Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes.

abstract：BACKGROUND/OBJECTIVE:Restrictive eligibility criteria have hampered enrollment into trials for new drugs for youth with type 2 diabetes (T2D). We utilized Pediatric Diabetes Consortium (PDC) T2D Registry enrollment data to estimate the percentage of patients who would be excluded from current T2D trials based on out-of...

journal_title：Pediatric diabetes

authors： Tamborlane WV,Chang P,Kollman C,Klingensmith GJ,Ruedy K,Gal RL,Van Name M,Bacha F,Willi S,Beck RW,Pediatric Diabetes Consortium.

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a comorbidity of childhood obesity. OBJECTIVE:We examined whole-body substrate metabolism and metabolic characteristics in obese adolescents with vs. without NAFLD. SUBJECTS:Twelve obese (BMI ≥ 95th percentile) adolescents with and without NAFLD [intrahepatic tr...

journal_title：Pediatric diabetes

authors： Lee S,Rivera-Vega M,Alsayed HM,Boesch C,Libman I

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To examine risk factors for re-hospitalization after diagnosis of diabetes mellitus amongst urban minority children. METHODS:Families of insulin-treated African-American and Latino patients aged < 18 yr at diagnosis (n = 216) were interviewed about sociodemographics and other characteristics, on average 5.9 yr...

journal_title：Pediatric diabetes

authors： Lipton RB,Zierold KM,Drum ML,Klein-Gitelman M,Kohrman AF

更新日期：2002-03-01 00:00:00

abstract：:Because amylin is co-secreted with insulin from beta cells, patients with type 1 diabetes (T1DM) are deficient in both insulin and amylin. Amylin delays gastric emptying and suppresses glucagon in the postprandial period. Hence, we hypothesized that children with complication-naive T1DM have accelerated gastric emptyi...

journal_title：Pediatric diabetes

authors： Heptulla RA,Rodriguez LM,Mason KJ,Haymond MW

更新日期：2008-12-01 00:00:00

abstract：:Beta cell replacement is a valid alternative to exogenous insulin injections to treat type 1 diabetic patients. The rate of success obtained after whole-pancreas transplantation, performed alone or in combination with kidney, and, as shown recently, by islet transplantation, justifies optimism and sets the stage for a...

journal_title：Pediatric diabetes

authors： Bottino R,Balamurugan AN,Giannoukakis N,Trucco M

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Mechanisms underlying the role of non-human leukocyte antigen (HLA) genetic risk variants in type 1 diabetes (T1D) are poorly understood. We aimed to test the association between methylation and non-HLA genetic risk. METHODS:We conducted a methylation quantitative trait loci (mQTL) analysis in a nested case-...

journal_title：Pediatric diabetes

authors： Carry PM,Vanderlinden LA,Johnson RK,Dong F,Steck AK,Frohnert BI,Rewers M,Yang IV,Kechris K,Norris JM

更新日期：2020-06-01 00:00:00

abstract：:Diabetic ketoacidosis (DKA) is one of the most common causes of morbidity and mortality in new onset type 1 diabetes mellitus (T1DM). Children have a higher rate of neurological complications from DKA when compared to adults. The differential for sudden focal neurological deterioration in the setting of DKA is cerebra...

journal_title：Pediatric diabetes

authors： Finn BP,Power C,McSweeney N,Breen D,Wyse G,O'Connell SM

更新日期：2018-12-01 00:00:00

abstract：AIM:The aim of this study was to compare genetic (HLA-DQ) and immune markers in a large population of type 1 diabetic (T1D) children and adolescents residing in the same environment, but of different ethnic origin: European Caucasians (EC), Moghrabin Caucasians (MC), Black Africans (BA) and of Mixed Origin (MO). METHO...

journal_title：Pediatric diabetes

authors： Stoupa A,Dorchy H

更新日期：2016-08-01 00:00:00

abstract：:Inactivating mutations in the pancreatic beta cell ATP-sensitive potassium (K(ATP) ) channel genes are identified by sequencing in approximately 80% of patients with diazoxide-unresponsive hyperinsulinaemic hypoglycaemia (HH). Genetic testing is clinically important as the mode of inheritance of a K(ATP) channel mutat...

journal_title：Pediatric diabetes

authors： Flanagan S,Damhuis A,Banerjee I,Rokicki D,Jefferies C,Kapoor R,Hussain K,Ellard S

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Regulatory T cells (Tregs) play an important role in maintaining tolerance to self-antigens. Defects in the frequency and function of polyclonal Tregs have been reported in type 1 diabetes (T1D). However, characteristics of proinsulin (PI)-specific Tregs in human T1D have not yet been explored...

