Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth.


OBJECTIVE:It is unknown whether measurement site of visceral adipose tissue (VAT) influences the relationship between VAT and associated health risk in youth and if so, whether ethnic differences exist in this relationship. We examined the influence of the measurement site of VAT on the relationships between VAT and metabolic syndrome (MetS) in African-American (AA) and American-White (AW) youth. SUBJECTS:Healthy AA (n = 54) and AW (n = 54) children and adolescents (age: 8-18 yr; BMI: 15.3-42.5 kg/m(2)). MEASUREMENTS:VAT mass was derived using a series of five transverse images measured by magnetic resonance imaging, extending from 5 cm below to 15 cm above L4-L5. MetS was defined using a modified IDF criteria. RESULTS:In AA, VAT measure at 5 cm above L4-L5 (R(2) = 0.93) was most strongly (p < 0.05) correlated with VAT mass and was a significantly (p < 0.05) stronger correlate as compared to L4-L5 (R(2) = 0.84). In AW, VAT measures at 5 cm (R(2) = 0.93) and 10 cm (R(2) = 0.93) above L4-L5 were most strongly (p < 0.05) correlated with VAT mass; however, these were not stronger correlates as compared to L4-L5 (R(2) = 0.91). In AW, all VAT measures were significantly (p < 0.05) associated with an increased odds ratio (OR) for prevalent MetS, wherein the VAT mass [OR = 5.32(1.9-15.0)] and VAT at L4-L5[OR = 5.99(1.9-18.4)] were most strongly associated with MetS. In contrast, only VAT at 10 cm above L4-L5 [OR = 4.39 (1.1-18.1)] was significantly (p < 0.05) associated with MetS in AA. CONCLUSION:In AA and AW youth, the measurement site for VAT has impact on the estimation of total VAT and the magnitude of the association with obesity-related health risks.


Pediatr Diabetes


Pediatric diabetes


Lee S,Kuk JL,Kim Y,Arslanian SA




Has Abstract


2011-05-01 00:00:00




3 Pt 2








  • Eligibility for clinical trials is limited for youth with type 2 diabetes: Insights from the Pediatric Diabetes Consortium T2D Clinic Registry.

    abstract:BACKGROUND/OBJECTIVE:Restrictive eligibility criteria have hampered enrollment into trials for new drugs for youth with type 2 diabetes (T2D). We utilized Pediatric Diabetes Consortium (PDC) T2D Registry enrollment data to estimate the percentage of patients who would be excluded from current T2D trials based on out-of...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Tamborlane WV,Chang P,Kollman C,Klingensmith GJ,Ruedy K,Gal RL,Van Name M,Bacha F,Willi S,Beck RW,Pediatric Diabetes Consortium.

    更新日期:2018-12-01 00:00:00

  • Monogenic diabetes: A single center experience from South India.

    abstract::Monogenic forms of diabetes in children are frequently misclassified as either type 1 diabetes or young-onset type 2 diabetes. There is a paucity of literature regarding pediatric monogenic diabetes in the Indian population. A retrospective analysis of case records of 37 children with monogenic diabetes who were diagn...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Lakshmanan NK,Pavithran PV,Bhavani N,Abraham N,Kumar H,Nair V,Menon U,Menon AS,Narayanan P,Lakshmi G

    更新日期:2021-02-01 00:00:00

  • Glycemic control and self-rated health among ethnically diverse adolescents with type 1 diabetes.

    abstract:OBJECTIVE:Patient-reported outcomes have received increased attention as treatment outcomes and indicators of wellbeing. A1c has been criticized as lacking patient-centered relevance because individuals are often unaware of their A1c, and studies also often fail to show a benefit of intensive control on quality of life...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Kane NS,Hoogendoorn CJ,Commissariat PV,Schulder TE,Gonzalez JS

    更新日期:2020-02-01 00:00:00

  • Aerobic exercise capacity in normal adolescents and those with type 1 diabetes mellitus.

    abstract:OBJECTIVE:To compare the aerobic exercise capacity between normal adolescents and those with type 1 diabetes mellitus (T1DM). METHODS:An experimental group with 72 individuals diagnosed with T1DM aged 9--20, time from diagnosis 4.9 +/- 3.6 yr, without clinical cardiopulmonary disease or anemia and a control group (C) ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Komatsu WR,Gabbay MA,Castro ML,Saraiva GL,Chacra AR,de Barros Neto TL,Dib SA

    更新日期:2005-09-01 00:00:00

  • Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary--the rising trend continues (or peaks and highlands?).

    abstract::The aim of this study was to examine secular trends in the incidence of type 1 diabetes in children aged 0-14 yr in Hungary over the period 1989-2009. Newly diagnosed children with type 1 diabetes aged 0-14 yr in Hungary were prospectively registered from 1989 to 2009. Primary ascertainment of cases was by prospective...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Gyurus EK,Patterson C,Soltesz G,Hungarian Childhood Diabetes Epidemiology Group.

