Abstract:
BACKGROUND:The use of ventricular assist devices (VADs) in children with heart failure may be of particular benefit to those with accompanying renal failure, as improved renal function is seen in some, but not all recipients. We hypothesized that persistent renal dysfunction at 7 days and/or 1 month after VAD implantation would predict chronic kidney disease (CKD) 1 year after heart transplantation (HT). METHODS:Linkage analysis of all VAD patients enrolled in both the PEDIMACS and PHTS registries between 2012 and 2016. Persistent acute kidney injury (P-AKI), defined as a serum creatinine ≥1.5× baseline, was assessed at post-implant day 7. Estimated glomerular filtration rate (eGFR) was determined at implant, 30 days thereafter, and 12 months post-HT. Pre-implant eGFR, eGFR normalization (to ≥90 mL/min/1.73 m2 ), and P-AKI were used to predict post-HT CKD (eGFR <90 mL/min/1.73 m2 ). RESULTS:The mean implant eGFR was 85.4 ± 46.5 mL/min/1.73 m2 . P-AKI was present in 19/188 (10%). Mean eGFR at 1 month post-VAD implant was 131.1 ± 62.1 mL/min/1.73 m2 , significantly increased above baseline (P < 0.001). At 1 year post-HT (n = 133), 60 (45%) had CKD. Lower pre-implant eGFR was associated with post-HT CKD (OR 0.99, CI: 0.97-0.99, P = 0.005); P-AKI was not (OR 0.96, CI: 0.3-3.0, P = 0.9). Failure to normalize renal function 30 days after implant was highly associated with CKD at 1 year post-transplant (OR 12.5, CI 2.8-55, P = 0.003). CONCLUSIONS:Renal function improves after VAD implantation. Lower pre-implant eGFR and failure to normalize renal function during the support period are risk factors for CKD development after HT.
journal_name
Pediatr Transplantjournal_title
Pediatric transplantationauthors
Hollander SA,Cantor RS,Sutherland SM,Koehl DA,Pruitt E,McDonald N,Kirklin JK,Ravekes WJ,Ameduri R,Chrisant M,Hoffman TM,Lytrivi ID,Conway Jdoi
10.1111/petr.13477subject
Has Abstractpub_date
2019-08-01 00:00:00pages
e13477issue
5eissn
1397-3142issn
1399-3046journal_volume
23pub_type
杂志文章abstract::Combined enzyme replacement therapy (ERT) and stem cell transplant (SCT) were done for a two year old boy with severe Hurler syndrome(HS) with the aim to decrease transplant related complications. He tolerated both the procedures well without any major complications. Urine glycosaminoglycans (GAGs) decreased post-tran...
journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
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abstract::Several studies suggested that the incidence of new-onset diabetes following pediatric kidney transplantation has increased markedly in recent years, with reported incidence of up to 20%. However, limited information is available regarding the incidence and features of pretransplant status of abnormal glucose toleranc...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2006.00459.x
更新日期:2006-02-01 00:00:00
abstract:UNLABELLED:The Latin American Pediatric Nephrology Association (ALANEPE) reports the first regional kidney transplant registry in Latin America. A mean range of 75%, 30% to 100% renal transplant recipients under 21 yr old were included. Out of 20 countries invited to participate, 14 performed renal transplant, 11 had u...
journal_title:Pediatric transplantation
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doi:10.1111/j.1399-3046.2010.01331.x
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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abstract::BKV reactivation is associated with impaired graft function in kidney transplant patients. The objective of our study was to determine the prevalence of BKV infection in consecutive pediatric kidney transplant recipients at our center. Fifty-eight pediatric kidney transplant recipients were studied. The mean age at sc...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2011.01640.x
更新日期:2012-03-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2004.00212.x
更新日期:2004-10-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13337
更新日期:2019-03-01 00:00:00
abstract::Abdominal closure in children less than 10 kg following liver or kidney transplantation can be challenging. Excessive pressure attained from a tight closure can result in abdominal compartment syndrome, graft compromise and loss. Concerns over using prosthetic patches are that of infection and dehiscence. We report a ...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2008.01086.x
更新日期:2009-05-01 00:00:00
abstract::Rabbit antithymocyte globulin (ATG-F) is an extensively used induction agent. To our knowledge, no study to date has assessed reduced ATG-F dosage in children undergoing renal transplantation. This was a retrospective analysis of pediatric renal recipients in the Department of Kidney Transplantation, The First Affilia...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.12224
更新日期:2014-05-01 00:00:00
abstract::RTx is currently the best treatment for children with ESRD. This study retrospectively analyzed the outcomes of growth after RTx using the pediatric-to-pediatric allocation strategy and some factors that may affect it. From March 2012 to August 2016, 8 en bloc and 38 single pediatric RTxs were performed at our center ...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13306
更新日期:2019-02-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1034/j.1399-3046.2000.00130.x
更新日期:2000-11-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.12443
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Studies of HRQoL after kidney transplant have yielded conflicting results. We sought to assess the impact of kidney transplant on HRQoL. METHODS:We performed a retrospective study using the PedsQL3.0ESRD module during dialysis and at 3 and 12 months following kidney transplant in 56 recipients. For the enti...
journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/petr.13333
更新日期:2019-03-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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journal_title:Pediatric transplantation
pub_type: 杂志文章
doi:10.1111/j.1399-3046.2007.00842.x
更新日期:2008-02-01 00:00:00
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journal_title:Pediatric transplantation
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journal_title:Pediatric transplantation
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Pediatric transplantation
pub_type: 杂志文章,评审
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更新日期:2020-05-01 00:00:00
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journal_title:Pediatric transplantation
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更新日期:2016-06-01 00:00:00