A multivariate model exploring the predictive value of demographic, adolescent, and family factors on glycemic control in adolescents with type 1 diabetes.

Abstract:

OBJECTIVE:The current study examined how a comprehensive set of variables from multiple domains, including at the adolescent and family level, were predictive of glycemic control in adolescents with type 1 diabetes (T1D). METHODS:Participants included 100 adolescents with T1D ages 10-16 yrs and their parents. Participants were enrolled in a longitudinal study about youth decision-making involvement in chronic illness management of which the baseline data were available for analysis. Bivariate associations with glycemic control (HbA1C) were tested. Hierarchical linear regression was implemented to inform the predictive model. RESULTS:In bivariate analyses, race, family structure, household income, insulin regimen, adolescent-reported adherence to diabetes self-management, cognitive development, adolescent responsibility for T1D management, and parent behavior during the illness management discussion were associated with HbA1c. In the multivariate model, the only significant predictors of HbA1c were race and insulin regimen, accounting for 17% of the variance. Caucasians had better glycemic control than other racial groups. Participants using pre-mixed insulin therapy and basal-bolus insulin had worse glycemic control than those on insulin pumps. CONCLUSIONS:This study shows that despite associations of adolescent and family-level variables with glycemic control at the bivariate level, only race and insulin regimen are predictive of glycemic control in hierarchical multivariate analyses. This model offers an alternative way to examine the relationship of demographic and psychosocial factors on glycemic control in adolescents with T1D.

journal_name

Pediatr Diabetes

journal_title

Pediatric diabetes

authors

Agarwal S,Jawad AF,Miller VA

doi

10.1111/pedi.12331

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

500-508

issue

7

eissn

1399-543X

issn

1399-5448

journal_volume

17

pub_type

杂志文章
  • Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

    abstract:BACKGROUND:Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12222

    authors: Skärstrand H,Vaziri-Sani F,Delli AJ,Törn C,Elding Larsson H,Ivarsson S,Agardh D,Lernmark Å,Skåne study group.

    更新日期:2015-12-01 00:00:00

  • Permanent neonatal diabetes with arthrogryposis multiplex congenita and neurogenic bladder - a new syndrome?

    abstract::Neonatal diabetes mellitus is a rare (1/400 000 newborns) but potentially devastating condition, which may be transient or permanent; typical symptoms occur within the first 4 wk of life. The transient form is a developmental insulin production disorder that resolves postnatally. Fifty to 60% of cases can be seen as t...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2006.00201.x

    authors: Goksen D,Darcan S,Coker M,Aksu G,Yildiz B,Kara S,Kültürsay N

    更新日期:2006-10-01 00:00:00

  • Long-term metabolic consequences of being born small for gestational age.

    abstract::This review highlights the evidence of linking small for gestational age (SGA) with metabolic/cardiovascular disturbances (dysmetabolic syndrome) in later life. The metabolic and cardiovascular complications associated with in utero undernutrition have been identified during the past 10 yr. Reduced fetal growth is ind...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-543X.2004.00057.x

    authors: Levy-Marchal C,Jaquet D

    更新日期:2004-09-01 00:00:00

  • Longitudinal assessment of hippocampus structure in children with type 1 diabetes.

    abstract::The extant literature finds that children with type 1 diabetes mellitus (T1D) experience mild cognitive alterations compared to healthy age-matched controls. The neural basis of these cognitive differences is unclear but may relate in part to the effects of dysglycemia on the developing brain. We investigated longitud...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12683

    authors: Foland-Ross LC,Reiss AL,Mazaika PK,Mauras N,Weinzimer SA,Aye T,Tansey MJ,White NH,Diabetes Research in Children Network (DirecNet).

    更新日期:2018-04-19 00:00:00

  • A 5-yr follow-up nerve conduction study for the detection of subclinical diabetic neuropathy in children with newly diagnosed insulin-dependent diabetes mellitus.

    abstract:OBJECTIVE:To investigate the changes of peripheral nerve conduction in children with insulin-dependent diabetes mellitus (IDDM) prospectively from diagnosis and to know how those results were related to clinical risk factors. METHODS:A total of 37 patients (14 males and 23 females) aged 3-19 yr (mean 12.0 ± 3.7) with ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2009.00636.x

    authors: Lee SS,Han HS,Kim H

    更新日期:2010-12-01 00:00:00

  • The pancreatic ductal epithelium serves as a potential pool of progenitor cells.