    更新日期:2012-02-01 00:00:00

  • Health-related quality of life in intensively treated young patients with type 1 diabetes.

    abstract::This study aimed to analyse the impact of the disease and treatment on health-related quality of life (HRQOL) in intensively treated young patients with diabetes. Our main hypothesis was that metabolic control, gender, age and socio-economic status predict HRQOL. All children and adolescents (n = 400, 191 girls) and p...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Hanberger L,Ludvigsson J,Nordfeldt S

    更新日期:2009-09-01 00:00:00

  • Association of serum uric acid levels to inflammation biomarkers and endothelial dysfunction in obese prepubertal children.

    abstract:BACKGROUND:High serum uric acid (SUA) levels are present in patients with metabolic syndrome (MetS), when the latter is associated with endothelial dysfunction, inflammation, and hypertension. This increase in SUA levels may have a key role in cardiovascular diseases. OBJECTIVE:We aim to quantify the differences in in...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Valle M,Martos R,Cañete MD,Valle R,van Donkelaar EL,Bermudo F,Cañete R

    更新日期:2015-09-01 00:00:00

  • Safety and efficacy of autoantigen-specific therapy with 2 doses of alum-formulated glutamate decarboxylase in children with multiple islet autoantibodies and risk for type 1 diabetes: A randomized clinical trial.

    abstract:OBJECTIVE:Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity. METHODS:In an...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,随机对照试验


    authors: Elding Larsson H,Lundgren M,Jonsdottir B,Cuthbertson D,Krischer J,DiAPREV-IT Study Group.

    更新日期:2018-05-01 00:00:00

  • Changes to Care Delivery at Nine International Pediatric Diabetes Clinics in Response to the COVID-19 Global Pandemic.

    abstract:BACKGROUND:Pediatric diabetes clinics around the world rapidly adapted care in response to COVID-19. We explored provider perceptions of care delivery adaptations and challenges for providers and patients across nine international pediatric diabetes clinics. METHODS:Providers in a quality improvement collaborative com...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Cristello Sarteau A,Souris KJ,Wang J,Ramadan AA,Addala A,Bowlby D,Corathers S,Forsander G,King B,Law JR,Liu W,Malik F,Pihoker C,Seid M,Smart C,Sundberg F,Tandon N,Yao M,Headley T,Mayer-Davis E

    更新日期:2021-01-19 00:00:00

  • Comparison of the effectiveness of simple carbohydrates on hypoglycemic episodes in children and adolescents with type 1 diabetes mellitus: A randomized study in a diabetes camp.

    abstract:BACKGROUND:Hypoglycemia is the most common and severe complication of insulin treatment during the management of type 1 diabetes mellitus (T1DM). Despite its importance, there is a lack of data about the efficacy and superiority of the carbohydrate sources used in hypoglycemia management in children and adolescents. O...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Erbas IM,Abaci A,Anik A,Simsek E,Tuhan HU,Kocyigit C,Yıldız M,Dundar BN,Bober E,Catli G

    更新日期:2020-07-13 00:00:00

  • Type 2 diabetes mellitus in Danish children and adolescents in 2014.

    abstract:BACKGROUND/OBJECTIVE:The global increase in childhood obesity has in some countries been followed by an increase in type 2 diabetes mellitus (T2DM); however, the prevalence of T2DM among Danish children and adolescents is currently unknown. The aims of this cross-sectional study were to determine the prevalence of T2DM...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Oester IM,Kloppenborg JT,Olsen BS,Johannesen J

    更新日期:2016-08-01 00:00:00

  • Faster-acting insulin aspart provides faster onset and greater early exposure vs insulin aspart in children and adolescents with type 1 diabetes mellitus.

    abstract:BACKGROUND:Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide). In adults, faster aspart provides faster onset and greater early exposure and action vs IAsp. AIM:This randomized, double-blind, 2-period crossover trial invest...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,随机对照试验


    authors: Fath M,Danne T,Biester T,Erichsen L,Kordonouri O,Haahr H

    更新日期:2017-12-01 00:00:00

  • Predictive hyperglycemia and hypoglycemia minimization: In-home double-blind randomized controlled evaluation in children and young adolescents.

