Abstract:
:In children with type 1 diabetes (T1DM), altered adaptive responses to exercise (secretion of growth factors, inflammatory cytokines, and glucoregulatory mediators) may have potential implications in growth and development, early onset of disease complications, and incidence of hypoglycemia. We therefore measured a broad spectrum of exercise responses in 12 children with T1DM (seven males and five females) and 12 controls (six males / six females) aged 11-15 yr, during a 30-min exercise challenge @ 80% VO(2)max. Euglycemia was strictly controlled during exercise, and in diabetic patients a basal rate of i.v. insulin was allowed to maintain baseline insulin concentrations. Throughout the experiment, interleukin-6 (IL-6) concentrations (pg/mL) were markedly higher in T1DM vs. controls (preexercise: 5.0+/-1.3 vs. 1.9+/-0.6, p<0.02; end-exercise 5.3+/-1.2 vs. 2.7+/-1.0, p<0.05; 30-min postexercise: 8.2+/-2.2 vs. 3.9+/-0.8, p<0.05). A similar pattern was also observed with norepinephrine. Growth hormone (GH) concentration was similar in both groups at baseline and end-exercise, but in T1DM the exercise-induced GH remained significantly elevated 30 min after exercise (9.2+/-2.2 vs. 3.1+/-0.9 ng/L, p<0.01). The exercise-induced increase in glucagon elicited by exercise in controls was similar to that previously observed in healthy adults (10+/-3 pg/mL); however, it was significantly blunted in T1DM children (2+/-2 pg/mL, p<0.05). In conclusion, T1DM children displayed significant alterations in multiple aspects of their adaptive response to intense exercise.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Galassetti PR,Iwanaga K,Crisostomo M,Zaldivar FP,Larson J,Pescatello Adoi
10.1111/j.1399-543X.2006.00140.xkeywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
16-24issue
1eissn
1399-543Xissn
1399-5448pii
PDI140journal_volume
7pub_type
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更新日期:2016-06-01 00:00:00
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-05-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00823.x
更新日期:2012-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2000.010202.x
更新日期:2000-06-01 00:00:00
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
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更新日期:2012-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
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更新日期:2017-05-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12928
更新日期:2020-02-01 00:00:00
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更新日期:2018-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12267
更新日期:2016-06-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1399-5448.2010.00693.x
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00