当前位置： SCI文献检索 > PEDIATRIC DIABETES期刊下所有文献 > A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants.

A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants.

Abstract：

OBJECTIVE:We assessed whether differing autoantibody screening criteria for type 1 diabetes (T1D) prevention trials result in different baseline metabolic profiles of those who screen positive. METHODS:Diabetes Prevention Trial-Type 1 (DPT-1) participants were screened for islet cell autoantibodies, whereas TrialNet Natural History Study (TNNHS) participants were screened for biochemical autoantibodies. In both studies, those determined to be autoantibody positive underwent baseline oral glucose tolerance tests (OGTTs) in which glucose and C-peptide were measured. RESULTS:The percentage of those with an OGTT in the diabetic range was higher among the DPT-1 participants (10.0% of 956 vs. 6.4% of 645, p < 0.01). In a logistic regression analysis with adjustments for age and gender, the difference persisted (p < 0.01). Among those in the non-diabetic range (n = 860 for DPT-1 and n = 604 for the TNNHS), glucose levels were similar at all time points, except for higher fasting glucose levels in the TNNHS participants (p < 0.001). There was a higher percentage of impaired fasting glucose (IFG) in the TNNHS participants (10.9 vs. 6.7%, p < 0.01); however, with adjustments for age and gender, there was no longer a significant difference. There was no significant difference in the percentages with impaired glucose tolerance. C-peptide levels were much lower in the DPT-1 cohort at all OGTT time points (p < 0.001 for all). DISCUSSION:Differing criteria for autoantibody screening can result in marked differences in the baseline metabolic profiles of prospective participants of T1D prevention trials.

journal_name

Pediatr Diabetes

journal_title

Pediatric diabetes

authors

Sosenko JM,Mahon J,Rafkin L,Lachin JM,Krause-Steinrauf H,Krischer JP,Cuthbertson D,Palmer JP,Thompson C,Greenbaum CJ,Skyler JS,Diabetes Prevention Trial-Type 1 and TrialNet Study Groups.

doi

10.1111/j.1399-5448.2010.00662.x

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

85-90

issue

2

eissn

1399-543X

issn

1399-5448

pii

PDI662

journal_volume

12

pub_type

杂志文章

相关文献

PEDIATRIC DIABETES文献大全
  • Aerobic exercise capacity in normal adolescents and those with type 1 diabetes mellitus.

    abstract：OBJECTIVE:To compare the aerobic exercise capacity between normal adolescents and those with type 1 diabetes mellitus (T1DM). METHODS:An experimental group with 72 individuals diagnosed with T1DM aged 9--20, time from diagnosis 4.9 +/- 3.6 yr, without clinical cardiopulmonary disease or anemia and a control group (C) ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-543X.2005.00120.x

    authors： Komatsu WR,Gabbay MA,Castro ML,Saraiva GL,Chacra AR,de Barros Neto TL,Dib SA

    更新日期：2005-09-01 00:00:00

  • Measurement of diabetes stress in older children and adolescents with type 1 diabetes mellitus.

    abstract：OBJECTIVE:Studies indicate general psychological stress plays a role in the glycemic control of individuals with type 1 diabetes mellitus (T1DM). Disease-specific rather than general measures may be more closely related to measures of health outcomes. Therefore, measurement of diabetes-related stress is needed to advan...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2012.00894.x

    authors： Delamater AM,Patiño-Fernández AM,Smith KE,Bubb J

    更新日期：2013-02-01 00:00:00

  • Glycemic extremes in youth with T1DM: the structural and functional integrity of the developing brain.

    abstract：:The adult brain accounts for a disproportionally large percentage of the body’s total energy consumption (1). However, during brain development,energy demand is even higher, reaching the adult rate by age 2 and increasing to nearly twice the adult rate by age 10, followed by gradual reduction toward adult levels in th...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,评审

    doi：10.1111/pedi.12088

    authors： Arbelaez AM,Semenkovich K,Hershey T

    更新日期：2013-12-01 00:00:00

  • Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.

    abstract：AIMS:Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS:In 47 healthy children with GADA and at ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12023

    authors： Andersson C,Carlsson A,Cilio C,Cedervall E,Ivarsson SA,Jonsdottir B,Jönsson B,Larsson K,Neiderud J,Lernmark A,Elding Larsson H,DiAPREV-IT Study Group.

