Pathogenicity of a glucokinase gene mutation and description of its clinical phenotype.

abstract：AIMS:We aimed to analyze the relationship between epilepsy and glutamic acid decarboxylase autoantibodies (GADA) in patients with type 1 diabetes mellitus (T1DM) and the impact of GADA on demographic, clinical, and metabolic data in T1DM patients with epilepsy. METHODS:We searched for patients with T1DM ≤20 years and ...

journal_title：Pediatric diabetes

authors： de Sousa GJ,Tittel SR,Häusler M,Holterhus PM,Berger G,Holder M,Kamrath C,Golembowski S,Herrlinger S,Holl RW

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity. METHODS:In an...

journal_title：Pediatric diabetes

authors： Elding Larsson H,Lundgren M,Jonsdottir B,Cuthbertson D,Krischer J,DiAPREV-IT Study Group.

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:We set out to explore associations between the stool bacteriome profiles and early-onset islet autoimmunity, taking into account the interactions with the virus component of the microbiome. METHODS:Serial stool samples were longitudinally collected from 18 infants and toddlers with early-onset islet autoimm...

journal_title：Pediatric diabetes

authors： Cinek O,Kramna L,Lin J,Oikarinen S,Kolarova K,Ilonen J,Simell O,Veijola R,Autio R,Hyöty H

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To examine the extent to which self-regulation skills of adolescents with type 1 diabetes (T1D), including executive functioning and emotion regulation, relate to treatment adherence and glycemic control. METHOD:Participants were 109 adolescents aged 12-18 yr with TID and their primary caregiver who attended...

journal_title：Pediatric diabetes

authors： Graziano PA,Geffken GR,Williams LB,Lewin AB,Duke DC,Storch EA,Silverstein JH

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Hypoglycemia is the most common and severe complication of insulin treatment during the management of type 1 diabetes mellitus (T1DM). Despite its importance, there is a lack of data about the efficacy and superiority of the carbohydrate sources used in hypoglycemia management in children and adolescents. O...

journal_title：Pediatric diabetes

authors： Erbas IM,Abaci A,Anik A,Simsek E,Tuhan HU,Kocyigit C,Yıldız M,Dundar BN,Bober E,Catli G

更新日期：2020-07-13 00:00:00

abstract：OBJECTIVE:Despite increased diabetes device use, few adolescents with type 1 diabetes (T1D) meet glycemic targets. We examine associations between utilization of insulin pumps and continuous glucose monitoring (CGM) and glycemic control. RESEARCH DESIGN AND METHODS:This prospective cohort study included 80 youths (10-...

journal_title：Pediatric diabetes

authors： Faulds ER,Hoffman RP,Grey M,Tan A,Tubbs-Cooley H,Militello LK,Happ MB

更新日期：2020-12-01 00:00:00

abstract：AIMS:Intravenous glucose tolerance testing (IVGTT) is a common test of β-cell function in which a glucose load is administered and insulin and/or C-peptide responses are monitored. Since the first IVGTT may be more stressful and stress may alter β-cell secretion or hepatic insulin extraction, we asked whether there was...

journal_title：Pediatric diabetes

authors： Ismail HM,White KS,Krischer JP,Chase HP,Cuthbertson D,Palmer JP,DPT-1 Study Group.

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:The main objective of this work was to follow-up the development of diabetic neuropathy (DN) and its severity in patients with type 1 diabetes over 10 yr. Our intention was also to observe risk factor changes and verify which of them influence the development of neuropathy. The other objective was longitudina...

journal_title：Pediatric diabetes

authors： Hajas G,Kissova V,Tirpakova A

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and carotid intima-medial thickness (CIMT) in Chinese youth and adolescents with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Ninety-eight subjects aged 10-24 yr with newly-diagnosed T2DM...

journal_title：Pediatric diabetes

authors： Li X,Deng YP,Yang M,Wu YW,Sun SX,Sun JZ

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Children born small-for-gestational-age (SGA) who experience rapid postnatal catch-up in weight are at risk for central adiposity and hyperinsulinemia. OBJECTIVES:To study the effects of prepubertal metformin intervention over 24 months on the body composition and endocrine-metabolic profile of catch-up SGA...