    abstract:OBJECTIVE:The primary objective of this trial was to evaluate the feasibility, safety, and efficacy of a predictive hyperglycemia and hypoglycemia minimization (PHHM) system vs predictive low glucose suspension (PLGS) alone in optimizing overnight glucose control in children 6 to 14 years old. RESEARCH DESIGN AND METH...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,随机对照试验


    authors: Forlenza GP,Raghinaru D,Cameron F,Wayne Bequette B,Peter Chase H,Paul Wadwa R,Maahs DM,Jost E,Ly TT,Wilson DM,Norlander L,Ekhlaspour L,Min H,Clinton P,Njeru N,Lum JW,Kollman C,Beck RW,Buckingham BA,In-Home Closed-Lo

    更新日期:2018-05-01 00:00:00

  • Characterization of proinsulin-specific regulatory T cells in type 1 diabetes at different ages of onset.

    abstract:BACKGROUND AND OBJECTIVES:Regulatory T cells (Tregs) play an important role in maintaining tolerance to self-antigens. Defects in the frequency and function of polyclonal Tregs have been reported in type 1 diabetes (T1D). However, characteristics of proinsulin (PI)-specific Tregs in human T1D have not yet been explored...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Paul M,Dayal D,Bhansali A,Sachdeva N

    更新日期:2019-05-01 00:00:00

  • Gastric emptying and postprandial glucose excursions in adolescents with type 1 diabetes.

    abstract::Because amylin is co-secreted with insulin from beta cells, patients with type 1 diabetes (T1DM) are deficient in both insulin and amylin. Amylin delays gastric emptying and suppresses glucagon in the postprandial period. Hence, we hypothesized that children with complication-naive T1DM have accelerated gastric emptyi...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Heptulla RA,Rodriguez LM,Mason KJ,Haymond MW

    更新日期:2008-12-01 00:00:00

  • Ponderal gain, waist-to-hip ratio, and pubertal development in girls with type-1 diabetes mellitus.

    abstract:OBJECTIVES:We assessed pubertal development, height, weight, and waist-to-hip ratio (WHR), an index of central adiposity during puberty, in girls with type-1 diabetes mellitus (T1DM), compared to a contemporary control group. METHODS:Pubertal development, weight, height and WHR were studied in 100 pubertal girls with ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Codner E,Barrera A,Mook-Kanamori D,Bazaes RA,Unanue N,Gaete X,Avila A,Ugarte F,Torrealba I,Pérez V,Panteón E,Cassorla F

    更新日期:2004-12-01 00:00:00

  • The IDF Life for a Child Program Index of diabetes care for children and youth.

    abstract:BACKGROUND AND OBJECTIVES:Care for children and youth with diabetes varies markedly around the world. We developed a standardized, reproducible measure that can be used to document and compare critical factors influencing treatment outcomes. METHODS:A questionnaire consisting of 36 multiple-choice questions covering m...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Ogle GD,Middlehurst AC,Silink M

    更新日期:2016-08-01 00:00:00

  • Establishing the feasibility of a community and primary health care intervention to raise awareness of symptoms of Type 1 Diabetes-The Early Detection of Type 1 Diabetes in Youth (EDDY) study.

    abstract:AIMS:To design, develop, and evaluate the feasibility of delivering a multi-component community based intervention to parents and primary health care professionals to raise awareness of the symptoms of Type 1 diabetes (T1D) in childhood in 3 adjoining borough counties of South Wales. MATERIALS AND METHODS:Parent and p...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Townson J,Gregory JW,Cowley L,Gallagher D,Channon S,Robling M,Williams D,Hughes C,Murphy S,Lowes L

    更新日期:2017-12-01 00:00:00

  • Socioeconomic position is associated with glycemic control in youth and young adults with type 1 diabetes.

    abstract:OBJECTIVE:Health inequities persist in youth and young adults (YYA) with type 1diabetes in achieving optimal glycemic control. The purpose of this study was to assess the contribution of multiple indicators of social need to these inequities. RESEARCH DESIGN AND METHODS:Two hundred and twenty two YYA withtype 1 diabet...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Sutherland MW,Ma X,Reboussin BA,Mendoza JA,Bell BA,Kahkoska AR,Sauder KA,Lawrence JM,Pihoker C,Liese AD

    更新日期:2020-12-01 00:00:00

  • Pediatric endocrine society survey of diabetes practices in the United States: What is the current state?

    abstract:BACKGROUND:The Practice Management Committee (PMC) of the Pediatric Endocrine Society (PES) conducted a survey of its membership in February/March, 2016 to assess the current state of pediatric diabetes care delivery across multiple practice types in the United States. METHODS:The PES distributed an anonymous electron...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Guttmann-Bauman I,Thornton P,Adhikari S,Reifschneider K,Wood MA,Hamby T,Rubin K

