Evaluation of arterial structure and function in pediatric patients with end-stage renal disease on dialysis and after renal transplantation.

Abstract:

:CVD is a major cause of morbidity and mortality in pediatric patients with CKD. It is unclear whether vascular abnormalities in these patients are reversible, and if transplantation portends salutary effects on arterial function. We compared FMD, PWV, AI75, and CIMT in 15 dialysis (D), 14 transplant patients (T), and 15 controls (C), and their associations with cardiovascular risk factors. There was stepwise lower FMD (p < 0.001), higher AI75 (p < 0.001), higher PWV (p = 0.01), and higher CIMT SDS for age (p = 0.03) and height (p = 0.006) in the D group than T and C groups. FMD, PWV, and CIMT were unrelated to dialysis duration or time from transplantation. On multivariate analysis, group status was independently associated with FMD (β = 3.15, p = 0.002), AI75 (β = -5.95, p = 0.01), PWV (β = -0.57, p = 0.07) and CIMT (β = -0.02, p = 0.04) and CIMT SDS for height (β = -0.541, p = 0.009). FMD is lower and AI75, PWV and CIMT are higher in pediatric patients maintained on D than T/C. T patients have similar AI75, PWV and CIMT to C although FMD remains reduced. These findings suggest that transplantation stabilizes or improves CKD associated arteriopathy.

journal_name

Pediatr Transplant

authors

Tawadrous H,Kamran H,Salciccioli L,Schoeneman MJ,Lazar J

doi

10.1111/j.1399-3046.2012.01721.x

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

480-5

issue

5

eissn

1397-3142

issn

1399-3046

journal_volume

16

pub_type

杂志文章
  • Impact of pulmonary hypertension on transplant outcomes in pediatric cardiomyopathy patients.

    abstract::Controversy exists over whether PHTN in heart transplant candidates increases post-transplant mortality. We performed analysis of data reported to UNOS for children who underwent primary heart transplantation for cardiomyopathy from January 1994 to June 2010. Patients were divided into two groups depending on their pr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01678.x

    authors: Buddhe S,Du W,L'Ecuyer T

    更新日期:2012-06-01 00:00:00

  • Comparative outcome analysis of pediatric kidney transplant in posterior urethral valves children with or without pretransplant Mitrofanoff procedure.

    abstract:BACKGROUND:Urinary diversion using catheterizable channel among posterior urethral valve (PUV) patients may help to alleviate the functional concerns of the bladder on the allograft. Herein, we review our series of PUV patients undergoing renal transplants at a single institution to determine outcomes between those wit...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13798

    authors: Rickard M,Chua ME,Zu'bi F,Dos Santos J,Koyle MA,Lorenzo AJ,Farhat WA

    更新日期:2020-12-01 00:00:00

  • Pulmonary function following allogeneic stem cell transplantation in childhood: a retrospective cohort study of 51 patients.

    abstract::HSCT is associated with a high risk of late morbidity. The aim of this study was to evaluate the frequency, time frame, risk factors, and possible etiology of pulmonary dysfunction following allogeneic HSCT in childhood. We evaluated the pulmonary function of 51 HSCT patients (>6 yr), by including FVC and FEV1 values ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12313

    authors: Madanat-Harjuoja LM,Valjento S,Vettenranta K,Kajosaari M,Dyba T,Taskinen M

    更新日期:2014-09-01 00:00:00

  • Prevalence of clinical rejection after surveillance biopsies in pediatric renal transplants: does early subclinical rejection predispose to subsequent rejection episodes?

    abstract::We analyzed rates of both SCR and CR in children receiving SB at three months post-transplant to determine if SCR predisposed patients to acute CR. Acute rejection was defined according to Banff criteria to include borderline classification or higher. All cases of SCR and CR were treated with anti-rejection protocols....

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01200.x

    authors: Hymes LC,Warshaw BL,Hennigar RA,Amaral SG,Greenbaum LA

    更新日期:2009-11-01 00:00:00

  • Latin American Registry of Pediatric Renal Transplantation 2004-2008.

    abstract:UNLABELLED:The Latin American Pediatric Nephrology Association (ALANEPE) reports the first regional kidney transplant registry in Latin America. A mean range of 75%, 30% to 100% renal transplant recipients under 21 yr old were included. Out of 20 countries invited to participate, 14 performed renal transplant, 11 had u...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01331.x

    authors: Latin American Pediatric Nephrology Association.,Latin American Pediatric Renal Transplant Cooperative Study.

