Handgrip strength is associated with insulin resistance and glucose metabolism in adolescents: Evidence from National Health and Nutrition Examination Survey 2011 to 2014.

Abstract:

BACKGROUND:Previous studies have reported that handgrip strength, a measure of muscular fitness, is associated with insulin resistance in children and adolescents, with conflicting results. Further, no studies have examined the association between handgrip strength with 2-hour glucose levels. OBJECTIVE:We tested the association of handgrip strength with measures of insulin resistance (fasting insulin and homeostasis model assessment of insulin resistance [HOMA-IR]) and glucose metabolism (fasting and 2-hour glucose levels) in adolescents from the National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. METHODS:The study included 959 participants aged 12 to 19 years who underwent a handgrip test and a glucose tolerance test. General linear models were used to examine the associations between handgrip strength and the outcome variables. RESULTS:After adjustment for age, race, sex, body mass index, and physical activities, handgrip strength was inversely associated with fasting insulin levels (P = .017) and HOMA-IR (P = .025). Although there was no association between handgrip strength and fasting glucose levels (P = .77), handgrip strength was inversely associated with 2-hour glucose levels (P < .0001). Insulin and 2-hour glucose levels decreased linearly as handgrip strength increased from the bottom quartile to the top quartile (P for trend: .045 for fasting insulin levels and .004 for 2-hour glucose levels). CONCLUSIONS:Muscular fitness, measured by handgrip strength, is associated with insulin resistance and glucose metabolism in adolescents, which indicates that increasing muscular fitness may have beneficial effects for early prevention of insulin resistance and type 2 diabetes.

journal_name

Pediatr Diabetes

journal_title

Pediatric diabetes

authors

Li S,Zhang R,Pan G,Zheng L,Li C

doi

10.1111/pedi.12596

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

375-380

issue

3

eissn

1399-543X

issn

1399-5448

journal_volume

19

pub_type

杂志文章
  • Measurement of diabetes stress in older children and adolescents with type 1 diabetes mellitus.

    abstract:OBJECTIVE:Studies indicate general psychological stress plays a role in the glycemic control of individuals with type 1 diabetes mellitus (T1DM). Disease-specific rather than general measures may be more closely related to measures of health outcomes. Therefore, measurement of diabetes-related stress is needed to advan...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2012.00894.x

    authors: Delamater AM,Patiño-Fernández AM,Smith KE,Bubb J

    更新日期:2013-02-01 00:00:00

  • Renal Doppler indices in diabetic children with insulin resistance syndrome.

    abstract::End-stage renal failure is still a leading cause of mortality among type 1 diabetes patients. Insulin resistance plays a larger role in type 1 diabetes disease process than is commonly recognized. Detection of diabetic nephropathy as early as possible currently offers the best chance of delaying or possibly preventing...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2009.00628.x

    authors: Abd El Ghaffar S,El Kaffas K,Hegazy R,Mostafa M

    更新日期:2010-11-01 00:00:00

  • Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes.

    abstract:OBJECTIVES:To assess the ability of reactive hyperemia-peripheral artery tonometry (RH-PAT) to serve as a surrogate marker of endothelial dysfunction in children with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:Forty-four children with T1D [age 14.6 +/- 2.7 yr; duration of diabetes 6.01 +/- 4 yr; range of diabe...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2007.00246.x

    authors: Haller MJ,Stein J,Shuster J,Theriaque D,Silverstein J,Schatz DA,Earing MG,Lerman A,Mahmud FH

    更新日期:2007-08-01 00:00:00

  • Monogenic diabetes: A single center experience from South India.

    abstract::Monogenic forms of diabetes in children are frequently misclassified as either type 1 diabetes or young-onset type 2 diabetes. There is a paucity of literature regarding pediatric monogenic diabetes in the Indian population. A retrospective analysis of case records of 37 children with monogenic diabetes who were diagn...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.13040

    authors: Lakshmanan NK,Pavithran PV,Bhavani N,Abraham N,Kumar H,Nair V,Menon U,Menon AS,Narayanan P,Lakshmi G

