Increased acetylcholine esterase activity produced by the administration of an aqueous extract of the seed kernel of Thevetia peruviana and its role on acute and subchronic intoxication in mice.

Abstract:

BACKGROUND:The real mechanism for Thevetia peruviana poisoning remains unclear. Cholinergic activity is important for cardiac function regulation, however, the effect of T. peruviana on cholinergic activity is not well-known. OBJECTIVE:To study the effect of the acute administration of an aqueous extract of the seed kernel of T. peruviana on the acetylcholine esterase (AChE) activity in CD1 mice as well its implications in the sub-chronic toxicity of the extract. MATERIALS AND METHODS:A dose of 100 mg/kg of the extract was administered to CD1 mice and after 7 days, serum was obtained for ceruloplasmin (CP) quantitation and liver function tests. Another group of mice received a 50 mg/kg dose of the extract 3 times within 1 h time interval and AChE activity was determined for those animals. Heart tissue histological preparation was obtained from a group of mice that received a daily 50 mg/kg dose of the extract by a 30-days period. RESULTS:CP levels for the treated group were higher than those for the control group (Student's t-test, P ≤ 0.001). AChE activity in the treated group was significantly higher than the control group (Tukey test, control vs. T. peruviana, P ≤ 0.001). Heart tissue histological preparations showed leukocyte infiltrates and necrotic areas, consistent with infarcts. CONCLUSION:The increased levels of AChE and the hearth tissue infiltrative lesions induced by the aqueous seed kernel extract of T. peruviana explains in part the poisoning caused by this plant, which can be related to an inflammatory process.

journal_name

Pharmacogn Mag

journal_title

Pharmacognosy magazine

authors

Marroquín-Segura R,Calvillo-Esparza R,Mora-Guevara JL,Tovalín-Ahumada JH,Aguilar-Contreras A,Hernández-Abad VJ

doi

10.4103/0973-1296.127370

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

S171-5

issue

Suppl 1

eissn

0973-1296

issn

0976-4062

pii

PM-10-171

journal_volume

10

pub_type

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