The challenge of long-term follow-up of survivors of childhood acute leukemia after hematopoietic stem cell transplantation in resource-limited countries: A single-center report from Brazil.

Abstract:

:With the number of long-term HSCT survivors steadily increasing, attention needs to be focused on the late complications and quality of life. We therefore analyzed the outcome of 101 pediatric patients (<18 years old at the time of HSCT) transplanted for acute leukemia between 1981 and 2015 at Complexo Hospital de Clínicas, Federal University of Paraná, Brazil, and who survived at least two years after HSCT. The median follow-up was 5.9 years (2.0-29.0); median age at follow-up was 17.5 years (2.98-39.0). The 5-year cumulative incidence of relapse was 27.5% (95% CI 18.6%-36.4%). Two-year cumulative incidence of chronic GVHD was 21.8% (95% CI 13.7%-29.8%). Of the 101 patients, 72 patients (71.3%) presented with late effects. Those surviving longer after HSCT experienced more complications. Patients who received TBI-based regimen developed more late effects (P = .013) and more endocrinological complications (P = .024). Endocrinological complications were the most common late sequelae found in this study. For childhood survivors, quality of life was not influenced by age (at HSCT or at last visit), time from HSCT, gender, donor, or GVHD. For survivors that no longer were children, only age at last visit impacted financial domain measures, irrespective of gender, donor, or GVHD. The current study confirms the high burden late complications after pediatric HSCT have on the survivors and underlines the importance of extended follow-up.

journal_name

Pediatr Transplant

authors

Marinho DH,Ribeiro LL,Nichele S,Loth G,Koliski A,Mousquer RTG,Funke VAM,Page K,Fasth A,Pasquini R,Boguszewski MCDS,Bonfim C

doi

10.1111/petr.13691

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

e13691

issue

4

eissn

1397-3142

issn

1399-3046

journal_volume

24

pub_type

杂志文章
  • Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience.

    abstract::Delayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, some of the previous studies have shown that ELT seems to enhance platelet recovery for post-allogen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13962

    authors: Yaman Y,Elli M,Şahin Ş,Özdilli K,Bilgen H,Bayram N,Nepesov S,Anak S

    更新日期:2021-01-16 00:00:00

  • Heart transplantation in children: indications. Report of the Ad Hoc Subcommittee of the Pediatric Committee of the American Society of Transplantation (AST).

    abstract::This review details the indications for heart transplantation in children. Contraindications have evolved from absolute to relative. Controversial issues remain and this paper represents a consensus of more than a dozen centers that have programs that remain active performing pediatric heart transplants. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.1999.00045.x

    authors: Fricker FJ,Addonizio L,Bernstein D,Boucek M,Boucek R,Canter C,Chinnock R,Chin C,Kichuk M,Lamour J,Pietra B,Morrow R,Rotundo K,Shaddy R,Schuette EP,Schowengerdt KO,Sondheimer H,Webber S

    更新日期:1999-11-01 00:00:00

  • Intravenous and oral sequential itraconazole antifungal prophylaxis in paediatric stem cell transplantation recipients: a pilot study for evaluation of safety and efficacy.

    abstract::This single-centre, retrospective, observational pilot study was performed to evaluate the safety and efficacy of intravenous and oral itraconazole prophylaxis in paediatric haematopoietic stem cell transplantation (HCT). Study end-points were proven invasive fungal infection (IFI), survival, adverse reactions and gra...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00643.x

    authors: Grigull L,Kuehlke O,Beilken A,Sander A,Linderkamp C,Schmid H,Seidemann K,Sykora KW,Schuster FR,Welte K

    更新日期:2007-05-01 00:00:00

  • Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient.

    abstract::EBV is associated with various malignancies in patients with acquired or induced immune impairment. EBV-SMT is very uncommon in immunocompromised patients, and a kidney localization has been described only anecdotally. We report the case of a 17-yr-old kidney transplant recipient diagnosed as having an EBV-SMT inside ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01213.x

    authors: Belingheri M,Comoli P,Locatelli F,Baldanti F,Martina V,Giani M,Ferraresso M,Cro L,Edefonti A,Ghio L

    更新日期:2010-12-01 00:00:00

  • Approaches to acute liver failure in children.

    abstract::Acute liver failure (ALF) is a rare but often fatal disorder in childhood. Its aetiology includes infections, toxins, metabolic disorders, infiltrative diseases, autoimmune hepatitis, ischaemia, irradiation damage, but in a high proportion of cases it remains unknown. In contrast to adults, in children with ALF hepati...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00292.x

    authors: Dhawan A,Cheeseman P,Mieli-Vergani G

    更新日期:2004-12-01 00:00:00

  • Factors predicting health-related quality of life in pediatric liver transplant recipients in the functional outcomes group.

