The significance of a defect on DMSA scan in children with renal transplants.

Abstract:

:Since December 1995, pediatric renal transplant recipients in our unit have received a DMSA scan as soon as possible post-transplant in order to provide a baseline for comparison in the event of subsequent complications. We retrospectively reviewed the case notes and DMSA scans of the 45 patients who underwent a scan within 9 wk of their transplant to see if pre or peri-transplant factors or post-transplant complications were associated with defects on scanning. Forty percentage of scans had defects. The presence of defects was not associated with potential predisposing factors such as patient or donor age, cadaveric or live donation, cold ischemia time, multiple donor vessels, the use of non-heart beating donors, the mean time to scan, the serum creatinine, or the presence of structural renal tract anomalies predisposing to UTI. However, 87% of patients had complications before the scan, including UTI, rejection, acute tubular necrosis, transplant biopsy and drug toxicity. Children with no clinical complications had a significantly reduced risk of a defect (p = 0.035), while biopsy was associated with the presence of defects (p = 0.0034). Twenty patients had one or more follow up DMSA scans: one patient developed a new focal defect. In conclusion, renal transplant defects are frequently found on DMSA scanning even early after transplantation and are non-specifically associated with many different complications.

journal_name

Pediatr Transplant

authors

Hutchinson C,Beckett M,Kiratli P,Gordon I,Trompeter RS,Rees L

doi

10.1046/j.1399-3046.2003.00073.x

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

441-5

issue

6

eissn

1397-3142

issn

1399-3046

journal_volume

7

pub_type

杂志文章
  • Preparing for a kidney transplant: Medical nephrectomy in children with nephrotic syndrome.

    abstract::Nephrotic syndrome is characterized by proteinuria, hypoalbuminemia, and general edema. These symptoms may persist in children who reach ESRD, which is unfavorable for the patient's allograft outcome. In addition, this may hamper early diagnosis of a relapse after transplantation. Surgical bilateral nephrectomy is oft...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13703

    authors: Vos E,Koster-Kamphuis L,van de Kar NCAJ,Bootsma-Robroeks CMHHT,Cornelissen EAM,Schreuder MF

    更新日期:2020-06-01 00:00:00

  • Pediatric heart transplant from an incompletely treated influenza A-positive donor.

    abstract::There is a shortage of pediatric donor hearts for waitlisted children, and yet nearly 50% of organs offered are not transplanted. Donor quality is often cited as a reason for declining organs offered from donors infected with influenza, presumably due to concern about disease transmission at transplant leading to seve...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13585

    authors: Smith CJ,McCulloch MD,Shirley DA,L'Ecuyer TJ

    更新日期:2019-12-01 00:00:00

  • Tacrolimus withdrawal and conversion to sirolimus at three months post-pediatric renal transplantation.

    abstract:UNLABELLED:Nephrotoxicity caused by CNI may adversely affect long-term graft outcomes. For this reason, we have adopted a protocol for withdrawing TAC and converting to SRL at three months post-renal transplantation. All recipients received basiliximab induction and TAC, MMF, and prednisone. Patients without acute reje...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.00906.x

    authors: Hymes LC,Warshaw BL,Amaral SG,Greenbaum LA

    更新日期:2008-11-01 00:00:00

  • Hematopoietic stem cell transplantation from unrelated donors in children with DOCK8 deficiency.

    abstract::DIDS is a unique form of combined immune deficiency characterized by an unusual susceptibility to cutaneous viral infections, severe allergies with eosinophilia and elevated immunoglobulin E titers, autoimmunity, and cancer. HSCT is considered the standard of care for this deadly disease. We have retrospectively analy...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13015

    authors: Uygun DFK,Uygun V,Reisli İ,Keleş S,Özen A,Yılmaz M,Sayar EH,Daloğlu H,Öztürkmen SI,Çakı S,Karasu GT,Yeşilipek A

    更新日期:2017-11-01 00:00:00

  • Aspergillus "fungus ball" of the bladder after hematopoietic transplantation in a pediatric patient: successful treatment with intravesical voriconazole and surgery.

    abstract::Aspergillosis is an important cause of mortality in allogeneic HSCT. A "fungus ball" formation of Aspergillus in the bladder has seldom been reported. We report a child that underwent HSCT and developed possible disseminated aspergillosis with an intravesical "fungus ball," diagnosed by genitourinary MRI and PCR of th...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00871.x

    authors: González-Vicent M,Lassaletta A,López-Pino MA,Romero-Tejada JC,de la Fuente-Trabado M,Díaz MA

    更新日期:2008-03-01 00:00:00

  • What is the long-term outlook for young people following liver transplant? A single-centre retrospective analysis of physical and psychosocial outcomes.

