Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus in a randomized, prospective comparison.

abstract：:Diabetic ketoacidosis (DKA) is one of the most common causes of morbidity and mortality in new onset type 1 diabetes mellitus (T1DM). Children have a higher rate of neurological complications from DKA when compared to adults. The differential for sudden focal neurological deterioration in the setting of DKA is cerebra...

journal_title：Pediatric diabetes

authors： Finn BP,Power C,McSweeney N,Breen D,Wyse G,O'Connell SM

更新日期：2018-12-01 00:00:00

abstract：:This review highlights the evidence of linking small for gestational age (SGA) with metabolic/cardiovascular disturbances (dysmetabolic syndrome) in later life. The metabolic and cardiovascular complications associated with in utero undernutrition have been identified during the past 10 yr. Reduced fetal growth is ind...

journal_title：Pediatric diabetes

authors： Levy-Marchal C,Jaquet D

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To determine the roles of complement C4A and C4B gene copy-number variations and their plasma protein concentrations in residual insulin secretion and loss of pancreatic β-cell function in new-onset type 1 diabetes (T1D) patients. METHODS:We studied 34 patients of European ancestry with new-onset T1D, aged b...

journal_title：Pediatric diabetes

authors： Kingery SE,Wu YL,Zhou B,Hoffman RP,Yu CY

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. OBJECTIVES:Ongoing...

journal_title：Pediatric diabetes

authors： Elding Larsson H

更新日期：2016-07-01 00:00:00

abstract：:Hypertension and dyslipidemia are often suboptimally managed in teens with type 1 diabetes (T1D). Teen and parent perspectives on hypertension and dyslipidemia management need further study to enhance the development of cardiovascular disease (CVD) risk factor management plans. We sought to describe barriers to and st...

journal_title：Pediatric diabetes

authors： Katz ML,Guo Z,Cheema A,Laffel LM

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:The primary objective of this trial was to evaluate the feasibility, safety, and efficacy of a predictive hyperglycemia and hypoglycemia minimization (PHHM) system vs predictive low glucose suspension (PLGS) alone in optimizing overnight glucose control in children 6 to 14 years old. RESEARCH DESIGN AND METH...

journal_title：Pediatric diabetes

authors： Forlenza GP,Raghinaru D,Cameron F,Wayne Bequette B,Peter Chase H,Paul Wadwa R,Maahs DM,Jost E,Ly TT,Wilson DM,Norlander L,Ekhlaspour L,Min H,Clinton P,Njeru N,Lum JW,Kollman C,Beck RW,Buckingham BA,In-Home Closed-Lo

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Patient Reported Outcomes Measurement Information System (PROMIS) includes numerous domains to assess functioning among the pediatric population. These domains, however, have not been evaluated for use in children with type 1 diabetes (T1D). The objective of this study was to determine the measurement propert...

journal_title：Pediatric diabetes

authors： Singh A,Dasgupta M,Retherford D,Fiallo-Scharer R,Simpson PM,Panepinto JA

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:Children born small-for-gestational-age (SGA) who experience rapid postnatal catch-up in weight are at risk for central adiposity and hyperinsulinemia. OBJECTIVES:To study the effects of prepubertal metformin intervention over 24 months on the body composition and endocrine-metabolic profile of catch-up SGA...

journal_title：Pediatric diabetes

authors： Díaz M,Bassols J,López-Bermejo A,de Zegher F,Ibáñez L

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:To assess the ability of reactive hyperemia-peripheral artery tonometry (RH-PAT) to serve as a surrogate marker of endothelial dysfunction in children with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:Forty-four children with T1D [age 14.6 +/- 2.7 yr; duration of diabetes 6.01 +/- 4 yr; range of diabe...

journal_title：Pediatric diabetes

authors： Haller MJ,Stein J,Shuster J,Theriaque D,Silverstein J,Schatz DA,Earing MG,Lerman A,Mahmud FH

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. SUBJECTS AND METHODS:We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6...

journal_title：Pediatric diabetes

authors： RISE Consortium.