    更新日期:2010-09-01 00:00:00

  • Tacrolimus-related seizure after pediatric liver transplantation--a single-center experience.

    abstract::To identify the risk factors for new-onset seizures after pediatric LT and to assess their clinical implications and long-term prognosis. The clinical and laboratory data of 27 consecutive children who underwent LT from January 2007 to December 2010 in our center were analyzed retrospectively. Patients were divided in...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12198

    authors: Xie M,Rao W,Sun LY,Zhu ZJ,Deng YL,Shen ZY,Jia JD

    更新日期:2014-02-01 00:00:00

  • Impaired graft survival in pediatric renal transplant recipients with donor-specific antibodies detected by solid-phase assays.

    abstract::SAB assays have increased the sensitivity and specificity to detect HLA alloantibodies, but there is uncertainty about the clinical relevance of SAB-positive alloantibodies when the FCXM is negative. We performed a retrospective study to evaluate the clinical significance of SAB-detected DSA in 82 pediatric recipients...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01281.x

    authors: Verghese PS,Smith JM,McDonald RA,Schwartz SM,Nelson KA,Warner PR

    更新日期:2010-09-01 00:00:00

  • Recurrence of non-alcoholic steatohepatitis after liver transplantation in a 13-yr-old boy.

    abstract::Nonalcoholic steatohepatitis (NASH) is the most severe form of non-alcoholic fatty liver disease (NAFLD). The aim of our study was to highlight NASH as a rare but possible problem in children. We present a case of 13-yr-boy with a well-established diagnosis of liver cirrhosis secondary to NASH, who underwent orthotopi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00767.x

    authors: Jankowska I,Socha P,Pawlowska J,Teisseyre M,Gliwicz D,Czubkowski P,Kalicinski P,Cielecka-Kuszyk J,Socha J

    更新日期:2007-11-01 00:00:00

  • Unrelated HSCT in an adolescent affected by congenital erythropoietic porphyria.

    abstract::CEP is a rare inborn error of porphyrin-heme synthesis. Clinical manifestations can range from mild to severe and include erythrodontia, reddish-colored urine, and hemolytic anemia that can be mild or severe and may result in splenomegaly. Completely avoiding exposure to the sun is crucial. Attempts to reduce erythrop...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00842.x

    authors: Faraci M,Morreale G,Boeri E,Lanino E,Dallorso S,Dini G,Scuderi F,Cohen A,Cappelli B

    更新日期:2008-02-01 00:00:00

  • Liver transplantation as a treatment option for three siblings with homozygous familial hypercholesterolemia.

    abstract::FH is a hereditary inherited disorder of cholesterol metabolism. Homozygous form of the disease associates severe form of atherosclerotic disease. Clinicians have been tried to inhibit the progression of the homozygous FH with medical and surgical treatment. We here present three siblings with homozygous FH who were s...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01469.x

    authors: Küçükkartallar T,Yankol Y,Kanmaz T,Topaloğlu S,Acarli K,Kalayoglu M

    更新日期:2011-05-01 00:00:00

  • Increased p53 protein expression as a potential predictor of early relapse after hematopoietic stem cell transplantation in children with acute myelogenous leukemia.

    abstract::Dysregulation of genes involved in the cell cycle such as TP53, P21, P16, and PTEN plays a key role in oncogenesis. We have earlier reported increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with more aggressive, rare chronic myeloid malignancies. The aim of this stud...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12585

    authors: Mattsson K,Honkaniemi E,Barbany G,Gustafsson B

    更新日期:2015-11-01 00:00:00

  • Tracking of blood pressure and its impact on graft function in pediatric renal transplant patients.

    abstract::We studied tracking of BP and its impact on GFR in 44 PRTP followed for 56 months. Three months PT 77% had elevated SBP percentile. First year SBP and DBP correlated positively with final values (p < 0.0001, 0.0002, respectively). Pretransplant and three month PT SBP correlated positively (p = 0.02). At one yr, SBP an...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00753.x

    authors: Silverstein DM,Leblanc P,Hempe JM,Ramcharan T,Boudreaux JP

    更新日期:2007-12-01 00:00:00

  • Pharmacodynamic monitoring of cyclosporine A by NFAT-regulated gene expression and the relationship with infectious complications in pediatric renal transplant recipients.

    abstract::Pharmacokinetic monitoring of CsA is unsatisfactory, because at comparable CsA blood concentrations, the frequency and severity of adverse effects vary considerably among patients. We have therefore recently developed a precise, reliable, and robust whole-blood pharmacodynamic assay that measures the suppression of Cs...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01354.x

    authors: Billing H,Giese T,Sommerer C,Zeier M,Feneberg R,Meuer S,Tönshoff B

    更新日期:2010-11-01 00:00:00

  • Hematopoietic stem cell transplantation-associated thrombotic microangiopathy accompanied by renal arteriolar C4d deposition.