    abstract::LT is a successful treatment for end-stage liver disease. The long-term outcome of patients transplanted in childhood has not previously been widely reported. This project assessed the long-term impact of transplantation in patients surviving >15 years. Retrospective data on growth, end-organ damage and psychosocial d...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13782

    authors: Ruth N,Sharif K,Legarda M,Smith M,Lewis P,Lloyd C,Mirza D,Kelly D

    更新日期:2020-11-01 00:00:00

  • Successful resolution of inflammation and increased regulatory T cells in sirolimus-treated post-transplant allograft hepatitis.

    abstract::This retrospective case series reviews our center's experience with sirolimus and a CNI as alternative therapy for the treatment of PTAH. It also characterizes regulatory T cells (Tregs) in PTAH. LT recipients with PTAH who had received or were receiving treatment with sirolimus were retrospectively identified (n = 12...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2012.01648.x

    authors: Ekong UD,Mathew J,Melin-Aldana H,Wang D,Alonso EM

    更新日期:2012-03-01 00:00:00

  • Recurrence of primary disease in children after renal transplantation: an evidence-based update.

    abstract::The availability of new and more effective anti-rejection therapy has succeeded in reducing the incidence of acute cellular rejection in first months post-renal transplant. This in turn has escalated the order of significance of recurrence of primary disease in the renal allograft as a cause for patient morbidity and ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1046/j.1399-3046.2003.00151.x

    authors: Seikaly MG

    更新日期:2004-04-01 00:00:00

  • Medication adherence in pediatric renal transplant patients: The role of family functioning and parent health locus of control.

    abstract::Children and adolescents with renal disease experience daily social, emotional, and medical challenges. Renal transplantation can help to improve quality of life but requires a lifelong regimen of immunosuppressant medication to maintain health. Adherence to a daily complex regimen can be difficult, particularly for a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13346

    authors: Kraenbring MM,Zelikovsky N,Meyers KEC

    更新日期:2019-03-01 00:00:00

  • Donor-specific HLA antibodies and graft function in kidney-transplanted children - the Vienna cohort.

    abstract::In the pediatric population, little is known on de novo DSA development, its impact on graft function, and association with suboptimal IS. We assessed the prevalence of de novo DSA in the Vienna cohort of 40 renal transplanted children and adolescents and prospectively followed its association with clinical parameters...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章

    doi:10.1111/petr.12707

    authors: Rusai K,Dworak J,Potemkina A,Fischer G,Csaicsich D,Arbeiter K,Aufricht C,Müller-Sacherer T

    更新日期:2016-06-01 00:00:00

  • Clinical features and mutational survey of NPHS2 (podocin) in Japanese children with focal segmental glomerulosclerosis who underwent renal transplantation.

    abstract::Recurrent FSGS is a major challenge in the field of nephrology. To clarify the role of NPHS2 defects in the pathogenesis of FSGS recurrence, we sequenced all eight exons of NPHS2 in 11 Japanese pediatric FSGS patients with or without post-transplant recurrence. All patients had biopsy-proven primary FSGS, had no famil...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2007.00752.x

    authors: Furue T,Hattori M,Tsukaguchi H,Kitamura A,Oomori T,Ogino D,Nakakura H,Ashida A,Miura K,Hisano M,Takahashi K,Chikamoto H,Akioka Y,Sakano T

    更新日期:2008-05-01 00:00:00

  • Second transplant with two unrelated cord blood units for early graft failure after cord blood transplantation for thalassemia.

    abstract::Early GF is a frequent complication following hematopoietic stem cell transplantation for patients with thalassemia. We report the outcome of double-unit CBT in three patients who developed early GF after CBT. The initial conditioning regimen consisted of i.v. Bu 14 mg/kg (day -9 to -6), i.v. Cy 200 mg/kg (day -5 to -...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2008.01021.x

    authors: Jaing TH,Hung IJ,Yang CP,Tsai MH,Lee WI,Sun CF

    更新日期:2009-09-01 00:00:00

  • Bilateral laparoscopic nephrectomy with simultaneous peritoneal dialysis catheter implantation.

    abstract::Bilateral nephrectomy prior to transplantation is indicated in some patients with end-stage renal disease. The indications for bilateral nephrectomy include persistent heavy proteinuria, refractory hypertension, and urinary tract infections. We report an eight-month-old baby with male pseudohermaphroditism and renal f...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2006.00624.x

    authors: Martínez Urrutia MJ,Olivares Arnal P,López Pereira P,Lobato Romera R,Alonso Melgar A,Jaureguizar Monereo E

    更新日期:2007-03-01 00:00:00

  • Ureterocystoplasty (bladder augmentation) with a solitary kidney.

    abstract::Children who develop end-stage renal disease (ESRD) as a result of obstructive uropathies require evaluation and treatment of associated bladder dysfunction to ensure a good outcome following renal transplantation. Bladder dynamics can often be optimized medically, although surgical intervention is occasionally necess...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1034/j.1399-3046.2002.01078.x

    authors: Kurzrock EA,Butani L,Kakker SP,Perez RV,Lavjay Butani.

