Successful allogeneic stem cell transplant for leukocyte adhesion deficiency using an adjusted busulfan-containing regimen.

Abstract:

:LAD is a rare and fatal congenital disorder in which there is a defect of the leukocyte adhesion molecule (CD18) on neutrophils. Severe LAD results in frequent and potentially fatal infections. Although allogeneic HSCT is the only curative treatment for severe LAD, strategies for HSCT remain to be established since a high engraftment failure rate and severe persistent infection are still seen. We report a four-month-old boy with LAD who was successfully treated with allogeneic HSCT from an HLA-complete matched sibling following a conditioning regimen of pharmacokinetically adjusted individual busulfan doses.

journal_name

Pediatr Transplant

authors

Yoshimoto A,Hashii Y,Kashiwagi H,Koizumi M,Tokimasa S,Fujisaki H,Ohta H,Hanai N,Ozono K,Hara J

doi

10.1111/j.1399-3046.2007.00723.x

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

453-5

issue

4

eissn

1397-3142

issn

1399-3046

pii

PTR723

journal_volume

11

pub_type

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