Non-invasive biological quantification of acute gastrointestinal graft-versus-host disease in children by plasma citrulline.

Abstract:

:Clinical grading of GI involvement during acute GVHD remains a challenging issue, especially in children. Plasma citrulline, a non-protein amino acid selectively produced and released by enterocytes, is a suitable surrogate endpoint for small intestinal epithelial cell mass, irrespective of the underlying cause of cell loss. Children referred for allogeneic bone marrow transplantation who were free from chronic malabsorption or constitutional disease involving the GI tract were consecutively included in this prospective study. Plasma citrulline and albumin concentration was measured every week between day 7 and day 28 of BMT until resolution of the aGVHD or occurrence of chronic GVHD. In total, 31 children were included between 2008 and 2011. After a CR, citrulline levels fell to a minimum level on day 7 and then increased to reach the initial value on day 28. After day 28, plasma citrulline but not albumin was strongly linked to the occurrence of GI GVHD, the threshold being set at 10 μmol/L. The correlation with clinical grade of GI-aGVHD now needs to be assessed in larger populations. In pediatric patients, citrulline is valuable as a suitable non-invasive marker of GI involvement in acute GVHD.

journal_name

Pediatr Transplant

authors

Merlin E,Minet-Quinard R,Pereira B,Rochette E,Auvrignon A,Oudot C,Sapin V,Deméocq F,Kanold J

doi

10.1111/petr.12128

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

683-7

issue

7

eissn

1397-3142

issn

1399-3046

journal_volume

17

pub_type

杂志文章
  • Increased p53 protein expression as a potential predictor of early relapse after hematopoietic stem cell transplantation in children with acute myelogenous leukemia.

    abstract::Dysregulation of genes involved in the cell cycle such as TP53, P21, P16, and PTEN plays a key role in oncogenesis. We have earlier reported increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with more aggressive, rare chronic myeloid malignancies. The aim of this stud...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12585

    authors: Mattsson K,Honkaniemi E,Barbany G,Gustafsson B

    更新日期:2015-11-01 00:00:00

  • Outcome of kidney transplantation in Canadian Aboriginal children in the province of British Columbia.

    abstract::Renal transplantation remains the therapy of choice for children and adolescents with ESRD. Differences in graft survival are observed in kidney transplant recipients of different race and ethnicities. Data in pediatric populations are limited and confounded by disparities in access to health care. We performed a retr...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01074.x

    authors: Matsuda-Abedini M,Al-AlSheikh K,Hurley RM,Matsell DG,Chow J,Carter JE,Lirenman DS

    更新日期:2009-11-01 00:00:00

  • Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient.

    abstract::EBV is associated with various malignancies in patients with acquired or induced immune impairment. EBV-SMT is very uncommon in immunocompromised patients, and a kidney localization has been described only anecdotally. We report the case of a 17-yr-old kidney transplant recipient diagnosed as having an EBV-SMT inside ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01213.x

    authors: Belingheri M,Comoli P,Locatelli F,Baldanti F,Martina V,Giani M,Ferraresso M,Cro L,Edefonti A,Ghio L

    更新日期:2010-12-01 00:00:00

  • Significance of Epstein-Barr virus status and post-transplant lymphoproliferative disease in pediatric thoracic transplantation.

    abstract::Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD) is a serious complication of organ and bone marrow transplantation. The importance of EBV matching between recipient and donor remains unclear. Between October 1987 and December 1997, 64 pediatric cardio-pulmonary transplants were p...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.1999.00019.x

    authors: Harwood JS,Gould FK,McMaster A,Hamilton JR,Corris PA,Hasan A,Gennery AR,Dark JH

    更新日期:1999-05-01 00:00:00

  • Extracorporeal membrane oxygenation use in the first 24 hours following pediatric heart transplantation: Incidence, risk factors, and outcomes.

    abstract::Primary graft dysfunction following HTx is associated with significant morbidity and mortality. This study aimed to assess the incidence of, risk factors for, and outcomes of children requiring ECMO within 24 hours of HTx. This study utilized a linked PHIS/SRTR database of pediatric HTx recipients (2002-2016). Post-HT...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13414

    authors: Godown J,Bearl DW,Thurm C,Hall M,Feingold B,Soslow JH,Mettler BA,Smith AH,Profita EL,Singh TP,Dodd DA

    更新日期:2019-06-01 00:00:00

  • Liver transplantation for neonatal hemochromatosis: analysis of the UNOS database.

    abstract::NH is the most common identifiable cause of ALF in the neonate. LT is the definitive treatment for neonates with NH who have failed medical therapy. Our aim was to determine the outcomes of LT in infants with NH. Patients (less than one yr of age) with NH who were listed for LT and patients who underwent LT between 19...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12418

    authors: Sheflin-Findling S,Annunziato RA,Chu J,Arvelakis A,Mahon D,Arnon R

    更新日期:2015-03-01 00:00:00

  • Hepatic veno-occlusive disease.

