Abstract:
AIMS:We aimed to analyze the relationship between epilepsy and glutamic acid decarboxylase autoantibodies (GADA) in patients with type 1 diabetes mellitus (T1DM) and the impact of GADA on demographic, clinical, and metabolic data in T1DM patients with epilepsy. METHODS:We searched for patients with T1DM ≤20 years and GADA measurements, and within this group for patients with epilepsy. We formed groups: T1DM + Epilepsy + GADA positive; T1DM + Epilepsy + GADA negative; T1DM + GADA positive; T1DM + GADA negative. We used logistic regression to analyze the relationship between epilepsy and GADA with odds ratio adjusted for sex, duration of diabetes (DOD), and age at diabetes onset (ADO). We used logistic regression with odds ratio adjusted for DOD and ADO onset using epilepsy as a dependent variable and GADA, HbA1c, ketoacidosis, severe hypoglycemia (SH), sex, celiac disease, and autoimmune thyroiditis as independent variables. We conducted regression analyses adjusted for sex, DOD, and ADO to analyze differences in clinical/metabolic parameters between the groups. RESULTS:Epilepsy was not more frequent in GADA-positive patients (GPP). Logistic regression including all patients with GADA measurements showed that hypoglycemia with coma (HC) correlated with epilepsy when compared to no SH. We found no differences in clinical and metabolic data between GPP and GADA-negative patients (GNP) with epilepsy. SH occurred more often in GPP with epilepsy in comparison to GPP without epilepsy. GNP with epilepsy had a higher rate of HC than GPP without epilepsy. CONCLUSION:We found no relationship between epilepsy and GADA. A relationship between T1DM and epilepsy might be explainable by SH.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
de Sousa GJ,Tittel SR,Häusler M,Holterhus PM,Berger G,Holder M,Kamrath C,Golembowski S,Herrlinger S,Holl RWdoi
10.1111/pedi.13034subject
Has Abstractpub_date
2020-08-01 00:00:00pages
766-773issue
5eissn
1399-543Xissn
1399-5448journal_volume
21pub_type
杂志文章abstract::In children with type 1 diabetes (T1DM), altered adaptive responses to exercise (secretion of growth factors, inflammatory cytokines, and glucoregulatory mediators) may have potential implications in growth and development, early onset of disease complications, and incidence of hypoglycemia. We therefore measured a br...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-543X.2006.00140.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:Effects of pump treatment vs. four times daily injections were explored in children with diabetes with regard to quality of life and impact of disease as well as adverse effects and parameters of metabolic control. METHODS:An open, parallel, randomized controlled prospective comparative study lasting 14 mont...
journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2008.00396.x
更新日期:2008-07-28 00:00:00
abstract:OBJECTIVE:To determine whether the association between family history of diabetes (FHD) and impaired fasting glucose (IFG) is independent of body mass index (BMI) in children and adolescents. METHODS:In all 443 (11.9%) children and adolescents with FHD, and 3280 (88.1%) without FHD were enrolled in a population-based ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00590.x
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The aim of the study was to search for mutations in the NEUROD1 and IPF-1 genes in patients with clinical characteristics of maturity-onset diabetes of the young (MODY) but with no mutations in the HNF-4A (MODY1), GCK (MODY2) and TCF1 (MODY3) genes. METHODS:We studied 30 unrelated Czech probands with a clin...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00379.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) ≤ 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. METHODS:We analyzed the preval...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12999
更新日期:2020-06-01 00:00:00
abstract::We report an interesting and unique case of an overweight adolescent with a novel mutation of the maturity-onset diabetes of the young (MODY)3 gene [hepatocyte nuclear factor-1 alpha (HNF-1alpha)] and positive islet cell autoantibodies. The patient is a 17-yr-old Caucasian female, who was diagnosed with type 2 diabete...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2007.00335.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be assoc...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12598
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Dysglycemia is prevalent in cystic fibrosis (CF) but screening with annual oral glucose tolerance tests (OGTT) can be burdensome. We investigated alternate glycemic markers-hemoglobin A1c (HbA1c), 1,5-anhydroglucitol (1,5AG), fructosamine (FA), and glycated albumin (GA)-as screening tests for CF-related diabe...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12914
更新日期:2019-12-01 00:00:00
abstract:CONTEXT:Type 1 diabetes mellitus (T1DM) is a pro-inflammatory stress state, which, with its attendant hyperglycemia, likely disrupts hypothalamo-pituitary-adrenal (HPA) control, further dysregulating glucose homeostasis. OBJECTIVE:To test the hypothesis that endogenous adrenocorticotropic hormone (ACTH)-cortisol dose-...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12108
更新日期:2014-09-01 00:00:00
abstract::Despite the increased prevalence of type 2 diabetes mellitus (T2DM) in the pediatric population, there is limited information about the relative effectiveness of treatment approaches. This article describes the rationale and design of a National Institutes of Health-sponsored multi-site, randomized, parallel group cli...
journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1399-5448.2007.00237.x
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Mild hypoglycemia is commonly observed in children treated for type 1 diabetes mellitus (T1DM). Hypoglycemia disturbs cognition and learning. OBJECTIVE:To describe how and to what extent hypoglycemia in young children with T1DM is detected in everyday life. To learn how parents and caregivers treat hypoglyc...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12057
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Higher birthweight is associated with increased type 1 diabetes mellitus (T1DM) risk, but the contribution of higher adiposity or lean mass is unclear. In this Tasmanian infant cohort, early upper respiratory infection has been associated with higher asthma risk. PATIENTS AND METHODS:Eligible infants repres...
journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1399-5448.2010.00693.x
更新日期:2011-06-01 00:00:00
abstract::End-stage renal failure is still a leading cause of mortality among type 1 diabetes patients. Insulin resistance plays a larger role in type 1 diabetes disease process than is commonly recognized. Detection of diabetic nephropathy as early as possible currently offers the best chance of delaying or possibly preventing...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00628.x
更新日期:2010-11-01 00:00:00
abstract::The Juvenile Diabetes Research Foundation International (JDRF) was founded in 1970 by parents of children with juvenile diabetes to find a cure for diabetes and its complications through the support of research. The foundation was an early supporter of stem cell research, recognizing the promise of stem cells to quick...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-543X.2004.00085.x
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:The Environmental Determinants of Diabetes in the Young (TEDDY) study seeks to identify environmental triggers of autoimmunity and type 1 diabetes mellitus (T1DM) in children at increased human-leukocyte-antigen conferred genetic risk for this disease. The objective of this study was to identify predictors of...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2010.00686.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the degree of left ventricular (LV) dysfunction and its determinants in adolescents with type 2 diabetes (T2D). We hypothesized that adolescents with T2D would display impaired LV diastolic function and that these cardiovascular complications would be exacerbated in youth exposed...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12954
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Incidence rates of type 1 diabetes have long been on the rise across the globe, however, there is emerging evidence that the rate of rise may be slowing. The objective of this study was to describe trends in the incidence and prevalence of type 1 diabetes in a sample of Canadian children and yo...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12566
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The prevalence of macrovascular complications is probably underestimated in children with type 1 diabetes (T1D). Arterial stiffness (AS) is a subclinical marker of cardiovascular (CV) risk. The most validated, non-invasive method for AS measurement is pulse wave velocity (PWV). Only a few PWV studies have be...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12385
更新日期:2017-06-01 00:00:00
abstract::A subgroup of diabetic patients presents with features typical of type 1 diabetes, but over months to years has variable insulin requirements and develops features of type 2 diabetes. This subgroup is referred to as atypical diabetes mellitus (ADM). Over a span of 50 yr, reports on disease epidemiology, clinical chara...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1046/j.1399543x.2000.010409.x
更新日期:2000-12-01 00:00:00
abstract:AIM:Study of the clinical presentation and laboratory data of type 1 diabetes in the Eastern Province of Saudi Arabia. METHODS:The medical records of all affected children during the period 1986-1997 were reviewed for the analysis of clinical and laboratory data. RESULTS:Type 1 diabetes was diagnosed in 46 children, ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1046/j.1399-543x.2001.00000.x
更新日期:2001-03-01 00:00:00
abstract:AIMS:Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS:In 47 healthy children with GADA and at ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12023
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:The accuracy of blood pressure (BP) measurement is a prerequisite for the reliable diagnosis and management of hypertension. OBJECTIVES:This survey evaluated the use of office and out-of-office BP measurements and the antihypertensive pharmacological treatment in expert pediatric diabetes centers. METHOD...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13114
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The incidence of type 1 diabetes mellitus (T1DM) among children and adolescents increased during the last 50 yr. The T1DM incidence in Croatia was 8.87/100.000/yr over 1995-2003, with an annual increase of 9%, which placed Croatia among countries with moderate risk for T1DM. AIM:To investigate incidence rat...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12197
更新日期:2015-09-01 00:00:00
abstract:AIMS:Intravenous glucose tolerance testing (IVGTT) is a common test of β-cell function in which a glucose load is administered and insulin and/or C-peptide responses are monitored. Since the first IVGTT may be more stressful and stress may alter β-cell secretion or hepatic insulin extraction, we asked whether there was...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12064
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Dominant inactivating mutations in HNF1A and HNF4A have been described to cause hyperinsulinism (HI) before evolving to diabetes. However, information available in the literature regarding the clinical phenotype is limited. OBJECTIVE:To report the prevalence of HNF1A and HNF4A mutations in a large cohort of...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12655
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI75 ) were used to measure arterial stiffness...
journal_title:Pediatric diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/pedi.12389
更新日期:2017-06-01 00:00:00
abstract::Diabetic ketoacidosis (DKA) is one of the most common causes of morbidity and mortality in new onset type 1 diabetes mellitus (T1DM). Children have a higher rate of neurological complications from DKA when compared to adults. The differential for sudden focal neurological deterioration in the setting of DKA is cerebra...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12760
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To explore the outcomes of monthly video consultations for children with diabetes. METHODS:The Virtual Outpatient Diabetes Clinic for Children and Youth (VIDIKI) was a 6-month multicenter controlled clinical trial followed by an extension phase. The 240 participants (1-16 years), all using a CGM, were quasi-...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13133
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Adults with type 2 diabetes mellitus (T2DM) have broad impairments in beta-cell function, including severe attenuation of the first-phase insulin response to glucose, and reduced beta-cell mass. In adolescents with T2DM, there is some evidence that beta-cell dysfunction may be less severe. Our objective was ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00601.x
更新日期:2010-08-01 00:00:00
abstract::Hypoglycemia is an inevitable consequence of the treatment of type 1 diabetes in childhood. Nocturnal hypoglycemia is often considered as merely the submerged part of this serious complication yet there are reasons to believe that hypoglycemia occurring during sleep may be different in physiological terms. Glucose hom...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2002.30203.x
更新日期:2002-06-01 00:00:00