    更新日期:2021-02-01 00:00:00

  • Health-related quality of life in intensively treated young patients with type 1 diabetes.

    abstract::This study aimed to analyse the impact of the disease and treatment on health-related quality of life (HRQOL) in intensively treated young patients with diabetes. Our main hypothesis was that metabolic control, gender, age and socio-economic status predict HRQOL. All children and adolescents (n = 400, 191 girls) and p...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2008.00496.x

    authors: Hanberger L,Ludvigsson J,Nordfeldt S

    更新日期:2009-09-01 00:00:00

  • Pathogenicity of a glucokinase gene mutation and description of its clinical phenotype.

    abstract::Glucokinase gene (GCK) mutations comprise approximately 10% of cases of maturity-onset diabetes of the young (MODY). Over 800 different mutations in GCK have been reported in the Human Gene Mutation Database, the vast majority of which result in MODY type 2. The missense mutation p.Leu122Val is listed in that database...

    journal_title:Pediatric diabetes

    pub_type:

    doi:10.1111/pedi.13058

    authors: Hunter JD,Staton H,Constantacos C,Walsh ET,Crudo DF

    更新日期:2020-09-01 00:00:00

  • Sweet dreams?--nocturnal hypoglycemia in children with type 1 diabetes.

    abstract::Hypoglycemia is an inevitable consequence of the treatment of type 1 diabetes in childhood. Nocturnal hypoglycemia is often considered as merely the submerged part of this serious complication yet there are reasons to believe that hypoglycemia occurring during sleep may be different in physiological terms. Glucose hom...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1034/j.1399-5448.2002.30203.x

    authors: Matyka KA

    更新日期:2002-06-01 00:00:00

  • Changes in body composition after a 12-wk aerobic exercise program in obese boys.

    abstract:UNLABELLED:Previous studies have shown that vigorous aerobic training programs for obese children result in minimal weight changes, and concluded that they may not be beneficial. Weight change alone may not detect important beneficial changes in body composition associated with vigorous training in these children. Fift...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1034/j.1399-5448.2000.010202.x

    authors: DeStefano RA,Caprio S,Fahey JT,Tamborlane WV,Goldberg B

    更新日期:2000-06-01 00:00:00

  • Worldwide childhood type 1 diabetes incidence--what can we learn from epidemiology?

    abstract::Type 1 diabetes is the most common form of diabetes in most part of the world, although reliable data are still unavailable in several countries. Wide variations exist between the incidence rates of different populations, incidence is lowest in China and Venezuela (0.1 per 100,000 per year) and highest in Finland and ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2007.00280.x

    authors: Soltesz G,Patterson CC,Dahlquist G,EURODIAB Study Group.

    更新日期:2007-10-01 00:00:00

  • Aerobic exercise capacity in normal adolescents and those with type 1 diabetes mellitus.

    abstract:OBJECTIVE:To compare the aerobic exercise capacity between normal adolescents and those with type 1 diabetes mellitus (T1DM). METHODS:An experimental group with 72 individuals diagnosed with T1DM aged 9--20, time from diagnosis 4.9 +/- 3.6 yr, without clinical cardiopulmonary disease or anemia and a control group (C) ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-543X.2005.00120.x

    authors: Komatsu WR,Gabbay MA,Castro ML,Saraiva GL,Chacra AR,de Barros Neto TL,Dib SA

    更新日期:2005-09-01 00:00:00

  • Blood pressure measurement methodology and technology in the SWEET diabetes centers: An international SWEET database survey.

    abstract:INTRODUCTION:The accuracy of blood pressure (BP) measurement is a prerequisite for the reliable diagnosis and management of hypertension. OBJECTIVES:This survey evaluated the use of office and out-of-office BP measurements and the antihypertensive pharmacological treatment in expert pediatric diabetes centers. METHOD...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.13114

    authors: Gerasimidi-Vazeou A,Birkebaek NH,Iotova V,Cherubini V,Piccini B,Biester T,Stipancic G,Jefferies C,Maffeis C,Stergiou GS,SWEET study group.

