Association of mast cells and liver allograft rejection.

Abstract:

:MCs are important effector cells in a broad range of immune responses. Their role in liver allograft rejection is not clear. Twenty-one liver transplant recipients (mean age +/- s.d.; 10.2 +/- 4.1 yr) who experienced a rejection episode are included in this study. Biopsy specimens from normal livers (allograft biopsy with normal histopathology n = 5 and naive livers n = 6), transplanted livers with CR (n = 5), and transplanted livers with ACR (n = 26) were studied. The total number of PT in each biopsy specimen was documented, and the number of PT that contained MCs was expressed as a percentage of the total number of PT. MCs, percentage of PT containing MCs and the average number of MCs/PT was significantly higher in rejection specimens than in control biopsy samples. All parameters were significantly higher in CR group than AR groups. Increasing grades of rejection was also associated with progressively more MCs and MC/PT (r = 0.68 p = 0.000; r = 0.58 p = 0.002). Only serum bilirubin level was related to the MCs in AR group. Only MC/PT was detected as an independent predictor of graft survival (p = 0.011, RR 2.87 95% CI 1.3-6.5). Despite the fact that the role of MCs in liver allograft rejection is still unknown; they exist in inflammatory infiltrates during pediatric liver allograft rejection. MC-rich portal infiltrates may distinguish chronic liver rejection from other inflammatory states such as AR, hepatitis and biliary obstruction.

journal_name

Pediatr Transplant

authors

Arikan C,Nart D,Kilic M,Yuksekkaya HA,Aydogdu S

doi

10.1111/j.1399-3046.2007.00819.x

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

347-52

issue

3

eissn

1397-3142

issn

1399-3046

pii

PTR819

journal_volume

12

pub_type

杂志文章
  • Liver transplantation in a child with multifocal hepatocellular carcinoma hepatitis C and management of post-transplant viral recurrence using boceprevir.

    abstract::HCV infection is the leading cause of liver transplantation in the adult population in the United States. HCV infection occurs in 0.2-0.4% of the pediatric population and progression to HCC is uncommon. Liver transplantation for HCV in children is rare. In this report, we present a case of pediatric patient with HCV a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12223

    authors: Malik S,Dekio F,Wen JW

    更新日期:2014-03-01 00:00:00

  • Airway plaque presenting after alteration of immunosuppression in a pediatric patient remote from heart transplantation.

    abstract::Success after solid organ transplantation is dependent on the proper balance of immunosuppression to prevent rejection of the allograft while limiting the risk of developing infections and malignancy. We present a 9-year-old girl, remote from transplant, who presented with airway plaque after a change in immunosuppres...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13046

    authors: Ryan TD,Absalon MJ,de Alarcon A,Gupta A,Peters AL,Lorts A,Danziger-Isakov LA,Chin C

    更新日期:2017-11-01 00:00:00

  • Endoscopic treatment in biliary strictures after pediatric liver transplantation.

    abstract:BACKGROUND AND AIM:The aim of the study was to assess efficacy and safety of endoscopic treatment in BS after pediatric LTx. METHODS:We retrospectively reviewed data of patients with DDA who developed BS and underwent ERCP. RESULTS:Of 189 transplanted patients with DDA, strictures developed in 30 (16%). In this subgr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13271

    authors: Czubkowski P,Pertkiewicz J,Markiewicz-Kijewska M,Kaliciński P,Rurarz M,Jankowska I,Pawłowska J

    更新日期:2018-11-01 00:00:00

  • The effects of gender on health-related quality of life in pediatric live-donor kidney transplantation: a single-center experience in a developing country.

    abstract::To evaluate the effects of gender on HRQOL and overall health status in our pediatric kidney transplants. We performed a cross-sectional study in 77 children who received living renal allo-transplants in our center between 1981 and 2003. The patients were given a questionnaire at a post-transplant visit. After complet...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01174.x

    authors: El-Husseini A,Hassan R,Sobh M,Ghoneim M

    更新日期:2010-03-01 00:00:00

  • Use of a virtual community as a psychosocial support system in pediatric transplantation.

    abstract::Despite significant interest by pediatric transplant patients in meeting others who have undergone transplantation, geographic distances combined with their daily routines make this difficult. This mixed-method study describes the use of Zora, a Web-based virtual community designed to create a support system for these...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01271.x

    authors: Bers MU,Beals LM,Chau C,Satoh K,Blume ED,DeMaso DR,Gonzalez-Heydrich J

    更新日期:2010-03-01 00:00:00

  • Reversal of tacrolimus-related hypertrophic cardiomyopathy after conversion to rapamycin in a pediatric liver transplant recipient.