    更新日期:2018-08-01 00:00:00

  • An Egyptian family with H syndrome due to a novel mutation in SLC29A3 illustrating overlapping features with pigmented hypertrichotic dermatosis with insulin-dependent diabetes and Faisalabad histiocytosis.

    abstract::The SLC29A3 gene, encoding hENT3, a member of the equilibrative nucleoside transporter family, has recently been found mutated in Faisalabad histiocytosis, pigmented hypertrichotic dermatosis with insulin-dependent diabetes, familial sinus histiocytosis with massive lymphadenopathy (SHML), and H syndromes. We here rep...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Elbarbary NS,Tjora E,Molnes J,Lie BA,Habib MA,Salem MA,Njølstad PR

    更新日期:2013-09-01 00:00:00

  • Renal Doppler indices in diabetic children with insulin resistance syndrome.

    abstract::End-stage renal failure is still a leading cause of mortality among type 1 diabetes patients. Insulin resistance plays a larger role in type 1 diabetes disease process than is commonly recognized. Detection of diabetic nephropathy as early as possible currently offers the best chance of delaying or possibly preventing...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Abd El Ghaffar S,El Kaffas K,Hegazy R,Mostafa M

    更新日期:2010-11-01 00:00:00

  • Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: A longitudinal study.

    abstract:OBJECTIVE:Type 1 diabetes (T1D) develops in distinct stages, before and after disease onset. Whether the natural course translates into different immunologic patterns is still uncertain. This study aimed at identifying peripheral immune patterns at key time-points, in T1D children undergoing remission phase. METHODS:C...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Fitas AL,Martins C,Borrego LM,Lopes L,Jörns A,Lenzen S,Limbert C

    更新日期:2018-08-01 00:00:00

  • Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

    abstract:BACKGROUND:Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Skärstrand H,Vaziri-Sani F,Delli AJ,Törn C,Elding Larsson H,Ivarsson S,Agardh D,Lernmark Å,Skåne study group.

    更新日期:2015-12-01 00:00:00

  • A multivariate model exploring the predictive value of demographic, adolescent, and family factors on glycemic control in adolescents with type 1 diabetes.

    abstract:OBJECTIVE:The current study examined how a comprehensive set of variables from multiple domains, including at the adolescent and family level, were predictive of glycemic control in adolescents with type 1 diabetes (T1D). METHODS:Participants included 100 adolescents with T1D ages 10-16 yrs and their parents. Particip...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Agarwal S,Jawad AF,Miller VA

    更新日期:2016-11-01 00:00:00

  • Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes.

    abstract::Despite the increased prevalence of type 2 diabetes mellitus (T2DM) in the pediatric population, there is limited information about the relative effectiveness of treatment approaches. This article describes the rationale and design of a National Institutes of Health-sponsored multi-site, randomized, parallel group cli...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: TODAY Study Group.,Zeitler P,Epstein L,Grey M,Hirst K,Kaufman F,Tamborlane W,Wilfley D

    更新日期:2007-04-01 00:00:00

  • Plasma insulin levels in childhood are related to maternal factors--results of the Ulm Birth Cohort Study.

    abstract:AIMS:The cardiovascular risk factor profile of a child as well as the development of body weight are influenced by genetic and childhood factors. Circulating insulin concentrations reflect the metabolic cardiovascular risk and may trigger weight gain. We aimed at identifying parental and childhood factors which may inf...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Brandt S,Moß A,Lennerz B,Koenig W,Weyermann M,Rothenbacher D,Brenner H,Wabitsch M

    更新日期:2014-09-01 00:00:00

  • Handgrip strength is associated with insulin resistance and glucose metabolism in adolescents: Evidence from National Health and Nutrition Examination Survey 2011 to 2014.

    abstract:BACKGROUND:Previous studies have reported that handgrip strength, a measure of muscular fitness, is associated with insulin resistance in children and adolescents, with conflicting results. Further, no studies have examined the association between handgrip strength with 2-hour glucose levels. OBJECTIVE:We tested the a...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Li S,Zhang R,Pan G,Zheng L,Li C

    更新日期:2018-05-01 00:00:00

  • Sweet dreams?--nocturnal hypoglycemia in children with type 1 diabetes.

    abstract::Hypoglycemia is an inevitable consequence of the treatment of type 1 diabetes in childhood. Nocturnal hypoglycemia is often considered as merely the submerged part of this serious complication yet there are reasons to believe that hypoglycemia occurring during sleep may be different in physiological terms. Glucose hom...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: Matyka KA

    更新日期:2002-06-01 00:00:00

  • Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults.

    abstract:BACKGROUND:Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. SUBJECTS AND METHODS:We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章


    authors: RISE Consortium.

    更新日期:2019-11-01 00:00:00