Premeal insulin decreases arterial stiffness in children with type 1 diabetes.


OBJECTIVE:To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI75 ) were used to measure arterial stiffness. Children were randomized to receive or omit premeal insulin and completed the crossover portion of the study on a subsequent day. AI75 was determined when fasting, 1, and 2 h postmeal. RESULTS:When comparing change in AI75 from baseline to 1 h and baseline to 2 h, when subjects received premeal insulin vs. no insulin, AI75 was 4.5 units lower at 1 h (p = 0.011, 95% CI:1.1 lower to 8 lower) and 4.3 units lower at 2 h (p = 0.062, 95% CI: 0.2 higher to 8.9 lower) (n = 40). CONCLUSIONS:Arterial stiffness is decreased by premeal insulin in children with type 1 diabetes.


Pediatr Diabetes


Pediatric diabetes


Meehan CS,Kethireddy PL,Ashcraft JK,Shuster JJ,Haller MJ




Has Abstract


2017-06-01 00:00:00












  • Good glycemic control remains crucial in prevention of late diabetic complications--the Linköping Diabetes Complications Study.

    abstract:BACKGROUND:Several intervention studies have convincingly demonstrated the importance of good glycemic control to avoid long-term diabetic complications, but the importance of other risk factors remains controversial. We previously reported a markedly reduced incidence of severe retinopathy and nephropathy during the p...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Nordwall M,Arnqvist HJ,Bojestig M,Ludvigsson J

    更新日期:2009-05-01 00:00:00

  • HLA-DQ genotypes - but not immune markers - differ by ethnicity in patients with childhood onset type 1 diabetes residing in Belgium.

    abstract:AIM:The aim of this study was to compare genetic (HLA-DQ) and immune markers in a large population of type 1 diabetic (T1D) children and adolescents residing in the same environment, but of different ethnic origin: European Caucasians (EC), Moghrabin Caucasians (MC), Black Africans (BA) and of Mixed Origin (MO). METHO...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Stoupa A,Dorchy H

    更新日期:2016-08-01 00:00:00

  • Influence of initial insulin dosage on blood glucose dynamics of children and adolescents with newly diagnosed type 1 diabetes mellitus.

    abstract:OBJECTIVE:To investigate the effect of initial insulin dosage on blood glucose (BG) dynamics, β-cell protection, and oxidative stress in type 1 diabetes mellitus. METHODS:Sixty newly diagnosed type 1 diabetes mellitus patients were randomly assigned to continuous subcutaneous insulin infusions of 0.6 ± 0.2 IU/kg/d (gr...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,随机对照试验


    authors: Wang Y,Gong C,Cao B,Meng X,Wei L,Wu D,Liang X,Li W,Liu M,Gu Y,Su C

    更新日期:2017-05-01 00:00:00

  • Instability of different adolescent metabolic syndrome definitions tracked into early adulthood metabolic syndrome: Tehran Lipid and Glucose Study (TLGS).

    abstract:BACKGROUND AND OBJECTIVE:There are substantial controversies about the clinical utility of adolescent metabolic syndrome (MetS). The current study examined the stability of adolescent MetS by assessing the agreement and discriminative abilities of four different definitions of adolescent MetS and the adult MetS definit...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Asghari G,Eftekharzadeh A,Hosseinpanah F,Ghareh S,Mirmiran P,Azizi F

    更新日期:2017-02-01 00:00:00

  • Diabetic neuropathy in children and adolescents.

    abstract::Diabetic neuropathy (DN) represents a major complication of type 1 diabetes mellitus (T1DM) but there is considerable uncertainty as to its incidence, prevalence, diagnosis and prognosis in pediatric population. Generally, DN is classified as polyneuropathy, focal neuropathy and autonomic neuropathy. The latter seems ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,评审


    authors: Trotta D,Verrotti A,Salladini C,Chiarelli F

    更新日期:2004-03-01 00:00:00

  • A 10-yr follow-up study for the detection of peripheral neuropathy in young patients with type 1 diabetes.

