New insights into the functions of B cells.

Abstract:

:Organ transplants between genetically different individuals elicit powerful immune responses that invariably cause rejection in the absence of immune suppression. Among the immune responses elicited by organ allografts, B-cell responses causing antibody-mediated rejection are one of the most vexing. However, recent advances in the field indicate that B cells and antibodies' contribution to immunity extends well beyond the traditional functions ascribed to antibodies. Here we review "non-humoral" functions of B cells and the implications of these functions to transplantation.

journal_name

Pediatr Transplant

authors

Balin SJ,Platt JL,Cascalho M

doi

10.1111/j.1399-3046.2007.00867.x

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

510-5

issue

5

eissn

1397-3142

issn

1399-3046

pii

PTR867

journal_volume

12

pub_type

杂志文章
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