    更新日期:2002-06-01 00:00:00

  • Quantitation of allograft fibrosis and chronic allograft nephropathy.

    abstract::Despite improvements in the prevention and treatment of acute renal allograft rejection, the long-term survival of renal transplants has not increased. Immunologic and non-immunologic factors contribute to the gradual deterioration of graft function and to the histologic lesion characterized by vascular and interstiti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1034/j.1399-3046.1999.00044.x

    authors: Grimm PC,Nickerson P,Gough J,McKenna R,Jeffery J,Birk P,Rush DN

    更新日期:1999-11-01 00:00:00

  • Antithrombotic management and thrombosis rates in children post-liver transplantation: A case series and literature review.

    abstract::Thrombosis is a major postoperative complication in pediatric liver transplantation. There is marked heterogeneity in prophylactic antithrombotic therapies used, without established guidelines. This review summarizes current worldwide incidence of thrombotic events and compares antithrombotic therapies in children pos...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:10.1111/petr.13420

    authors: Flynn E,Huang JY,Hardikar W,Herd L,Hodgson A,Monagle P

    更新日期:2019-06-01 00:00:00

  • Focal segmental glomerulosclerosis associated with acute cytomegalovirus infection in a renal transplant.

    abstract::Focal segmental glomerulosclerosis (FSGS) occurring in association with cytomegalovirus (CMV) infection in a renal transplant patient with no previous history of FSGS has rarely been reported. We present a case of a 16-year-old renal transplant recipient who developed acute hepatitis, leukopenia, nephrotic syndrome, a...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13538

    authors: Wynd E,Stewart A,Burke J

    更新日期:2019-09-01 00:00:00

  • Liver transplantation for hepatoblastoma: indications and contraindications in the modern era.

    abstract::In the past 20 yr, a dramatic improvement has been achieved in the outcome of children with hepatoblastoma by combining cisplatin based chemotherapy and surgery. Treatment of patients in the USA is an exception to the rule that all patients should receive neoadjuvant chemotherapy. It is paramount that surgical resecti...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2005.00354.x

    authors: Otte JB,de Ville de Goyet J,Reding R

    更新日期:2005-10-01 00:00:00

  • Parental functioning improves the developmental quotient of pediatric liver transplant recipients.

    abstract::Psychomotor development in pediatric liver transplant (LT) recipients depends on several factors. Our aim was to evaluate the importance of parental involvement and family dynamics on psychomotor development by assessing (i) children and parents individually, (ii) the parent-child relationship, and (iii) the correlati...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12080

    authors: Posfay-Barbe KM,Barbe RP,Wetterwald R,Belli DC,McLin VA

    更新日期:2013-06-01 00:00:00

  • ABO-incompatible deceased donor pediatric liver transplantation: Novel titer-based management protocol and outcomes.

    abstract::ABO-ILT have re-emerged as an alternate option for select patients awaiting transplant. However, treatment protocols for children undergoing deceased donor ABO-ILT are not standardized. We implemented a novel IS protocol for children undergoing deceased donor ABO-ILT based on pretransplant IH titers. Children with hig...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13263

    authors: Mysore KR,Himes RW,Rana A,Teruya J,Desai MS,Srivaths PR,Zaruca K,Calvert A,Guffey D,Minard CG,Morita E,Hensch L,Losos M,Kostousov V,Hui SR,Orange JS,Goss JA,Nicholas SK

    更新日期:2018-11-01 00:00:00

  • Resistance to growth hormone in children with chronic liver disease.

    abstract::Malnutrition adversely affects mortality and morbidity before and after liver transplantation. Outcome might be improved if liver transplant recipients were in a better nutritional state at the time of transplantation. In this review, we will examine the potential use of GH and IGF-I to improve nutritional status in p...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审

    doi:

    authors: Bucuvalas JC,Horn JA,Chernausek SD

    更新日期:1997-08-01 00:00:00

  • Neuroradiologic findings in children with renal transplantation under 5 years of age.

    abstract::Chronic renal failure (CRF) is known to have adverse effects on the neurodevelopmental outcome of affected children. Some of these effects can be ameliorated by transplantation (TX). The cause and nature of the underlying brain injury is not known. We performed a brain magnetic resonance imaging (MRI) study on a group...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1046/j.1397-3142.2003.00125.x

    authors: Valanne L,Qvist E,Jalanko H,Holmberg C,Pihko H

    更新日期:2004-02-01 00:00:00

  • Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging.