    更新日期：2013-08-01 00:00:00

  • Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring--the ABIS study.

    abstract：OBJECTIVE:To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. METHODS:Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2009.00563.x

    authors： Brekke HK,Ludvigsson J

    更新日期：2010-06-01 00:00:00

  • The changing presentation of children with newly diagnosed type 1 diabetes mellitus.

    abstract：:Although it is known that the incidence of type 1 diabetes mellitus (DM) in childhood is progressively increasing, it is less clear whether the presentation of newly diagnosed DM is changing. The aim of this study was to establish whether any biochemical or clinical presentation parameters have altered over time. A re...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1034/j.1399-5448.2001.20403.x

    authors： Jackson W,Hofman PL,Robinson EM,Elliot RB,Pilcher CC,Cutfield WS

    更新日期：2001-12-01 00:00:00

  • Corrigendum.

    abstract：:In connection with the article entitled "A randomized trial comparing the rate of hypoglycemia – assessed using continuous glucose monitoring – in 125 preschool children with type 1 diabetes treated with insulin glargine or NPH insulin (the PRESCHOOL study)" which appeared in [1], we wish to bring the following correc...

    journal_title：Pediatric diabetes

    pub_type： 已发布勘误

    doi：10.1111/pedi.12207

    authors：

    更新日期：2015-09-01 00:00:00

  • Barriers to the treatment of adolescent type 2 diabetes--a survey of provider perceptions.

    abstract：OBJECTIVE:Type 2 diabetes mellitus (T2DM) is increasingly common among children and adolescents. However, achievement of good metabolic control has been difficult in this population. The aim of this study was to survey pediatric endocrine and diabetes specialists regarding the issues they consider to be barriers to suc...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1034/j.1399-5448.2003.00027.x

    authors： Pinhas-Hamiel O,Zeitler P

    更新日期：2003-03-01 00:00:00

  • Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes.

    abstract：:Despite the increased prevalence of type 2 diabetes mellitus (T2DM) in the pediatric population, there is limited information about the relative effectiveness of treatment approaches. This article describes the rationale and design of a National Institutes of Health-sponsored multi-site, randomized, parallel group cli...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1399-5448.2007.00237.x

    authors： TODAY Study Group.,Zeitler P,Epstein L,Grey M,Hirst K,Kaufman F,Tamborlane W,Wilfley D

    更新日期：2007-04-01 00:00:00

  • Detection and treatment efficacy of hypoglycemic events in the everyday life of children younger than 7 yr.

    abstract：BACKGROUND:Mild hypoglycemia is commonly observed in children treated for type 1 diabetes mellitus (T1DM). Hypoglycemia disturbs cognition and learning. OBJECTIVE:To describe how and to what extent hypoglycemia in young children with T1DM is detected in everyday life. To learn how parents and caregivers treat hypoglyc...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12057

    authors： Sundberg F,Forsander G

    更新日期：2014-02-01 00:00:00

  • Premeal insulin decreases arterial stiffness in children with type 1 diabetes.

    abstract：OBJECTIVE:To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI75 ) were used to measure arterial stiffness...

    journal_title：Pediatric diabetes

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/pedi.12389

    authors： Meehan CS,Kethireddy PL,Ashcraft JK,Shuster JJ,Haller MJ

    更新日期：2017-06-01 00:00:00

  • Handgrip strength is associated with insulin resistance and glucose metabolism in adolescents: Evidence from National Health and Nutrition Examination Survey 2011 to 2014.

    abstract：BACKGROUND:Previous studies have reported that handgrip strength, a measure of muscular fitness, is associated with insulin resistance in children and adolescents, with conflicting results. Further, no studies have examined the association between handgrip strength with 2-hour glucose levels. OBJECTIVE:We tested the a...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12596

    authors： Li S,Zhang R,Pan G,Zheng L,Li C

    更新日期：2018-05-01 00:00:00

  • Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults.

    abstract：BACKGROUND:Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. SUBJECTS AND METHODS:We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12883

    authors： RISE Consortium.

    更新日期：2019-11-01 00:00:00

  • Triglyceride to high-density lipoprotein cholesterol ratio and carotid intima-medial thickness in Chinese adolescents with newly diagnosed type 2 diabetes mellitus.

    abstract：OBJECTIVE:To investigate the relationship between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and carotid intima-medial thickness (CIMT) in Chinese youth and adolescents with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Ninety-eight subjects aged 10-24 yr with newly-diagnosed T2DM...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12250

    authors： Li X,Deng YP,Yang M,Wu YW,Sun SX,Sun JZ

    更新日期：2016-03-01 00:00:00

  • The proportion of familial cases of type 1 diabetes is increasing simultaneously with the disease incidence: Eighteen years of the Israeli Pediatric Diabetes Registry.

    abstract：BACKGROUND:The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need for genetic susceptibility has lessened over time, we hypothesized that the rise in T1D incidence is...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12617

    authors： Zung A,Na'amnih W,Bluednikov Y,Mery N,Blumenfeld O,Israel IDDM Registry Study Group (IRRSG).

