NODM is a common metabolic complication after liver transplantation. Presentation of post-liver transplant diabetes mellitus with DKA is rare especially among pediatric patients. We reported three pediatric patients who presented with DKA after liver transplantation. The underlying diseases leading ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01117.x

    authors: Dehghani SM,Nikeghbalian S,Eshraghian A,Haghighat M,Imanieh MH,Bahador A,Kazemi K,Malek-Hosseini SA

    更新日期:2009-08-01 00:00:00