journal_title：Pediatric diabetes

authors： Díaz M,Bassols J,López-Bermejo A,de Zegher F,Ibáñez L

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Mild hypoglycemia is commonly observed in children treated for type 1 diabetes mellitus (T1DM). Hypoglycemia disturbs cognition and learning. OBJECTIVE:To describe how and to what extent hypoglycemia in young children with T1DM is detected in everyday life. To learn how parents and caregivers treat hypoglyc...

journal_title：Pediatric diabetes

authors： Sundberg F,Forsander G

更新日期：2014-02-01 00:00:00

abstract：AIM:To explore racial differences in adiponectin, and leptin and their relationship with islet autoimmunity in children with new-onset type 1 diabetes (T1D). METHODS:Medical records were reviewed from a cohort of new-onset clinically diagnosed T1D subjects matched by race, age, gender, and year of diagnosis. Sera were...

journal_title：Pediatric diabetes

authors： Hecht Baldauff N,Tfayli H,Dong W,Arena VC,Gurtunca N,Pietropaolo M,Becker DJ,Libman IM

更新日期：2016-06-01 00:00:00

abstract：:This study aimed to analyse the impact of the disease and treatment on health-related quality of life (HRQOL) in intensively treated young patients with diabetes. Our main hypothesis was that metabolic control, gender, age and socio-economic status predict HRQOL. All children and adolescents (n = 400, 191 girls) and p...

journal_title：Pediatric diabetes

authors： Hanberger L,Ludvigsson J,Nordfeldt S

更新日期：2009-09-01 00:00:00

abstract：:Beta cell replacement is a valid alternative to exogenous insulin injections to treat type 1 diabetic patients. The rate of success obtained after whole-pancreas transplantation, performed alone or in combination with kidney, and, as shown recently, by islet transplantation, justifies optimism and sets the stage for a...

journal_title：Pediatric diabetes

authors： Bottino R,Balamurugan AN,Giannoukakis N,Trucco M

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:To describe insulin pump use by youth since introduction of universal funding in Ontario, Canada and to explore the relationship between pump use and pediatric diabetes center characteristics and the relationship between discontinuation and center and patient characteristics. RESEARCH DESIGN AND METHODS:Obse...

journal_title：Pediatric diabetes

authors： Shulman R,Stukel TA,Miller FA,Newman A,Daneman D,Guttmann A

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Regulatory T cells (Tregs) play an important role in maintaining tolerance to self-antigens. Defects in the frequency and function of polyclonal Tregs have been reported in type 1 diabetes (T1D). However, characteristics of proinsulin (PI)-specific Tregs in human T1D have not yet been explored...

journal_title：Pediatric diabetes

authors： Paul M,Dayal D,Bhansali A,Sachdeva N

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Type 2 Diabetes (T2DM) is increasing in childhood especially among females and South-Asians. Our objective was to report outcomes from a national cohort of children and adolescents with T2DM 1 year following diagnosis. METHODS:Clinician reported, 1-year follow-up of a cohort of children (<17 years...

journal_title：Pediatric diabetes

authors： Candler TP,Mahmoud O,Lynn RM,Majbar AA,Barrett TG,Shield JPH

更新日期：2018-12-01 00:00:00

abstract：:Regulatory T cells (Tregs) are responsible for the maintenance of peripheral tolerance. Animal studies have shown that administration of Tregs can prevent type 1 diabetes (DM1). Several clinical trials attempted to induce Tregs with various agents, and thus provide long-term tolerance of β cells in DM1. Nevertheless, ...

journal_title：Pediatric diabetes

authors： Marek-Trzonkowska N,Myśliwec M,Siebert J,Trzonkowski P

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Teens with type 1 diabetes (T1D) experience increased sleep disturbances, which have been linked to problems with adherence and glycemic control. As such, sleep represents a novel target to improve outcomes in teens. OBJECTIVE:To evaluate the feasibility, acceptability, and preliminary efficacy of a sleep-p...

journal_title：Pediatric diabetes

authors： Jaser SS,Hamburger ER,Bergner EM,Williams R,Slaughter JC,Simmons JH,Malow BA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the effectiveness of directly integrating self-monitoring blood glucose (BG) information with insulin pump therapy on overall glycemic control. METHODS:In this randomized trial, 34 youth with type 1 diabetes using insulin pump therapy were trained on the use of the ...