    abstract::Hepatic veno-occlusive disease (VOD) after stem cell transplantation is a toxic manifestation of the conditioning regimen most probably emphasized by the allogeneic reaction. Its overall mortality rate is < 4% in adults as well as in children. Recent progress has been achieved in the diagnosis of this complication. Ho...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.1999.00077.x

    authors: Ribaud P,Gluckman E

    更新日期:1999-01-01 00:00:00

  • Low incidence of adverse events in outpatient pediatric renal allograft biopsies.

    abstract::In 1999, our center implemented a policy of outpatient protocol biopsies as standard practice for the clinical management of pediatric renal allograft recipients. In order to determine the safety of this procedure, we conducted a retrospective chart audit of all outpatient renal allograft biopsies performed at our cen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00659.x

    authors: Birk PE,Blydt-Hansen TD,Dart AB,Kaita LM,Proulx C,Taylor G

    更新日期:2007-03-01 00:00:00

  • Proven Epstein-Barr encephalitis with negative EBV-DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia.

    abstract::We report a case of EBV encephalitis in a seven-yr-old child with Ph+ ALL. Two months after an allogeneic HSCT from his HLA mismatched mother, the patient showed an altered sensorium, generalized seizures, and a left hemiparesis. Brain MRI demonstrated multiple lesions highly suggestive for viral encephalitis. Blood a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12386

    authors: Barberi W,Perrone S,Iori AP,Torelli GF,Testi AM,Moleti ML,Ceglie T,Papoff P,Caresta E,Antonelli M,Gianno F,Melone A,Badiali M,Giangaspero F,Foà R,Gentile G

    更新日期:2015-02-01 00:00:00

  • De novo development of antibodies to kidney-associated self-antigens angiotensin II receptor type I, collagen IV, and fibronectin occurs at early time points after kidney transplantation in children.

    abstract::Chronic rejection is the leading cause of graft loss following pediatric kidney transplantation. Our group and others have demonstrated an association between the development of Abs to self-antigens and chronic rejection following adult lung and heart transplantation. The goal of this study was to determine whether Ab...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12531

    authors: Hesemann LE,Subramanian V,Mohanakumar T,Dharnidharka VR

    更新日期:2015-08-01 00:00:00

  • Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study.

    abstract::The development of malignancy in a renal transplant graft is an uncommon phenomenon. A renal neoplasm developing in the adult donor kidney of a pediatric transplant recipient has only rarely been reported. We report a case of collecting duct carcinoma arising in association with BK virus nephropathy in an adult living...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00855.x

    authors: Emerson LL,Carney HM,Layfield LJ,Sherbotie JR

    更新日期:2008-08-01 00:00:00

  • Successful liver retransplantation for recurrent hepatopulmonary syndrome.

    abstract::HPS is defined as arterial hypoxemia because of pulmonary vasodilation as a result of cirrhotic or non-cirrhotic portal hypertension. This report describes a teenager with HPS because of primary sclerosing cholangitis/autoimmune hepatitis overlap syndrome requiring OLT. HPS resolved completely within three months of O...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00790.x

    authors: Rajwal SR,Davison SM,Prasad R,Brownlee K,McClean P

    更新日期:2007-12-01 00:00:00

  • Matched related donor hematopoietic stem cell transplantation results in a long-term follow-up of a pediatric acquired severe aplastic anemia subset: A stem cell source perspective.

    abstract::HSCT has substantially improved pediatric acquired SAA patients' outcomes. Retrospectively, we attempted to assess the outcome of MRD HSCT in 65 pediatric patients referred to a single center from 1992 to 2012. We were particularly interested to find out whether source of SC (PB, n = 40 and BM, n = 25) significantly i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12458

    authors: Hamidieh AA,Mozafari M,Noshad S,Alimoghaddam K,Behfar M,Ghavamzadeh A

    更新日期:2015-06-01 00:00:00

  • Liver retransplantation in an infant requiring cavoportal hemi transposition.

    abstract::Historically inability to achieve portal inflow to the liver allograft operatively was felt to be a contraindication to orthotopic liver transplantation (OLTx). Cavoportal hemi transposition has been utilized more recently in adult OLTx recipients but rarely in pediatric recipients. Here we report the case of a 10-mon...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2004.00196.x

    authors: Verran D,Crawford M,Stormon M,Shun A

    更新日期:2004-08-01 00:00:00

  • Minimum mycophenolic acid levels are associated with donor-specific antibody formation.

