Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning.

Abstract:

:Treatment of severe aplastic anemia (SAA) patients who lack human leukocyte antigen (HLA)-matched donors and failed immunosuppressive therapy (IST) is challenging. Recently, umbilical cord blood transplantation (CBT) after non-myeloablative therapy has been reported in adult but not in childhood SAA. However, most cases resulted in mixed donor chimerism and incomplete hematological recovery. We reported an 11-yr-old girl with recurred SAA 5 yr after IST who underwent unrelated donor CBT after a modified regimen. This patient had renal and cardiac dysfunction, and lacked suitable bone marrow donors. The 3.9 x 10(7)/kg CB cells from an HLA one-locus mismatched unrelated donor were infused after conditioning with total body irradiation (5 Gy), melphalan (120 mg/m(2)), and fludarabin (120 mg/m(2)). Hematological recovery was favorable in complete chimerism. A major complication was only skin graft-versus-host disease (grade I). CB could be an alternate stem cell source for childhood SAA after modified preparative regimen.

journal_name

Pediatr Transplant

authors

Ohga S,Ichino K,Goto K,Hattori S,Nomura A,Takada H,Nakamura K,Hara T

doi

10.1111/j.1399-3046.2006.00486.x

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

497-500

issue

4

eissn

1397-3142

issn

1399-3046

pii

PTR486

journal_volume

10

pub_type

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