journal_title：Pediatric diabetes

authors： Cobry E,Chase HP,Burdick P,McFann K,Yetzer H,Scrimgeour L

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) ≤ 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. METHODS:We analyzed the preval...

journal_title：Pediatric diabetes

authors： Camilo DS,Pradella F,Paulino MF,Baracat ECE,Marini SH,Guerra G Jr,Pavin EJ,Parisi C,Longhini ALF,Marques SB,Guariento EG,Lieber SR,Macedo CF,Gama E Silva L,Farias AS,Santos LMB,Volpini WMG

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be assoc...

journal_title：Pediatric diabetes

authors： Bjornstad P,Cree-Green M,Baumgartner A,Coe G,Reyes YG,Schäfer M,Pyle L,Regensteiner JG,Reusch JE,Nadeau KJ

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:It is unknown whether measurement site of visceral adipose tissue (VAT) influences the relationship between VAT and associated health risk in youth and if so, whether ethnic differences exist in this relationship. We examined the influence of the measurement site of VAT on the relationships between VAT and me...

journal_title：Pediatric diabetes

authors： Lee S,Kuk JL,Kim Y,Arslanian SA

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Few diabetes-specific quality of life (QOL) tools are available for young children. OBJECTIVES:To design and evaluate, a new age-specific QOL questionnaire and its associations with treatment regimens and metabolic control. METHODS:Clinical, demographic data and centrally analyzed HbA1c were collected on 1...

journal_title：Pediatric diabetes

authors： Hoey H,Lange K,Skinner TC,Mortensen H,Swift P,Aanstoot HJ,Castaňo L,Cameron F,de Beaufort C,Hvidoere International Study Group.

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Children who inject insulin need clear guidelines as to the length of needle best for them. We studied the distance from surface to muscle in children in order to make needle choices which are evidence-based. METHODS:One hundred one children with type 1 diabetes were divided into three groups according to a...

journal_title：Pediatric diabetes

authors： Lo Presti D,Ingegnosi C,Strauss K

更新日期：2012-11-01 00:00:00

abstract：:Although it is known that the incidence of type 1 diabetes mellitus (DM) in childhood is progressively increasing, it is less clear whether the presentation of newly diagnosed DM is changing. The aim of this study was to establish whether any biochemical or clinical presentation parameters have altered over time. A re...

journal_title：Pediatric diabetes

authors： Jackson W,Hofman PL,Robinson EM,Elliot RB,Pilcher CC,Cutfield WS

更新日期：2001-12-01 00:00:00

abstract：:A subgroup of diabetic patients presents with features typical of type 1 diabetes, but over months to years has variable insulin requirements and develops features of type 2 diabetes. This subgroup is referred to as atypical diabetes mellitus (ADM). Over a span of 50 yr, reports on disease epidemiology, clinical chara...

journal_title：Pediatric diabetes

authors： Egede LE,Willi SM

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Care for children and youth with diabetes varies markedly around the world. We developed a standardized, reproducible measure that can be used to document and compare critical factors influencing treatment outcomes. METHODS:A questionnaire consisting of 36 multiple-choice questions covering m...

journal_title：Pediatric diabetes

authors： Ogle GD,Middlehurst AC,Silink M

更新日期：2016-08-01 00:00:00

abstract：:Type 1 diabetes is often accompanied with acute hypoinsulinemia that may theoretically inhibit the conversion of essential fatty acids to their longer-chain metabolites. Previously, we found significant reduction in plasma arachidonic (C20:4n-6) and docosahexaenoic (C22:6n-3) acid values in a group of diabetic childre...

journal_title：Pediatric diabetes

authors： Szabó E,Marosvölgyi T,Kozári A,Erhardt E,Soltész G,Decsi T

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:In the non-diabetic population, intramyocellular lipid (IMCL) accumulation is associated with obesity and poor muscle oxygen supply. IMCL levels are increased in type 1 diabetes, but their significance is less clear. METHODS:We studied a group of 16 prepubertal boys (age 6.4-9.9 yr) with type 1 diabetes and...

journal_title：Pediatric diabetes

authors： Ling AH,Donaghue KC,Howard NJ,Arrowsmith FE,Ward JA,Baur LA,Thompson CH

更新日期：2003-09-01 00:00:00