    abstract::Data from 997 pediatric LT recipients were used to model demographic and medical variables as predictors of lower levels of HRQOL. Data were collected through SPLIT FOG project. Patients were between 2 and 18 yr of age and survived LT by at least 12 months. Parents and children (age ≥ 8 yr) completed PedsQL™ 4.0 Gener...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12126

    authors: Alonso EM,Martz K,Wang D,Yi MS,Neighbors K,Varni JW,Bucuvalas JC,Studies of Pediatric Liver Transplantation (SPLIT) Functional Outcomes Group (FOG).

    更新日期:2013-11-01 00:00:00

  • Transfusion requirements during cadaveric and living donor pediatric liver transplantation.

    abstract::Surgical techniques that have been used during liver transplantation (LT) together with patient's coagulation profile and institutional practices are reported to have an effect on transfusion requirements. The aim of this study is to evaluate the transfusion requirement in both cadaveric (CDLT, n = 22) and living dono...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00284.x

    authors: Ulukaya S,Acar L,Ayanoglu HO

    更新日期:2005-06-01 00:00:00

  • Pneumatosis intestinalis and diarrhea in a child following renal transplantation.

    abstract::Pneumatosis intestinalis is an uncommon finding beyond the neonatal period, but it has been reported in immunocompromized pediatric patients. The association of pneumatosis intestinalis in children following renal transplantation has to the best of our knowledge been only reported once in children. We describe a 4-yea...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.2003.00061.x

    authors: Chelimsky G,Blanchard S,Sivit C,Davis I,Czinn S

    更新日期:2003-06-01 00:00:00

  • Imaging in pediatric renal transplantation.

    abstract::Renal transplantation is the therapy of choice in children with ESKD. Radiological investigations are required in both pre- and post-transplant assessment, although there is paucity of both consensus-based statements and evidence-based imaging guidelines in pediatric renal transplantation. The phases of pediatric ESKD...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.12885

    authors: Damasio MB,Ording Muller LS,Piaggio G,Marks SD,Riccabona M

    更新日期:2017-05-01 00:00:00

  • Successful treatment of influenza A virus by oseltamivir in bone marrow transplant recipients.

    abstract::INFVA is an important cause of pulmonary infections in patients receiving BMT, and is associated with considerable morbidity and mortality for a readily preventable and treatable infection. Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT. The aim of thi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01114.x

    authors: Mellouli F,Ouederni M,Dhouib N,Hajkacem MA,Slim A,Bejaoui M

    更新日期:2010-03-01 00:00:00

  • Lower socioeconomic status is associated with worse outcomes after both listing and transplanting children with heart failure.

    abstract::The relationship between SES and outcomes surrounding pediatric cardiac transplantation is complex and influenced by recipient race. Broad-based studies of SES have not been performed. A retrospective review of all 5125 primary pediatric heart transplants performed in the United States between 2000 and 2011. Patients ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12117

    authors: Davies RR,Russo MJ,Reinhartz O,Maeda K,Rosenthal DN,Chin C,Bernstein D,Mallidi HR

    更新日期:2013-09-01 00:00:00

  • Liver transplantation for neonatal hemochromatosis: analysis of the UNOS database.

    abstract::NH is the most common identifiable cause of ALF in the neonate. LT is the definitive treatment for neonates with NH who have failed medical therapy. Our aim was to determine the outcomes of LT in infants with NH. Patients (less than one yr of age) with NH who were listed for LT and patients who underwent LT between 19...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12418

    authors: Sheflin-Findling S,Annunziato RA,Chu J,Arvelakis A,Mahon D,Arnon R

    更新日期:2015-03-01 00:00:00

  • Outcomes of pediatric liver transplant are unaffected by the time or day of surgery.

    abstract:BACKGROUND:In adults, the time of day for LT does not affect post-transplant outcomes. Whether this is true or not in children is unknown. In this study, we aimed to evaluate if weekend and weeknight liver transplants are associated with worse patient and graft survival in children. METHODS:We interrogated the UNOS da...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13826

    authors: Rogers ME,Egberg MD,Sylvester F,Lichtman S,Lin FC

    更新日期:2020-12-01 00:00:00

  • The effects of gender on health-related quality of life in pediatric live-donor kidney transplantation: a single-center experience in a developing country.