    更新日期:2020-12-01 00:00:00

  • Care delivery in youth with type 2 diabetes - are we meeting clinical practice guidelines?

    abstract:BACKGROUND:Studies indicate high rates of treatment failure and early onset diabetes-related complications in youth-onset type 2 diabetes (T2D). We aim to describe the quality of care provided to children and youth with T2D. METHODS:This prospective cohort study used administrative datasets to describe individuals age...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12147

    authors: Amed S,Nuernberger K,Reimer K,Krueger H,Aydede SK,Ayers D,Collet JP

    更新日期:2014-11-01 00:00:00

  • Diabetes knowledge in adolescents with type 1 diabetes and their parents and glycemic control.

    abstract:OBJECTIVE:To evaluate diabetes knowledge and skills (DKS) in adolescents (>10 year) with type 1 diabetes (T1D) and their parents, and its effect on glycemic control. METHODS:A ready-to-use program and a standardized questionnaire comprising 50 true-false questions based on this program, were elaborated by a National C...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,多中心研究

    doi:10.1111/pedi.12458

    authors: Martin D,Elie C,Dossier C,Godot C,Gagnayre R,Choleau C,Cahané M,Robert JJ,AJD Study Group.

    更新日期:2017-11-01 00:00:00

  • Predictive hyperglycemia and hypoglycemia minimization: In-home double-blind randomized controlled evaluation in children and young adolescents.

    abstract:OBJECTIVE:The primary objective of this trial was to evaluate the feasibility, safety, and efficacy of a predictive hyperglycemia and hypoglycemia minimization (PHHM) system vs predictive low glucose suspension (PLGS) alone in optimizing overnight glucose control in children 6 to 14 years old. RESEARCH DESIGN AND METH...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/pedi.12603

    authors: Forlenza GP,Raghinaru D,Cameron F,Wayne Bequette B,Peter Chase H,Paul Wadwa R,Maahs DM,Jost E,Ly TT,Wilson DM,Norlander L,Ekhlaspour L,Min H,Clinton P,Njeru N,Lum JW,Kollman C,Beck RW,Buckingham BA,In-Home Closed-Lo

    更新日期:2018-05-01 00:00:00

  • Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations.

    abstract:BACKGROUND:Dominant inactivating mutations in HNF1A and HNF4A have been described to cause hyperinsulinism (HI) before evolving to diabetes. However, information available in the literature regarding the clinical phenotype is limited. OBJECTIVE:To report the prevalence of HNF1A and HNF4A mutations in a large cohort of...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12655

    authors: Tung JY,Boodhansingh K,Stanley CA,De León DD

    更新日期:2018-08-01 00:00:00

  • Exploring self-management characteristics in youths with type 1 diabetes mellitus: does membership in a glycemic control category matter?

    abstract:BACKGROUND:Hemoglobin A1c (HbA1c) levels have been shown to worsen in adolescence and be related to long-term diabetes complications. Although categories of diabetes control (e.g., ideal, satisfactory, and poor) are routinely used in clinical practice, research has not fully explored whether these categories meaningful...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2010.00638.x

    authors: Kichler JC,Kaugars AS,Ellis J,Alemzadeh R

    更新日期:2010-12-01 00:00:00

  • Comprehensive assessment of postischemic vascular reactivity in Hispanic children and adults with and without diabetes mellitus.

    abstract:BACKGROUND:To examine the whole postischemic hyperemic response period in Hispanic children and adults with and without type 2 diabetes mellitus (T2DM) and offer insight into the potential adaptive mechanisms involved in the arterial response to disturbances in vascular homeostasis. METHODS:Ninety-eight adults and 124...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2006.00209.x

    authors: Wajcberg E,Thoppil N,Patel S,Fernandez M,Hale D,DeFronzo R,Cersosimo E

    更新日期:2006-12-01 00:00:00

  • Self-management among pre-teen and adolescent diabetes device users.