    abstract::With the increasing success of islet transplantation, beta-cell replacement therapy has had renewed interest. To make such a therapy available to more than a few of the thousands of patients with diabetes, new sources of insulin-producing cells must become readily available. The most promising sources are stem cells, ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-543X.2004.00075.x

    authors: Bonner-Weir S,Toschi E,Inada A,Reitz P,Fonseca SY,Aye T,Sharma A

    更新日期:2004-01-01 00:00:00

  • HLA-class II and class I genotypes among Japanese children with Type 1A diabetes and their families.

    abstract:OBJECTIVE:To determine the HLA-DRB1, DQB1, DPB1, A, C, and B genotypes among Japanese children with autoimmune type 1 diabetes. METHODS:Four hundred and thirty patients who were GADAb and/or IA-2Ab-positive (Type 1A) were recruited from 37 medical centers as part of a nationwide multicenter collaborative study. DNA sa...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1399-5448.2011.00833.x

    authors: Sugihara S,Ogata T,Kawamura T,Urakami T,Takemoto K,Kikuchi N,Takubo N,Tsubouchi K,Horikawa R,Kobayashi K,Kasahara Y,Kikuchi T,Koike A,Mochizuki T,Minamitani K,Takaya R,Mochizuki H,Nishii A,Yokota I,Kizaki Z,Mori T

    更新日期:2012-02-01 00:00:00

  • Gender differences in the relationship between parental report of self-regulation skills and adolescents' management of type 1 diabetes.

    abstract:OBJECTIVE:To examine the extent to which self-regulation skills of adolescents with type 1 diabetes (T1D), including executive functioning and emotion regulation, relate to treatment adherence and glycemic control. METHOD:Participants were 109 adolescents aged 12-18 yr with TID and their primary caregiver who attended...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2010.00692.x

    authors: Graziano PA,Geffken GR,Williams LB,Lewin AB,Duke DC,Storch EA,Silverstein JH

    更新日期:2011-06-01 00:00:00

  • Type 1 diabetes incidence and prevalence trends in a cohort of Canadian children and youth.

    abstract:BACKGROUND AND OBJECTIVE:Incidence rates of type 1 diabetes have long been on the rise across the globe, however, there is emerging evidence that the rate of rise may be slowing. The objective of this study was to describe trends in the incidence and prevalence of type 1 diabetes in a sample of Canadian children and yo...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12566

    authors: Fox DA,Islam N,Sutherland J,Reimer K,Amed S

    更新日期:2018-05-01 00:00:00

  • Measuring psychological flexibility in youth with type 1 diabetes.

    abstract:OBJECTIVE:To determine reliability and validity of the acceptance and action diabetes questionnaire (AADQ) and the diabetes acceptance and action scale for children and adolescents (DAAS), measures of diabetes-specific psychological flexibility. METHODS:One hundred and eight-one youth with type 1 diabetes completed th...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.13110

    authors: Berlin KS,Keenan ME,Cook JL,Ankney RL,Klages KL,Semenkovich K,Rybak TM,Banks GG,Alemzadeh R,Eddington AR

    更新日期:2020-12-01 00:00:00

  • Acute chorea and type 1 diabetes mellitus: clinical and neuroimaging findings.

    abstract::The association of type 1 diabetes mellitus (T1DM) and acute chorea is rare. We report an 8-yr-old boy with T1DM who developed acute hemichorea-hemiballism of the right arm in whom magnetic resonance imaging (MRI) of the brain revealed hyperintense signal in putamen and considerable atrophy and focal area of gliosis i...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-5448.2012.00856.x

    authors: Alves C,Sampaio S,Barbosa V,Machado M

    更新日期:2012-09-01 00:00:00

  • Self-management among pre-teen and adolescent diabetes device users.

    abstract:OBJECTIVE:Despite increased diabetes device use, few adolescents with type 1 diabetes (T1D) meet glycemic targets. We examine associations between utilization of insulin pumps and continuous glucose monitoring (CGM) and glycemic control. RESEARCH DESIGN AND METHODS:This prospective cohort study included 80 youths (10-...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.13131

    authors: Faulds ER,Hoffman RP,Grey M,Tan A,Tubbs-Cooley H,Militello LK,Happ MB

    更新日期:2020-12-01 00:00:00

  • Management of cardiovascular disease risk in teens with type 1 diabetes: Perspectives of teens with and without dyslipidemia and parents.

    abstract::Hypertension and dyslipidemia are often suboptimally managed in teens with type 1 diabetes (T1D). Teen and parent perspectives on hypertension and dyslipidemia management need further study to enhance the development of cardiovascular disease (CVD) risk factor management plans. We sought to describe barriers to and st...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12771

    authors: Katz ML,Guo Z,Cheema A,Laffel LM

    更新日期:2019-03-01 00:00:00

  • Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.