    abstract:OBJECTIVE:The main objective of this work was to follow-up the development of diabetic neuropathy (DN) and its severity in patients with type 1 diabetes over 10 yr. Our intention was also to observe risk factor changes and verify which of them influence the development of neuropathy. The other objective was longitudina...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Hajas G,Kissova V,Tirpakova A

    更新日期:2016-12-01 00:00:00

  • Metabolic inflexibility and insulin resistance in obese adolescents with non-alcoholic fatty liver disease.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a comorbidity of childhood obesity. OBJECTIVE:We examined whole-body substrate metabolism and metabolic characteristics in obese adolescents with vs. without NAFLD. SUBJECTS:Twelve obese (BMI ≥ 95th percentile) adolescents with and without NAFLD [intrahepatic tr...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Lee S,Rivera-Vega M,Alsayed HM,Boesch C,Libman I

    更新日期:2015-05-01 00:00:00

  • Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults.

    abstract:BACKGROUND:Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. SUBJECTS AND METHODS:We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: RISE Consortium.

    更新日期:2019-11-01 00:00:00

  • Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary--the rising trend continues (or peaks and highlands?).

    abstract::The aim of this study was to examine secular trends in the incidence of type 1 diabetes in children aged 0-14 yr in Hungary over the period 1989-2009. Newly diagnosed children with type 1 diabetes aged 0-14 yr in Hungary were prospectively registered from 1989 to 2009. Primary ascertainment of cases was by prospective...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Gyurus EK,Patterson C,Soltesz G,Hungarian Childhood Diabetes Epidemiology Group.

    更新日期:2012-02-01 00:00:00

  • Insulin Resistance during normal child growth and development is associated with a distinct blood metabolic phenotype (Earlybird 72).

    abstract:BACKGROUND:While insulin resistance (IR) is associated with specific metabolite signatures in adults, there have been few truly longitudinal studies in healthy children, either to confirm which abnormalities are present, or to determine whether they precede or result from IR. Therefore, we investigated the association ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Hosking J,Pinkney J,Jeffery A,Cominetti O,Da Silva L,Collino S,Kussmann M,Hager J,Martin FP

    更新日期:2019-11-01 00:00:00

  • Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation.

    abstract::Activating mutations in the K(ATP)-channel cause neonatal diabetes mellitus (NDM), and patients have been safely transitioned from insulin to sulfonylureas. We report a male infant with permanent NDM (PNDM), born to a PNDM mother. Blood glucose began to rise on day of life (DOL) 2, and sulfonylurea (glyburide) therapy...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Wambach JA,Marshall BA,Koster JC,White NH,Nichols CG

    更新日期:2010-06-01 00:00:00

  • Screening for cystic fibrosis-related diabetes and prediabetes: Evaluating 1,5-anhydroglucitol, fructosamine, glycated albumin, and hemoglobin A1c.

    abstract:OBJECTIVE:Dysglycemia is prevalent in cystic fibrosis (CF) but screening with annual oral glucose tolerance tests (OGTT) can be burdensome. We investigated alternate glycemic markers-hemoglobin A1c (HbA1c), 1,5-anhydroglucitol (1,5AG), fructosamine (FA), and glycated albumin (GA)-as screening tests for CF-related diabe...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Tommerdahl KL,Brinton JT,Vigers T,Nadeau KJ,Zeitler PS,Chan CL

    更新日期:2019-12-01 00:00:00

  • Glucose metabolism in children and adolescents: Population-based reference values and comparisons to children and adolescents enrolled in obesity treatment.

    abstract:BACKGROUND:Alterations in glucose metabolism that lead to the development of metabolic and cardiovascular disease may begin already in childhood. OBJECTIVE:This study aims to generate pediatric age and sex-specific reference values for fasting concentrations of glucose, hemoglobin A1c (HbA1c), insulin, C-peptide, and ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Frithioff-Bøjsøe C,Lund MAV,Kloppenborg JT,Nielsen TTH,Fonvig CE,Lausten-Thomsen U,Hedley PL,Hansen T,Pedersen OB,Christiansen M,Baker JL,Hansen T,Holm JC

    更新日期:2019-08-01 00:00:00

  • The pancreatic ductal epithelium serves as a potential pool of progenitor cells.

