Abstract:
BACKGROUND:Type 1 diabetes is an autoimmune disease occurring in genetically susceptible individuals. The precipitating cause is unclear. Recently, the Second Lebanon War exposed a large civilian population in northern Israel to significant psychological stress in the form of repeated barrages of missile attacks. HYPOTHESIS:We hypothesized that trends in regional incidence of type 1 diabetes before and after the war would reflect an association with stress. METHODS:All type 1 diabetes patients aged 0-17 yr who were reported to the Israel Juvenile Diabetes Register (n = 1822) in the four pre-war (2002-2005) and two post-war years (2006-2007) were included in the study. The patients were stratified by gender, age, ethnicity, family history of type 1 diabetes, season at diagnosis, and region of residency, namely, those who lived in the northern regions that were attacked and those in other regions. RESULTS:The post-war incidence of type 1 diabetes was increased in the northern regions (rate ratio, RR = 1.27; p = 0.037), with no change in the other regions. This change was more prominent in males (RR = 1.55; p = 0.005) but similar in summer and winter, in different ages, and in different ethnic groups. There was no change in the proportion of new patients with a family history of the disease. CONCLUSIONS:For the first time in a large population, we found a positive association between the trauma of war and an increase in the incidence of type 1 diabetes in children and adolescents. The increase in incidence was not associated with genetic susceptibility to the disease.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Zung A,Blumenfeld O,Shehadeh N,Dally Gottfried O,Tenenbaum Rakover Y,Hershkovitz E,Gillis D,Zangen D,Pinhas-Hamiel O,Hanukoglu A,Rachmiel M,Shalitin S,Israel IDDM Registry Study Group.doi
10.1111/j.1399-5448.2011.00838.xsubject
Has Abstractpub_date
2012-06-01 00:00:00pages
326-33issue
4eissn
1399-543Xissn
1399-5448journal_volume
13pub_type
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journal_title:Pediatric diabetes
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更新日期:2018-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,评审
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2007.00268.x
更新日期:2008-04-01 00:00:00
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journal_title:Pediatric diabetes
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更新日期:2019-06-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00807.x
更新日期:2012-02-01 00:00:00
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更新日期:2020-06-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12222
更新日期:2015-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00826.x
更新日期:2012-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1399-5448.2011.00812.x
更新日期:2012-02-01 00:00:00
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journal_title:Pediatric diabetes
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2010.00686.x
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更新日期:2018-05-20 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
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更新日期:2011-06-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00604.x
更新日期:2010-09-01 00:00:00
abstract:AIMS:Intravenous glucose tolerance testing (IVGTT) is a common test of β-cell function in which a glucose load is administered and insulin and/or C-peptide responses are monitored. Since the first IVGTT may be more stressful and stress may alter β-cell secretion or hepatic insulin extraction, we asked whether there was...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12064
更新日期:2015-03-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2008.00463.x
更新日期:2009-05-01 00:00:00
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journal_title:Pediatric diabetes
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更新日期:2017-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
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更新日期:2014-03-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00628.x
更新日期:2010-11-01 00:00:00