更新日期：2019-11-01 00:00:00

abstract：:Although the factors responsible for the recent increase in the prevalence of diabetes worldwide are not entirely known, the morbidity associated with this disease results in substantial health and economic burden on society. Epigenetic modifications, including DNA methylation have been identified as one mechanism by ...

journal_title：Pediatric diabetes

authors： Bansal A,Pinney SE

更新日期：2017-05-01 00:00:00

abstract：:Inactivating mutations in the pancreatic beta cell ATP-sensitive potassium (K(ATP) ) channel genes are identified by sequencing in approximately 80% of patients with diazoxide-unresponsive hyperinsulinaemic hypoglycaemia (HH). Genetic testing is clinically important as the mode of inheritance of a K(ATP) channel mutat...

journal_title：Pediatric diabetes

authors： Flanagan S,Damhuis A,Banerjee I,Rokicki D,Jefferies C,Kapoor R,Hussain K,Ellard S

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Incidence rates of type 1 diabetes have long been on the rise across the globe, however, there is emerging evidence that the rate of rise may be slowing. The objective of this study was to describe trends in the incidence and prevalence of type 1 diabetes in a sample of Canadian children and yo...

journal_title：Pediatric diabetes

authors： Fox DA,Islam N,Sutherland J,Reimer K,Amed S

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need for genetic susceptibility has lessened over time, we hypothesized that the rise in T1D incidence is...

journal_title：Pediatric diabetes

authors： Zung A,Na'amnih W,Bluednikov Y,Mery N,Blumenfeld O,Israel IDDM Registry Study Group (IRRSG).

更新日期：2018-06-01 00:00:00

abstract：:The Juvenile Diabetes Research Foundation International (JDRF) was founded in 1970 by parents of children with juvenile diabetes to find a cure for diabetes and its complications through the support of research. The foundation was an early supporter of stem cell research, recognizing the promise of stem cells to quick...

journal_title：Pediatric diabetes

authors： Nierras CR,Stallard J,Goldstein RA,Insel R

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:The global increase in childhood obesity has in some countries been followed by an increase in type 2 diabetes mellitus (T2DM); however, the prevalence of T2DM among Danish children and adolescents is currently unknown. The aims of this cross-sectional study were to determine the prevalence of T2DM...

journal_title：Pediatric diabetes

authors： Oester IM,Kloppenborg JT,Olsen BS,Johannesen J

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:We aimed to assess the prevalence of autoantibodies against the 4A subunit of the gastric proton pump (ATP4A) in pediatric type 1 diabetes (T1D) patients and explore the relationship between ATP4A positivity and blood cell count, iron turnover, and vitamin B12 concentration. SUBJECTS:The study included 94 (5...

journal_title：Pediatric diabetes

authors： Chobot A,Rusak E,Wenzlau J,Davidson H,Adamczyk P,Krzywicka A,Mazur B,Polańska J,Rewers M

更新日期：2018-02-01 00:00:00

abstract：:Glucokinase gene (GCK) mutations comprise approximately 10% of cases of maturity-onset diabetes of the young (MODY). Over 800 different mutations in GCK have been reported in the Human Gene Mutation Database, the vast majority of which result in MODY type 2. The missense mutation p.Leu122Val is listed in that database...

journal_title：Pediatric diabetes

authors： Hunter JD,Staton H,Constantacos C,Walsh ET,Crudo DF

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Mild hypoglycemia is commonly observed in children treated for type 1 diabetes mellitus (T1DM). Hypoglycemia disturbs cognition and learning. OBJECTIVE:To describe how and to what extent hypoglycemia in young children with T1DM is detected in everyday life. To learn how parents and caregivers treat hypoglyc...

journal_title：Pediatric diabetes

authors： Sundberg F,Forsander G

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The current study examined how a comprehensive set of variables from multiple domains, including at the adolescent and family level, were predictive of glycemic control in adolescents with type 1 diabetes (T1D). METHODS:Participants included 100 adolescents with T1D ages 10-16 yrs and their parents. Particip...

journal_title：Pediatric diabetes

authors： Agarwal S,Jawad AF,Miller VA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Few diabetes-specific quality of life (QOL) tools are available for young children. OBJECTIVES:To design and evaluate, a new age-specific QOL questionnaire and its associations with treatment regimens and metabolic control. METHODS:Clinical, demographic data and centrally analyzed HbA1c were collected on 1...

journal_title：Pediatric diabetes

authors： Hoey H,Lange K,Skinner TC,Mortensen H,Swift P,Aanstoot HJ,Castaňo L,Cameron F,de Beaufort C,Hvidoere International Study Group.