    abstract::Although de novo DSA are associated with inferior graft survival, there are no effective strategies to prevent their formation. Underexposure to MPA (prodrug: MMF) also contributes to rejection rates early after transplantation, but the effect of this phenomenon on the formation of DSA long-term post-transplantation i...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12637

    authors: Filler G,Todorova EK,Bax K,Alvarez-Elías AC,Huang SH,Kobrzynski MC

    更新日期:2016-02-01 00:00:00

  • Living donor liver transplantation for hepatoblastoma with Beckwith-Wiedemann syndrome.

    abstract::BWS is one of the most well-known somatic overgrowth syndromes, which is characterized by macroglossia, organomegaly, abdominal wall defects, and predisposition to embryonal tumors, such as Wilms' tumor, hepatoblastoma, and adrenocortical carcinoma. We report a case of BWS in a girl with unresectable hepatoblastoma, w...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2009.01198.x

    authors: Sasaki K,Kasahara M,Fukuda A,Shigeta T,Tanaka H,Nakagawa S,Mitsui K,Harada R,Nakagawa A

    更新日期:2010-11-01 00:00:00

  • Primary HHV 6 infection after liver transplantation with acute graft rejection and multi-organ failure: successful treatment with a 2.5-fold dose of cidofovir and reduction of immunosuppression.

    abstract::HHV type 6 has been reported with enhanced pathogenicity in immunocompromised patients. Herein, we report about a two-yr-old girl who experienced primary HHV 6 infection after liver transplantation. She clinically presented with graft rejection and necrotic hepatitis as well as high fever, pneumonitis with respiratory...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01310.x

    authors: Dohna-Schwake C,Fiedler M,Gierenz N,Gerner P,Ballauf A,Breddemann A,Läer S,Baba HA,Hoyer PF

    更新日期:2011-09-01 00:00:00

  • Successful second bone marrow transplantation in Omenn's syndrome after bone marrow aplasia: a case report.

    abstract::Omenn's syndrome is a rare inherited variant of SCID. It is inevitably fatal, unless treated by bone marrow or stem cell transplantation. However, treatment-related complications and graft rejection are major obstacles to the success of transplantation. In this report, we describe an eight-month-old baby with Omenn's ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2010.01413.x

    authors: Wahadneh A,Bin-Dahman H,Habahbeh Z,Abu-Shukear M,Ajarmeh M,Zyood R,Khaled A

    更新日期:2012-03-01 00:00:00

  • High prevalence of latent tuberculosis in hematopoietic stem cell transplant recipients: A First Report.

    abstract::TB is an increasing health problem, and patients undergoing HSCT are more prone to develop tuberculosis. The aim of our study was to evaluate prevalence of latent tuberculosis in HSCT recipients. In this study, 84 patients (2 months to 18 years) who were candidates for HSCT at the referral hospital of Tehran Children'...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13770

    authors: Mahmoudi S,Pourakbari B,Sadeghi RH,Hamidieh AA,Safari Sharari A,Salajegheh P,Aziz-Ahari A,Mamishi S

    更新日期:2020-09-01 00:00:00

  • Pediatric heart transplant from an incompletely treated influenza A-positive donor.

    abstract::There is a shortage of pediatric donor hearts for waitlisted children, and yet nearly 50% of organs offered are not transplanted. Donor quality is often cited as a reason for declining organs offered from donors infected with influenza, presumably due to concern about disease transmission at transplant leading to seve...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13585

    authors: Smith CJ,McCulloch MD,Shirley DA,L'Ecuyer TJ

    更新日期:2019-12-01 00:00:00

  • Hematopoietic stem cell transplantation from unrelated donors in children with DOCK8 deficiency.

    abstract::DIDS is a unique form of combined immune deficiency characterized by an unusual susceptibility to cutaneous viral infections, severe allergies with eosinophilia and elevated immunoglobulin E titers, autoimmunity, and cancer. HSCT is considered the standard of care for this deadly disease. We have retrospectively analy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13015

    authors: Uygun DFK,Uygun V,Reisli İ,Keleş S,Özen A,Yılmaz M,Sayar EH,Daloğlu H,Öztürkmen SI,Çakı S,Karasu GT,Yeşilipek A

    更新日期:2017-11-01 00:00:00

  • Impact of pretransplant minimal residual disease on the post-transplant outcome of pediatric acute lymphoblastic leukemia.

    abstract::There are few reports on the clinical significance of MRD before HSCT in pediatric ALL. We retrospectively analyzed the clinical significance of FCM-based detection of MRD (FCM-MRD) before allogeneic HSCT in pediatric ALL. Of 38 pediatric patients who underwent allogeneic HSCT for the first time between 1998 and 2014,...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12732

    authors: Umeda K,Hiramatsu H,Kawaguchi K,Iwai A,Mikami M,Nodomi S,Saida S,Heike T,Ohomori K,Adachi S