journal_title：Pediatric diabetes

authors： Paul M,Dayal D,Bhansali A,Sachdeva N

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI75 ) were used to measure arterial stiffness...

journal_title：Pediatric diabetes

authors： Meehan CS,Kethireddy PL,Ashcraft JK,Shuster JJ,Haller MJ

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To explore the outcomes of monthly video consultations for children with diabetes. METHODS:The Virtual Outpatient Diabetes Clinic for Children and Youth (VIDIKI) was a 6-month multicenter controlled clinical trial followed by an extension phase. The 240 participants (1-16 years), all using a CGM, were quasi-...

journal_title：Pediatric diabetes

authors： von Sengbusch S,Eisemann N,Mueller-Godeffroy E,Lange K,Doerdelmann J,Erdem A,Menrath I,Bokelmann J,Krasmann M,Kaczmarczyk P,Bertram B,Hiort O,Katalinic A,Frielitz FS

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:It is unknown whether measurement site of visceral adipose tissue (VAT) influences the relationship between VAT and associated health risk in youth and if so, whether ethnic differences exist in this relationship. We examined the influence of the measurement site of VAT on the relationships between VAT and me...

journal_title：Pediatric diabetes

authors： Lee S,Kuk JL,Kim Y,Arslanian SA

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the effectiveness of directly integrating self-monitoring blood glucose (BG) information with insulin pump therapy on overall glycemic control. METHODS:In this randomized trial, 34 youth with type 1 diabetes using insulin pump therapy were trained on the use of the ...

journal_title：Pediatric diabetes

authors： Cobry E,Chase HP,Burdick P,McFann K,Yetzer H,Scrimgeour L

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) ≤ 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. METHODS:We analyzed the preval...

journal_title：Pediatric diabetes

authors： Camilo DS,Pradella F,Paulino MF,Baracat ECE,Marini SH,Guerra G Jr,Pavin EJ,Parisi C,Longhini ALF,Marques SB,Guariento EG,Lieber SR,Macedo CF,Gama E Silva L,Farias AS,Santos LMB,Volpini WMG

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:To compare outcomes of diabetic ketoacidosis (DKA) 6 yrs before and 6 yrs after changing rehydration fluids from ½ normal saline to Lactated Ringer's and decreasing the total intended fluid volume administered in the first 24 hrs from 3500 mL/m(2) /d to ≤ 2500 mL/m(2) /d at Texas Children's Hospital (TCH) in ...

journal_title：Pediatric diabetes

authors： Hsia DS,Tarai SG,Alimi A,Coss-Bu JA,Haymond MW

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Identify and evaluate current treatment recommendations in Europe for the care of children with diabetes in view of the European Union (EU) recommendations for Reference Centers. METHODS:A questionnaire was sent in 2008 to representatives of all EU countries and Norway, all known to be actively involved in p...

journal_title：Pediatric diabetes

authors： de Beaufort C,Vazeou A,Sumnik Z,Cinek O,Hanas R,Danne T,Aschemeier B,Forsander G,SWEET group.

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be assoc...

journal_title：Pediatric diabetes

authors： Bjornstad P,Cree-Green M,Baumgartner A,Coe G,Reyes YG,Schäfer M,Pyle L,Regensteiner JG,Reusch JE,Nadeau KJ

更新日期：2018-05-01 00:00:00

abstract：:Type 1 diabetes is the most common form of diabetes in most part of the world, although reliable data are still unavailable in several countries. Wide variations exist between the incidence rates of different populations, incidence is lowest in China and Venezuela (0.1 per 100,000 per year) and highest in Finland and ...

journal_title：Pediatric diabetes

authors： Soltesz G,Patterson CC,Dahlquist G,EURODIAB Study Group.

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:We assessed pubertal development, height, weight, and waist-to-hip ratio (WHR), an index of central adiposity during puberty, in girls with type-1 diabetes mellitus (T1DM), compared to a contemporary control group. METHODS:Pubertal development, weight, height and WHR were studied in 100 pubertal girls with ...

journal_title：Pediatric diabetes

authors： Codner E,Barrera A,Mook-Kanamori D,Bazaes RA,Unanue N,Gaete X,Avila A,Ugarte F,Torrealba I,Pérez V,Panteón E,Cassorla F

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Managing type 1 diabetes can be challenging, especially for youth, so there is a need for effective interventions to help youth live with diabetes. OBJECTIVE:To determine the efficacy of a coping skills training (CST) program for Chinese youth with type 1 diabetes and to explore whether the efficacy of the ...