    abstract::Tacrolimus (Tac)-related hypertrophic cardiomyopathy (HCM) has been reported to be an unusual but serious complication affecting pediatric patients after solid organ transplantation. Herein, we present a case of young liver transplant recipient with Tac-induced HCM, treated by discontinuation of Tac followed by conver...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00633.x

    authors: Turska-Kmieć A,Jankowska I,Pawłowska J,Kaliciński P,Kawalec W,Tomyn M,Markiewicz M,Teisseyre J,Czubkowski P,Rekawek J,Socha J

    更新日期:2007-05-01 00:00:00

  • Predictive value of pretransplantation cyclosporine pharmacokinetic studies on initial post-transplantation dosing in pediatric kidney allograft recipients.

    abstract::Despite the introduction of a variety of new immunosuppressive agents, cyclosporine A (CsA) has maintained a strong position in pediatric transplantation (Tx). Post-Tx dosing with CsA is a challenging task because of the narrow therapeutic window of the drug, the great individual variability of metabolism and the lack...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00025.x

    authors: Seikku P,Hoppu K,Jalanko H,Holmberg C

    更新日期:2003-04-01 00:00:00

  • Preliminary quantitative investigation of predictors of treatment non-adherence in pediatric transplantation: a brief report.

    abstract::The examination of predictors of non-adherence in transplantation populations offers the potential to identify high-risk individuals and concomitantly generate effective adherence-promoting interventions. The present paper aggregated quantitative estimates of various correlates of treatment adherence in studies of ped...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1399-3046.2007.00864.x

    authors: Kahana SY,Frazier TW,Drotar D

    更新日期:2008-09-01 00:00:00

  • Pulmonary function following allogeneic stem cell transplantation in childhood: a retrospective cohort study of 51 patients.

    abstract::HSCT is associated with a high risk of late morbidity. The aim of this study was to evaluate the frequency, time frame, risk factors, and possible etiology of pulmonary dysfunction following allogeneic HSCT in childhood. We evaluated the pulmonary function of 51 HSCT patients (>6 yr), by including FVC and FEV1 values ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12313

    authors: Madanat-Harjuoja LM,Valjento S,Vettenranta K,Kajosaari M,Dyba T,Taskinen M

    更新日期:2014-09-01 00:00:00

  • Waiting for transplant: physical, psychosocial, and nutritional status considerations for pediatric candidates and implications for care.

    abstract::The waiting period for an organ transplant has been described as a time of tremendous uncertainty and vulnerability, posing unique challenges and stressors for pediatric transplant candidates and their families. It has been identified as the most stressful stage of the transplant journey, yet little attention has been...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12305

    authors: Anthony SJ,Annunziato RA,Fairey E,Kelly VL,So S,Wray J

    更新日期:2014-08-01 00:00:00

  • Mycophenolate mofetil and reduced doses of cyclosporine in pediatric liver transplantation with chronic renal dysfunction: changes in the immune responses.

    abstract::The aim of this study was to study the incidence of chronic renal dysfunction in patients with more than 5 yr of follow-up following liver transplantation and to evaluate the benefit of decreasing cyclosporine A (CsA) dose combined with mycophenolate mofetil (MMF) on renal function and immune response in these patient...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00172.x

    authors: Ferraris JR,Duca P,Prigoshin N,Tambutti ML,Boldrini G,Cardoni RL,D'Agostino D

    更新日期:2004-10-01 00:00:00

  • Outcome of hematopoietic stem cell transplant in children with congenital heart disease.

    abstract::CHD is the most commonly occurring birth defect in the United States. Improvements in supportive care for CHD result in increasing numbers of survivors who may develop benign or malignant conditions for which HSCT is indicated. However, the ability of individuals with CHD to tolerate HSCT is unknown. Retrospective med...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01317.x

    authors: Guinan EC,Hewett EK,Domaney NM,Margossian R

    更新日期:2011-02-01 00:00:00

  • Experience of 100 solid organ transplants over a five-yr period from the first successful pediatric multi-organ transplant program in India.

    abstract::To analyze the clinical profile and outcome of pediatric patients who had undergone a liver and/or RT at our center over a five yr period, case records of all the patients who had undergone a liver or RT were analyzed retrospectively. One hundred solid organ transplants were performed at our center between January 200...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12324

    authors: Sibal A,Malhotra S,Guru FR,Bhatia V,Kapoor A,Seth S,Jerath N,Jasuja S,Rajkumari V,Wadhawan M,Aggarwal DK,Guleria S,Shrivastava RN,Gupta S