    更新日期:2016-08-01 00:00:00

  • Does renal transplant in children with LUTD improve their bladder function?

    abstract::Much is still unknown about LUT function after receiving renal graft. Graft function was the main focus of different studies discussing the same issue. However, these studies ignored the effects of the graft on lower tract function and more demand for bladder cycling and growth of the child. Therefore, we aimed at eva...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13735

    authors: Aboulela W,Fawzy AM,Abdelmawla MA,Salah DM,Eldin MS,Mohamed Anwar AZ,El Ghoneimy M,Shouman AM,Shoukry AI,Bazaraa H,Tawfiek ER,Fadel F,Badawy H,Morsi HA,Ghoneima W

    更新日期:2020-09-01 00:00:00

  • Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury.

    abstract::Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two gen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12712

    authors: Csohány R,Prókai Á,Sziksz E,Balicza-Himer L,Pap D,Kosik A,Sugár D,Vannay Á,Kis-Petik K,Fekete A,Szabó AJ

    更新日期:2016-08-01 00:00:00

  • Re-evaluation of the indications for liver transplantation in Wilson's disease based on the outcomes of patients referred to a transplant center.

    abstract::The aim of this study was to re-evaluate the indications and timing of LT for WD. From 2000 to 2009, eight patients with WD who had been referred to our institution for LT were enrolled in this study. The mean patient age was 15.9 yr (range, 7-37 yr). Four patients could not receive LT, because there were no available...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12085

    authors: Ohya Y,Okajima H,Honda M,Hayashida S,Suda H,Matsumoto S,Lee KJ,Yamamoto H,Takeichi T,Mitsubuchi H,Asonuma K,Endo F,Inomata Y

    更新日期:2013-06-01 00:00:00

  • En bloc kidney transplantation from infant donors younger than 10 months into pediatric recipients.

    abstract::Early graft loss and poor graft function limit the use of kidneys from infant donors. Six en bloc kidney transplantations were performed from infant donors younger than 10 months into pediatric recipients between November 2012 and September 2015 at our center. We retrospectively analyzed recipient and donor demographi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12845

    authors: Wang HY,Li J,Liu LS,Deng RH,Fu Q,Ko DS,Zhang HX,Deng SX,Wang CX

    更新日期:2017-03-01 00:00:00

  • Focal segmental glomerulosclerosis associated with acute cytomegalovirus infection in a renal transplant.

    abstract::Focal segmental glomerulosclerosis (FSGS) occurring in association with cytomegalovirus (CMV) infection in a renal transplant patient with no previous history of FSGS has rarely been reported. We present a case of a 16-year-old renal transplant recipient who developed acute hepatitis, leukopenia, nephrotic syndrome, a...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13538

    authors: Wynd E,Stewart A,Burke J

    更新日期:2019-09-01 00:00:00

  • Non-adherence in pediatric liver transplant recipients--an assessment of risk factors and natural history.

    abstract::Despite the fact that non-adherence to medical therapy is one of the major causes of late morbidity and mortality in pediatric liver transplant recipients, little is known of the risk factors involved in this behavior. Three cases of fatal non-adherence are reported. Factors associated with non-adherence were investig...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2000.00110.x

    authors: Lurie S,Shemesh E,Sheiner PA,Emre S,Tindle HL,Melchionna L,Shneider BL

    更新日期:2000-08-01 00:00:00

  • Acute kidney injury and chronic kidney disease after combined heart-liver transplant in patients with congenital heart disease: A retrospective case series.

    abstract::Although it is known that children undergoing heart transplantation are at increased risk for both AKI and CKD, renal function following CHLT remains understudied. All pediatric CHLT patients from 2006 to 2019 were included. The prevalence of AKI in the first 7 post-operative days, renal recovery at 30 post-operative ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13833

    authors: Lee A,Concepcion W,Gonzales S,Sutherland SM,Hollander SA

    更新日期:2020-11-01 00:00:00

  • Therapeutic drug monitoring of tacrolimus in pediatric liver transplant patients.

    abstract::The clinical utility of tacrolimus monitoring in adults has been well documented. The present study compared tacrolimus monitoring in a pediatric population of 34 liver transplant patients in four US centers with an adult population of 111 patients in six US centers. Subjects (adult and pediatric) were evaluated, at d...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2000.00000.x

    authors: MacFarlane GD,Venkataramanan R,McDiarmid SV,Pirsch JD,Scheller DG,Ersfeld DL,Fitzsimmons WE

    更新日期:2001-04-01 00:00:00