    abstract::With the increasing success of islet transplantation, beta-cell replacement therapy has had renewed interest. To make such a therapy available to more than a few of the thousands of patients with diabetes, new sources of insulin-producing cells must become readily available. The most promising sources are stem cells, ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,评审


    authors: Bonner-Weir S,Toschi E,Inada A,Reitz P,Fonseca SY,Aye T,Sharma A

    更新日期:2004-01-01 00:00:00

  • Barriers to the treatment of adolescent type 2 diabetes--a survey of provider perceptions.

    abstract:OBJECTIVE:Type 2 diabetes mellitus (T2DM) is increasingly common among children and adolescents. However, achievement of good metabolic control has been difficult in this population. The aim of this study was to survey pediatric endocrine and diabetes specialists regarding the issues they consider to be barriers to suc...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Pinhas-Hamiel O,Zeitler P

    更新日期:2003-03-01 00:00:00

  • DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young.

    abstract:OBJECTIVE:Mechanisms underlying the role of non-human leukocyte antigen (HLA) genetic risk variants in type 1 diabetes (T1D) are poorly understood. We aimed to test the association between methylation and non-HLA genetic risk. METHODS:We conducted a methylation quantitative trait loci (mQTL) analysis in a nested case-...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Carry PM,Vanderlinden LA,Johnson RK,Dong F,Steck AK,Frohnert BI,Rewers M,Yang IV,Kechris K,Norris JM

    更新日期:2020-06-01 00:00:00

  • HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes.

    abstract:BACKGROUND:The prevalence of macrovascular complications is probably underestimated in children with type 1 diabetes (T1D). Arterial stiffness (AS) is a subclinical marker of cardiovascular (CV) risk. The most validated, non-invasive method for AS measurement is pulse wave velocity (PWV). Only a few PWV studies have be...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Obermannova B,Petruzelkova L,Sulakova T,Sumnik Z

    更新日期:2017-06-01 00:00:00

  • Re-hospitalization after diagnosis of diabetes varies by gender and socioeconomic status in urban African-American and Latino young people.

    abstract:PURPOSE:To examine risk factors for re-hospitalization after diagnosis of diabetes mellitus amongst urban minority children. METHODS:Families of insulin-treated African-American and Latino patients aged < 18 yr at diagnosis (n = 216) were interviewed about sociodemographics and other characteristics, on average 5.9 yr...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Lipton RB,Zierold KM,Drum ML,Klein-Gitelman M,Kohrman AF

    更新日期:2002-03-01 00:00:00

  • A novel 3' untranslated region mutation in the SLC29A3 gene associated with pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus syndrome.

    abstract:BACKGROUND:Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) is one of the rare H syndrome diseases mainly characterized by hyperpigmentation, hypertrichosis, sensorineural hearing loss, cardiac complications, developmental delay, and diabetes mellitus (DM). Mutations in the coding...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Riachi M,Bas F,Darendeliler F,Hussain K

    更新日期:2019-06-01 00:00:00

  • School-aged children with type 1 diabetes benefit more from a coping skills training program than adolescents in China: 12-month outcomes of a randomized clinical trial.

    abstract:BACKGROUND:Managing type 1 diabetes can be challenging, especially for youth, so there is a need for effective interventions to help youth live with diabetes. OBJECTIVE:To determine the efficacy of a coping skills training (CST) program for Chinese youth with type 1 diabetes and to explore whether the efficacy of the ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Guo J,Luo J,Yang J,Huang L,Wiley J,Liu F,Li X,Zhou Z,Whittemore R

    更新日期:2020-05-01 00:00:00

  • Skin and subcutaneous thickness at injecting sites in children with diabetes: ultrasound findings and recommendations for giving injection.

    abstract:BACKGROUND:Children who inject insulin need clear guidelines as to the length of needle best for them. We studied the distance from surface to muscle in children in order to make needle choices which are evidence-based. METHODS:One hundred one children with type 1 diabetes were divided into three groups according to a...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Lo Presti D,Ingegnosi C,Strauss K

    更新日期:2012-11-01 00:00:00

  • C-peptide in the classification of diabetes in children and adolescents.

    abstract:AIM:To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes. METHODS:A nation-wide cohort, the Better Diabetes Diagnosis study was used to determine serum C-peptide at diagnosis in 2734 children and adolescents. Clinical data were collected at diagnosis and follow-up....

