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A new flavan-3-ol dimer from Ficus spragueana leaves and its cytotoxic activity.

Abstract：

BACKGROUND:Isolation and structure elucidation of flavan-3-ol constituents from the leaves of Ficus spragueana and their cytotoxic activity. MATERIALS AND METHODS:Different open silica gel column chromatographic techniques with different solvent systems were used for the separation of the constituents of the ethyl acetate-soluble fraction of the alcoholic extract of Ficus spragueana leaves. The structures of these compounds were assigned on the basis of spectroscopic analyses and comparison with literature data. MTT colorimetric assay method (Viability assay) was used for the evaluation of cytotoxic activity of compound 1 against human breast cancer (MCF-7) and human liver cancer (HepG2) cell lines. RESULTS:The isolation of one flavan-3-ol dimer and was identified as (-)-afzelechin-(4α→8)-epicatechin 1, and two flavan-3-ol monomers and were identified as (-)-epiafzelechin 2 and (-)-epicatechin 3. Compound 1 was relatively inactive against human breast cancer (MCF-7) cell line at the tested concentrations as compared with the standard. However, at a concentration (50 ΅g) it was found to give inhibition upon the proliferation of examined human liver (HepG2) tumor cell line. CONCLUSIONS:Compound 1 is a new flavan-3-ol dimer and it showed a potent cytotoxic activity against human liver (HepG2) tumor cell line.

journal_name

Pharmacogn Mag

journal_title

Pharmacognosy magazine

authors

Ragab EA,Mohammed Ael-S,Abbass HS,Kotb SI

doi

10.4103/0973-1296.111274

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

144-8

issue

34

eissn

0973-1296

issn

0976-4062

pii

PM-9-144

journal_volume

9

pub_type

杂志文章

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