    abstract:OBJECTIVE:Despite increased diabetes device use, few adolescents with type 1 diabetes (T1D) meet glycemic targets. We examine associations between utilization of insulin pumps and continuous glucose monitoring (CGM) and glycemic control. RESEARCH DESIGN AND METHODS:This prospective cohort study included 80 youths (10-...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.13131

    authors: Faulds ER,Hoffman RP,Grey M,Tan A,Tubbs-Cooley H,Militello LK,Happ MB

    更新日期:2020-12-01 00:00:00

  • Alterations in left ventricular, left atrial, and right ventricular structure and function to cardiovascular risk factors in adolescents with type 2 diabetes participating in the TODAY clinical trial.

    abstract::Data on cardiovascular disease (CVD) risk in adolescents with type 2 diabetes (T2D) are limited. Echocardiography was performed in the last year of the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial (median 4½ yr from diagnosis of T2D, average age 18 yr), including MMode and 2D m...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/pedi.12119

    authors: Levitt Katz L,Gidding SS,Bacha F,Hirst K,McKay S,Pyle L,Lima JA,TODAY Study Group.

    更新日期:2015-02-01 00:00:00

  • Comparison of the effectiveness of simple carbohydrates on hypoglycemic episodes in children and adolescents with type 1 diabetes mellitus: A randomized study in a diabetes camp.

    abstract:BACKGROUND:Hypoglycemia is the most common and severe complication of insulin treatment during the management of type 1 diabetes mellitus (T1DM). Despite its importance, there is a lack of data about the efficacy and superiority of the carbohydrate sources used in hypoglycemia management in children and adolescents. O...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.13077

    authors: Erbas IM,Abaci A,Anik A,Simsek E,Tuhan HU,Kocyigit C,Yıldız M,Dundar BN,Bober E,Catli G

    更新日期:2020-07-13 00:00:00

  • Bilirubin is an independent factor inversely associated with glycated hemoglobin level in pediatric patients with type 1 diabetes.

    abstract:OBJECTIVE:Bilirubin is a potent antioxidant, and serum total bilirubin (STB) concentrations correlate negatively with cardiovascular risk. In adult diabetic patients and in healthy adults, a negative correlation between STB and glycated hemoglobin (HbA1c) has been reported. We investigated whether there is such an asso...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12102

    authors: Mianowska B,Kamińska A,Fendler W,Szadkowska A,Młynarski W

    更新日期:2014-08-01 00:00:00

  • Evaluation of a portable ambulatory prototype for automated overnight closed-loop insulin delivery in young people with type 1 diabetes.

    abstract:OBJECTIVE:To evaluate an ambulatory, portable prototype, overnight automated closed-loop (CL) system and to explore optimal time of CL initiation. METHODS:We performed a randomized crossover study and compared automated overnight glucose control started at the time of an evening-meal or at bedtime. Eight young people ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-5448.2012.00903.x

    authors: Elleri D,Allen JM,Biagioni M,Kumareswaran K,Leelarathna L,Caldwell K,Nodale M,Wilinska ME,Acerini CL,Dunger DB,Hovorka R

    更新日期:2012-09-01 00:00:00

  • Type 2 diabetes in Asian Indian youth.

    abstract::The prevalence of youth-onset type 2 diabetes is increasing worldwide in parallel with the obesity epidemic. In India, the age at onset of type 2 diabetes had traditionally been a decade or two earlier compared with the western population. Hence, it is not surprising that the prevalence of youth-onset type 2 diabetes ...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-5448.2007.00328.x

    authors: Mohan V,Jaydip R,Deepa R

    更新日期:2007-12-01 00:00:00

  • Impact of deprivation, ethnicity, and insulin pump therapy on developmental trajectories of diabetes control in COB type 1 diabetes.