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To describe insulin pump use by youth since introduction of universal funding in Ontario, Canada and to explore the relationship between pump use and pediatric diabetes center characteristics and the relationship between discontinuation and center and patient characteristics. RESEARCH DESIGN AND METHODS:Obse...

journal_title：Pediatric diabetes

authors： Shulman R,Stukel TA,Miller FA,Newman A,Daneman D,Guttmann A

更新日期：2017-02-01 00:00:00

abstract：:Neonatal diabetes mellitus is a rare (1/400 000 newborns) but potentially devastating condition, which may be transient or permanent; typical symptoms occur within the first 4 wk of life. The transient form is a developmental insulin production disorder that resolves postnatally. Fifty to 60% of cases can be seen as t...

journal_title：Pediatric diabetes

authors： Goksen D,Darcan S,Coker M,Aksu G,Yildiz B,Kara S,Kültürsay N

更新日期：2006-10-01 00:00:00

abstract：:Families of children with diabetes increasingly obtain health information from a variety of sources. Doctor-patient relationships have accordingly become more fluid and dynamic with input from other parties. These outside parties include representatives from the diabetes health care industry-industry third parties (IT...

journal_title：Pediatric diabetes

authors： Cameron FJ,Moore B,Gillam L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Previous studies have reported that handgrip strength, a measure of muscular fitness, is associated with insulin resistance in children and adolescents, with conflicting results. Further, no studies have examined the association between handgrip strength with 2-hour glucose levels. OBJECTIVE:We tested the a...

journal_title：Pediatric diabetes

authors： Li S,Zhang R,Pan G,Zheng L,Li C

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Diabetes ketoacidosis (DKA) is a common presentation and complication of type 1 diabetes (T1D). While intravenous insulin is typically used to treat acute metabolic abnormalities, the transition from intravenous to subcutaneous treatment can present a challenge. We hypothesize that co-administration of glarg...

journal_title：Pediatric diabetes

authors： Harrison VS,Rustico S,Palladino AA,Ferrara C,Hawkes CP

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:To examine the whole postischemic hyperemic response period in Hispanic children and adults with and without type 2 diabetes mellitus (T2DM) and offer insight into the potential adaptive mechanisms involved in the arterial response to disturbances in vascular homeostasis. METHODS:Ninety-eight adults and 124...

journal_title：Pediatric diabetes

authors： Wajcberg E,Thoppil N,Patel S,Fernandez M,Hale D,DeFronzo R,Cersosimo E

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Insulin deficiency with glucagon excess leads to the release of ketone bodies (KBs) by the liver and excretion in the urine. So far, only KB monitoring in urine has been used during assessment of children with diabetes. Currently used nitroprusside strips for urine KB detection react only with acetoacetate (...

journal_title：Pediatric diabetes

authors： Prisco F,Picardi A,Iafusco D,Lorini R,Minicucci L,Martinucci ME,Toni S,Cerutti F,Rabbone I,Buzzetti R,Crino A,Pozzilli P

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to investigate the importance of trust in researchers and other reasons that participating parents, former participants, and non-participants had for participating, or not participating, in a longitudinal cohort study on prediction and development of diabetes in children. STUD...

journal_title：Pediatric diabetes

authors： Helgesson G,Hansson MG,Ludvigsson J,Swartling U

更新日期：2009-09-01 00:00:00

abstract：:The prevalence of youth-onset type 2 diabetes is increasing worldwide in parallel with the obesity epidemic. In India, the age at onset of type 2 diabetes had traditionally been a decade or two earlier compared with the western population. Hence, it is not surprising that the prevalence of youth-onset type 2 diabetes ...

journal_title：Pediatric diabetes

authors： Mohan V,Jaydip R,Deepa R

更新日期：2007-12-01 00:00:00