Metformin treatment to reduce central adiposity after prenatal growth restraint: a placebo-controlled pilot study in prepubertal children.

abstract：BACKGROUND:We set out to explore associations between the stool bacteriome profiles and early-onset islet autoimmunity, taking into account the interactions with the virus component of the microbiome. METHODS:Serial stool samples were longitudinally collected from 18 infants and toddlers with early-onset islet autoimm...

journal_title：Pediatric diabetes

authors： Cinek O,Kramna L,Lin J,Oikarinen S,Kolarova K,Ilonen J,Simell O,Veijola R,Autio R,Hyöty H

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To investigate carbohydrate (CARB) and supplementary fat/protein (CFP) counting using normal and dual-wave bolus in pump therapy of children and young people with type 1 diabetes (T1D). STUDY DESIGN AND METHODS:A randomized clinical trial was conducted in 42 patients (age 6-21 yr) with T1D for at least 1 yr ...

journal_title：Pediatric diabetes

authors： Kordonouri O,Hartmann R,Remus K,Bläsig S,Sadeghian E,Danne T

更新日期：2012-11-01 00:00:00

abstract：:Diabetic neuropathy (DN) represents a major complication of type 1 diabetes mellitus (T1DM) but there is considerable uncertainty as to its incidence, prevalence, diagnosis and prognosis in pediatric population. Generally, DN is classified as polyneuropathy, focal neuropathy and autonomic neuropathy. The latter seems ...

journal_title：Pediatric diabetes

authors： Trotta D,Verrotti A,Salladini C,Chiarelli F

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Several intervention studies have convincingly demonstrated the importance of good glycemic control to avoid long-term diabetic complications, but the importance of other risk factors remains controversial. We previously reported a markedly reduced incidence of severe retinopathy and nephropathy during the p...

journal_title：Pediatric diabetes

authors： Nordwall M,Arnqvist HJ,Bojestig M,Ludvigsson J

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes mellitus (T2DM) is increasingly common among children and adolescents. However, achievement of good metabolic control has been difficult in this population. The aim of this study was to survey pediatric endocrine and diabetes specialists regarding the issues they consider to be barriers to suc...

journal_title：Pediatric diabetes

authors： Pinhas-Hamiel O,Zeitler P

更新日期：2003-03-01 00:00:00

abstract：:Because amylin is co-secreted with insulin from beta cells, patients with type 1 diabetes (T1DM) are deficient in both insulin and amylin. Amylin delays gastric emptying and suppresses glucagon in the postprandial period. Hence, we hypothesized that children with complication-naive T1DM have accelerated gastric emptyi...

journal_title：Pediatric diabetes

authors： Heptulla RA,Rodriguez LM,Mason KJ,Haymond MW

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The prevalence of macrovascular complications is probably underestimated in children with type 1 diabetes (T1D). Arterial stiffness (AS) is a subclinical marker of cardiovascular (CV) risk. The most validated, non-invasive method for AS measurement is pulse wave velocity (PWV). Only a few PWV studies have be...

journal_title：Pediatric diabetes

authors： Obermannova B,Petruzelkova L,Sulakova T,Sumnik Z

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Type 1 diabetes is an autoimmune disease occurring in genetically susceptible individuals. The precipitating cause is unclear. Recently, the Second Lebanon War exposed a large civilian population in northern Israel to significant psychological stress in the form of repeated barrages of missile attacks. HYPO...

journal_title：Pediatric diabetes

authors： Zung A,Blumenfeld O,Shehadeh N,Dally Gottfried O,Tenenbaum Rakover Y,Hershkovitz E,Gillis D,Zangen D,Pinhas-Hamiel O,Hanukoglu A,Rachmiel M,Shalitin S,Israel IDDM Registry Study Group.

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Hemoglobin A1c (HbA1c) levels have been shown to worsen in adolescence and be related to long-term diabetes complications. Although categories of diabetes control (e.g., ideal, satisfactory, and poor) are routinely used in clinical practice, research has not fully explored whether these categories meaningful...

journal_title：Pediatric diabetes

authors： Kichler JC,Kaugars AS,Ellis J,Alemzadeh R

更新日期：2010-12-01 00:00:00

abstract：AIM:To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes. METHODS:A nation-wide cohort, the Better Diabetes Diagnosis study was used to determine serum C-peptide at diagnosis in 2734 children and adolescents. Clinical data were collected at diagnosis and follow-up....

journal_title：Pediatric diabetes

authors： Ludvigsson J,Carlsson A,Forsander G,Ivarsson S,Kockum I,Lernmark A,Lindblad B,Marcus C,Samuelsson U

