Abstract:
BACKGROUND:It is known that when crude Pinelliae rhizome and Pinelliae rhizoma preparatum are combined with Aconiti Radix Cocta respectively, the toxicity of the combination varies. However, the component's transformation between different compatibility have remained unclear. OBJECTIVE:In this paper, a novel approach using rapid resolution liquid chromatography-quadrupole time-of-flight mass spectrometry (RRLC-Q-TOF-MS) coupled with multivariate statistical analysis was established for exploring the influence of processing adjuvants (PAs) on the compatibility of Aconiti Radix Cocta and Pinelliae rhizome. MATERIALS AND METHODS:In order to obtain information about the representative markers between different groups, an exhaustive study of different protocols based on adding or removing different PAs step by step was carried out and the influence of PAs on compatibility was investigated. RESULTS:It was found that lime can facilitate diester diterpenoid alkaloids with high toxicity in Aconiti Radix Cocta to be converted into low-toxic or non-toxic derivatives. Glycyrrhizae Radix et Rhizoma had no remarkable effect on the process. CONCLUSION:The established method in this study will be of great significance to process research mechanism and study on traditional Chinese Medicine compatibility and clinical application.
journal_name
Pharmacogn Magjournal_title
Pharmacognosy magazineauthors
Wang Y,Li Y,Zhang X,Xu Y,Wang H,Zhang Ydoi
10.4103/0973-1296.141771subject
Has Abstractpub_date
2014-10-01 00:00:00pages
483-90issue
40eissn
0973-1296issn
0976-4062pii
PM-10-483journal_volume
10pub_type
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