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Ludvigsson J,Carlsson A,Forsander G,Ivarsson S,Kockum I,Lernmark A,Lindblad B,Marcus C,Samuelsson U

    更新日期:2012-02-01 00:00:00

  • Eligibility for clinical trials is limited for youth with type 2 diabetes: Insights from the Pediatric Diabetes Consortium T2D Clinic Registry.

    abstract:BACKGROUND/OBJECTIVE:Restrictive eligibility criteria have hampered enrollment into trials for new drugs for youth with type 2 diabetes (T2D). We utilized Pediatric Diabetes Consortium (PDC) T2D Registry enrollment data to estimate the percentage of patients who would be excluded from current T2D trials based on out-of...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Tamborlane WV,Chang P,Kollman C,Klingensmith GJ,Ruedy K,Gal RL,Van Name M,Bacha F,Willi S,Beck RW,Pediatric Diabetes Consortium.

    更新日期:2018-12-01 00:00:00

  • Worldwide childhood type 1 diabetes incidence--what can we learn from epidemiology?

    abstract::Type 1 diabetes is the most common form of diabetes in most part of the world, although reliable data are still unavailable in several countries. Wide variations exist between the incidence rates of different populations, incidence is lowest in China and Venezuela (0.1 per 100,000 per year) and highest in Finland and ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Soltesz G,Patterson CC,Dahlquist G,EURODIAB Study Group.

    更新日期:2007-10-01 00:00:00

  • The IDF Life for a Child Program Index of diabetes care for children and youth.

    abstract:BACKGROUND AND OBJECTIVES:Care for children and youth with diabetes varies markedly around the world. We developed a standardized, reproducible measure that can be used to document and compare critical factors influencing treatment outcomes. METHODS:A questionnaire consisting of 36 multiple-choice questions covering m...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Ogle GD,Middlehurst AC,Silink M

    更新日期:2016-08-01 00:00:00

  • ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12.

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    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Chobot A,Rusak E,Wenzlau J,Davidson H,Adamczyk P,Krzywicka A,Mazur B,Polańska J,Rewers M

    更新日期:2018-02-01 00:00:00

  • Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth.

    abstract:OBJECTIVE:It is unknown whether measurement site of visceral adipose tissue (VAT) influences the relationship between VAT and associated health risk in youth and if so, whether ethnic differences exist in this relationship. We examined the influence of the measurement site of VAT on the relationships between VAT and me...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Lee S,Kuk JL,Kim Y,Arslanian SA

    更新日期:2011-05-01 00:00:00

  • Metformin treatment to reduce central adiposity after prenatal growth restraint: a placebo-controlled pilot study in prepubertal children.

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    journal_title:Pediatric diabetes

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Díaz M,Bassols J,López-Bermejo A,de Zegher F,Ibáñez L

    更新日期:2015-11-01 00:00:00

  • Insulin allergy desensitization with simultaneous intravenous insulin and continuous subcutaneous insulin infusion.

    abstract::Persistent 'IgE-mediated' insulin allergy (type 1 allergy) (1), unresponsive to changes in insulin type or the use of antihistamines, necessitates desensitization. A number of case reports (2-7) and recent reviews (8, 9) have demonstrated that desensitization can be achieved with continuous subcutaneous insulin infusi...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Neville KA,Verge CF,Wainstein BK,Woodhead HJ,Ziegler JB,Walker JL

    更新日期:2008-08-01 00:00:00

  • Differences in sleep architecture according to body mass index in children with type 1 diabetes.

    abstract::Slow wave sleep (SWS), or deep sleep, is thought to be the most restorative stage of sleep and may be of a particular interest in the pathophysiology of obesity. The aim of this study was to investigate differences in sleep architecture based on body mass index (BMI) among a pediatric population with type 1 diabetes m...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,评审


    authors: Elrokhsi SH,Bluez GP,Chin CN,Wheeler MD,Silva GE,Perfect MM

    更新日期:2020-02-01 00:00:00