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Real-time continuous glucose monitoring systems (RT-CGMS) are a recently introduced technology for type 1 diabetes and experience in children is limited. OBJECTIVE:To assess patient and caregiver's perception of benefits and disadvantages of RT-CGMS in children or young adults with type 1 diabetes mellitus ...

journal_title：Pediatric diabetes

authors： Cemeroglu AP,Stone R,Kleis L,Racine MS,Postellon DC,Wood MA

更新日期：2010-05-01 00:00:00

abstract：:We report an interesting and unique case of an overweight adolescent with a novel mutation of the maturity-onset diabetes of the young (MODY)3 gene [hepatocyte nuclear factor-1 alpha (HNF-1alpha)] and positive islet cell autoantibodies. The patient is a 17-yr-old Caucasian female, who was diagnosed with type 2 diabete...

journal_title：Pediatric diabetes

authors： Bowden SA,Hoffman RP

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes (T2D) in youth is recognized as a pediatric disease, but few reports describe the characteristics during diagnosis. We describe the clinical presentation of 503 youth with T2D. METHODS:The Pediatric Diabetes Consortium (PDC) T2D Clinic Registry enrolled T2D participants from eight pediatric d...

journal_title：Pediatric diabetes

authors： Klingensmith GJ,Connor CG,Ruedy KJ,Beck RW,Kollman C,Haro H,Wood JR,Lee JM,Willi SM,Cengiz E,Tamborlane WV,Pediatric Diabetes Consortium.

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Avoiding complications is paramount in diabetes management, but little is known about how, when, and what diabetes professionals disclose to parents and youths about this topic. RESEARCH DESIGN AND METHOD:Pediatric diabetes experts (n = 534) were surveyed about their practices and attitudes regarding informi...

journal_title：Pediatric diabetes

authors： Lochrie AS,Wysocki T,Burnett J,Buckloh LM,Antal H

更新日期：2009-02-01 00:00:00

abstract：:This study aimed to analyse the impact of the disease and treatment on health-related quality of life (HRQOL) in intensively treated young patients with diabetes. Our main hypothesis was that metabolic control, gender, age and socio-economic status predict HRQOL. All children and adolescents (n = 400, 191 girls) and p...

journal_title：Pediatric diabetes

authors： Hanberger L,Ludvigsson J,Nordfeldt S

更新日期：2009-09-01 00:00:00

abstract：:Despite the increased prevalence of type 2 diabetes mellitus (T2DM) in the pediatric population, there is limited information about the relative effectiveness of treatment approaches. This article describes the rationale and design of a National Institutes of Health-sponsored multi-site, randomized, parallel group cli...

journal_title：Pediatric diabetes

authors： TODAY Study Group.,Zeitler P,Epstein L,Grey M,Hirst K,Kaufman F,Tamborlane W,Wilfley D

更新日期：2007-04-01 00:00:00

abstract：:A subgroup of diabetic patients presents with features typical of type 1 diabetes, but over months to years has variable insulin requirements and develops features of type 2 diabetes. This subgroup is referred to as atypical diabetes mellitus (ADM). Over a span of 50 yr, reports on disease epidemiology, clinical chara...

journal_title：Pediatric diabetes

authors： Egede LE,Willi SM

更新日期：2000-12-01 00:00:00

abstract：AIM:The aim of this study was to compare genetic (HLA-DQ) and immune markers in a large population of type 1 diabetic (T1D) children and adolescents residing in the same environment, but of different ethnic origin: European Caucasians (EC), Moghrabin Caucasians (MC), Black Africans (BA) and of Mixed Origin (MO). METHO...

journal_title：Pediatric diabetes

authors： Stoupa A,Dorchy H

更新日期：2016-08-01 00:00:00

abstract：:This review highlights the evidence of linking small for gestational age (SGA) with metabolic/cardiovascular disturbances (dysmetabolic syndrome) in later life. The metabolic and cardiovascular complications associated with in utero undernutrition have been identified during the past 10 yr. Reduced fetal growth is ind...

journal_title：Pediatric diabetes

authors： Levy-Marchal C,Jaquet D

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. METHODS:Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding ...

journal_title：Pediatric diabetes

authors： Brekke HK,Ludvigsson J

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of initial insulin dosage on blood glucose (BG) dynamics, β-cell protection, and oxidative stress in type 1 diabetes mellitus. METHODS:Sixty newly diagnosed type 1 diabetes mellitus patients were randomly assigned to continuous subcutaneous insulin infusions of 0.6 ± 0.2 IU/kg/d (gr...