    abstract::HSCT-associated thrombotic microangiopathy (TA-TMA) is a severe complication with a poor prognosis. Recently, it has been reported that complement system dysregulation, such as CFH autoantibodies and deletions CFH-related genes 3 and 1, induced TA-TMA. In addition, C4d-positive renal arterioles are both a good marker ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12450

    authors: Sakamoto K,Imamura T,Osone S,Nishimura A,Nishida M,Ishida H,Hosoi H

    更新日期:2015-06-01 00:00:00

  • Association of mast cells and liver allograft rejection.

    abstract::MCs are important effector cells in a broad range of immune responses. Their role in liver allograft rejection is not clear. Twenty-one liver transplant recipients (mean age +/- s.d.; 10.2 +/- 4.1 yr) who experienced a rejection episode are included in this study. Biopsy specimens from normal livers (allograft biopsy ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00819.x

    authors: Arikan C,Nart D,Kilic M,Yuksekkaya HA,Aydogdu S

    更新日期:2008-05-01 00:00:00

  • Calcineurin-inhibitor-induced pain syndrome after a second allogeneic bone marrow transplantation for a child with aplastic anemia.

    abstract::We report a 10-yr-old boy who developed CIPS after a second allogeneic BMT for severe aplastic anemia. He received the second BMT from the same HLA-matched sibling donor 16 months after the first BMT due to secondary graft failure. The preparative regimen for the second BMT consisted of fludarabine, cyclophosphamide, ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01009.x

    authors: Nishikawa T,Okamoto Y,Tanabe T,Shinkoda Y,Kodama Y,Tsuru Y,Kawano Y

    更新日期:2009-08-01 00:00:00

  • The efficacy of serum brain natriuretic peptide for the early detection of portopulmonary hypertension in biliary atresia patients before liver transplantation.

    abstract::Severe portopulmonary hypertension (POPH) is a contraindication for liver transplantation (LT) because of the high risk of postoperative heart failure. The early detection of POPH is important for patients with biliary atresia (BA). Brain natriuretic peptide (BNP) is known to be correlated with liver fibrosis in patie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13203

    authors: Yoshimaru K,Matsuura T,Takahashi Y,Yanagi Y,Nagata H,Ohga S,Taguchi T

    更新日期:2018-08-01 00:00:00

  • Vesico-ureteral reflux in pediatric kidney transplants: clinical relevance to graft and patient outcome.

    abstract::From June 1985 to December 1998, 173 pediatric renal transplants were carried out in 170 patients at our center. From this pool, 73 patients (34 males and 39 females) with a follow-up of 48 months were examined. In all patients, ureteroneocystostomy was performed according to the Lich-Grégoire procedure. All patients ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.1999.00017.x

    authors: Fontana I,Ginevri F,Arcuri V,Basile G,Nocera A,Beatini M,Bonato L,Barocci S,Bertocchi M,Manolitsi O,Valente R,Draghi P,Gusmano R,Valente U

    更新日期:1999-08-01 00:00:00

  • Genetic variation and hematopoietic stem cell transplantation: expansion of the paradigm.

    abstract::Genetic variation has been the mainstay of hematopoietic stem cell transplantation since the first transplants were attempted. A significant expansion of genetic knowledge is under way, as the draft sequence of the human genome is annotated. Hematopoietic stem cell transplantation is a field that will greatly benefit ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.7.s3.4.x

    authors: Savage SA,Chanock S

    更新日期:2003-01-01 00:00:00

  • Multiple rare-earth magnet bead ingestion in a pediatric liver-small bowel-pancreas transplant recipient: A case report and lessons learned.

    abstract::Ingestion of rare-earth magnet beads in children has been a public health concern. The potential risk of swallowing multiple magnets is related to magnet attraction to each other, resulting in serious gastrointestinal complications, such as entero-enteric fistula formation, peritonitis, bowel ischemia or necrosis, bow...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13915

    authors: Miri A,Nakayuenyongsuk W,Vargas L,Langnas A,Vo HD

    更新日期:2020-11-20 00:00:00

  • Donor-specific HLA antibodies in paediatric cardiac transplant recipients are associated with poor graft survival.

    abstract::There is increasing evidence that DSA are associated with poor graft survival, although there are little data in children. We aimed to describe the incidence of DSA in this group and to determine correlation with graft survival. HLA antibodies were analysed in 59 paediatric cardiac transplant recipients. Mean age 10.4...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01446.x

    authors: Irving C,Carter V,Parry G,Hasan A,Kirk R

    更新日期:2011-03-01 00:00:00

  • EBV-negative lymphoproliferative disease with hyper-IgA, in a child with combined liver and small bowel transplantation.

    abstract::A 4-year-old boy presented 14 months after liver and small bowel transplantation with fever, diarrhea, elevated liver enzymes, thrombocytopenia and autoantibodies. Total gammaglobulins level was normal but the level of plasma IgA1 was very high. The blood PCR for Epstein-Barr virus (EBV) was negative. The ileal biopsy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00174.x

    authors: Robert CD,Lacaille F,Canioni D,Quartier-dit-Maire P,Talbotec C,Goulet O

    更新日期:2004-06-01 00:00:00

  • Percutaneous endovascular management of ascending aortic pseudoaneurysm after heart transplantation in a pediatric patient.