    更新日期:2014-11-01 00:00:00

  • Multiple rare-earth magnet bead ingestion in a pediatric liver-small bowel-pancreas transplant recipient: A case report and lessons learned.

    abstract::Ingestion of rare-earth magnet beads in children has been a public health concern. The potential risk of swallowing multiple magnets is related to magnet attraction to each other, resulting in serious gastrointestinal complications, such as entero-enteric fistula formation, peritonitis, bowel ischemia or necrosis, bow...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13915

    authors: Miri A,Nakayuenyongsuk W,Vargas L,Langnas A,Vo HD

    更新日期:2020-11-20 00:00:00

  • Hepatitis C viral recurrence in a pediatric patient following liver transplantation.

    abstract::Hepatitis C virus (HCV) infections are known to have a more benign course in children than in adults. Although the natural history of HCV recurrence after liver transplantation has been well studied in adult patients, much less is known about HCV recurrence after liver transplantation in pediatric patients. Herein, we...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00519.x

    authors: Udell IW,Barshes NR,Finegold MJ,Lee TC,Scott JD,Carter B,Karpen S,Goss JA

    更新日期:2006-08-01 00:00:00

  • Pediatric cardiac transplant: results using a steroid-free maintenance regimen.

    abstract::We report on survival, rejection, lymphoma and renal function following cardiac transplant using a steroid-free maintenance immunosuppressive regimen. We have performed 73 cardiac transplants in 71 children under 16 yr of age in the last 12 yr. There were eight perioperative and four late deaths giving actuarial survi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2003.00014.x

    authors: Leonard H,Hornung T,Parry G,Dark JH

    更新日期:2003-02-01 00:00:00

  • Behavioral economics-A framework for donor organ decision-making in pediatric heart transplantation.

    abstract::The high discard rate of pediatric donor hearts presents a major challenge for children awaiting heart transplantation. Recent literature identifies several factors that contribute to the disparities in pediatric donor heart usage, including regulatory oversight, the absence of guidelines on pediatric donor heart acce...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13655

    authors: Butler A,Chapman G,Johnson JN,Amodeo A,Böhmer J,Camino M,Davies RR,Dipchand AI,Godown J,Miera O,Pérez-Blanco A,Rosenthal DN,Zangwill S,Kirk R

    更新日期:2020-05-01 00:00:00

  • Use of genetic risks in pediatric organ transplantation listing decisions: A national survey.

    abstract::There is a limited supply of organs for all those who need them for survival. Thus, careful decisions must be made about who is listed for transplant. Studies show that manifesting genetic disease can impact listing eligibility. What has not yet been studied is the impact genetic risks for future disease have on a pat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/petr.13402

    authors: Graf M,Char D,Hanson-Kahn A,Magnus D

    更新日期:2019-06-01 00:00:00

  • Value of soluble adhesion molecules and plasma coagulation markers in assessing transplant coronary artery disease in pediatric heart transplant recipients.

    abstract:BACKGROUND:With an increasing number of heart transplantations (HTx) performed in children and an extended long-term survival of these patients, the importance of transplant coronary artery disease (TCAD) rises in this group of transplant recipients. Reliable serum markers for diagnosis or non-invasive monitoring of th...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00488.x

    authors: Hilgendorff A,Kraemer U,Afsharian M,Bauer J,Tillmanns H,Kemkes-Matthes B,Kreuder J,Hoelschermann H

    更新日期:2006-06-01 00:00:00

  • The impact of length and weight on survival after heart transplantation in children less than 24 months of age.

    abstract::Adults, older children, and adolescent patients with a BMI categorized as overweight or obese have decreased survival after HTx. Anthropometric correlates of survival after HTx in infants have not been well defined. In a retrospective analysis of the UNOS registry, patients age 0-24 months were classified according to...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12822

    authors: McKee C,Tumin D,Hayes D Jr,Tobias JD

    更新日期:2016-12-01 00:00:00

  • Significant morbidity associated with RSV infection in immunosuppressed children following liver transplantation: case report and discussion regarding need of routine prophylaxis.

    abstract::Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in infants and young children. In immunocompromised children, RSV infection poses a serious health threat with significantly increased and prolonged virus shedding and the development of severe respiratory disease. We report t...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00583.x

    authors: Blanchard SS,Gerrek M,Siegel C,Czinn SJ

    更新日期:2006-11-01 00:00:00

  • Parents in transition: Experiences of parents of young people with a liver transplant transferring to adult services.