    abstract:BACKGROUND:We set out to explore associations between the stool bacteriome profiles and early-onset islet autoimmunity, taking into account the interactions with the virus component of the microbiome. METHODS:Serial stool samples were longitudinally collected from 18 infants and toddlers with early-onset islet autoimm...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,多中心研究

    doi:10.1111/pedi.12468

    authors: Cinek O,Kramna L,Lin J,Oikarinen S,Kolarova K,Ilonen J,Simell O,Veijola R,Autio R,Hyöty H

    更新日期:2017-11-01 00:00:00

  • Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations.

    abstract:BACKGROUND:Dominant inactivating mutations in HNF1A and HNF4A have been described to cause hyperinsulinism (HI) before evolving to diabetes. However, information available in the literature regarding the clinical phenotype is limited. OBJECTIVE:To report the prevalence of HNF1A and HNF4A mutations in a large cohort of...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12655

    authors: Tung JY,Boodhansingh K,Stanley CA,De León DD

    更新日期:2018-08-01 00:00:00

  • Alterations in left ventricular, left atrial, and right ventricular structure and function to cardiovascular risk factors in adolescents with type 2 diabetes participating in the TODAY clinical trial.

    abstract::Data on cardiovascular disease (CVD) risk in adolescents with type 2 diabetes (T2D) are limited. Echocardiography was performed in the last year of the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial (median 4½ yr from diagnosis of T2D, average age 18 yr), including MMode and 2D m...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/pedi.12119

    authors: Levitt Katz L,Gidding SS,Bacha F,Hirst K,McKay S,Pyle L,Lima JA,TODAY Study Group.

    更新日期:2015-02-01 00:00:00

  • Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring--the ABIS study.

    abstract:OBJECTIVE:To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. METHODS:Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2009.00563.x

    authors: Brekke HK,Ludvigsson J

    更新日期:2010-06-01 00:00:00

  • Partial remission in Brazilian children and adolescents with type 1 diabetes. Association with a haplotype of class II human leukocyte antigen and synthesis of autoantibodies.

    abstract:OBJECTIVE:Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) ≤ 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. METHODS:We analyzed the preval...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12999

    authors: Camilo DS,Pradella F,Paulino MF,Baracat ECE,Marini SH,Guerra G Jr,Pavin EJ,Parisi C,Longhini ALF,Marques SB,Guariento EG,Lieber SR,Macedo CF,Gama E Silva L,Farias AS,Santos LMB,Volpini WMG

    更新日期:2020-06-01 00:00:00

  • Inflammatory cytokine, growth factor and counterregulatory responses to exercise in children with type 1 diabetes and healthy controls.

    abstract::In children with type 1 diabetes (T1DM), altered adaptive responses to exercise (secretion of growth factors, inflammatory cytokines, and glucoregulatory mediators) may have potential implications in growth and development, early onset of disease complications, and incidence of hypoglycemia. We therefore measured a br...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-543X.2006.00140.x

    authors: Galassetti PR,Iwanaga K,Crisostomo M,Zaldivar FP,Larson J,Pescatello A

    更新日期:2006-02-01 00:00:00

  • Discontinuation of insulin pump treatment in children, adolescents, and young adults. A multicenter analysis based on the DPV database in Germany and Austria.

    abstract:BACKGROUND:Insulin pump therapy is well established in the treatment of children and adolescents with type 1 diabetes. Most studies focus on outcome parameters like hemoglobin A1c (HbA1c), hypoglycemia, and quality of life, whereas few reports address patients who discontinue pump therapy. OBJECTIVE:This survey focuse...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2009.00546.x

    authors: Hofer SE,Heidtmann B,Raile K,Fröhlich-Reiterer E,Lilienthal E,Berghaeuser MA,Holl RW,DPV-Science-Initiative and the German working group for insulin pump treatment in pediatric patients.