    abstract::To evaluate the effects of gender on HRQOL and overall health status in our pediatric kidney transplants. We performed a cross-sectional study in 77 children who received living renal allo-transplants in our center between 1981 and 2003. The patients were given a questionnaire at a post-transplant visit. After complet...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01174.x

    authors: El-Husseini A,Hassan R,Sobh M,Ghoneim M

    更新日期:2010-03-01 00:00:00

  • Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry "MYKKE".

    abstract::Myocarditis represents an important cause for acute heart failure. MYKKE, a prospective multicenter registry of pediatric patients with myocarditis, aims to gain knowledge on courses, diagnostics, and therapy of pediatric myocarditis. The role of mechanical circulatory support (MCS) in children with severe heart failu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,多中心研究

    doi:10.1111/petr.13548

    authors: Schubert S,Opgen-Rhein B,Boehne M,Weigelt A,Wagner R,Müller G,Rentzsch A,Zu Knyphausen E,Fischer M,Papakostas K,Wiegand G,Ruf B,Hannes T,Reineker K,Kiski D,Khalil M,Steinmetz M,Fischer G,Pickardt T,Klingel K,Messr

    更新日期:2019-11-01 00:00:00

  • Extracorporeal membrane oxygenation use in the first 24 hours following pediatric heart transplantation: Incidence, risk factors, and outcomes.

    abstract::Primary graft dysfunction following HTx is associated with significant morbidity and mortality. This study aimed to assess the incidence of, risk factors for, and outcomes of children requiring ECMO within 24 hours of HTx. This study utilized a linked PHIS/SRTR database of pediatric HTx recipients (2002-2016). Post-HT...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13414

    authors: Godown J,Bearl DW,Thurm C,Hall M,Feingold B,Soslow JH,Mettler BA,Smith AH,Profita EL,Singh TP,Dodd DA

    更新日期:2019-06-01 00:00:00

  • Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury.

    abstract::Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two gen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12712

    authors: Csohány R,Prókai Á,Sziksz E,Balicza-Himer L,Pap D,Kosik A,Sugár D,Vannay Á,Kis-Petik K,Fekete A,Szabó AJ

    更新日期:2016-08-01 00:00:00

  • Complications in pediatric intestine transplantation in the absence of peri-operative donor or recipient bowel decontamination.

    abstract::This study reports the clinical complication and infection rates of an active pediatric IT program that has never utilized bowel decontamination in either the donor or the recipient. All patients undergoing IT from 2003 to 2015 at a single pediatric IT center were reviewed. Post-transplant surgical, infectious, and im...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13164

    authors: Clouse JW,Kubal CA,Fridell JA,Mangus RS

    更新日期:2018-05-01 00:00:00

  • Fludrocortisone-a treatment for tubulopathy post-paediatric renal transplantation: A national paediatric nephrology unit experience.

    abstract::Calcineurin inhibitors post-renal transplantation are recognized to cause tubulopathies in the form of hyponatremia, hyperkalemia, and acidosis. Sodium supplementation may be required, increasing medication burden and potentially resulting in poor compliance. Fludrocortisone has been beneficial in addressing tubulopat...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13134

    authors: Ali SR,Shaheen I,Young D,Ramage I,Maxwell H,Hughes DA,Athavale D,Shaikh MG

    更新日期:2018-03-01 00:00:00

  • Bilateral lung transplant in Gauchers type-1 disease.

    abstract::We report a case of a patient who received a bilateral lung transplant for end-stage lung disease secondary to Gauchers type-1 disease with no evidence of recurrence of the disease in the transplanted lung. ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00251.x

    authors: Rao AR,Parakininkas D,Hintermeyer M,Segura AD,Rice TB

    更新日期:2005-04-01 00:00:00

  • Prevalence and subtypes of BK virus in pediatric renal transplant recipients in Russia.

    abstract::BKV reactivation is associated with impaired graft function in kidney transplant patients. The objective of our study was to determine the prevalence of BKV infection in consecutive pediatric kidney transplant recipients at our center. Fifty-eight pediatric kidney transplant recipients were studied. The mean age at sc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01640.x

    authors: Momynaliev KT,Gorbatenko EV,Shevtsov AB,Gribanov OG,Babenko NN,Kaabak MM

    更新日期:2012-03-01 00:00:00

  • Mycophenolate mofetil and reduced doses of cyclosporine in pediatric liver transplantation with chronic renal dysfunction: changes in the immune responses.

    abstract::The aim of this study was to study the incidence of chronic renal dysfunction in patients with more than 5 yr of follow-up following liver transplantation and to evaluate the benefit of decreasing cyclosporine A (CsA) dose combined with mycophenolate mofetil (MMF) on renal function and immune response in these patient...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00172.x

    authors: Ferraris JR,Duca P,Prigoshin N,Tambutti ML,Boldrini G,Cardoni RL,D'Agostino D