    更新日期：2018-06-01 00:00:00

  • Clinical picture of childhood type 1 diabetes mellitus in the Eastern Province of Saudi Arabia.

    abstract：AIM:Study of the clinical presentation and laboratory data of type 1 diabetes in the Eastern Province of Saudi Arabia. METHODS:The medical records of all affected children during the period 1986-1997 were reviewed for the analysis of clinical and laboratory data. RESULTS:Type 1 diabetes was diagnosed in 46 children, ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1046/j.1399-543x.2001.00000.x

    authors： Kulaylat NA,Narchi H

    更新日期：2001-03-01 00:00:00

  • Maternal diabetes distress is linked to maternal depressive symptoms and adolescents' glycemic control.

    abstract：OBJECTIVE:Mothers of youth with type 1 diabetes experience increased levels of stress and depression related to the burden of diabetes management, but the concept of diabetes distress, or distress linked specifically to diabetes and its management, has not been applied to mothers. The current study examined diabetes di...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12350

    authors： Rumburg TM,Lord JH,Savin KL,Jaser SS

    更新日期：2017-02-01 00:00:00

  • Partial ABCC8 gene deletion mutations causing diazoxide-unresponsive hyperinsulinaemic hypoglycaemia.

    abstract：:Inactivating mutations in the pancreatic beta cell ATP-sensitive potassium (K(ATP) ) channel genes are identified by sequencing in approximately 80% of patients with diazoxide-unresponsive hyperinsulinaemic hypoglycaemia (HH). Genetic testing is clinically important as the mode of inheritance of a K(ATP) channel mutat...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2011.00821.x

    authors： Flanagan S,Damhuis A,Banerjee I,Rokicki D,Jefferies C,Kapoor R,Hussain K,Ellard S

    更新日期：2012-05-01 00:00:00

  • Practical matters, rather than lack of trust, motivate non-participation in a long-term cohort trial.

    abstract：OBJECTIVE:The objective of this study was to investigate the importance of trust in researchers and other reasons that participating parents, former participants, and non-participants had for participating, or not participating, in a longitudinal cohort study on prediction and development of diabetes in children. STUD...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2008.00498.x

    authors： Helgesson G,Hansson MG,Ludvigsson J,Swartling U

    更新日期：2009-09-01 00:00:00

  • Outpatient transition of an infant with permanent neonatal diabetes due to a KCNJ11 activating mutation from subcutaneous insulin to oral glyburide.

    abstract：:Neonatal diabetes mellitus is rare, may either be transient or permanent, and may be caused by mutations in any of the several different genes. Until recently, most forms of permanent neonatal diabetes required lifelong subcutaneous insulin for management; however, permanent neonatal diabetes due to activating mutatio...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2007.00316.x

    authors： Bremer AA,Ranadive S,Lustig RH

    更新日期：2008-06-01 00:00:00

  • Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes.

    abstract：BACKGROUND:In the non-diabetic population, intramyocellular lipid (IMCL) accumulation is associated with obesity and poor muscle oxygen supply. IMCL levels are increased in type 1 diabetes, but their significance is less clear. METHODS:We studied a group of 16 prepubertal boys (age 6.4-9.9 yr) with type 1 diabetes and...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1034/j.1399-5448.2003.00021.x

    authors： Ling AH,Donaghue KC,Howard NJ,Arrowsmith FE,Ward JA,Baur LA,Thompson CH

    更新日期：2003-09-01 00:00:00

  • β-cell autoimmunity in overweight non-diabetic youth: any implications?

    abstract：BACKGROUND AND OBJECTIVE:The presence of β-cell antibodies is associated with a high risk of type 1 diabetes. With increasing rates of obesity, the distinction between obese T1DM and T2DM has become difficult. Moreover, increasing body mass index (BMI) in at-risk children has been proposed not only as a possible contri...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2010.00697.x

    authors： Libman IM,Barinas-Mitchell E,Marcovina S,Bacha F,Hannon T,Tfayli H,Lee SJ,Bansal S,Robertson R,Arslanian S