    abstract::Ascending aortic pseudoaneurysm is a rare complication after HT. Surgery is the most conventional management, but in some patients, it is risky. We report the case of a ten-year-old child who underwent HT and developed an ascending aortic pseudoaneurysm in the aortic anastomosis. He was successfully treated with two c...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13958

    authors: Skrabonja-Crespo A,Chavarri-Velarde F,Pinto-Salinas M,Tauma-Arrué A

    更新日期:2020-12-17 00:00:00

  • Successful liver retransplantation for recurrent hepatopulmonary syndrome.

    abstract::HPS is defined as arterial hypoxemia because of pulmonary vasodilation as a result of cirrhotic or non-cirrhotic portal hypertension. This report describes a teenager with HPS because of primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome requiring OLT. HPS resolved completely within three months of O...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00790.x

    authors: Rajwal SR,Davison SM,Prasad R,Brownlee K,McClean P

    更新日期:2007-12-01 00:00:00

  • Lifesaving liver transplantation for multi-organ failure caused by Bacillus cereus food poisoning.

    abstract::Bacillus cereus is a spore-forming, gram-positive bacterium that causes food poisoning presenting with either emesis or diarrhea. Diarrhea is caused by proteinaceous enterotoxin complexes, mainly hemolysin BL, non-hemolytic enterotoxin (NHE), and cytotoxin K. In contrast, emesis is caused by the ingestion of the depsi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12378

    authors: Tschiedel E,Rath PM,Steinmann J,Becker H,Dietrich R,Paul A,Felderhoff-Müser U,Dohna-Schwake C

    更新日期:2015-02-01 00:00:00

  • Pediatric cardiac waitlist mortality-Still too high.

    abstract::Cardiac transplantation for children with end-stage cardiac disease with no other medical or surgical options is now standard. The number of children in need of cardiac transplant continues to exceed the number of donors considered "acceptable." Therefore, there is an urgent need to understand which recipients are in ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13671

    authors: Denfield SW,Azeka E,Das B,Garcia-Guereta L,Irving C,Kemna M,Reinhardt Z,Thul J,Dipchand AI,Kirk R,Davies RR,Miera O

    更新日期:2020-05-01 00:00:00

  • Improved outcomes in pediatric liver transplantation for acute liver failure.

    abstract:UNLABELLED:OLT is a life-saving option for ALF. AIM:To evaluate our outcomes in pediatric OLT for ALF. METHODS:Retrospective review of our data between 1992 and 2007. RESULTS:Of 142 children with ALF, 126 were listed, of which 40 spontaneously improved, nine died, and 77 underwent OLT (median waiting time four days)...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01356.x

    authors: Miloh T,Kerkar N,Parkar S,Emre S,Annunziato R,Mendez C,Arnon R,Suchy F,Rodriguez-Laiz G,Del Rio Martin J,Sturdevant M,Iyer K

    更新日期:2010-11-01 00:00:00

  • Glomerular and tubular function following orthotopic liver transplantation in children treated with tacrolimus.

    abstract::The aim of this study was to analyze the impact of TAC on medium term (three-yr follow-up) renal function in pediatric liver transplant (OLT) recipients. Glomerular and tubular indices were retrospectively analyzed in 24 consecutive OLT pediatric recipients on TAC. CrCl increased significantly each month post-OLT (p =...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01625.x

    authors: Anastaze Stelle K,Belli DC,Parvex P,Girardin E,Giroud A,Wildhaber B,McLin VA

    更新日期:2012-05-01 00:00:00

  • Mobilization of peripheral blood progenitor cells using 16 versus 10 mg/kg/d G-CSF in children with malignancies.

    abstract::Administration of hematopoietic growth factors, with or without chemotherapy, can augment progenitor cell numbers available for collection. The dose of granulocyte colony stimulating factor (G-CSF) used for mobilization of peripheral blood progenitor cells (PBPC) is controversial, and doses between 5 and 32 microg/kg/...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kurekci AE,Kiss JE,Koehler M

    更新日期:1998-05-01 00:00:00

  • Successful resolution of inflammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis.

    abstract::This retrospective case series reviews our center's experience with sirolimus and a CNI as alternative therapy for the treatment of PTAH. It also characterizes regulatory T cells (Tregs) in PTAH. LT recipients with PTAH who had received or were receiving treatment with sirolimus were retrospectively identified (n = 12...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01648.x

    authors: Ekong UD,Mathew J,Melin-Aldana H,Wang D,Alonso EM

    更新日期:2012-03-01 00:00:00