journal_title：Pediatric diabetes

authors： Guo J,Luo J,Yang J,Huang L,Wiley J,Liu F,Li X,Zhou Z,Whittemore R

更新日期：2020-05-01 00:00:00

abstract：:Activating mutations in the K(ATP)-channel cause neonatal diabetes mellitus (NDM), and patients have been safely transitioned from insulin to sulfonylureas. We report a male infant with permanent NDM (PNDM), born to a PNDM mother. Blood glucose began to rise on day of life (DOL) 2, and sulfonylurea (glyburide) therapy...

journal_title：Pediatric diabetes

authors： Wambach JA,Marshall BA,Koster JC,White NH,Nichols CG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Care for children and youth with diabetes varies markedly around the world. We developed a standardized, reproducible measure that can be used to document and compare critical factors influencing treatment outcomes. METHODS:A questionnaire consisting of 36 multiple-choice questions covering m...

journal_title：Pediatric diabetes

authors： Ogle GD,Middlehurst AC,Silink M

更新日期：2016-08-01 00:00:00

abstract：UNLABELLED:Previous studies have shown that vigorous aerobic training programs for obese children result in minimal weight changes, and concluded that they may not be beneficial. Weight change alone may not detect important beneficial changes in body composition associated with vigorous training in these children. Fift...

journal_title：Pediatric diabetes

authors： DeStefano RA,Caprio S,Fahey JT,Tamborlane WV,Goldberg B

更新日期：2000-06-01 00:00:00

abstract：:Neonatal diabetes mellitus is rare, may either be transient or permanent, and may be caused by mutations in any of the several different genes. Until recently, most forms of permanent neonatal diabetes required lifelong subcutaneous insulin for management; however, permanent neonatal diabetes due to activating mutatio...

journal_title：Pediatric diabetes

authors： Bremer AA,Ranadive S,Lustig RH

更新日期：2008-06-01 00:00:00

abstract：CONTEXT:Type 1 diabetes mellitus (T1DM) is a pro-inflammatory stress state, which, with its attendant hyperglycemia, likely disrupts hypothalamo-pituitary-adrenal (HPA) control, further dysregulating glucose homeostasis. OBJECTIVE:To test the hypothesis that endogenous adrenocorticotropic hormone (ACTH)-cortisol dose-...

journal_title：Pediatric diabetes

authors： Sharma AN,Wigham J,Veldhuis JD

更新日期：2014-09-01 00:00:00

abstract：:With the increasing success of islet transplantation, beta-cell replacement therapy has had renewed interest. To make such a therapy available to more than a few of the thousands of patients with diabetes, new sources of insulin-producing cells must become readily available. The most promising sources are stem cells, ...

journal_title：Pediatric diabetes

authors： Bonner-Weir S,Toschi E,Inada A,Reitz P,Fonseca SY,Aye T,Sharma A

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Trials in adults have demonstrated that interventions targeting lifestyle are effective in preventing or delaying type 2 diabetes (T2D). To address this need in youth, we developed ENCOURAGE Healthy Families (ENCOURAGE), based on the US Diabetes Prevention Program (DPP). STUDY DESIGN:Here, we present resu...

journal_title：Pediatric diabetes

authors： Hannon TS,Saha CK,Carroll AE,Palmer KN,O'Kelly Phillips E,Marrero DG

更新日期：2018-05-20 00:00:00

abstract：BACKGROUND:Pediatric diabetes clinics around the world rapidly adapted care in response to COVID-19. We explored provider perceptions of care delivery adaptations and challenges for providers and patients across nine international pediatric diabetes clinics. METHODS:Providers in a quality improvement collaborative com...

journal_title：Pediatric diabetes

authors： Cristello Sarteau A,Souris KJ,Wang J,Ramadan AA,Addala A,Bowlby D,Corathers S,Forsander G,King B,Law JR,Liu W,Malik F,Pihoker C,Seid M,Smart C,Sundberg F,Tandon N,Yao M,Headley T,Mayer-Davis E

更新日期：2021-01-19 00:00:00

abstract：:Hypertension and dyslipidemia are often suboptimally managed in teens with type 1 diabetes (T1D). Teen and parent perspectives on hypertension and dyslipidemia management need further study to enhance the development of cardiovascular disease (CVD) risk factor management plans. We sought to describe barriers to and st...

journal_title：Pediatric diabetes

authors： Katz ML,Guo Z,Cheema A,Laffel LM

更新日期：2019-03-01 00:00:00