    abstract:BACKGROUND:There is marked variation in diabetes outcomes for children and adolescents across the UK. We used modelling techniques to examine the independent contributions of deprivation, ethnicity, insulin pump use, and health service use on HbA1c trajectories across adolescence. METHODS:Prospective data from a large...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12407

    authors: Viner RM,White B,Amin R,Peters C,Khanolkar A,Christie D,Hindmarsh PC

    更新日期:2017-08-01 00:00:00

  • Maternal diabetes distress is linked to maternal depressive symptoms and adolescents' glycemic control.

    abstract:OBJECTIVE:Mothers of youth with type 1 diabetes experience increased levels of stress and depression related to the burden of diabetes management, but the concept of diabetes distress, or distress linked specifically to diabetes and its management, has not been applied to mothers. The current study examined diabetes di...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12350

    authors: Rumburg TM,Lord JH,Savin KL,Jaser SS

    更新日期:2017-02-01 00:00:00

  • Accuracy assessment of bolus and basal rate delivery of different insulin pump systems used in insulin pump therapy of children and adolescents.

    abstract:BACKGROUND:Continuous subcutaneous insulin infusion (CSII) is commonly used in patients with diabetes. Accurate and reliable delivery by insulin pumps is essential for a safe and effective therapy, particularly when using small doses. In this study, accuracy of bolus and basal rate delivery of various available insulin...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12993

    authors: Ziegler R,Waldenmaier D,Kamecke U,Mende J,Haug C,Freckmann G

    更新日期:2020-06-01 00:00:00

  • Corrigendum.

    abstract::In connection with the article entitled "A randomized trial comparing the rate of hypoglycemia – assessed using continuous glucose monitoring – in 125 preschool children with type 1 diabetes treated with insulin glargine or NPH insulin (the PRESCHOOL study)" which appeared in [1], we wish to bring the following correc...

    journal_title:Pediatric diabetes

    pub_type: 已发布勘误

    doi:10.1111/pedi.12207

    authors:

    更新日期:2015-09-01 00:00:00

  • Safety and efficacy of autoantigen-specific therapy with 2 doses of alum-formulated glutamate decarboxylase in children with multiple islet autoantibodies and risk for type 1 diabetes: A randomized clinical trial.

    abstract:OBJECTIVE:Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was safe and affected progression to type 1 diabetes in children with islet autoimmunity. METHODS:In an...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/pedi.12611

    authors: Elding Larsson H,Lundgren M,Jonsdottir B,Cuthbertson D,Krischer J,DiAPREV-IT Study Group.

    更新日期:2018-05-01 00:00:00

  • Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation.

    abstract::Activating mutations in the K(ATP)-channel cause neonatal diabetes mellitus (NDM), and patients have been safely transitioned from insulin to sulfonylureas. We report a male infant with permanent NDM (PNDM), born to a PNDM mother. Blood glucose began to rise on day of life (DOL) 2, and sulfonylurea (glyburide) therapy...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/j.1399-5448.2009.00557.x

    authors: Wambach JA,Marshall BA,Koster JC,White NH,Nichols CG

    更新日期:2010-06-01 00:00:00

  • Glycemic control and self-rated health among ethnically diverse adolescents with type 1 diabetes.

    abstract:OBJECTIVE:Patient-reported outcomes have received increased attention as treatment outcomes and indicators of wellbeing. A1c has been criticized as lacking patient-centered relevance because individuals are often unaware of their A1c, and studies also often fail to show a benefit of intensive control on quality of life...

    journal_title:Pediatric diabetes

    pub_type: 杂志文章

    doi:10.1111/pedi.12928

    authors: Kane NS,Hoogendoorn CJ,Commissariat PV,Schulder TE,Gonzalez JS

    更新日期:2020-02-01 00:00:00