    abstract::Predictors of successful transition from pediatric to adult services include ability to self-manage and engage with healthcare services. Parents have a key role in healthcare management throughout childhood and adolescence including encouraging development of self-management skills in their children. Transition to adu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12760

    authors: Wright J,Elwell L,McDonagh JE,Kelly DA,Wray J

    更新日期:2017-02-01 00:00:00

  • The challenge of long-term follow-up of survivors of childhood acute leukemia after hematopoietic stem cell transplantation in resource-limited countries: A single-center report from Brazil.

    abstract::With the number of long-term HSCT survivors steadily increasing, attention needs to be focused on the late complications and quality of life. We therefore analyzed the outcome of 101 pediatric patients (<18 years old at the time of HSCT) transplanted for acute leukemia between 1981 and 2015 at Complexo Hospital de Clí...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13691

    authors: Marinho DH,Ribeiro LL,Nichele S,Loth G,Koliski A,Mousquer RTG,Funke VAM,Page K,Fasth A,Pasquini R,Boguszewski MCDS,Bonfim C

    更新日期:2020-06-01 00:00:00

  • Option of pre-emptive nephrectomy and renal transplantation for Bartter's syndrome.

    abstract::Bartter's syndrome (BS) is an incurable genetic disease, with variable response to supportive therapy relating to fluid and electrolyte management. Poor control or therapy non-compliance may result in frequent life threatening episodes of dehydration, acidosis and hypokalemia, with resultant adverse effects on patient...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00435.x

    authors: Chaudhuri A,Salvatierra O Jr,Alexander SR,Sarwal MM

    更新日期:2006-03-01 00:00:00

  • Portal vein phlebolithiasis found post-liver transplantation in the native liver of a child with biliary atresia.

    abstract::Biliary atresia is defined as partial or total obliteration of the extra-hepatic bile ducts. In advanced cases, liver transplantation (LTx) is considered the most appropriate treatment. This report describes a female patient whose biliary atresia and subsequent cirrhosis required LTx at 1 yr of age. Macroscopic inspec...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2001.t01-1-00020.x

    authors: Bilezikçi B,Demirhan B,Kiyici H,Haberal M

    更新日期:2001-02-01 00:00:00

  • Double-unit unrelated cord blood transplantation for thalassemia major: Comparison with HLA-identical sibling bone marrow transplantation.

    abstract::UCBT recipients with TM are at high risk of EF related to low number of stem cells and prior alloimmunization after multiple blood transfusions. Here, we evaluated the safety and efficacy of double-unit UCBT using TT-containing conditioning regimens in TM. Retrospective analysis of children who underwent double-unit U...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13901

    authors: Feng J,Lee V,Leung AWK,Lam GKS,Chow TTW,Cheng FWT,Yan CLS,Lee CK,Yuen PMP,Li CK

    更新日期:2020-11-02 00:00:00

  • National risk factors and estimated costs for redo ureteroneocystostomy after pediatric renal transplant.

    abstract::Approximately 800 pediatric renal transplants are performed annually in the United States. VUR or obstruction may cause graft failure requiring redo ureteroneocystostomy. We examined possible risk factors and cost using the PHIS national database. We examined the PHIS for 8.5 yr to determine the association between re...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12522

    authors: Godebu E,Palazzi K,Bush R,Marietti S,Chiang G

    更新日期:2015-08-01 00:00:00

  • Donor-specific HLA antibodies in paediatric cardiac transplant recipients are associated with poor graft survival.

    abstract::There is increasing evidence that DSA are associated with poor graft survival, although there are little data in children. We aimed to describe the incidence of DSA in this group and to determine correlation with graft survival. HLA antibodies were analysed in 59 paediatric cardiac transplant recipients. Mean age 10.4...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01446.x

    authors: Irving C,Carter V,Parry G,Hasan A,Kirk R

    更新日期:2011-03-01 00:00:00

  • Should we retransplant a patient who is non-adherent? A literature review and critical reflection.

    abstract::The majority of transplant centers around the world face an ethical debate whether to retransplant a young non-adherent patient. Non-adherence to lifelong immunosuppressants presents a significant risk for graft loss, yet rates remain consistently high. Despite a number of these patients presenting for retransplantati...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2011.01633.x

    authors: Dobbels F,Hames A,Aujoulat I,Heaton N,Samyn M

    更新日期:2012-02-01 00:00:00

  • The reduced left lateral segment in pediatric liver transplantation: an alternative to the monosegment graft.

    abstract::Tailoring graft size to small paediatric recipients is a challenge. We have developed a reduced left lateral segment as an alternative to monosegment transplantation for small size recipients. Since November 2000, 89 children have been transplanted with 100 deceased donor liver grafts in our unit. Our median patient a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00882.x

    authors: Attia MS,Stringer MD,McClean P,Prasad KR

    更新日期:2008-09-01 00:00:00