    更新日期：2011-05-01 00:00:00

  • Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations.

    abstract：BACKGROUND:Dominant inactivating mutations in HNF1A and HNF4A have been described to cause hyperinsulinism (HI) before evolving to diabetes. However, information available in the literature regarding the clinical phenotype is limited. OBJECTIVE:To report the prevalence of HNF1A and HNF4A mutations in a large cohort of...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12655

    authors： Tung JY,Boodhansingh K,Stanley CA,De León DD

    更新日期：2018-08-01 00:00:00

  • Vitamin D status in youth with type 1 and type 2 diabetes enrolled in the Pediatric Diabetes Consortium (PDC) is not worse than in youth without diabetes.

    abstract：OBJECTIVE:To describe vitamin D levels and prevalence of vitamin D sufficiency, insufficiency and deficiency in a large, ethnically/racially diverse population of youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) in comparison to national data and examine the associations between clinical/demographic factors a...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12340

    authors： Wood JR,Connor CG,Cheng P,Ruedy KJ,Tamborlane WV,Klingensmith G,Schatz D,Gregg B,Cengiz E,Willi S,Bacha F,Beck RW,Pediatric Diabetes Consortium.

    更新日期：2016-12-01 00:00:00

  • Use of a real-time continuous glucose monitoring system in children and young adults on insulin pump therapy: patients' and caregivers' perception of benefit.

    abstract：BACKGROUND:Real-time continuous glucose monitoring systems (RT-CGMS) are a recently introduced technology for type 1 diabetes and experience in children is limited. OBJECTIVE:To assess patient and caregiver's perception of benefits and disadvantages of RT-CGMS in children or young adults with type 1 diabetes mellitus ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2009.00549.x

    authors： Cemeroglu AP,Stone R,Kleis L,Racine MS,Postellon DC,Wood MA

    更新日期：2010-05-01 00:00:00

  • Insulin Resistance during normal child growth and development is associated with a distinct blood metabolic phenotype (Earlybird 72).

    abstract：BACKGROUND:While insulin resistance (IR) is associated with specific metabolite signatures in adults, there have been few truly longitudinal studies in healthy children, either to confirm which abnormalities are present, or to determine whether they precede or result from IR. Therefore, we investigated the association ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12884

    authors： Hosking J,Pinkney J,Jeffery A,Cominetti O,Da Silva L,Collino S,Kussmann M,Hager J,Martin FP

    更新日期：2019-11-01 00:00:00

  • DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young.

    abstract：OBJECTIVE:Mechanisms underlying the role of non-human leukocyte antigen (HLA) genetic risk variants in type 1 diabetes (T1D) are poorly understood. We aimed to test the association between methylation and non-HLA genetic risk. METHODS:We conducted a methylation quantitative trait loci (mQTL) analysis in a nested case-...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12995

    authors： Carry PM,Vanderlinden LA,Johnson RK,Dong F,Steck AK,Frohnert BI,Rewers M,Yang IV,Kechris K,Norris JM

    更新日期：2020-06-01 00:00:00

  • Glargine co-administration with intravenous insulin in pediatric diabetic ketoacidosis is safe and facilitates transition to a subcutaneous regimen.

    abstract：BACKGROUND:Diabetes ketoacidosis (DKA) is a common presentation and complication of type 1 diabetes (T1D). While intravenous insulin is typically used to treat acute metabolic abnormalities, the transition from intravenous to subcutaneous treatment can present a challenge. We hypothesize that co-administration of glarg...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12462

    authors： Harrison VS,Rustico S,Palladino AA,Ferrara C,Hawkes CP

    更新日期：2017-12-01 00:00:00

  • A Swedish approach to the prevention of type 1 diabetes.

    abstract：BACKGROUND:The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. OBJECTIVES:Ongoing...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,评审

    doi：10.1111/pedi.12325

    authors： Elding Larsson H

    更新日期：2016-07-01 00:00:00

  • Metabolic inflexibility and insulin resistance in obese adolescents with non-alcoholic fatty liver disease.

    abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a comorbidity of childhood obesity. OBJECTIVE:We examined whole-body substrate metabolism and metabolic characteristics in obese adolescents with vs. without NAFLD. SUBJECTS:Twelve obese (BMI ≥ 95th percentile) adolescents with and without NAFLD [intrahepatic tr...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12141

    authors： Lee S,Rivera-Vega M,Alsayed HM,Boesch C,Libman I

    更新日期：2015-05-01 00:00:00