    更新日期:2004-10-01 00:00:00

  • Eltrombopag for secondary failure of platelet recovery post-allogeneic hematopoietic stem cell transplant in children.

    abstract::Secondary failure of platelet engraftment occurs in 20% of patients undergoing allogeneic HSCT and is associated with poor outcome. Currently, there are no guidelines for treatment of late thrombocytopenia and platelet transfusion is the mainstay of treatment. Here, we describe the use of Eltrombopag to treat secondar...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13017

    authors: Ali S,Gassas A,Kirby-Allen M,Krueger J,Ali M,Schechter T

    更新日期:2017-09-01 00:00:00

  • Pediatric discard risk index for predicting pediatric liver allograft discard.

    abstract:BACKGROUND:Of the 600 pediatric candidates added to the liver waiting list annually, 100 will remain waiting while over 100 liver allografts are discarded, often for subjective reasons. METHODS:We created a risk index to predict discard to better optimize donor supply. We used the UNOS database to retrospectively anal...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13963

    authors: Malik T,Joshi M,Godfrey E,Galvan T,O'Mahony CA,Cotton R,Goss J,Rana A

    更新日期:2021-01-06 00:00:00

  • Outcome of allogeneic hematopoietic stem cell transplantation for children with acute myelogenous leukemia in second complete remission: single center experience.

    abstract::We reviewed 26 consecutive patients with AML who were transplanted in second CR2 between 1994 and 2005. The most common conditioning regimen was CY and TBI. Median age at transplant was 8.9 yr (range 2.2-18.2). Nine patients received related donor, 16 patients received unrelated donors, and one patient received unrela...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01101.x

    authors: Ishaqi MK,Afzal S,Dupuis A,Doyle J,Gassas A

    更新日期:2009-12-01 00:00:00

  • Growth of pediatric recipients after renal transplantation from small pediatric deceased donors weighing less than 15 kg.

    abstract::RTx is currently the best treatment for children with ESRD. This study retrospectively analyzed the outcomes of growth after RTx using the pediatric-to-pediatric allocation strategy and some factors that may affect it. From March 2012 to August 2016, 8 en bloc and 38 single pediatric RTxs were performed at our center ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13306

    authors: Liu Z,Zhao WY,Zhang L,Zhu YH,Zeng L

    更新日期:2019-02-01 00:00:00

  • Nocturnal hypertension and left ventricular hypertrophy in pediatric renal transplant recipients in South India.

    abstract::HTN after renal transplantation is associated with cardiovascular morbidity. ABPM allows diagnosis of masked HTN and isolated nocturnal HTN. Longitudinal ABPM data in children post-transplant are limited. ABPM was performed in children post-transplant and repeated in 6-12 months. BP indices were used to determine the ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13710

    authors: Pais P,Dello Strologo L,Iyengar A,Velusamy V,Greenbaum LA

    更新日期:2020-06-01 00:00:00

  • Social framework of pediatric heart recipients who have survived more than 15 post-transplant years: A single-center experience.

    abstract::To evaluate social development of pediatric heart transplant (tx) recipients who have lived 15 or more years after transplantation. Among 498 pediatric patients, age less than 18 years, who underwent heart transplantation, at a single institution, 337 were performed between 1985 and 1998. We identified all who survive...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12853

    authors: Copeland H,Razzouk A,Beckham A,Chinnock R,Hasaniya N,Bailey L

    更新日期:2017-03-01 00:00:00

  • Evaluation of cardiac manifestations in pediatric liver transplant candidates.

    abstract::Knowledge concerning the involvement of the cardiovascular system in children awaiting liver transplant is limited. Therefore, no guidelines have been established on evaluating this group of patients for cardiac disease. This review examines the diverse cardiovascular manifestations of liver disease in children. We al...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-3046.2012.01667.x

    authors: Madan N,Arnon R,Arnon R

    更新日期:2012-06-01 00:00:00

  • Potential influence of tacrolimus and steroid avoidance on early graft function in pediatric renal transplantation.

    abstract::With the increasing adoption of steroid-sparing immunosuppression protocols in renal transplantation, it is important to evaluate any adverse effects of steroid avoidance on graft function. Early graft function, measured by CrCl was retrospectively studied in 158 consecutive pediatric renal transplant recipients from ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00884.x

    authors: Li L,Weintraub L,Concepcion W,Martin JP,Miller K,Salvatierra O,Sarwal MM

    更新日期:2008-09-01 00:00:00