    更新日期:2010-03-01 00:00:00

  • Premeal insulin decreases arterial stiffness in children with type 1 diabetes.

    abstract:OBJECTIVE:To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI75 ) were used to measure arterial stiffness...

    journal_title:Pediatric diabetes

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/pedi.12389

    authors: Meehan CS,Kethireddy PL,Ashcraft JK,Shuster JJ,Haller MJ

    更新日期:2017-06-01 00:00:00

  • A novel 3' untranslated region mutation in the SLC29A3 gene associated with pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus syndrome.

    abstract:BACKGROUND:Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) is one of the rare H syndrome diseases mainly characterized by hyperpigmentation, hypertrichosis, sensorineural hearing loss, cardiac complications, developmental delay, and diabetes mellitus (DM). Mutations in the coding...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12839

    authors: Riachi M,Bas F,Darendeliler F,Hussain K

    更新日期:2019-06-01 00:00:00

  • Two's company, is three a crowd? Ethical cognition in decision making and the role of industry third parties in pediatric diabetes care.

    abstract::Families of children with diabetes increasingly obtain health information from a variety of sources. Doctor-patient relationships have accordingly become more fluid and dynamic with input from other parties. These outside parties include representatives from the diabetes health care industry-industry third parties (IT...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,评审

    doi:10.1111/pedi.12786

    authors: Cameron FJ,Moore B,Gillam L

    更新日期:2019-02-01 00:00:00

  • Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth.

    abstract:OBJECTIVE:It is unknown whether measurement site of visceral adipose tissue (VAT) influences the relationship between VAT and associated health risk in youth and if so, whether ethnic differences exist in this relationship. We examined the influence of the measurement site of VAT on the relationships between VAT and me...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2010.00705.x

    authors: Lee S,Kuk JL,Kim Y,Arslanian SA

    更新日期:2011-05-01 00:00:00

  • Corrigendum.

    abstract::In connection with the article entitled "A randomized trial comparing the rate of hypoglycemia – assessed using continuous glucose monitoring – in 125 preschool children with type 1 diabetes treated with insulin glargine or NPH insulin (the PRESCHOOL study)" which appeared in [1], we wish to bring the following correc...

    journal_title:Pediatric diabetes

    pub_type: 已发布勘误

    doi:10.1111/pedi.12207

    authors:

    更新日期:2015-09-01 00:00:00

  • Diabetes knowledge in adolescents with type 1 diabetes and their parents and glycemic control.

    abstract:OBJECTIVE:To evaluate diabetes knowledge and skills (DKS) in adolescents (>10 year) with type 1 diabetes (T1D) and their parents, and its effect on glycemic control. METHODS:A ready-to-use program and a standardized questionnaire comprising 50 true-false questions based on this program, were elaborated by a National C...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,多中心研究

    doi:10.1111/pedi.12458

    authors: Martin D,Elie C,Dossier C,Godot C,Gagnayre R,Choleau C,Cahané M,Robert JJ,AJD Study Group.

    更新日期:2017-11-01 00:00:00

  • Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus in a randomized, prospective comparison.

    abstract:OBJECTIVE:Effects of pump treatment vs. four times daily injections were explored in children with diabetes with regard to quality of life and impact of disease as well as adverse effects and parameters of metabolic control. METHODS:An open, parallel, randomized controlled prospective comparative study lasting 14 mont...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-5448.2008.00396.x

    authors: Nuboer R,Borsboom GJ,Zoethout JA,Koot HM,Bruining J

    更新日期:2008-07-28 00:00:00

  • Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults.

    abstract:BACKGROUND:Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. SUBJECTS AND METHODS:We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12883

    authors: RISE Consortium.

    更新日期:2019-11-01 00:00:00

  • Screening for cystic fibrosis-related diabetes and prediabetes: Evaluating 1,5-anhydroglucitol, fructosamine, glycated albumin, and hemoglobin A1c.

    abstract:OBJECTIVE:Dysglycemia is prevalent in cystic fibrosis (CF) but screening with annual oral glucose tolerance tests (OGTT) can be burdensome. We investigated alternate glycemic markers-hemoglobin A1c (HbA1c), 1,5-anhydroglucitol (1,5AG), fructosamine (FA), and glycated albumin (GA)-as screening tests for CF-related diabe...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12914

    authors: Tommerdahl KL,Brinton JT,Vigers T,Nadeau KJ,Zeitler PS,Chan CL

    更新日期:2019-12-01 00:00:00

  • Glucose metabolism in children and adolescents: Population-based reference values and comparisons to children and adolescents enrolled in obesity treatment.

    abstract:BACKGROUND:Alterations in glucose metabolism that lead to the development of metabolic and cardiovascular disease may begin already in childhood. OBJECTIVE:This study aims to generate pediatric age and sex-specific reference values for fasting concentrations of glucose, hemoglobin A1c (HbA1c), insulin, C-peptide, and ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12859

    authors: Frithioff-Bøjsøe C,Lund MAV,Kloppenborg JT,Nielsen TTH,Fonvig CE,Lausten-Thomsen U,Hedley PL,Hansen T,Pedersen OB,Christiansen M,Baker JL,Hansen T,Holm JC

    更新日期:2019-08-01 00:00:00