    abstract:UNLABELLED:Liver transplantation treats the hepatic affectation of UCDs; however, irreversible neurologic damage pretransplant is difficult to assess providing transplant teams with ethical dilemmas for liver transplantation. The purpose of our study was to determine whether pretransplant neuroimaging can predict devel...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12520

    authors: Bolton SM,Campbell KM,Kukreja M,Kohli R

    更新日期:2015-08-01 00:00:00

  • The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients.

    abstract::SR-aGVHD remains a significant cause of morbidity and mortality in allogeneic HCT recipients. Alemtuzumab has been used with success in adult patients but has not been studied in the pediatric setting. To estimate the effectiveness of alemtuzumab for the treatment of SR-aGVHD in pediatric patients, we retrospectively ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12183

    authors: Khandelwal P,Lawrence J,Filipovich AH,Davies SM,Bleesing JJ,Jordan MB,Mehta P,Jodele S,Grimley MS,Kumar A,Myers K,Marsh RA

    更新日期:2014-02-01 00:00:00

  • Successful kidney transplantation in a patient with neonatal-onset ILNEB.

    abstract:BACKGROUND:ILNEB constitute an autosomal recessive disorder caused by homozygous or compound heterozygous mutation of the gene for the ITGA3. To date, 8 ILNEB patients have been reported, but all 6 neonatal-onset ILNEB patients suffered early death within 2 years. The most common cause of death among previously reporte...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13971

    authors: Okamoto T,Nakamura A,Hayashi A,Yamaguchi T,Ogawa Y,Natsuga K,Yanagi K,Hotta K

    更新日期:2021-01-20 00:00:00

  • Sex differences in renin response and changes of capillary diameters after renal ischemia/reperfusion injury.

    abstract::Activation of the RAS has a crucial role in the progression of ischemia/reperfusion-associated CAD. The regulation of RAS differs in the two genders. However, the extent of gender differences and locations of renin production have not been revealed yet. We investigated in vivo the local renin production in the two gen...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12712

    authors: Csohány R,Prókai Á,Sziksz E,Balicza-Himer L,Pap D,Kosik A,Sugár D,Vannay Á,Kis-Petik K,Fekete A,Szabó AJ

    更新日期:2016-08-01 00:00:00

  • Diet quality of children post-liver transplantation does not differ from healthy children.

    abstract::Little has been studied regarding the diets of children following LTX. The study aim was to assess and compare dietary intake and DQ of healthy children and children post-LTX. Children and adolescents (2-18 years) post-LTX (n=27) and healthy children (n=28) were studied. Anthropometric and demographic data and two 24-...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.12944

    authors: Alzaben AS,MacDonald K,Robert C,Haqq A,Gilmour SM,Yap J,Mager DR

    更新日期:2017-09-01 00:00:00

  • Acute kidney injury and chronic kidney disease after combined heart-liver transplant in patients with congenital heart disease: A retrospective case series.

    abstract::Although it is known that children undergoing heart transplantation are at increased risk for both AKI and CKD, renal function following CHLT remains understudied. All pediatric CHLT patients from 2006 to 2019 were included. The prevalence of AKI in the first 7 post-operative days, renal recovery at 30 post-operative ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/petr.13833

    authors: Lee A,Concepcion W,Gonzales S,Sutherland SM,Hollander SA

    更新日期:2020-11-01 00:00:00

  • Sequential liver-kidney transplantation in a boy with congenital hepatic fibrosis and nephronophthisis from a living donor.

    abstract::A five-yr-old boy developed chronic liver failure and ESKD because of CHF and juvenile NPHP. He underwent sequential liver and kidney transplantation with a compatible blood type from his father, at five yr, seven months and five yr, 11 months old, respectively. Because the patient was not in ESKD, we initially perfor...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章

    doi:10.1111/j.1399-3046.2011.01611.x

    authors: Udagawa T,Kamei K,Ogura M,Tsutsumi A,Noda S,Kasahara M,Fukuda A,Sakamoto S,Shigeta S,Tanaka H,Kuroda T,Matsuoka K,Nakazawa A,Nagai T,Uemura O,Ito S

    更新日期:2012-11-01 00:00:00

  • Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia.

    abstract::AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for ...

    journal_title:Pediatric transplantation

    pub_type:

    doi:10.1111/petr.13291

    authors: Abu-Arja RF,Dargart JL,Bajwa RPS,Kahwash SB,Auletta JJ,Rangarajan HG

    更新日期:2018-12-01 00:00:00