journal_title：Pediatric diabetes

authors： Wang Y,Gong C,Cao B,Meng X,Wei L,Wu D,Liang X,Li W,Liu M,Gu Y,Su C

更新日期：2017-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Adolescents with type 1 diabetes (T1D) often have a less atherogenic-appearing fasting lipid profile than controls, despite increased rates of cardiovascular disease (CVD) as adults. We previously reported an atherogenic lipoprotein subfraction cholesterol distribution associated with insulin resistance...

journal_title：Pediatric diabetes

authors： Cree-Green M,Maahs DM,Ferland A,Hokanson JE,Wang H,Pyle L,Kinney GL,King M,Eckel RH,Nadeau KJ

更新日期：2016-06-01 00:00:00

abstract：:Inadequate treatment adherence impedes achievement of glycemic control targets in type 1 diabetes (T1D). Valid and reliable measurement of treatment adherence is a prerequisite to rigorous evaluation of pertinent interventions. The diabetes self-management profile (DSMP), a structured interview measure of T1D adherenc...

journal_title：Pediatric diabetes

authors： Wysocki T,Buckloh LM,Antal H,Lochrie A,Taylor A

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Type 2 Diabetes (T2DM) is increasing in childhood especially among females and South-Asians. Our objective was to report outcomes from a national cohort of children and adolescents with T2DM 1 year following diagnosis. METHODS:Clinician reported, 1-year follow-up of a cohort of children (<17 years...

journal_title：Pediatric diabetes

authors： Candler TP,Mahmoud O,Lynn RM,Majbar AA,Barrett TG,Shield JPH

更新日期：2018-12-01 00:00:00

abstract：:Neonatal diabetes mellitus is rare, may either be transient or permanent, and may be caused by mutations in any of the several different genes. Until recently, most forms of permanent neonatal diabetes required lifelong subcutaneous insulin for management; however, permanent neonatal diabetes due to activating mutatio...

journal_title：Pediatric diabetes

authors： Bremer AA,Ranadive S,Lustig RH

更新日期：2008-06-01 00:00:00

abstract：:Beta cell replacement is a valid alternative to exogenous insulin injections to treat type 1 diabetic patients. The rate of success obtained after whole-pancreas transplantation, performed alone or in combination with kidney, and, as shown recently, by islet transplantation, justifies optimism and sets the stage for a...

journal_title：Pediatric diabetes

authors： Bottino R,Balamurugan AN,Giannoukakis N,Trucco M

更新日期：2002-12-01 00:00:00

abstract：AIMS:We aimed to analyze the relationship between epilepsy and glutamic acid decarboxylase autoantibodies (GADA) in patients with type 1 diabetes mellitus (T1DM) and the impact of GADA on demographic, clinical, and metabolic data in T1DM patients with epilepsy. METHODS:We searched for patients with T1DM ≤20 years and ...

journal_title：Pediatric diabetes

authors： de Sousa GJ,Tittel SR,Häusler M,Holterhus PM,Berger G,Holder M,Kamrath C,Golembowski S,Herrlinger S,Holl RW

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To examine risk factors for re-hospitalization after diagnosis of diabetes mellitus amongst urban minority children. METHODS:Families of insulin-treated African-American and Latino patients aged < 18 yr at diagnosis (n = 216) were interviewed about sociodemographics and other characteristics, on average 5.9 yr...

journal_title：Pediatric diabetes

authors： Lipton RB,Zierold KM,Drum ML,Klein-Gitelman M,Kohrman AF

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Insulin pump therapy is well established in the treatment of children and adolescents with type 1 diabetes. Most studies focus on outcome parameters like hemoglobin A1c (HbA1c), hypoglycemia, and quality of life, whereas few reports address patients who discontinue pump therapy. OBJECTIVE:This survey focuse...

journal_title：Pediatric diabetes

authors： Hofer SE,Heidtmann B,Raile K,Fröhlich-Reiterer E,Lilienthal E,Berghaeuser MA,Holl RW,DPV-Science-Initiative and the German working group for insulin pump treatment in pediatric patients.

更新日期：2010-03-01 00:00:00

abstract：:The prevalence of youth-onset type 2 diabetes is increasing worldwide in parallel with the obesity epidemic. In India, the age at onset of type 2 diabetes had traditionally been a decade or two earlier compared with the western population. Hence, it is not surprising that the prevalence of youth-onset type 2 diabetes ...

journal_title：Pediatric diabetes

authors： Mohan V,Jaydip R,Deepa R

更新日期：2007-12-01 00:00:00